Tumor necrosis factor in children with malignancies.

abstract：:Human breast cancer (HBC) cell growth suppression by okadaic acid (OA) was previously found to involve elevated expression of oncogenes c-myc and c-fos and apoptosis. Since, c-Myc influences diverse pathways of cell growth, we hypothesized that elevated levels of c-Myc are involved in HBC growth suppression. Here, we ...

journal_title：Cancer research

authors： Zhang L,Wali A,Ramana CV,Rishi AK

更新日期：2007-11-01 00:00:00

abstract：:Little is known about the genetic changes underlying invasive tumor growth in bladder cancer. Because alterations that are linked to invasive tumor growth may be detectable in minimally invasive (stage pT1) but not in noninvasive (stage pTa) tumors, we searched for genetic differences between 28 pTa and 28 papillary p...

journal_title：Cancer research

authors： Richter J,Jiang F,Görög JP,Sartorius G,Egenter C,Gasser TC,Moch H,Mihatsch MJ,Sauter G

更新日期：1997-07-15 00:00:00

abstract：:The serum half-life of 5-fluorouracil (5-FUra) in humans is best described as a biexponential decay function, with t1/2 alpha = 7.8 +/- 2.6 (S.E.) min and t1/2 beta = 36.8 +/- 13.5 min during initial courses of this drug alone. Pharmacokinetics of 5-FUra during courses of daily therapy (for 5 days) revealed prolongati...

journal_title：Cancer research

authors： Kirkwood JM,Ensminger W,Rosowsky A,Papathanasopoulos N,Frei E 3rd

更新日期：1980-01-01 00:00:00

abstract：:Constitutively active RAS small GTPases promote the genesis of human cancers. An important goal in cancer biology is to identify means of countervailing activated RAS signaling to reverse malignant transformation. Oncogenic K-RAS mutations are found in virtually all pancreatic adenocarcinomas, making the RAS pathway a...

journal_title：Cancer research

authors： Schmidt RL,Park CH,Ahmed AU,Gundelach JH,Reed NR,Cheng S,Knudsen BE,Tang AH

更新日期：2007-12-15 00:00:00

abstract：:Previous laboratory investigations, case reports, and a hospital-based case-control study have suggested that marijuana use may be a risk factor for squamous cell head and neck cancer. We conducted a population-based case-control study to determine whether marijuana use is associated with the development of oral squam...

journal_title：Cancer research

authors： Rosenblatt KA,Daling JR,Chen C,Sherman KJ,Schwartz SM

更新日期：2004-06-01 00:00:00

abstract：:beta-Lapachone and certain of its derivatives directly bind and inhibit topoisomerase I (Topo I) DNA unwinding activity and form DNA-Topo I complexes, which are not resolvable by SDS-K+ assays. We show that beta-lapachone can induce apoptosis in certain cells, such as in human promyelocytic leukemia (HL-60) and human ...

journal_title：Cancer research

authors： Planchon SM,Wuerzberger S,Frydman B,Witiak DT,Hutson P,Church DR,Wilding G,Boothman DA

更新日期：1995-09-01 00:00:00

abstract：:The influence of pretreatment with piperonylbutoxide (PIP) on the biological effects of N-nitrosodiethylamine (DEN) in vivo in Syrian golden hamsters was investigated. PIP pretreatment significantly reduced covalent binding of N-[ethyl-1-14C]DEN to tissue macromolecules in trachea, lung, and liver, while it did not ch...

journal_title：Cancer research

authors： Schuller HM,McMahon JB

更新日期：1985-06-01 00:00:00

abstract：:The possibility that the female sex steroid progesterone plays a role in meningioma proliferation has been suggested by a number of investigators; and it had been shown that many meningiomas have high affinity progesterone binding sites. The aim of this study was to examine the expression of progesterone receptor mRNA...

journal_title：Cancer research

authors： Carroll RS,Glowacka D,Dashner K,Black PM

更新日期：1993-03-15 00:00:00

abstract：:HL-60 cells were treated with the differentiating agent N-methylformamide and early changes in gene expression and protein content were investigated. Analysis of protein synthesis had previously shown an early (< 12 h) fall in the synthesis of M(r) 70,000 heat shock proteins (F. M. Richards, A. Watson, and J. A. Hickm...

journal_title：Cancer research

authors： Beere HM,Morimoto RI,Hickman JA

更新日期：1993-07-01 00:00:00

abstract：:The effect of schedule of drug administration on the biochemical and therapeutic effects of the combination of 1-beta-D-arabinofuranosylcytosine (ara-C) and asparaginase was investigated in vivo and in vitro using the murine leukemia L5178Y. Treatment of cells in vitro with either ara-C (10(-6) M) or asparaginase (0.5...

journal_title：Cancer research

authors： Schwartz SA,Morgenstern B,Capizzi RL

更新日期：1982-06-01 00:00:00

abstract：:Homogeneously staining regions (HSRs) were found in hypodiploid cells (40%) of a subline of the human melanoma cell line, MeWo, (MeWo-C) but were absent from the hypotetraploid cells (60%). Another subline (MeWo-B) was also shown to contain two populations of cells, 70% hypodiploid and 30% hypotetraploid. None of the ...

