Estrogen Receptor α Promotes Breast Cancer by Reprogramming Choline Metabolism.

Abstract:

:Estrogen receptor α (ERα) is a key regulator of breast growth and breast cancer development. Here, we report how ERα impacts these processes by reprogramming metabolism in malignant breast cells. We employed an integrated approach, combining genome-wide mapping of chromatin-bound ERα with estrogen-induced transcript and metabolic profiling, to demonstrate that ERα reprograms metabolism upon estrogen stimulation, including changes in aerobic glycolysis, nucleotide and amino acid synthesis, and choline (Cho) metabolism. Cho phosphotransferase CHPT1, identified as a direct ERα-regulated gene, was required for estrogen-induced effects on Cho metabolism, including increased phosphatidylcholine synthesis. CHPT1 silencing inhibited anchorage-independent growth and cell proliferation, also suppressing early-stage metastasis of tamoxifen-resistant breast cancer cells in a zebrafish xenograft model. Our results showed that ERα promotes metabolic alterations in breast cancer cells mediated by its target CHPT1, which this study implicates as a candidate therapeutic target. Cancer Res; 76(19); 5634-46. ©2016 AACR.

journal_name

Cancer Res

journal_title

Cancer research

authors

Jia M,Andreassen T,Jensen L,Bathen TF,Sinha I,Gao H,Zhao C,Haldosen LA,Cao Y,Girnita L,Moestue SA,Dahlman-Wright K

doi

10.1158/0008-5472.CAN-15-2910

subject

Has Abstract

pub_date

2016-10-01 00:00:00

pages

5634-5646

issue

19

eissn

0008-5472

issn

1538-7445

pii

0008-5472.CAN-15-2910

journal_volume

76

pub_type

杂志文章
  • Commentary on "Proteasome Inhibitors: A Novel Class of Potent and Effective Antitumor Agents".

    abstract::The relatively recent clinical success of bortezomib, particularly in multiple myeloma, has established the validity of the proteasome as a viable target for anticancer drug development. This highly cited 1999 Cancer Research article from Adams and colleagues was published during the period when this drug was transiti...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-16-1974

    authors: Tew KD

    更新日期:2016-09-01 00:00:00

  • New sublines of Chinese hamster CHL stably expressing human NAT1 or NAT2 N-acetyltransferases or Salmonella typhimurium O-acetyltransferase: comparison of the sensitivities to nitroarenes and aromatic amines using the in vitro micronucleus test.

    abstract::New sublines of Chinese hamster CHL cells stably expressing human NAT1 or NAT2 N-acetyltransferases or O-acetyltransferase of Salmonella typhimurium were established, and their sensitivities to carcinogenic nitroarenes and aromatic amines were compared using the in vitro micronucleus test. The subline expressing human...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Watanabe M,Matsuoka A,Yamazaki N,Hayashi M,Deguchi T,Nohmi T,Sofuni T

    更新日期:1994-04-01 00:00:00

  • CpG island methylator phenotype is a strong determinant of poor prognosis in neuroblastomas.

    abstract::Neuroblastoma, one of the most common pediatric solid tumors, is characterized by two extreme disease courses, spontaneous regression and life-threatening progression. Here, we conducted a genome-wide search for differences in DNA methylation that distinguish between neuroblastomas of the two types. Three CpG islands ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Abe M,Ohira M,Kaneda A,Yagi Y,Yamamoto S,Kitano Y,Takato T,Nakagawara A,Ushijima T

    更新日期:2005-02-01 00:00:00

  • Deregulated CDC25A expression promotes mammary tumorigenesis with genomic instability.

    abstract::Checkpoint pathways help cells maintain genomic integrity, delaying cell cycle progression in response to various risks of fidelity, such as genotoxic stresses, compromised DNA replication, and impaired spindle control. Cancer cells frequently exhibit genomic instability, and recent studies showed that checkpoint path...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-06-3927

    authors: Ray D,Terao Y,Fuhrken PG,Ma ZQ,DeMayo FJ,Christov K,Heerema NA,Franks R,Tsai SY,Papoutsakis ET,Kiyokawa H

    更新日期:2007-02-01 00:00:00

  • Cancer morbidity and mortality in phosphate workers.

    abstract::Phosphate ore mining and processing operations are associated with dusty conditions and potential exposure to gamma radiation and radon daughter products. Although most current measurements are within Occupational Safety and Health Administration (OSHA) guidelines, no measurements exist for the era preceding modern st...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Block G,Matanoski GM,Seltser R,Mitchell T

    更新日期:1988-12-15 00:00:00

  • No evidence for the presence of an imprinted neuroblastoma suppressor gene within chromosome sub-band 1p36.3.

