Analysis of the inhibitory effects of VP-16-213 (etoposide) and podophyllotoxin on thymidine transport and metabolism in Ehrlich ascites tumor cells in vitro.

abstract：:A novel monoclonal antibody was raised by immunization of mice with colorectal tumor cell lines. The fusion was screened by immunohistochemistry for binding to primary colorectal tumors. Subsequent analysis on primary disaggregated colorectal tumors show that the antibody recognizes a cell surface antigen expressed by...

journal_title：Cancer research

authors： Durrant LG,Harding SJ,Green NH,Buckberry LD,Parsons T

更新日期：2006-06-01 00:00:00

abstract：:The specific binding of labeled porcine insulin, human prolactin, and human growth hormone was studied in 63 human breast tumors and 15 nonmalignant breast tissues. Most (90%) of the tumors demonstrated significant binding of insulin, as did 80% of nonmalignant tissues. Autoradiographic studies indicated that insulin ...

journal_title：Cancer research

authors： Holdaway IM,Friesen HG

更新日期：1977-07-01 00:00:00

abstract：:A major challenge in treating cancer is the difficulty of bringing therapy to poorly perfused areas of solid tumors, which are often most resistant to chemotherapy and radiation. GRP94 is a chaperone protein localized in the endoplasmic reticulum with antiapoptotic properties. We report here that in vitro the proximal...

journal_title：Cancer research

authors： Reddy RK,Dubeau L,Kleiner H,Parr T,Nichols P,Ko B,Dong D,Ko H,Mao C,DiGiovanni J,Lee AS

更新日期：2002-12-15 00:00:00

abstract：:Normal young and postmenopausal women were placed into groups according to the ratio of the estrogens in their urine. Women whose ratio was greater than 1.3 if young and greater than 3.2 if postmenopausal were compared to women whose ratio was less than 0.7 and less than 2.1 for young and postmenopausal, respectively....

journal_title：Cancer research

authors： Longcope C,Pratt JH

更新日期：1978-11-01 00:00:00

abstract：:O6-Alkylguanine, a DNA adduct formed by nitrosoureas, becomes the site of a point mutation during DNA synthesis by preferentially base mispairing with thymine rather than correctly base pairing with cytosine. To repair this adduct, cells contain a limited amount of O6-alkylguanine-DNA alkyltransferase (alkyltransferas...

journal_title：Cancer research

authors： Gerson SL,Trey JE,Miller K,Benjamin E

更新日期：1987-01-01 00:00:00

abstract：:Clinical and pathological studies of cutaneous T-cell lymphomas (CTCL) reveal variations in tumor cell morphology and surface membrane phenotype that are of diagnostic and prognostic importance. Our study investigates blastic transformation and surface antigen change on CTCL cells in vitro under the influence of tumor...

journal_title：Cancer research

authors： Kadin ME,Nasu K,Sako D,Su IJ

更新日期：1984-08-01 00:00:00

abstract：:Strategies for the prevention of cancer include those aimed at reducing the incidence of cancer (primary prevention) and cancer mortality through early detection of tumors (secondary prevention). The efficacy of prevention interventions is evaluated by clinical trials. The conduct of clinical trials is aided by the us...

journal_title：Cancer research

authors： Helzlsouer KJ

更新日期：1994-04-01 00:00:00

abstract：:We investigated the relationship between age-related changes in natural resistance and antitumor effects using a spontaneously hypertensive rat (SHR rat) strain which shows a progressive decline of the number of T-cells and their functions as a result of aging. The growth of a weakly antigenic mammary adenocarcinoma S...

journal_title：Cancer research

authors： Matsuoka T,Takeichi N,Kobayashi H

更新日期：1987-07-01 00:00:00

abstract：:(-)-Epigallocatechin-3-gallate (EGCG), the principal polyphenol in green tea, has been shown to inhibit the growth of many cancer cell lines and to suppress the phosphorylation of epidermal growth factor receptor (EGFR). We observed similar effects of EGCG in esophageal squamous cell carcinoma KYSE 150 cells and epide...

journal_title：Cancer research

authors： Hou Z,Sang S,You H,Lee MJ,Hong J,Chin KV,Yang CS

更新日期：2005-09-01 00:00:00

abstract：:Chromosomal passenger complex (CPC) has been demonstrated to be a potential target of cancer therapy by inhibiting Aurora B or survivin in different types of cancer including neuroblastoma. However, chemical inhibition of either Aurora B or survivin does not target CPC specifically due to off-target effects or CPC-ind...

journal_title：Cancer research

authors： Sun M,Veschi V,Bagchi S,Xu M,Mendoza A,Liu Z,Thiele CJ

更新日期：2019-10-01 00:00:00

abstract：:The rat pancreatic carcinoma cell line AR4-2J was screened for growth-associated genes linked to the mitogenic effect of the novel gut brain hormone, pituitary adenylate cyclase activating polypeptide (PACAP). Using the mRNA differential display technique, we identified and sequenced an unknown rat gene, PACAP-respons...

