Pharmacokinetics of vincristine in the cerebrospinal fluid of humans.

abstract：:The papillomaviruses associated with human anogenital carcinomas encode two transforming genes, E6 and E7. The oncoprotein products of these two genes complex with the tumor suppressor gene products p53 and pRB, respectively. The loss of the normal function of these tumor suppressor gene products, either as a conseque...

journal_title：Cancer research

authors： Howley PM

更新日期：1991-09-15 00:00:00

abstract：:Seventeen young women with clinically confirmed mammary dysplasia and six age-matched controls were treated with alpha-tocopherol. Serum samples collected during the luteal phase of each woman at monthly intervals for the 4-month duration of the study were analyzed for serum luteinizing hormone, follicle-stimulating h...

journal_title：Cancer research

authors： Sundaram GS,London R,Margolis S,Wenk R,Lustgarten J,Nair PP,Goldstein P

更新日期：1981-09-01 00:00:00

abstract：:A series of mouse mammary tumor subpopulation lines were compared for growth properties and sensitivity to chemotherapeutic drugs when grown as boluses in a collagen gel matrix versus in monolayer culture. Although the cell lines exhibited characteristic rates of bolus expansion in collagen, this growth was not parall...

journal_title：Cancer research

authors： Miller BE,Miller FR,Heppner GH

更新日期：1985-09-01 00:00:00

abstract：:Activated leukocyte cell adhesion molecule (ALCAM/CD166/MEMD) could function as a cell surface sensor for cell density, controlling the transition between local cell proliferation and tissue invasion in melanoma progression. We have tested the hypothesis that progressive cell clustering controls the proteolytic cascad...

journal_title：Cancer research

authors： Lunter PC,van Kilsdonk JW,van Beek H,Cornelissen IM,Bergers M,Willems PH,van Muijen GN,Swart GW

更新日期：2005-10-01 00:00:00

abstract：:Human cancer cell lines are commonly used in basic cancer research to understand the behavior of primary tumors. Aberrations in the DNA methylation patterns are nowadays recognized as a hallmark of the cancer cell. However, no comprehensive study defines the DNA methylation environment present in the established cance...

journal_title：Cancer research

authors： Paz MF,Fraga MF,Avila S,Guo M,Pollan M,Herman JG,Esteller M

更新日期：2003-03-01 00:00:00

abstract：:The relevance of cysteine metabolism in cancer has gained considerable interest in recent years, largely focusing on its role in generating the antioxidant glutathione. Through metabolomic profiling using a combination of high-throughput liquid and gas chromatography-based mass spectrometry on a total of 69 patient-de...

journal_title：Cancer research

authors： Prabhu A,Sarcar B,Kahali S,Yuan Z,Johnson JJ,Adam KP,Kensicki E,Chinnaiyan P

更新日期：2014-02-01 00:00:00

abstract：:The "a disintegrin and metalloprotease" (ADAM) family contributes to regulation of the cell-cell and cell-matrix interactions that are critical determinants of malignancy. To determine the relationship between metastasis and ADAM proteins, we compared the mRNA levels of ADAM9, -10, -12, -15, and -17 in sublines of an ...

journal_title：Cancer research

authors： Shintani Y,Higashiyama S,Ohta M,Hirabayashi H,Yamamoto S,Yoshimasu T,Matsuda H,Matsuura N

更新日期：2004-06-15 00:00:00

abstract：:GPRC5A is a G-protein-coupled receptor expressed in lung tissue but repressed in most human lung cancers. Studies in Gprc5a(-/-) mice have established its role as a tumor-suppressor function in this setting, but the basis for its role has been obscure. Here, we report that GPRC5A functions as a negative modulator of E...

journal_title：Cancer research

authors： Zhong S,Yin H,Liao Y,Yao F,Li Q,Zhang J,Jiao H,Zhao Y,Xu D,Liu S,Song H,Gao Y,Liu J,Ma L,Pang Z,Yang R,Ding C,Sun B,Lin X,Ye X,Guo W,Han B,Zhou BP,Chin YE,Deng J

