Abstract：
:Shorter alleles of a polymorphic [CAG](n) repeat in exon 1 of the androgen receptor (AR) have been associated with increased risk of prostate cancer and decreased risk of breast cancer. We prospectively assessed the association between the [CAG](n) repeat polymorphism in the androgen receptor and breast cancer risk among Caucasian women in a case-control study nested within the Nurses' Health Study cohort (cases, n = 727; controls, n = 969). In addition, we assessed whether androgen receptor genotype influences endogenous steroid hormone levels in women and whether the associations between androgen receptor alleles and breast cancer risk differed according to established breast cancer risk factors. Women with one or more long AR [CAG](n) repeat alleles (>or=22 repeats) were not at increased risk of breast cancer [odds ratio (OR), 1.06; 95% confidence interval (CI), 0.83-1.35]. Significant associations were not observed between AR genotypes comprised of two short alleles ([CAG](n)
journal_name
Cancer Resjournal_title
Cancer researchauthors
Haiman CA,Brown M,Hankinson SE,Spiegelman D,Colditz GA,Willett WC,Kantoff PW,Hunter DJsubject
Has Abstractpub_date
2002-02-15 00:00:00pages
1045-9issue
4eissn
0008-5472issn
1538-7445journal_volume
62pub_type
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