Abstract：
:Two human erythroleukemia cell lines, HEL and K562, express transglutaminase activity. The enzyme was identified as a tissue transglutaminase following chromatographic purification. All-trans-retinoic acid (10 microM) stimulated differentiation in HEL cells as judged by a 4-fold increase in hemoglobin content and a reduction in cell proliferation. The transglutaminase activity increased 9-fold. This increase in transglutaminase was the result of a pretranslational regulation of the gene as revealed by Northern blot analysis of mRNA. These changes were not a result of cell apoptosis, since parallel DNA degradation catalyzed by a Ca2(+)-dependent endonuclease could not be demonstrated. The K562 cells, in contrast, showed no transglutaminase induction following exposure to retinoic acid and displayed no changes in maturation markers or cell growth.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Suedhoff T,Birckbichler PJ,Lee KN,Conway E,Patterson MK Jrsubject
Has Abstractpub_date
1990-12-15 00:00:00pages
7830-4issue
24eissn
0008-5472issn
1538-7445journal_volume
50pub_type
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