journal_title：Cancer research

authors： Shtromas I,White BN,Holden JJ,Reimer DL,Roder JC

更新日期：1985-02-01 00:00:00

abstract：:The mouse breast cancer cell lines 4T1, 4T07, and 67NR are highly tumorigenic but vary in metastatic potential: 4T1 widely disseminates, resulting in secondary tumors in the lung, liver, bone, and brain; 4T07 spreads to the lung and liver but is unable to establish metastatic nodules; 67NR is unable to metastasize. Th...

journal_title：Cancer research

authors： Manka D,Spicer Z,Millhorn DE

更新日期：2005-12-15 00:00:00

abstract：:To date, no prospective studies have explored the relationship between the use of aspirin, other nonsteroidal anti-inflammatory medications (NSAID), and acetaminophen and endometrial adenocarcinoma. Of the 82,971 women enrolled in a prospective cohort study, 747 developed medical record-confirmed invasive endometrial ...

journal_title：Cancer research

authors： Viswanathan AN,Feskanich D,Schernhammer ES,Hankinson SE

更新日期：2008-04-01 00:00:00

abstract：:Bortezomib is a proteasome inhibitor with proven efficacy in multiple myeloma and non-Hodgkin's lymphoma. This study reports the effects of bortezomib in B-cell lymphoma cell lines with differing sensitivity to bortezomib to investigate factors that influence sensitivity. Bortezomib induced a time- and concentration-d...

journal_title：Cancer research

authors： Strauss SJ,Higginbottom K,Jüliger S,Maharaj L,Allen P,Schenkein D,Lister TA,Joel SP

更新日期：2007-03-15 00:00:00

abstract：:Osteoprotegerin (OPG), a novel, secreted tumor necrosis factor receptor family member that inhibits osteoclast formation and activity was examined for its activity in a syngeneic tumor model of humoral hypercalcemia of malignancy. Normal mice bearing Colon-26 tumors develop increases in both parathyroid hormone-relate...

journal_title：Cancer research

authors： Capparelli C,Kostenuik PJ,Morony S,Starnes C,Weimann B,Van G,Scully S,Qi M,Lacey DL,Dunstan CR

更新日期：2000-02-15 00:00:00

abstract：:The development of prophylactic cancer vaccines that protect healthy hosts from tumor development leaves open the question whether such vaccines are also effective against established tumors and metastases. We tested the therapeutic activity of a proven prophylactic anti-HER-2/neu vaccine against successive stages of ...

journal_title：Cancer research

authors： Nanni P,Nicoletti G,Palladini A,Croci S,Murgo A,Antognoli A,Landuzzi L,Fabbi M,Ferrini S,Musiani P,Iezzi M,De Giovanni C,Lollini PL

更新日期：2007-11-15 00:00:00

abstract：:Specific progesterone binding by cultured human breast carcinoma T47D, MCF-7, and ZR75-1 cells was decreased 25-40% by epidermal growth factor (EGF), with a 50% effective dose of 0.1 nM EGF. Studies with the soluble and particulate fractions prepared after homogenization of T47D cells grown in glass roller bottles rev...

journal_title：Cancer research

authors： Sarup JC,Rao KV,Fox CF

更新日期：1988-09-15 00:00:00

abstract：:(E)-2'-Deoxy-(fluoromethylene)cytidine (FMdC) is known as an inhibitor of ribonucleoside diphosphate reductase, a key enzyme in the de novo pathway of DNA synthesis. FMdC was tested as a modifier of radiation response in vitro on a human colon carcinoma cell line (WiDr), and the observed radiosensitization was confirm...

journal_title：Cancer research

authors： Coucke PA,Decosterd LA,Li YX,Cottin E,Chen X,Sun LQ,Stern S,Paschoud N,Denekamp J

更新日期：1999-10-15 00:00:00

abstract：:Cancer may arise from a cancer stem/progenitor cell that shares characteristics with its normal counterpart. We report the reconstitution of the original human prostate cancer specimen from epithelial cell lines (termed HPET for human prostate epithelial/hTERT) derived from this sample. These tumors can be described i...

journal_title：Cancer research

authors： Gu G,Yuan J,Wills M,Kasper S

更新日期：2007-05-15 00:00:00

abstract：:We describe two flow cytometric assays performed on populations of cells which have been stained with various fluorescent tracer molecules by the scrape-loading technique. One assay uses a simple one-color analysis on a flow cytometer by quantitating the fluorescence intensity of scrape-loaded lucifer yellow CH (LY) i...

journal_title：Cancer research

authors： Kavanagh TJ,Martin GM,el-Fouly MH,Trosko JE,Chang CC,Rabinovitch PS

更新日期：1987-11-15 00:00:00

abstract：:Energy restriction (ER) inhibits mammary carcinogenesis and results in a marked reduction in tumor size, effects likely to be explained by ER-mediated induction of apoptosis. The goal of this study was to investigate the molecular mechanism(s) accounting for apoptosis induction. To do this, chemically induced mammary ...

