当前位置： SCI文献检索 > CANCER RESEARCH期刊下所有文献 > Ulcerative colitis-associated colorectal cancer arises in a field of short telomeres, senescence, and inflammation.

Ulcerative colitis-associated colorectal cancer arises in a field of short telomeres, senescence, and inflammation.

Abstract：

:Inflammation plays a role in the progression to cancer and it is linked to the presence of senescent cells. Ulcerative colitis (UC) is a chronic inflammatory disease that predisposes to colorectal cancer. Tumorigenesis in this setting is associated with telomere shortening that can be observed in the nondysplastic epithelium of UC patients with high-grade dysplasia (HGD) or cancer (UC progressors). We hypothesized that a preneoplastic field of inflammation, telomere shortening, and senescence underlies tumor progression in UC progressors. Multiple biopsies of varying histologic grade were collected along the colon of nine UC progressors and analyzed for telomere length, DNA damage, senescence, p53, p16, and chronic and acute inflammation. Twenty biopsies from four UC nonprogressors and twenty-one biopsies from control individuals without UC were also analyzed. Short telomeres and increased DNA damage, senescence, and infiltrating leukocytes were observed in biopsies located less than 10 cm from HGD or cancer. Low-grade dysplasia (LGD) had the shortest telomeres along with the highest levels of senescence and infiltrating leukocytes, whereas HGD biopsies showed the opposite pattern. The expression of p16 and p53 was low in nondysplastic biopsies but progressively increased in LGD and HGD. In addition, high levels of infiltrating leukocytes were associated with telomere shortening, senescence, and reduced p53 expression. These results suggest that dysplasia arises in a preneoplastic field of chronic inflammation, which leads to telomere shortening, DNA damage, and senescence. Our findings argue that senescence acts as a tumor suppressor mechanism that is abrogated during the transition from LGD to HGD in UC.

journal_name

Cancer Res

journal_title

Cancer research

authors

Risques RA,Lai LA,Himmetoglu C,Ebaee A,Li L,Feng Z,Bronner MP,Al-Lahham B,Kowdley KV,Lindor KD,Rabinovitch PS,Brentnall TA

doi

10.1158/0008-5472.CAN-10-1966

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

1669-79

issue

5

eissn

0008-5472

issn

1538-7445

pii

0008-5472.CAN-10-1966

journal_volume

71

pub_type

杂志文章

相关文献

CANCER RESEARCH文献大全
  • Increased expression of transforming growth factor beta isoforms and basic fibroblast growth factor in complex hyperplasia and adenocarcinoma of the endometrium: evidence for paracrine and autocrine action.

    abstract：:Endometrial carcinoma is associated with antecedent simple and complex hyperplasia, and the endometrium is a target tissue for the action of cytokines and growth factors. Transforming growth factor (TGF)-beta s are potent cellular growth and differentiation regulatory factors. Therefore, we investigated the potential ...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Gold LI,Saxena B,Mittal KR,Marmor M,Goswami S,Nactigal L,Korc M,Demopoulos RI

    更新日期：1994-05-01 00:00:00

  • Identification of the MEK1(F129L) activating mutation as a potential mechanism of acquired resistance to MEK inhibition in human cancers carrying the B-RafV600E mutation.

    abstract：:Although targeting the Ras/Raf/MEK pathway remains a promising anticancer strategy, mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase (MEK) inhibitors in clinical development are likely to be limited in their ability to produce durable clinical responses due to the emergence of acquired drug...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-10-4351

    authors： Wang H,Daouti S,Li WH,Wen Y,Rizzo C,Higgins B,Packman K,Rosen N,Boylan JF,Heimbrook D,Niu H

    更新日期：2011-08-15 00:00:00

  • Acidosis Acts through HSP90 in a PHD/VHL-Independent Manner to Promote HIF Function and Stem Cell Maintenance in Glioma.

