Molecular dosimetry in rat urine of aflatoxin-N7-guanine and other aflatoxin metabolites by multiple monoclonal antibody affinity chromatography and immunoaffinity/high performance liquid chromatography.

abstract：:We have demonstrated previously that there is a marked decrease in the level of labeled fucose incorporated into an amino acid fucoside, i.e., fucosyl-N-acetylglucosaminylasparagine (FL4c) in SV40-transformed human embryonic lung cells (SV40-WI-38) as compared to WI-38 cells (Morton, P.A., Klinger, M. M., and Steiner,...

journal_title：Cancer research

authors： Steiner SM,Morton PA

更新日期：1984-10-01 00:00:00

abstract：:Inflammatory breast cancer (IBC) is the most aggressive form of breast cancer and is phenotypically distinct from other forms of locally advanced breast cancer. In a previous study, we identified specific genetic alterations of IBC that could account for a highly invasive phenotype. RhoC GTPase was overexpressed in 90...

journal_title：Cancer research

authors： van Golen KL,Wu ZF,Qiao XT,Bao LW,Merajver SD

更新日期：2000-10-15 00:00:00

abstract：:Neural stem cells (NSCs) are capable of tracking migrating glioma cells. To exploit this tropism to generate an antitumor T-cell response, particularly against disseminating tumor pockets, we inoculated intracranial glioma-bearing mice with interleukin 12 (IL-12) producing NSCs. Intratumoral therapy with IL-12-secreti...

journal_title：Cancer research

authors： Ehtesham M,Kabos P,Kabosova A,Neuman T,Black KL,Yu JS

更新日期：2002-10-15 00:00:00

abstract：:The invasive transformation of A-459 lung epithelial carcinoma cells has been linked to the autocrine regulation of malignant phenotypic changes by transforming growth factor beta (TGF-beta). Here we demonstrate, using stable 13C glucose isotopes, that the transformed phenotype is characterized by decreased CO2 produc...

journal_title：Cancer research

authors： Boros LG,Torday JS,Lim S,Bassilian S,Cascante M,Lee WN

更新日期：2000-03-01 00:00:00

abstract：:DNA methyltransferase 1 (DNMT1)-deficient mice are tumor-prone, and this has been proposed to result from the induction of genomic instability. To address whether loss of DNMT1, or the related protein DNMT3b, results in genomic instability in human cancer cells, we used a near-diploid human colorectal cancer cell line...

journal_title：Cancer research

authors： Karpf AR,Matsui S

更新日期：2005-10-01 00:00:00

abstract：:It has been proposed that common aphidicolin-inducible fragile sites, in general, predispose to specific chromosomal breakage associated with deletion, amplification, and/or translocation in certain forms of cancer. Although this appears to be the case for the fragile site FRA3B and may be the case for FRA7G, it is no...

journal_title：Cancer research

authors： Mangelsdorf M,Ried K,Woollatt E,Dayan S,Eyre H,Finnis M,Hobson L,Nancarrow J,Venter D,Baker E,Richards RI

更新日期：2000-03-15 00:00:00

abstract：:By using the newly developed adhesive tumor cell culture system, we analyzed the chromosomal constitutions of primary lung tumor and nonmalignant normal lung tissue from 10 previously untreated patients with non-small cell lung cancer. Chromosomal analyses were successfully carried out in banded chromosome preparation...

journal_title：Cancer research

authors： Lee JS,Pathak S,Hopwood V,Tomasovic B,Mullins TD,Baker FL,Spitzer G,Neidhart JA

更新日期：1987-12-01 00:00:00

abstract：:We have previously shown that mice simultaneously infected with the murine mammary tumor virus (MuMTV) and with certain slow murine leukemia viruses (MLV) have an increased resistance to the pathological effects of both agents. Here we report that milk-transmitted MuMTV also delays the development of the acute erythro...

journal_title：Cancer research

authors： Basolo F,Toniolo A,Bistocchi M,Fontanini G,Squartini F

更新日期：1986-08-01 00:00:00

abstract：:Caspase-8 is a proapoptotic protease that suppresses neuroblastoma metastasis by inducing programmed cell death. Paradoxically, caspase-8 can also promote cell migration among nonapoptotic cells; here, we show that caspase-8 can promote metastasis when apoptosis is compromised. Migration is enhanced by caspase-8 recru...

journal_title：Cancer research

authors： Barbero S,Mielgo A,Torres V,Teitz T,Shields DJ,Mikolon D,Bogyo M,Barilà D,Lahti JM,Schlaepfer D,Stupack DG

更新日期：2009-05-01 00:00:00

abstract：:The specific activity (dpm/mg protein) of the acid-soluble nuclear material extracted from spleens or lymph nodes (but not other tissues) of tumor-bearing BALB/c mice was approximately twice that of the corresponding tissues from tumor-free mice of the same age and sex following i.p. injection of L-[U-14C]lysine. Auto...