更新日期：2015-05-01 00:00:00

abstract：:Mutations in the p53 gene were identified in five of eight non-melanoma skin tumors in the sun-exposed areas of xeroderma pigmentosum patients by the polymerase chain reaction and single strand conformation polymorphism analysis followed by sequencing of the DNA. All mutations occurred at the dipyrimidine sites, indic...

journal_title：Cancer research

authors： Sato M,Nishigori C,Zghal M,Yagi T,Takebe H

更新日期：1993-07-01 00:00:00

abstract：:Fludarabine (9-beta-arabinofuranosyl-2-fluoroadenine-5'-monophosphate) is clinically active against chronic lymphocytic leukemia and low-grade lymphomas. We reported previously that fludarabine nucleoside synergistically enhanced cisplatin (CDDP)-induced cytotoxicity in vitro, and that the synergism was concomitant wi...

journal_title：Cancer research

authors： Li L,Liu X,Glassman AB,Keating MJ,Stros M,Plunkett W,Yang LY

更新日期：1997-04-15 00:00:00

abstract：:In order to determine the potential role of sex steroid and 1,25-dihydroxyvitamin D3 in the spreading of colorectal cancer, previously hypothesized from epidemiological and experimental data, specific androgen (AR, n = 94), estrogen (ER, n = 60), progesterone (PGR, n = 50), and 1,25-dihydroxyvitamin D3 receptors (VDR,...

journal_title：Cancer research

authors： Meggouh F,Lointier P,Saez S

更新日期：1991-02-15 00:00:00

abstract：:Elevated levels of TGFβ are a negative prognostic indicator for patients diagnosed with pancreatic cancer; as a result, the TGFβ pathway is an attractive target for therapy. However, clinical application of pharmacologic inhibition of TGFβ remains challenging because TGFβ has tumor suppressor functions in many epithel...

journal_title：Cancer research

authors： Ostapoff KT,Cenik BK,Wang M,Ye R,Xu X,Nugent D,Hagopian MM,Topalovski M,Rivera LB,Carroll KD,Brekken RA

更新日期：2014-09-15 00:00:00

abstract：:The carcinogenicities of a choline deficient L-amino acid defined (CDAA) diet and a semipurified choline deficient diet were comparatively examined. A total of 60 male Fischer 344 rats, 6 weeks old, were divided into 5 experimental groups each consisting of 12 rats. Group 1 received the CDAA diet chronically to the en...

journal_title：Cancer research

authors： Nakae D,Yoshiji H,Mizumoto Y,Horiguchi K,Shiraiwa K,Tamura K,Denda A,Konishi Y

更新日期：1992-09-15 00:00:00

abstract：:verapamil, a calcium-influx blocker, enhanced the cytotoxicity of vincristine (VCR) in vitro 6- to 12-fold in eight human hemopoietic tumor cell lines established from acute lymphatic leukemia, acute myelogenous leukemia, and Burkitt's lymphoma. Great enhancement of VCR cytotoxicity was obtained in a VCR-resistant sub...

journal_title：Cancer research

authors： Tsuruo T,Iida H,Tsukagoshi S,Sakurai Y

更新日期：1983-05-01 00:00:00

abstract：:Tumor infiltrating lymphocytes (TIL) were isolated from 22 tumors obtained from 15 patients with metastatic melanoma. In 18 of the 22 tumors, a substantial number of lymphocytes was isolated with an average lymphoid cell:tumor cell ratio of 1.26. The TIL were predominantly cytotoxic/suppressor T-lymphocytes with an av...

journal_title：Cancer research

authors： Itoh K,Tilden AB,Balch CM

更新日期：1986-06-01 00:00:00

abstract：:The s.c. administration of gamma-L-glutaminyl-4-hydroxybenzene (GHB) to neonatal black mice produced a prompt, generalized, and selective swelling and lysis of the melanocytes of the hair follicles. The findings indicate that this cytotoxic effect was dependent upon the intracellular activation of GHB by tyrosinase. S...

journal_title：Cancer research

authors： Burger PC,Kemper LA,Vogel FS

更新日期：1979-05-01 00:00:00

abstract：:Multidrug-resistant cells are thought to maintain low intracellular cytotoxic drug concentration though the active efflux of drugs across the cell membrane. It is presently believed that P-glycoprotein mediates this energy-dependent drug efflux by interacting directly with various lipophilic compounds. In this report,...

