Ulcerative colitis-associated colorectal cancer arises in a field of short telomeres, senescence, and inflammation.

abstract：:Experimentally induced breast cancer is often preceded by the appearance of preneoplastic lesions which possess the attributes of hyperplastic normal tissue. These lesions can be isolated and carried as stably transplantable outgrowth lines which continue to morphologically resemble differentiating mammary tissue (Med...

journal_title：Cancer research

authors： Smith GH,Vonderhaar BK,Graham DE,Medina D

更新日期：1984-08-01 00:00:00

abstract：:The increase of interleukin-4 (IL-4) level in tumor environment and the up-regulation of IL-4 receptor (IL-4R) on tumor cells have been long observed. However, their significance for tumor development has not been investigated. Here, we found that endogenous IL-4 promotes tumor growth because neutralizing IL-4 by 11B1...

journal_title：Cancer research

authors： Li Z,Jiang J,Wang Z,Zhang J,Xiao M,Wang C,Lu Y,Qin Z

更新日期：2008-11-01 00:00:00

abstract：:Cancer patients and tumor-bearing animals excrete high levels of modified purines and pyrimidines some of which, e.g., N2,N2-dimethylguanosine, can originate only from transfer RNA (tRNA). Until recently, it could not be ascertained whether the high level of excretion of such compounds is due to cell death or specific...

journal_title：Cancer research

authors： Borek E,Baliga BS,Gehrke CW,Kuo CW,Belman S,Troll W,Waalkes TP

更新日期：1977-09-01 00:00:00

abstract：:Four hundred and forty-seven human tumor specimens were accessioned and processed for clonogenic assay, yielding 374 specimens, representing 23 different histiotypes, adequate for culture. Different levels of viable cell inoculum density produced contrasting effects between 255 solid tumors as compared to 72 malignant...

journal_title：Cancer research

authors： Page RH,Tilchen EJ,Davis HL

更新日期：1988-07-15 00:00:00

abstract：:Glycine N-methyltransferase (GNMT) affects genetic stability by (a) regulating the ratio of S-adenosylmethionine to S-adenosylhomocystine and (b) binding to folate. Based on the identification of GNMT as a 4 S polyaromatic hydrocarbon-binding protein, we used liver cancer cell lines that expressed GNMT either transien...

journal_title：Cancer research

authors： Chen SY,Lin JR,Darbha R,Lin P,Liu TY,Chen YM

更新日期：2004-05-15 00:00:00

abstract：:We studied the role of glycosphingolipids expressed on the cell surfaces of a metastatic tumor cell line. Glycosphingolipid compositions of the low-metastatic murine lymphosarcoma cell line RAW117-P and its sub-line, RAW117-H10, which shows higher metastatic potential for the liver than P cells, were compared. Both ty...

journal_title：Cancer research

authors： Taki T,Ishikawa D,Ogura M,Nakajima M,Handa S

更新日期：1997-05-15 00:00:00

abstract：:An immunogenic tumor and a nonimmunogenic tumor were used in C57BL/Ka and CBA/Rij mice, respectively, in a study in which lymph node morphology was quantitatively measured. Lymph nodes were cut in semiseries, and a morphometrical analysis was done on the paracortical and cortical areas as major parts of the active lym...

journal_title：Cancer research

authors： van de Velde CJ,Meyer CJ,Cornellsse CJ,van der Velde EA,van Putten LM,Swaveling A

更新日期：1978-03-01 00:00:00

abstract：:5'-Deoxy-5-fluorouridine (5'-dFUrd; Roche 21-9738) is a recently synthesized antineoplastic agent with therapeutic potential. The sensitivity of Ehrlich ascites tumor cells in CF-1 mice to 5'-dFUrd, as well as to 5-fluorouridine, was established. 5'-dFUrd was a more effective antitumor agent and was less toxic over a ...

journal_title：Cancer research

authors： Armstrong RD,Diasio RB

更新日期：1980-09-01 00:00:00

abstract：:Streptavidin (SA)-biotin pretargeted radioimmunotherapy (PRIT) that targets CD20 in non-Hodgkin lymphoma (NHL) exhibits remarkable efficacy in model systems, but SA immunogenicity and interference by endogenous biotin may complicate clinical translation of this approach. In this study, we engineered a bispecific fusio...

journal_title：Cancer research

authors： Green DJ,Frayo SL,Lin Y,Hamlin DK,Fisher DR,Frost SH,Kenoyer AL,Hylarides MD,Gopal AK,Gooley TA,Orozco JJ,Till BG,O'Steen S,Orcutt KD,Wilbur DS,Wittrup KD,Press OW

更新日期：2016-11-15 00:00:00

abstract：:Tumor-initiating cells (TIC) perpetuate tumor growth, enable therapeutic resistance, and drive initiation of successive tumors. Virtually nothing is known about the role of mechanotransductive signaling in controlling TIC tumorigenesis, despite the recognized importance of altered mechanics in tissue dysplasia and the...