journal_title：Cancer research

authors： Mashburn LT

更新日期：1985-05-01 00:00:00

abstract：:Genetic differences in metabolism of benzo(a)pyrene (BP) were investigated using cultured epidermal keratinocytes and dermal fibroblasts isolated from four inbred strains of mice: C3H/HeJms and C57BL/6J that are responsive; and DBA/2 and AKR/Jms that are nonresponsive in terms of inducibility of aryl hydrocarbon hydro...

journal_title：Cancer research

authors： Hosomi J,Nemoto N,Kuroki T

更新日期：1983-08-01 00:00:00

abstract：:A nationwide study of all 3183 female patients with breast cancer in Israel diagnosed over a 7-year period (1960 to 1966) was conducted. Monthly series analysis showed a clear seasonal pattern in the symptomatology of the disease most pronounced in patients younger than 55 years, in all ethnic groups, mainly confined ...

journal_title：Cancer research

authors： Cohen P,Wax Y,Modan B

更新日期：1983-02-01 00:00:00

abstract：:A major objective of the emerging field of exercise-oncology research is to determine the efficacy of, and biological mechanisms by which, aerobic exercise affects cancer incidence, progression, and/or metastasis. There is a strong inverse association between self-reported exercise and the primary incidence of several...

journal_title：Cancer research

authors： Ashcraft KA,Peace RM,Betof AS,Dewhirst MW,Jones LW

更新日期：2016-07-15 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) levels are dramatically increased in human keratinocytes (HKc) immortalized with full-length human papillomavirus type 16 (HPV16) DNA (HKc/HPV16), but increases in EGFR levels actually precede immortalization. In some normal HKc strains, acute expression of HPV16 E6 (but not HPV...

journal_title：Cancer research

authors： Akerman GS,Tolleson WH,Brown KL,Zyzak LL,Mourateva E,Engin TS,Basaraba A,Coker AL,Creek KE,Pirisi L

更新日期：2001-05-01 00:00:00

abstract：:The Ral family of small G proteins has been implicated in tumorigenesis, invasion, and metastasis. However, little emphasis has been placed on clarifying the individual roles of the two Ral proteins, RalA and RalB, in these processes in view of their high sequence homology. Here we analyze the separate contributions o...

journal_title：Cancer research

authors： Oxford G,Owens CR,Titus BJ,Foreman TL,Herlevsen MC,Smith SC,Theodorescu D

更新日期：2005-08-15 00:00:00

abstract：:The transcription factor Dmp1 is a Ras/HER2-activated haplo-insufficient tumor suppressor that activates the Arf/p53 pathway of cell-cycle arrest. Recent evidence suggests that Dmp1 may activate p53 independently of Arf in certain cell types. Here, we report findings supporting this concept with the definition of an A...

journal_title：Cancer research

authors： Frazier DP,Kendig RD,Kai F,Maglic D,Sugiyama T,Morgan RL,Fry EA,Lagedrost SJ,Sui G,Inoue K

更新日期：2012-04-01 00:00:00

abstract：:Acute promyelocytic leukemia is associated with a t(15;17) translocation that generates a fusion product between PML and the retinoic acid receptor alpha. Recently, PML was shown to concentrate within subnuclear domains, referred to as nuclear bodies, that are disorganized in acute promyelocytic leukemia cells. This o...

journal_title：Cancer research

authors： Terris B,Baldin V,Dubois S,Degott C,Flejou JF,Hénin D,Dejean A

更新日期：1995-04-01 00:00:00

abstract：:Reduced oxygenation, or hypoxia, inhibits differentiation and facilitates stem cell maintenance. Hypoxia commonly occurs in solid tumors and promotes malignant progression. Hypoxic tumors are aggressive and exhibit stem cell-like characteristics. It remains unclear, however, whether and how hypoxia regulates cancer ce...

journal_title：Cancer research

authors： Kim Y,Lin Q,Zelterman D,Yun Z

更新日期：2009-12-15 00:00:00

abstract：:The activity of the serine protease plasminogen activator (PA), which correlates with tumorigenicity and metastatic capacity, was examined using the 125I-labeled fibrin plate assay in cell extracts from four human glioma lines as a function of growth in vitro. Cell-associated inhibitory activity to plasmin and urokina...

journal_title：Cancer research

authors： Gross JL,Behrens DL,Mullins DE,Kornblith PL,Dexter DL

更新日期：1988-01-15 00:00:00

abstract：:Signal transducers and activators of transcription 3 (Stat3) is activated by cytokines and growth factors in lung cancers and regulates expression of genes implicated in cell growth, survival, and transformation. Previously, we found that mice with a deletion of the G protein-coupled receptor, family C, group 5, membe...