journal_title：Cancer research

authors： Thompson HJ,Zhu Z,Jiang W

更新日期：2004-02-15 00:00:00

abstract：:While showing promise, vaccination strategies to treat cancer require further optimization. Likely barriers to efficacy involve cancer-associated immunosuppression and peripheral tolerance, which limit the generation of effective vaccine-specific cytotoxic T lymphocytes (CTL). Because CD4(+) T cells improve CTL respon...

journal_title：Cancer research

authors： Ahrends T,Bąbała N,Xiao Y,Yagita H,van Eenennaam H,Borst J

更新日期：2016-05-15 00:00:00

abstract：:Retinoic acid (RA)-treated HL-60 cells were used as a model to study differentiation of granulocytic leukemias. RA induces these cells to mature into granulocytes and to decrease growth. Mediators of these RA effects have not been identified definitively, but transforming growth factor-beta (TGF-beta) has been implica...

journal_title：Cancer research

authors： Nunes I,Kojima S,Rifkin DB

更新日期：1996-02-01 00:00:00

abstract：:Regulators of differentiated cell fate can offer targets for managing cancer development and progression. Here, we identify Runx2 as a new regulator of epithelial cell fate in mammary gland development and breast cancer. Runx2 is expressed in the epithelium of pregnant mice in a strict temporally and hormonally regula...

journal_title：Cancer research

authors： Owens TW,Rogers RL,Best S,Ledger A,Mooney AM,Ferguson A,Shore P,Swarbrick A,Ormandy CJ,Simpson PT,Carroll JS,Visvader J,Naylor MJ

更新日期：2014-09-15 00:00:00

abstract：:Disruption of one allele for the cytosine-DNA methyltransferase 1 (DNMT1) gene in mice with a germ-line mutation in a tumor suppressor gene was shown previously to reduce tumor formation in juvenile animals. This effect is now reproduced in our studies of mature mice where this genetic DNMT1 reduction leads to a 50% d...

journal_title：Cancer research

authors： Belinsky SA,Klinge DM,Stidley CA,Issa JP,Herman JG,March TH,Baylin SB

更新日期：2003-11-01 00:00:00

abstract：:Although radiotherapy (RT) decreases the incidence of locoregional recurrence in breast cancer, patients with triple-negative breast cancer (TNBC) have increased risk of local recurrence following breast-conserving therapy. The relationship between RT and local recurrence is unknown. Here, we tested the hypothesis tha...

journal_title：Cancer research

authors： Rafat M,Aguilera TA,Vilalta M,Bronsart LL,Soto LA,von Eyben R,Golla MA,Ahrari Y,Melemenidis S,Afghahi A,Jenkins MJ,Kurian AW,Horst KC,Giaccia AJ,Graves EE

更新日期：2018-08-01 00:00:00

abstract：:Multiple endocrine neoplasia 2B (MEN 2B) is an inherited syndrome of early onset endocrine tumors and developmental anomalies. The disease is caused primarily by a methionine to threonine substitution of residue 918 in the kinase domain of the RET receptor (2B-RET); however, the molecular mechanisms that lead to the d...

journal_title：Cancer research

authors： Gujral TS,Singh VK,Jia Z,Mulligan LM

更新日期：2006-11-15 00:00:00

abstract：:Solid tumors contain a subset of stem-like cells that are resistant to the cytotoxic effects of chemotherapy/radiotherapy, but their susceptibility to cytolytic T lymphocyte (CTL) effector mechanisms has not been well characterized. Using a panel of early-passage human brain tumor stem/initiating cell (BTSC) lines der...

journal_title：Cancer research

authors： Brown CE,Starr R,Martinez C,Aguilar B,D'Apuzzo M,Todorov I,Shih CC,Badie B,Hudecek M,Riddell SR,Jensen MC

更新日期：2009-12-01 00:00:00

abstract：:Membrane type-1 matrix metalloproteinase (MT1-MMP) is a promising drug target in malignancy. The structure of MT1-MMP includes the hemopexin domain (PEX) that is distinct from and additional to the catalytic domain. Current MMP inhibitors target the conserved active site in the catalytic domain and, as a result, repre...

journal_title：Cancer research

authors： Remacle AG,Golubkov VS,Shiryaev SA,Dahl R,Stebbins JL,Chernov AV,Cheltsov AV,Pellecchia M,Strongin AY

更新日期：2012-05-01 00:00:00

abstract：:Stomach cancer incidence rates vary by ethnic group in New Mexico, with American Indians and Hispanic Whites at higher risk than the state's non-Hispanic White population. To further characterize the descriptive epidemiology of this disease in New Mexico, we investigated temporal trends in stomach cancer mortality and...

journal_title：Cancer research

authors： Wiggins CL,Becker TM,Key CR,Samet JM

更新日期：1989-03-15 00:00:00