    abstract：:Hypoxia is a common feature of solid tumors, which controls multiple aspects of cancer progression. One important function of hypoxia and the hypoxia-inducible factors (HIF) is the maintenance of cancer stem-like cells (CSC), a population of tumor cells that possess stem cell-like properties and drives tumor growth. A...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-15-2630

    authors： Filatova A,Seidel S,Böğürcü N,Gräf S,Garvalov BK,Acker T

    更新日期：2016-10-01 00:00:00

  • Cancer-Associated MORC2-Mutant M276I Regulates an hnRNPM-Mediated CD44 Splicing Switch to Promote Invasion and Metastasis in Triple-Negative Breast Cancer.

    abstract：:Triple-negative breast cancer (TNBC) is the most lethal subtype of breast cancer, with a high propensity for distant metastasis and limited treatment options, yet its molecular underpinnings remain largely unknown. Microrchidia family CW-type zinc finger 2 (MORC2) is a newly identified chromatin remodeling protein who...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-17-1394

    authors： Zhang FL,Cao JL,Xie HY,Sun R,Yang LF,Shao ZM,Li DQ

    更新日期：2018-10-15 00:00:00

  • The need for a search for a proximal pathogenic principle of human AIDS.

    abstract：:Some of the unexplained aspects of HIV/AIDS epidemiology, virology, and pathology (6, 13) may thus be due to a lack of knowledge of the basic virology of the virus complex and its pathological interaction with cells of the host. There may be no need to call upon anomalous immune responses, vicious transactivating acti...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Haas M

    更新日期：1989-04-15 00:00:00

  • Functional activation of the estrogen receptor-α and aromatase by the HDAC inhibitor entinostat sensitizes ER-negative tumors to letrozole.

    abstract：:Approximately 25% of breast cancers do not express the estrogen receptor-α (ERα) and consequently do not respond to endocrine therapy. In these tumors, ERα repression is often due to epigenetic modifications such as methylation and histone deacetylation. For this reason, we investigated the ability of the histone deac...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-10-2458

    authors： Sabnis GJ,Goloubeva O,Chumsri S,Nguyen N,Sukumar S,Brodie AM

    更新日期：2011-03-01 00:00:00

  • Mammalian 3-methyladenine DNA glycosylase protects against the toxicity and clastogenicity of certain chemotherapeutic DNA cross-linking agents.

    abstract：:DNA repair status is recognized as an important determinant of the clinical efficacy of cancer chemotherapy. To assess the role that a mammalian DNA glycosylase plays in modulating the toxicity and clastogenicity of the chemotherapeutic DNA cross-linking alkylating agents, we compared the sensitivity of wild-type muri...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Allan JM,Engelward BP,Dreslin AJ,Wyatt MD,Tomasz M,Samson LD

    更新日期：1998-09-01 00:00:00

  • Polo-like kinase 1: target and regulator of anaphase-promoting complex/cyclosome-dependent proteolysis.

    abstract：:Polo-like kinase 1 (Plk1) is a key regulator of progression through mitosis. Although Plk1 seems to be dispensable for entry into mitosis, its role in spindle formation and exit from mitosis is crucial. Recent evidence suggests that a major role of Plk1 in exit from mitosis is the regulation of inhibitors of the anaph...

    journal_title：Cancer research

    pub_type： 杂志文章,评审

    doi：10.1158/0008-5472.CAN-06-0358

    authors： Eckerdt F,Strebhardt K

    更新日期：2006-07-15 00:00:00

  • Decrease in susceptibility toward induction of apoptosis and alteration in G1 checkpoint function as determinants of resistance of human lung cancer cells against the antisignaling drug UCN-01 (7-Hydroxystaurosporine).

    abstract：:7-Hydroxystaurosporine (UCN-01) is a protein kinase inhibitor that is under development as an anticancer agent in the United States and Japan. Long-term exposure of human A549 non-small cell lung cancer cells to UCN-01 furnished cells (A549/UCN) with acquired resistance against UCN-01. In this study, the sensitivity o...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Sugiyama K,Akiyama T,Shimizu M,Tamaoki T,Courage C,Gescher A,Akinaga S

    更新日期：1999-09-01 00:00:00

  • Progesterone receptor expression in neurofibromas.