    abstract::Deletion of the distal short arm of chromosome 1 occurs in 35% of primary neuroblastomas (NBs). These deletions tend to be large and extend to the telomere, but a common region within sub-band 1p36.3 is consistently lost. Despite intensive investigation, no candidate tumor suppressor gene within this region has been s...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Hogarty MD,Winter CL,Liu X,Guo C,White PS,Look AT,Brodeur GM,Maris JM

    更新日期:2002-11-15 00:00:00

  • Uptake and distribution of specific and control monoclonal antibodies in subcutaneous xenografts following intratumor injection.

    abstract::Nude mice bearing s.c. xenografts of the human colon adenocarcinoma HT29 were given intratumor injections of a mixture of 125I-labeled specific antibody (AUA1) and 131I-labeled control antibody (HMFG1), or with the labels reversed. After dissection at 1 and 4 h postadministration, both specific and control antibodies ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Rowlinson-Busza G,Bamias A,Krausz T,Epenetos AA

    更新日期:1991-06-15 00:00:00

  • A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation.

    abstract::MicroRNAs (miRNAs) are small noncoding RNAs, thought to be involved in physiologic and developmental processes by negatively regulating expression of target genes. We have previously reported frequent down-regulation of the let-7 miRNA family in lung cancers and, in the present study, assessed alteration in a panel of...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-05-2352

    authors: Hayashita Y,Osada H,Tatematsu Y,Yamada H,Yanagisawa K,Tomida S,Yatabe Y,Kawahara K,Sekido Y,Takahashi T

    更新日期:2005-11-01 00:00:00

  • Expression of the human T-cell-specific tyrosine kinase YT16 (lck) message in leukemic T-cell lines.

    abstract::To evaluate the role of the human T-cell-specific tyrosine kinase lck (YT16), we measured the levels of lck expression in thymocytes, peripheral T-cells, and leukemia T-cell lines which are arrested at different stages of thymic differentiation. The results indicate that higher levels of the lck message can be found i...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Koga Y,Kimura N,Minowada J,Mak TW

    更新日期:1988-02-15 00:00:00

  • Effect of concentration of D,L-2-difluoromethylornithine on murine mammary carcinogenesis.

    abstract::The appearance of chemically induced mammary gland carcinomas in virgin female Sprague-Dawley rats was blocked by the administration of D,L-2-difluoromethylornithine (DFMO) in drinking water during the stage of tumor promotion. Rats were given injections s.c. at 50 days of age with either 35 mg of 1-methyl-1-nitrosour...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Thompson HJ,Meeker LD,Herbst EJ,Ronan AM,Minocha R

    更新日期:1985-03-01 00:00:00

  • The protective role of ammonium trichloro(dioxoethylene-O,O')tellurate in combination with several cytotoxic drugs acting by different mechanisms of action.

    abstract::We have demonstrated previously that the immunomodulator AS101 can protect mice from acute lethal toxicity mediated by high doses of radiation or chemotherapy. The compound was shown to rescue mice from toxic effects of cyclophosphamide or 5-fluorouracil. The results presented herein demonstrate that pretreatment of m...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Kalechman Y,Shani A,Sotnik-Barkai I,Albeck M,Sredni B

    更新日期:1993-12-15 00:00:00

  • Multivalent DR5 peptides activate the TRAIL death pathway and exert tumoricidal activity.

    abstract::Ongoing clinical trials are exploring anticancer approaches based on signaling by TRAIL, a ligand for the cell death receptors DR4 and DR5. In this study, we report on the selective apoptotic effects of multivalent DR5 binding peptides (TRAIL(mim/DR5)) on cancer cells in vitro and in vivo. Surface plasmon resonance re...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-09-2889

    authors: Pavet V,Beyrath J,Pardin C,Morizot A,Lechner MC,Briand JP,Wendland M,Maison W,Fournel S,Micheau O,Guichard G,Gronemeyer H

    更新日期:2010-02-01 00:00:00

  • Regulation of carbonyl-reducing enzymes in rat liver by chemoprotectors.

    abstract::Feeding rats on diets containing the synthetic antioxidants ethoxyquin, butylated hydroxyanisole, and oltipraz results in 15-, 9-, and 6-fold increases, respectively, in the hepatic levels of aflatoxin B1-dialdehyde reductase (AFAR) protein. By contrast, treatment of rats with either of the inducing agents phenobarbit...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Ellis EM,Judah DJ,Neal GE,O'Connor T,Hayes JD

    更新日期:1996-06-15 00:00:00

  • High Levels of C-Reactive Protein Are Associated with an Increased Risk of Ovarian Cancer: Results from the Ovarian Cancer Cohort Consortium.

    abstract::Growing epidemiologic evidence supports chronic inflammation as a mechanism of ovarian carcinogenesis. An association between a circulating marker of inflammation, C-reactive protein (CRP), and ovarian cancer risk has been consistently observed, yet, potential heterogeneity of this association by tumor and patient cha...