journal_title：Cancer research

authors： Wong SY,Ulrich TA,Deleyrolle LP,MacKay JL,Lin JM,Martuscello RT,Jundi MA,Reynolds BA,Kumar S

更新日期：2015-03-15 00:00:00

abstract：:Prostate carcinoma is the most commonly diagnosed cancer in men and the second leading cause of death due to cancer in Western civilization. Androgen ablation therapy is effective in treating androgen-dependent tumors, but eventually, androgen-independent tumors recur and are refractory to conventional chemotherapeuti...

journal_title：Cancer research

authors： Libertini SJ,Tepper CG,Rodriguez V,Asmuth DM,Kung HJ,Mudryj M

更新日期：2007-10-01 00:00:00

abstract：:In the last decade, large-scale genomic studies in patients with hematologic malignancies identified recurrent somatic alterations in epigenetic modifier genes. Among these, the de novo DNA methyltransferase DNMT3A has emerged as one of the most frequently mutated genes in adult myeloid as well as lymphoid malignancie...

journal_title：Cancer research

authors： Venugopal K,Feng Y,Shabashvili D,Guryanova OA

更新日期：2021-01-15 00:00:00

abstract：:The plasma of dogs afflicted with mammary carcinoma was perfused through chambers bearing Staphylococcus aureus Cowan strain I in an attempt to remove tumor-promoting, immunosuppressive immune complexes from the peripheral blood of these animals. In this canine model of spontaneous mammary carcinoma, reduction of brea...

journal_title：Cancer research

authors： Holohan TV,Phillips TM,Bowles C,Deisseroth A

更新日期：1982-09-01 00:00:00

abstract：:Metallothioneins (MT) are major cysteine-rich proteins with poorly characterized functions. We have examined the MT amount, isotype expression, and subcellular distribution in 4 human hormone-independent prostatic carcinoma cell lines. Both PC-3 and DU-145 cells were thiol-rich cells with similar MT and glutathione le...

journal_title：Cancer research

authors： Kondo Y,Kuo SM,Watkins SC,Lazo JS

更新日期：1995-02-01 00:00:00

abstract：:Anti-VEGF therapy prolongs recurrence-free survival in patients with glioblastoma but does not improve overall survival. To address this discrepancy, we investigated immunologic resistance mechanisms to anti-VEGF therapy in glioma models. A screening of immune-associated alterations in tumors after anti-VEGF treatment...

journal_title：Cancer research

authors： Long Y,Tao H,Karachi A,Grippin AJ,Jin L,Chang YE,Zhang W,Dyson KA,Hou AY,Na M,Deleyrolle LP,Sayour EJ,Rahman M,Mitchell DA,Lin Z,Huang J

更新日期：2020-02-01 00:00:00

abstract：:The carcinogenicities of a choline deficient L-amino acid defined (CDAA) diet and a semipurified choline deficient diet were comparatively examined. A total of 60 male Fischer 344 rats, 6 weeks old, were divided into 5 experimental groups each consisting of 12 rats. Group 1 received the CDAA diet chronically to the en...

journal_title：Cancer research

authors： Nakae D,Yoshiji H,Mizumoto Y,Horiguchi K,Shiraiwa K,Tamura K,Denda A,Konishi Y

更新日期：1992-09-15 00:00:00

abstract：:von Hippel-Lindau (VHL) disease results from germline and somatic mutations in the VHL tumor suppressor gene and is characterized by highly vascularized tumors. VHL mutations lead to stabilization of hypoxia-inducible factor (HIF), which up-regulates proangiogenic factors such as vascular endothelial growth factor (VE...

journal_title：Cancer research

authors： Champion KJ,Guinea M,Dammai V,Hsu T

更新日期：2008-06-15 00:00:00

abstract：:Although chrysotile asbestos is a proven human carcinogen, several studies have concluded that these fibers are not mutagenic to cultured mammalian cells. We show here, on the other hand, that when tested using the AL cell system that detects both intragenic and multilocus mutations, chrysotile is indeed mutagenic and...

journal_title：Cancer research

authors： Hei TK,Piao CQ,He ZY,Vannais D,Waldren CA

更新日期：1992-11-15 00:00:00

abstract：:Transduction of mitogenic signals in cells can be mediated by molecules derived from the synthesis and breakdown of the major membrane phospholipid, phosphotidylcholine. Studies were performed on human mammary epithelial cells in culture to understand the impact of malignant transformation and progression on membrane ...

journal_title：Cancer research

authors： Aboagye EO,Bhujwalla ZM

更新日期：1999-01-01 00:00:00

abstract：:Expression of the ectonucleotidase CD73 by tumor cells, stromal cells, and immune cells is associated in cancer with immune suppression. In this study, we investigated the role of CD73 on the activity of the anti-HER2/ErbB2 monoclonal antibody (mAb) trastuzumab. In a prospective, randomized phase III clinical trial ev...

journal_title：Cancer research

authors： Turcotte M,Allard D,Mittal D,Bareche Y,Buisseret L,José V,Pommey S,Delisle V,Loi S,Joensuu H,Kellokumpu-Lehtinen PL,Sotiriou C,Smyth MJ,Stagg J