    abstract：:Neurofibromas are benign tumors of the peripheral nerve sheath, which occur sporadically and in association with the common familial cancer syndrome, neurofibromatosis type 1. There are intriguing links between the growth of neurofibromas and levels of circulating hormones: neurofibromas often first appear around the ...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： McLaughlin ME,Jacks T

    更新日期：2003-02-15 00:00:00

  • Developing Cancer Informatics Applications and Tools Using the NCI Genomic Data Commons API.

    abstract：:The NCI Genomic Data Commons (GDC) was launched in 2016 and makes available over 4 petabytes (PB) of cancer genomic and associated clinical data to the research community. This dataset continues to grow and currently includes over 14,500 patients. The GDC is an example of a biomedical data commons, which collocates bi...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-17-0598

    authors： Wilson S,Fitzsimons M,Ferguson M,Heath A,Jensen M,Miller J,Murphy MW,Porter J,Sahni H,Staudt L,Tang Y,Wang Z,Yu C,Zhang J,Ferretti V,Grossman RL,GDC Project.

    更新日期：2017-11-01 00:00:00

  • Unsaturated fatty acids are required for continuous proliferation of transformed androgen-dependent cells by fibroblast growth factor family proteins.

    abstract：:Increase in dietary fat intake has been reported to be associated with progression of hormone-dependent cancers. To explore its mechanism, we examined the effects of fatty acids on the growth of androgen-dependent SC-3 cells cloned from mouse mammary cancer (Shionogi carcinoma 115). Their androgen-dependent growth was...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Kasayama S,Koga M,Kouhara H,Sumitani S,Wada K,Kishimoto T,Sato B

    更新日期：1994-12-15 00:00:00

  • Combined array-comparative genomic hybridization and single-nucleotide polymorphism-loss of heterozygosity analysis reveals complex changes and multiple forms of chromosomal instability in colorectal cancers.

    abstract：:Cancers with chromosomal instability (CIN) are held to be aneuploid/polyploid with multiple large-scale gains/deletions, but the processes underlying CIN are unclear and different types of CIN might exist. We investigated colorectal cancer cell lines using array-comparative genomic hybridization (CGH) for copy number ...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-05-3285

    authors： Gaasenbeek M,Howarth K,Rowan AJ,Gorman PA,Jones A,Chaplin T,Liu Y,Bicknell D,Davison EJ,Fiegler H,Carter NP,Roylance RR,Tomlinson IP

    更新日期：2006-04-01 00:00:00

  • Potentiation of nitric oxide-induced apoptosis of MDA-MB-468 cells by farnesyltransferase inhibitor: implications in breast cancer.

    abstract：:High amounts of nitric oxide (NO) produced by activated macrophages or NO donors are required to induce cytotoxicity and apoptosis in pathogens and tumor cells. High concentrations of NO may lead to nonspecific toxicity thereby limiting the use of NO donors in the treatment of cancer. In this study, we tested the poss...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Pervin S,Singh R,Gau CL,Edamatsu H,Tamanoi F,Chaudhuri G

    更新日期：2001-06-15 00:00:00

  • bcl-2 suppresses expression of p21WAF1/CIP1 in breast epithelial cells.

    abstract：:The tumor suppressor gene p53 regulates G1 checkpoint prior to the initiation of DNA synthesis, which can either induce G1 arrest or signal apoptosis. The involvement of p53 in apoptosis may also be related to its ability to down-regulate transcription of the bcl-2 gene. The bcl-2 gene product prevents most types of a...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Upadhyay S,Li G,Liu H,Chen YQ,Sarkar FH,Kim HR

    更新日期：1995-10-15 00:00:00

  • Interglandular cytogenetic heterogeneity detected by comparative genomic hybridization in pancreatic cancer.

    abstract：:The aim of this study is to explore the mechanisms of intratumoral cytogenetic heterogeneity (ICH) in pancreatic cancer. Using comparative genomic hybridization (CGH) analysis, we investigated interglandular variation in 20 primary invasive ductal adenocarcinomas of the pancreas. Three or four adjacent neoplastic glan...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Harada T,Okita K,Shiraishi K,Kusano N,Kondoh S,Sasaki K

    更新日期：2002-02-01 00:00:00

  • Midkine promotes neuroblastoma through Notch2 signaling.

