Abstract：
:MCT-1 is an oncogene that was initially identified in a human T cell lymphoma and has been shown to induce cell proliferation as well as activate survival-related pathways. MCT-1 contains the PUA domain, a recently described RNA-binding domain that is found in several tRNA and rRNA modification enzymes. Here, we established that MCT-1 protein interacts with the cap complex through its PUA domain and recruits the density-regulated protein (DENR/DRP), containing the SUI1 translation initiation domain. Through the use of microarray analysis on polysome-associated mRNAs, we showed that up-regulation of MCT-1 was able to modulate the translation profiles of BCL2L2, TFDP1, MRE11A, cyclin D1, and E2F1 mRNAs, despite equivalent levels of mRNAs in the cytoplasm. Our data establish a role for MCT-1 in translational regulation, and support a linkage between translational control and oncogenesis.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Reinert LS,Shi B,Nandi S,Mazan-Mamczarz K,Vitolo M,Bachman KE,He H,Gartenhaus RBdoi
10.1158/0008-5472.CAN-06-1999subject
Has Abstractpub_date
2006-09-15 00:00:00pages
8994-9001issue
18eissn
0008-5472issn
1538-7445pii
66/18/8994journal_volume
66pub_type
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