    journal_title:Cancer research

    pub_type: 杂志文章,多中心研究

    doi:10.1158/0008-5472.CAN-19-1554

    authors: Peres LC,Mallen AR,Townsend MK,Poole EM,Trabert B,Allen NE,Arslan AA,Dossus L,Fortner RT,Gram IT,Hartge P,Idahl A,Kaaks R,Kvaskoff M,Magliocco AM,Merritt MA,Quirós JR,Tjonneland A,Trichopoulou A,Tumino R,van Gils

    更新日期:2019-10-15 00:00:00

  • Identification and characterization of differentially methylated CpG islands in pancreatic carcinoma.

    abstract::To identify CpG islands differentially methylated in pancreatic adenocarcinoma, we used methylated CpG island amplification (MCA) coupled with representational difference analysis. Of 42 CpG islands identified by MCA/representational difference analysis, 7 CpG islands [methylated in carcinoma of the pancreas (MICP)] w...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Ueki T,Toyota M,Skinner H,Walter KM,Yeo CJ,Issa JP,Hruban RH,Goggins M

    更新日期:2001-12-01 00:00:00

  • Enhancement of Bik antitumor effect by Bik mutants.

    abstract::Bik was initially identified as a BH3-domain-only protein that interacts with E1B 19K. Although systemically administered wild-type Bik significantly inhibited tumor growth and metastasis in an orthotopic nude mouse model, the proapoptotic potency of Bik can be modulated by posttranslational phosphorylation. Here, we ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Li YM,Wen Y,Zhou BP,Kuo HP,Ding Q,Hung MC

    更新日期:2003-11-15 00:00:00

  • Demethylation of the estrogen receptor gene in estrogen receptor-negative breast cancer cells can reactivate estrogen receptor gene expression.

    abstract::Approximately one third of breast cancers grow independently of estrogen, lack detectable estrogen receptor (ER) protein, and rarely respond to hormonal treatment. Previous studies correlated the lack of ER gene expression in ER-negative breast tumor cells with hypermethylation of a CpG island in the 5' region of the ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Ferguson AT,Lapidus RG,Baylin SB,Davidson NE

    更新日期:1995-06-01 00:00:00

  • Interactive classification of whole-slide imaging data for cancer researchers.

    abstract::Whole-slide histology images contain information that is valuable for clinical and basic science investigations of cancer, but extracting quantitative measurements from these images is challenging for researchers who are not image analysis specialists. In this paper, we describe HistomicsML2, a software tool for learn...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-20-0668

    authors: Lee S,Amgad M,Mobadersany P,McCormick M,Pollack BP,Elfandy H,Hussein H,Gutman DA,Cooper LA

    更新日期:2020-12-21 00:00:00

  • Expression of a splice variant of KAI1, a tumor metastasis suppressor gene, influences tumor invasion and progression.

    abstract::KAI1 (CD82) belongs to the transmembrane 4 superfamily in which members have inhibitory effects on tumor cell motility and metastasis. During reverse transcription-PCR analysis, we found a splice variant of KAI1 (spliced-KAI1) in which exon 7 was deleted. This exon encodes the 28 amino acids that span from the distal ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Lee JH,Seo YW,Park SR,Kim YJ,Kim KK

    更新日期:2003-11-01 00:00:00

  • Role and mutational heterogeneity of the p53 gene in hepatocellular carcinoma.

    abstract::The mutational spectrum of the p53 gene was analyzed in 53 hepatocellular carcinomas. Somatic mutations of the p53 gene were detected in 17 cases (32%). Among these 17 mutations, 9 were missense mutations; the mutations in the other 8 cases were nonsense mutations, deletions, or mutations at the intron-exon junctions....

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Nishida N,Fukuda Y,Kokuryu H,Toguchida J,Yandell DW,Ikenega M,Imura H,Ishizaki K

    更新日期:1993-01-15 00:00:00

  • A recurring translocation, t(3;6)(q27;p21), in non-Hodgkin's lymphoma results in replacement of the 5' regulatory region of BCL6 with a novel H4 histone gene.

    abstract::3q27 translocations affecting the BCL6 gene can involve not only immunoglobulin genes (IG) but also other as yet uncharacterized chromosomal loci as partners. Here, we describe cloning of the junctional area of a recurring translocation, t(3;6)(q27;p21), in non-Hodgkin's lymphoma of B-cell type and isolation of clones...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Akasaka T,Miura I,Takahashi N,Akasaka H,Yonetani N,Ohno H,Fukuhara S,Okuma M

    更新日期:1997-01-01 00:00:00

  • Survivin-3B potentiates immune escape in cancer but also inhibits the toxicity of cancer chemotherapy.