journal_title：Cancer research

authors： Schäfer H,Trauzold A,Siegel EG,Fölsch UR,Schmidt WE

更新日期：1996-06-01 00:00:00

abstract：:In normal tissues, the steady-state level of CD44 mRNA is low, and the variety of alternatively spliced transcripts produced by this complex gene is limited. Conversely, increased and disorderly expression of this gene has been observed in a number of types of cancer. This study analyzed the order in which the CD44 va...

journal_title：Cancer research

authors： Goodison S,Yoshida K,Sugino T,Woodman A,Gorham H,Bolodeoku J,Kaufmann M,Tarin D

更新日期：1997-08-01 00:00:00

abstract：:Two human erythroleukemia cell lines, HEL and K562, express transglutaminase activity. The enzyme was identified as a tissue transglutaminase following chromatographic purification. All-trans-retinoic acid (10 microM) stimulated differentiation in HEL cells as judged by a 4-fold increase in hemoglobin content and a re...

journal_title：Cancer research

authors： Suedhoff T,Birckbichler PJ,Lee KN,Conway E,Patterson MK Jr

更新日期：1990-12-15 00:00:00

abstract：:Mean plasma hypoxanthine (Hyp) concentrations determined by high-pressure liquid chromatography were 0.56 microM (range, 0.2 to 1.9 microM) in 16 normal subjects, 0.68 microM (range, 0.1 to 1.1 microM) in 10 untreated acute leukemic subjects, and 0.89 microM (range, 0.3 to 2.6 microM) in 14 solid tumor patients. Despi...

journal_title：Cancer research

authors： Wung WE,Howell SB

更新日期：1984-07-01 00:00:00

abstract：:Angiopoietin-1 (Ang1) mediates angiogenesis by enhancing endothelial cell survival and migration. It is also known that Ang1 activates Tie2, an endothelial-specific tyrosine kinase receptor, but the molecular mechanism of this process is not clear. In this study, we investigated whether reactive oxygen species (ROS) p...

journal_title：Cancer research

authors： Kim YM,Kim KE,Koh GY,Ho YS,Lee KJ

更新日期：2006-06-15 00:00:00

abstract：:The human colon cancer cell line HCT does not express any detectable HLA class I antigens on the cell surface. RNA blot analyses showed that HCT cells synthesize easily detectable levels of heavy chains as well as beta 2-microglobulin (beta 2m) transcripts. Experiments of immunoprecipitation revealed the presence of i...

journal_title：Cancer research

authors： Gattoni-Celli S,Kirsch K,Timpane R,Isselbacher KJ

更新日期：1992-03-01 00:00:00

abstract：:The degree of heterogeneity among cancer stem cells (CSC) remains ill-defined and may hinder effective anti-CSC therapy. Evaluation of oral cancers for such heterogeneity identified two compartments within the CSC pool. One compartment was detected using a reporter for expression of the H3K4me3 demethylase JARID1B to ...

journal_title：Cancer research

authors： Facompre ND,Harmeyer KM,Sole X,Kabraji S,Belden Z,Sahu V,Whelan K,Tanaka K,Weinstein GS,Montone KT,Roesch A,Gimotty PA,Herlyn M,Rustgi AK,Nakagawa H,Ramaswamy S,Basu D

更新日期：2016-09-15 00:00:00

abstract：:We describe a method to postlabel, in vivo, biotinylated monoclonal antibodies pretargeted onto tumor deposits when most of the non-tumor-bound antibodies have already been cleared as avidin-bound complexes. The application of this principle to tumor detection by immunoscintigraphy was tested in 20 patients with histo...

journal_title：Cancer research

authors： Paganelli G,Magnani P,Zito F,Villa E,Sudati F,Lopalco L,Rossetti C,Malcovati M,Chiolerio F,Seccamani E

更新日期：1991-11-01 00:00:00

abstract：:Immunohistochemical localization of estrogen receptor (ER) using specific monoclonal anti-human estrogen receptor antibody, H222, with an immunoperoxidase technique was performed on fresh frozen tissue derived from 100 endometrial adenocarcinomas. Immunohistochemical evaluation incorporated both intensity and distribu...

journal_title：Cancer research

authors： Budwit-Novotny DA,McCarty KS,Cox EB,Soper JT,Mutch DG,Creasman WT,Flowers JL,McCarty KS Jr

更新日期：1986-10-01 00:00:00

abstract：:The activity of the serine protease plasminogen activator (PA), which correlates with tumorigenicity and metastatic capacity, was examined using the 125I-labeled fibrin plate assay in cell extracts from four human glioma lines as a function of growth in vitro. Cell-associated inhibitory activity to plasmin and urokina...

journal_title：Cancer research

authors： Gross JL,Behrens DL,Mullins DE,Kornblith PL,Dexter DL

更新日期：1988-01-15 00:00:00

abstract：:Synovial sarcoma is a soft tissue malignancy characterized by the fusion of SS18 to either SSX1, SSX2, or SSX4 genes. SS18 and SSX are transcriptional cofactors involved in activation and repression of gene transcription, respectively. SS18 interacts with SWI/SNF, whereas SSX associates with the polycomb chromatin rem...