    abstract：:Midkine is a heparin-binding growth factor highly expressed in various cancers, including neuroblastoma, the most common extracranial pediatric solid tumor. Prognosis of patients with neuroblastoma in which MYCN is amplified remains particularly poor. In this study, we used a MYCN transgenic model for neuroblastoma in...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-12-3070

    authors： Kishida S,Mu P,Miyakawa S,Fujiwara M,Abe T,Sakamoto K,Onishi A,Nakamura Y,Kadomatsu K

    更新日期：2013-02-15 00:00:00

  • MUC1 is a potential target for the treatment of acute myeloid leukemia stem cells.

    abstract：:Acute myeloid leukemia (AML) is a malignancy of stem cells with an unlimited capacity for self-renewal. MUC1 is a secreted, oncogenic mucin that is expressed aberrantly in AML blasts, but its potential uses to target AML stem cells have not been explored. Here, we report that MUC1 is highly expressed on AML CD34(+)/li...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-13-0677

    authors： Stroopinsky D,Rosenblatt J,Ito K,Mills H,Yin L,Rajabi H,Vasir B,Kufe T,Luptakova K,Arnason J,Nardella C,Levine JD,Joyce RM,Galinsky I,Reiter Y,Stone RM,Pandolfi PP,Kufe D,Avigan D

    更新日期：2013-09-01 00:00:00

  • Neuropeptide Y expression in the developing adrenal gland and in childhood neuroblastoma tumors.

    abstract：:Neuropeptide Y (NPY) expression is limited to tissues of the central and peripheral nervous system. In the adrenal gland, NPY is found in a subset of cells of the adrenal medulla. Using in situ hybridization analysis, NPY mRNA expression was characterized during human fetal adrenal medullary development. We found a bi...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Cohen PS,Cooper MJ,Helman LJ,Thiele CJ,Seeger RC,Israel MA

    更新日期：1990-09-15 00:00:00

  • Hyperprolactinemia and steroid metabolism by rat mammary adenocarcinomas.

    abstract：:The metabolism of both testosterone and dehydroepiandrosterone by 10 adenocarcinomas induced and grown in the presence of high prolactin (plasma prolactin greater than 220 ng/ml) was compared with the metabolism of 10 adenocarcinomas induced and grown in the presence of normal levels (plasma prolactin less than 60 ng/...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Miller WR

    更新日期：1976-02-01 00:00:00

  • Thioredoxin reductase-1 mediates curcumin-induced radiosensitization of squamous carcinoma cells.

    abstract：:Curcumin, a plant polyphenol, is a widely studied chemopreventive agent with demonstrated antitumor activities in preclinical studies and low toxicity profiles in multiple clinical trials against human malignancies. We previously showed that curcumin radiosensitizes cervical tumor cells without increasing the cytotoxi...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-09-3025

    authors： Javvadi P,Hertan L,Kosoff R,Datta T,Kolev J,Mick R,Tuttle SW,Koumenis C

    更新日期：2010-03-01 00:00:00

  • Human cutaneous fatty acid-binding protein induces metastasis by up-regulating the expression of vascular endothelial growth factor gene in rat Rama 37 model cells.

    abstract：:Human cutaneous fatty acid-binding protein (C-FABP) gene is capable of inducing the metastatic phenotype when overexpressed in nonmetastatic rat Rama 37 cells. However, the mechanism of how it induces metastasis is not clear. Northern and slot blot analyses revealed that expression of the endogenous vascular endotheli...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Jing C,Beesley C,Foster CS,Chen H,Rudland PS,West DC,Fujii H,Smith PH,Ke Y

    更新日期：2001-06-01 00:00:00

  • Human prostate tissue antigens defined by murine monoclonal antibodies.

    abstract：:BALB/c mice were hyperimmunized against a membrane preparation derived from a pool of transurethral resection specimens which included three benign prostatic hyperplasia and one prostate adenocarcinoma tissue samples. The activated lymphocytes were fused with the NS-1 mouse myeloma cell line, and supernatants from imm...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Starling JJ,Sieg SM,Beckett ML,Wirth PR,Wahab Z,Schellhammer PF,Ladaga LE,Poleskic S,Wright GL Jr

