Abstract：
:The influence of pretreatment with piperonylbutoxide (PIP) on the biological effects of N-nitrosodiethylamine (DEN) in vivo in Syrian golden hamsters was investigated. PIP pretreatment significantly reduced covalent binding of N-[ethyl-1-14C]DEN to tissue macromolecules in trachea, lung, and liver, while it did not change the tissue distribution of the parent compound. In a chronic experiment, hamsters treated with PIP before each DEN injection did not develop any tumors or precancerous changes in the lungs, while 60% of the animals given DEN alone developed lung tumors with the morphology of Clara cells and endocrine cells. Tumor incidence in the trachea was also significantly reduced by PIP, but to a lesser extent than in the lungs.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Schuller HM,McMahon JBsubject
Has Abstractpub_date
1985-06-01 00:00:00pages
2807-12issue
6eissn
0008-5472issn
1538-7445journal_volume
45pub_type
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