    abstract::Dysregulation in patterns of alternative RNA splicing in cancer cells is emerging as a significant factor in cancer pathophysiology. In this study, we investigated the little known alternative splice isoform survivin-3B (S-3B) that is overexpressed in a tumor-specific manner. Ectopic overexpression of S-3B drove tumor...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-13-0036

    authors: Végran F,Mary R,Gibeaud A,Mirjolet C,Collin B,Oudot A,Charon-Barra C,Arnould L,Lizard-Nacol S,Boidot R

    更新日期:2013-09-01 00:00:00

  • Receptor channel TRPC6 is a key mediator of Notch-driven glioblastoma growth and invasiveness.

    abstract::Glioblastoma multiforme (GBM) is the most frequent and incurable type of brain tumor of adults. Hypoxia has been shown to direct GBM toward a more aggressive and malignant state. Here we show that hypoxia increases Notch1 activation, which in turn induces the expression of transient receptor potential 6 (TRPC6) in pri...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-09-2654

    authors: Chigurupati S,Venkataraman R,Barrera D,Naganathan A,Madan M,Paul L,Pattisapu JV,Kyriazis GA,Sugaya K,Bushnev S,Lathia JD,Rich JN,Chan SL

    更新日期:2010-01-01 00:00:00

  • Controlled environment culture of bone marrow explants from human myeloma.

    abstract::Bone marrow biopsy specimens from patients with myeloma were cultured in either 1 of 2 thin-film culture systems, a controlled environment steady state system or a rocker tube configuration of the system, for periods up to 42 days. Both functional and morphological characteristics of the myeloma cells were well-mainta...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Gailani S,McLimans WF,Mundy GR,Nussbaum A,Roholt O,Zeigel R

    更新日期:1976-04-01 00:00:00

  • Modulation of doxorubicin resistance by valinomycin (NSC 122023) and liposomal valinomycin in Chinese hamster ovary cells.

    abstract::Recently, we have reported that the toxicity of the membrane-active agent valinomycin (VM) can be reduced with maintenance and/or enhancement of its antitumor activity by incorporation in liposomes (S. S. Daoud and Juliano, Cancer Res., 46:5518-5525, 1986). Since the underlying defect(s) in multidrug resistance reside...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Daoud SS,Juliano RL

    更新日期:1989-05-15 00:00:00

  • Estramustine sensitizes human glioblastoma cells to irradiation.

    abstract::Estramustine is an estradiol-based antimicrotubule agent that accumulates in malignant glioma cells, resulting in a concentration-dependent inhibition of proliferation. This agent has been shown to synchronize human glioma cells at G2-M consistent with its known effects on the mitotic spindle and potentially could be ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Yoshida D,Piepmeier J,Weinstein M

    更新日期:1994-03-15 00:00:00

  • Improved growth of in vitro colonies in human acute leukemia with the feeding culture method.

    abstract::Bone marrow cells freshly aspirated from the 10 consecutive untreated adult patients with acute nonlymphocytic leukemia were cultured by 2 different methods: the conventional agar culture method for myeloid colony formation and its modification by daily feeding with culture medium. In 5 patients, colonies grew in much...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Park CH,Savin MA,Hoogstraten B,Amare M,Hathaway P

    更新日期:1977-12-01 00:00:00

  • Colony growth in agar by human melanoma cells.

    abstract::Colony-forming capacity of human melanoma cells was investigated in five established cell lines and isolated cells from seven metastatic or recurrent tumors. A single-cell suspension was added to 0.3% agar medium, and colonies were observed over 7 to 21 days. With the five cell lines, colony formation occurred in all ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Asano S,Riglar C

    更新日期:1981-03-01 00:00:00

  • Identification of Oncogenic and Drug-Sensitizing Mutations in the Extracellular Domain of FGFR2.

    abstract::The discovery of oncogenic driver mutations and the subsequent developments in targeted therapies have led to improved outcomes for subsets of lung cancer patients. The identification of additional oncogenic and drug-sensitive alterations may similarly lead to new therapeutic approaches for lung cancer. We identify an...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-14-3771

    authors: Tanizaki J,Ercan D,Capelletti M,Dodge M,Xu C,Bahcall M,Tricker EM,Butaney M,Calles A,Sholl LM,Hammerman PS,Oxnard GR,Wong KK,Jänne PA

    更新日期:2015-08-01 00:00:00

  • Increased synthesis of carbamoyl-phosphate synthase II (EC 6.3.5.5) in hepatoma 3924A.

    abstract::Carbamoyl-phosphate synthase II (glutamine-hydrolyzing) (EC 6.3.5.5) (synthase II) is the first and rate-limiting enzyme in the de novo UTP biosynthetic pathway. Leucine pulse-labeling in the rat demonstrated that in the rapidly proliferating hepatoma 3924A the ratio of radioactivity of synthase II to that of total cy...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Reardon MA,Weber G

    更新日期:1986-07-01 00:00:00