    更新日期：1986-01-01 00:00:00

  • Glycine N-methyltransferase tumor susceptibility gene in the benzo(a)pyrene-detoxification pathway.

    abstract：:Glycine N-methyltransferase (GNMT) affects genetic stability by (a) regulating the ratio of S-adenosylmethionine to S-adenosylhomocystine and (b) binding to folate. Based on the identification of GNMT as a 4 S polyaromatic hydrocarbon-binding protein, we used liver cancer cell lines that expressed GNMT either transien...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-03-3726

    authors： Chen SY,Lin JR,Darbha R,Lin P,Liu TY,Chen YM

    更新日期：2004-05-15 00:00:00

  • Liver tumor-promoting activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in TCDD-sensitive and TCDD-resistant rat strains.

    abstract：:Risk assessment of dioxins is currently based on induction of liver tumors in rats. The toxicity of dioxins is characterized by large sensitivity differences among animal species and even strains of the same species, which complicates the risk assessment. The significance of these differences in dioxin-induced carcino...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Viluksela M,Bager Y,Tuomisto JT,Scheu G,Unkila M,Pohjanvirta R,Flodström S,Kosma VM,Mäki-Paakkanen J,Vartiainen T,Klimm C,Schramm KW,Wärngård L,Tuomisto J

    更新日期：2000-12-15 00:00:00

  • Identification of the major protein components in breast secretions from women with benign and malignant breast diseases.

    abstract：:The protein composition of breast secretions from 99 premenopausal women with benign or malignant breast diseases and from 70 control women without breast pathologies has been studied by using polyacrylamide gel electrophoresis. These fluids have been classified into two types according to their major polypeptide comp...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Sánchez LM,Vizoso F,Díez-Itza I,López-Otín C

    更新日期：1992-01-01 00:00:00

  • Malignant potential of cells isolated from lymph node or brain metastases of melanoma patients and implications for prognosis.

    abstract：:We studied the correlation between the formation of brain metastasis and the malignant growth potential of seven human melanoma cell lines, isolated from lymph node metastases (A375-SM, TXM-1, DM-4) or from brain metastases (TXM-13, TXM-18, TXM-34, TXM-40), and the potential of three variants of the mouse K-1735 melan...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Zhang RD,Price JE,Schackert G,Itoh K,Fidler IJ

    更新日期：1991-04-15 00:00:00

  • Fidelity of Runx2 activity in breast cancer cells is required for the generation of metastases-associated osteolytic disease.

    abstract：:The osteolytic bone destruction associated with breast cancer skeletal metastases represents a serious and incurable clinical condition. However, the molecular mechanisms regulating tumor cell expression of factors involved in the generation of osteolytic disease remain elusive. We demonstrated recently that breast ca...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-03-3851

    authors： Barnes GL,Hebert KE,Kamal M,Javed A,Einhorn TA,Lian JB,Stein GS,Gerstenfeld LC

    更新日期：2004-07-01 00:00:00

  • Differential release of active proteinase inhibitors by two rat mammary adenocarcinoma variants possessing different metastatic potentials.

    abstract：:The ability of tumor cells to express elevated levels of proteinases capable of degrading tissue matrix and basement membrane components in vitro has been correlated to their invasive and metastatic potential. Many in vitro invasion assays have been performed either in the presence of serum or with tumor cells that ha...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Neri A,Bohoslawec O,Anderson TD,Tokes ZA

    更新日期：1991-02-15 00:00:00

  • Comparison of phenotypic and genotypic features in human primary large bowel carcinomas and lymph node metastases.

    abstract：:In order to test the contention that metastasis is a selective process and that therefore metastases might show a more restricted pattern of phenotypic and genotypic characteristics than primary tumors, we compared the expression of carcinoembryonic antigen, Ca 19-9, secretory component, serotonin, and mucin productio...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Arends JW,Schutte B,Wiggers T,Verstijnen CP,Blijham GH,Bosman FT

    更新日期：1987-08-15 00:00:00