更新日期：2017-10-15 00:00:00

abstract：:Dehydroepiandrosterone, an adrenal steroid that has been reported to be produced in subnormal amounts and found in lower plasma concentrations in women with benign and malignant breast tumors, protects cultured rat liver epithelial-like cells against aflatoxin B1-induced cytotoxicity and protects hamster embryonic fib...

journal_title：Cancer research

authors： Schwartz AG,Perantoni A

更新日期：1975-09-01 00:00:00

abstract：:Sustained proliferation of cancer cells requires telomerase to maintain telomeres that regulate chromosomal stability and cellular mitosis. Expression of human telomerase reverse transcriptase (hTERT) catalytic subunit, which modulates telomerase activity, is regulated at both the transcriptional level and via phospho...

journal_title：Cancer research

authors： Akiyama M,Hideshima T,Hayashi T,Tai YT,Mitsiades CS,Mitsiades N,Chauhan D,Richardson P,Munshi NC,Anderson KC

更新日期：2003-01-01 00:00:00

abstract：:C/EBPα is an essential transcription factor involved in regulating the expression or function of certain cell-cycle regulators, including in breast cancer cells. Although protein arginine methyltransferases have been shown to play oncogenic roles in a variety of cancers, little is known about the role of arginine meth...

journal_title：Cancer research

authors： Liu LM,Sun WZ,Fan XZ,Xu YL,Cheng MB,Zhang Y

更新日期：2019-06-01 00:00:00

abstract：:Patients with disseminated Ewing's family of tumors (ESFT) often experience drug-resistant relapse. We hypothesize that targeting minimal residual disease with the cytotoxic retinoid N-(4-hydroxyphenyl) retinamide (4-HPR; fenretinide) may decrease relapse. We determined the following: (a) 4-HPR cytotoxicity against 12...

journal_title：Cancer research

authors： Batra S,Reynolds CP,Maurer BJ

更新日期：2004-08-01 00:00:00

abstract：:This paper describes the use of the bromodeoxyuridine/propidium iodide method to assess the effects of bioactive and cytotoxic agents on the kinetic characteristics of acute myelogenous leukemia cells. By careful selection of gates, the following parameters can be measured simultaneously using only 50,000 cells: the p...

journal_title：Cancer research

authors： Preisler HD,Gopal V,Banavali SD,Finke D,Bokari SA

更新日期：1992-08-01 00:00:00

abstract：:Luzopeptins consist of two identical, substituted quinolines linked to a cyclic decadepsipeptide, with a 2-fold symmetry. Luzopeptin A, with two acetylated sites in its peptide ring, is active against several experimental animal tumor systems. Luzopeptin B (one acetylated site) is less active, and luzopeptin C (no ace...

journal_title：Cancer research

authors： Huang CH,Crooke ST

更新日期：1985-08-01 00:00:00

abstract：:Although in vivo targeting of tumors using fluorescently labeled probes has greatly gained in importance over the last few years, most of the clinically applied reagents lack tumor cell specificity. Our novel tumor cell-penetrating peptide-based probe (TPP) recognizes an epitope of Hsp70 that is exclusively present on...

journal_title：Cancer research

authors： Stangl S,Varga J,Freysoldt B,Trajkovic-Arsic M,Siveke JT,Greten FR,Ntziachristos V,Multhoff G

更新日期：2014-12-01 00:00:00

abstract：:Several genome-wide searches for common cancers have lead to the identification of a small number of loci that harbor low-risk cancer susceptibility markers. One marker, rs6983267 on chromosome 8q24, has been linked to both colon and prostate cancer, and is therefore a good candidate for a multicancer susceptibility m...

journal_title：Cancer research

authors： Wokolorczyk D,Gliniewicz B,Sikorski A,Zlowocka E,Masojc B,Debniak T,Matyjasik J,Mierzejewski M,Medrek K,Oszutowska D,Suchy J,Gronwald J,Teodorczyk U,Huzarski T,Byrski T,Jakubowska A,Górski B,van de Wetering T,Walczak

更新日期：2008-12-01 00:00:00

abstract：:A hormone-dependent subline of the transplantable rat mammary tumor MTW9 contains binding sites for both prolactin and estrogen. Prolactin binding is saturable (K-d similar to 2 times 10-9 M), hormone specific, and destroyed by proteases. By contrast, an autonomous subline derived from the same parent tumor has lost m...

journal_title：Cancer research

authors： Costlow ME,Buschow RA,Richert NJ,McGuire WL

更新日期：1975-04-01 00:00:00

abstract：:A sound rationale exists for antibody targeting of the MET receptor tyrosine kinase, but therapeutic agents that can broadly block HGF ligand binding and exon 14-mutated or amplified MET to induce receptor degradation have yet to be reported. Here we report the identification of several MET monoclonal antibodies (mAb)...

journal_title：Cancer research

authors： Yang Y,Mandiyan S,Robinson BS,McMahon G

更新日期：2016-10-01 00:00:00