journal_title：Cancer research

authors： Chen Y,Deng J,Fujimoto J,Kadara H,Men T,Lotan D,Lotan R

更新日期：2010-11-01 00:00:00

abstract：:OX40 is a potent costimulatory receptor that can potentiate T-cell receptor signaling on the surface of T lymphocytes, leading to their activation by a specifically recognized antigen. In particular, OX40 engagement by ligands present on dendritic cells dramatically increases the proliferation, effector function, and ...

journal_title：Cancer research

authors： Curti BD,Kovacsovics-Bankowski M,Morris N,Walker E,Chisholm L,Floyd K,Walker J,Gonzalez I,Meeuwsen T,Fox BA,Moudgil T,Miller W,Haley D,Coffey T,Fisher B,Delanty-Miller L,Rymarchyk N,Kelly T,Crocenzi T,Bernstein E,

更新日期：2013-12-15 00:00:00

abstract：:Recombinant tumor necrosis factor (TNF) stimulates the proliferation of two neuroblastoma cell lines, SKNFI and SKNBE, in both serum-free medium and fetal calf serum-supplemented medium but has no effect in medium without insulin. This effect is very similar with TNF doses ranging from 5 to 500 ng/ml but depends on th...

journal_title：Cancer research

authors： Goillot E,Combaret V,Ladenstein R,Baubet D,Blay JY,Philip T,Favrot MC

更新日期：1992-06-01 00:00:00

abstract：:Actinomycin D produces changes in the cell cycle kinetics of Chinese hamster (HA1) and mouse mammary tumor cells (EMT6) cultivated in vitro. There was a reduced rate of progression of the cells through S phase and a G2 arrest, the duration and degree of which were drug dose dependent. The lethal effects of the drug on...

journal_title：Cancer research

authors： Roots R,Smith KC

更新日期：1976-10-01 00:00:00

abstract：:A new high-pressure liquid chromatographic method was developed for the simultaneous determination of rubidazone and daunorubicin in human plasma at concentrations as low as 60 ng/ml. Clinical toxicity and the stability of rubidazone were studied in nine patients with advanced solid tumors. Rubidazone was administered...

journal_title：Cancer research

authors： Kovach JS,Ames MM,Sternad ML,O'Connell MJ

更新日期：1979-03-01 00:00:00

abstract：:Preclinical and clinical development of agents that inhibit cell-cycle progression have brought an understanding of the feasibility of targeting various cell-cycle regulators in patients with cancer. Small molecule inhibitors targeting key proteins that participate in cell-cycle progression including the cyclin-depend...

journal_title：Cancer research

authors： Mills CC,Kolb EA,Sampson VB

更新日期：2018-01-15 00:00:00

abstract：:The effect of schedule of drug administration on the biochemical and therapeutic effects of the combination of 1-beta-D-arabinofuranosylcytosine (ara-C) and asparaginase was investigated in vivo and in vitro using the murine leukemia L5178Y. Treatment of cells in vitro with either ara-C (10(-6) M) or asparaginase (0.5...

journal_title：Cancer research

authors： Schwartz SA,Morgenstern B,Capizzi RL

更新日期：1982-06-01 00:00:00

abstract：:Data are presented indicating marked antineoplastic activity for cis-dichlorodiammineplatinum(II) in MOPC 104E myeloma. One-eighteenth of the dose that produced 100% cures can be combined with noncurative, low doses of cyclophosphamide and 1,3-bis(2-chloroethyl)-1-nitrosourea to produce antineoplastic activity of the ...

journal_title：Cancer research

authors： Ghanta VK,Jones MT,Woodard DA,Durant JR,Hiramoto RN

更新日期：1977-03-01 00:00:00

abstract：:Angiostatin, a proteolytic fragment of plasminogen, is a potent angiogenesis inhibitor able to suppress tumor growth and metastasis through inhibition of endothelial cell proliferation and migration. Previously, we showed that angiostatin binds and inhibits F(1)F(o) ATP synthase on the endothelial cell surface and tha...

journal_title：Cancer research

authors： Chi SL,Pizzo SV

更新日期：2006-01-15 00:00:00

abstract：:Although peptide immunization often leads to the induction of strong T-cell responses, it is seldom effective against established tumors. One possibility is that these T-cell responses are not strong enough or do not last sufficiently long to have an effect in tumor eradication. Here, we examined the role of synthetic...

journal_title：Cancer research

authors： Davila E,Kennedy R,Celis E

更新日期：2003-06-15 00:00:00

abstract：:The failure and/or toxicity of conventional therapies for many types of human cancers underscore the need for development of safe and effective alternative treatments. Toward this goal, we describe the direct oncolytic activity of RNA-based vectors derived from poliovirus, termed replicons, which are genetically incap...

journal_title：Cancer research

authors： Ansardi DC,Porter DC,Jackson CA,Gillespie GY,Morrow CD

更新日期：2001-12-01 00:00:00