journal_title：Cancer research

authors： Lubieniecka JM,de Bruijn DR,Su L,van Dijk AH,Subramanian S,van de Rijn M,Poulin N,van Kessel AG,Nielsen TO

更新日期：2008-06-01 00:00:00

abstract：:Intrahepatic cholangiocarcinoma is a treatment refractory malignancy with a high mortality and an increasing incidence worldwide. Recent studies have observed that activation of Notch and AKT signaling within mature hepatocytes is able to induce the formation of tumors displaying biliary lineage markers, thereby raisi...

journal_title：Cancer research

authors： Guest RV,Boulter L,Kendall TJ,Minnis-Lyons SE,Walker R,Wigmore SJ,Sansom OJ,Forbes SJ

更新日期：2014-02-15 00:00:00

abstract：:Ten aminoacyl transfer RNA's prepared from human malignant trophoblastic cells (BeWo line) were compared with the corresponding aminoacyl transfer RNA's from normal human chorionic tissue by cochromatography on a RPC-5 column. Phenylalanyl transfer RNA (Phe-tRNA) of BeWo cells had, in addition to the single species of...

journal_title：Cancer research

authors： Kuchino Y,Borek E

更新日期：1976-08-01 00:00:00

abstract：:Myc oncoproteins exert tumorigenic effects by regulating expression of target oncogenes. Histone H3 lysine 79 (H3K79) methylation at Myc-responsive elements of target gene promoters is a strict prerequisite for Myc-induced transcriptional activation, and DOT1L is the only known histone methyltransferase that catalyzes...

journal_title：Cancer research

authors： Wong M,Tee AEL,Milazzo G,Bell JL,Poulos RC,Atmadibrata B,Sun Y,Jing D,Ho N,Ling D,Liu PY,Zhang XD,Hüttelmaier S,Wong JWH,Wang J,Polly P,Perini G,Scarlett CJ,Liu T

更新日期：2017-05-01 00:00:00

abstract：:S49 cyc- lymphoma cells contain a mutation resulting in loss of a functional guanine nucleotide regulatory protein rendering their adenylate cyclase refractory to most stimuli. S49 wild-type and cyc- clones were used in the present study to investigate the possible association of altered cAMP metabolism with tumorigen...

journal_title：Cancer research

authors： Stadel JM,Johnson RK,Mirabelli CK,Powers DA,Sung CM,Faucette LF,McCabe FL,Crooke ST

更新日期：1988-02-01 00:00:00

abstract：:The growth-inhibitory effect of 6-methylmercaptopurine riboside (MMPR) against leukemia L1210 cells in culture was dramatically potentiated by the addition of guanine nucleosides to the medium. In the presence of either deoxyguanosine or guanosine, the concentration of MMPR that caused 50% inhibition of growth was 35 ...

journal_title：Cancer research

authors： Grindey GB,Lowe JK,Divekar AY,Hakala MT

更新日期：1976-02-01 00:00:00

abstract：:Expression of some members of the cadherin family is reduced in several human tumors, and CDH13 (H-cadherin), located on chromosome 16q24.2-3, may function as a tumor suppressor gene. In human tumors, loss of expression of many tumor suppressor genes occurs by aberrant promoter region methylation. We examined the meth...

journal_title：Cancer research

authors： Toyooka KO,Toyooka S,Virmani AK,Sathyanarayana UG,Euhus DM,Gilcrease M,Minna JD,Gazdar AF

更新日期：2001-06-01 00:00:00

abstract：:Rapid or accelerated tumor cell repopulation after significant tumor cell killing induced by various cytotoxic agents often compromises the expected therapeutic benefit of such tumor responses. Here, we discuss the concept that tumor cell repopulation after certain cytotoxic therapies, using vascular disrupting agents...

journal_title：Cancer research

authors： Shaked Y,Kerbel RS

更新日期：2007-08-01 00:00:00

abstract：:Reported estimates of ras mutation prevalence in lung adenocarcinoma of 15-24% may be underestimates because of the insensitivity of the assays used. We have devised a rapid, non-radioactive assay for ras mutations, which detects 1 mutant allele/10(3) normal alleles and have used it to study DNA isolated from 53 lung ...

journal_title：Cancer research

authors： Mills NE,Fishman CL,Rom WN,Dubin N,Jacobson DR

更新日期：1995-04-01 00:00:00

abstract：:The concentration of potassium (K+) and sodium (Na+) was measured in breast cyst fluid (BCF) from 611 cysts greater than 3 ml aspirated in 520 women with gross cystic disease of the breast. These women were enrolled, from 1983 on, in a cohort study aimed at assessing the relationship between cyst type, as defined by t...

journal_title：Cancer research

authors： Naldoni C,Costantini M,Dogliotti L,Bruzzi P,Bucchi L,Buzzi G,Torta M,Angeli A

更新日期：1992-04-01 00:00:00