journal_title：Cancer research

authors： Zordan-Nudo T,Ling V,Liu Z,Georges E

更新日期：1993-12-15 00:00:00

abstract：:The aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 (AIMP2) splice variant designated DX2 is induced by cigarette smoke carcinogens and is often detected in human lung cancer specimens. However, the function of DX2 in lung carcinogenesis is obscure. In this study, we found that DX2 expression w...

journal_title：Cancer research

authors： Oh AY,Jung YS,Kim J,Lee JH,Cho JH,Chun HY,Park S,Park H,Lim S,Ha NC,Park JS,Park CS,Song GY,Park BJ

更新日期：2016-08-15 00:00:00

abstract：:Prior investigations on the beneficial effect of dietary processed tomato products and lycopene on prostate cancer risk suggested that lycopene may require the presence of other constituents to exert its chemopreventive potential. We investigated whether ketosamines, a group of carbohydrate derivatives present in dehy...

journal_title：Cancer research

authors： Mossine VV,Chopra P,Mawhinney TP

更新日期：2008-06-01 00:00:00

abstract：:Acquired resistance to cisplatin has been generated in vitro in two human ovarian carcinoma cell lines: 41M, established from a previously untreated patient; and CH1, from a patient previously treated with cisplatin and cis-diammine-1,1-cyclobutane dicarboxylatoplatinum(II) (carboplatin). In neither cell line with acq...

journal_title：Cancer research

authors： Kelland LR,Mistry P,Abel G,Loh SY,O'Neill CF,Murrer BA,Harrap KR

更新日期：1992-07-15 00:00:00

abstract：:Activation of c-Met signaling and beta-catenin mutations are frequent genetic events observed in liver cancer development. Recently, we demonstrated that activated beta-catenin can cooperate with c-Met to induce liver cancer formation in a mouse model. Cyclin D1 (CCND1) is an important cell cycle regulator that is con...

journal_title：Cancer research

authors： Patil MA,Lee SA,Macias E,Lam ET,Xu C,Jones KD,Ho C,Rodriguez-Puebla M,Chen X

更新日期：2009-01-01 00:00:00

abstract：:We have shown previously that IgM from Ehrlich tumor (ET)-immunized mice, recognizing ET cell surface carbohydrates, protects control mice to a subsequent tumor challenge. The factors involved in such IgM-mediated protection were unknown, since it was independent of complement activation. Here, we have extended these ...

journal_title：Cancer research

authors： Gil J,Alvarez R,Viñuela JE,Ruiz de Morales JG,Bustos A,De la Concha EG,Subiza JL

更新日期：1990-11-15 00:00:00

abstract：:Peripheral blood myeloblasts from five patients with acute myeloblastic leukemia and peripheral remission leukocytes from two of these patients were radiolabeled by the lactoperoxidase-catalyzed surface radioiodination technique and incubated in a nutrient medium at 37 degrees. Radioactive materials shed from viable c...

journal_title：Cancer research

authors： Taub RN,Roncari DA,Baker MA

更新日期：1978-12-01 00:00:00

abstract：:Busulfan causes long-lasting defects in the hematopoietic stem cells and in the immune system of mice. We designed studies to determine whether chloramphenicol further damaged the already defective hematopoietic stem cells of mice that were pretreated with busulfan, and we unexpectedly observed that mice given injecti...

journal_title：Cancer research

authors： Robin E,Berman M,Bhoopalam N,Cohen H,Fried W

更新日期：1981-09-01 00:00:00

abstract：:The macrophage content of spontaneous metastases has been quantified morphometrically for a panel of rodent tumors at different stages of metastatic tumor growth. Using a histochemical technique to selectively stain macrophages, we have evaluated the relative content of macrophages in spontaneous pulmonary metastases ...

journal_title：Cancer research

authors： Bugelski PJ,Corwin SP,North SM,Kirsh RL,Nicolson GL,Poste G

更新日期：1987-08-01 00:00:00

abstract：:Aberrant cholesterol metabolism is increasingly appreciated to be essential for prostate cancer initiation and progression. Transcript expression of the high-density lipoprotein-cholesterol receptor scavenger receptor B1 (SR-B1) is elevated in primary prostate cancer. Hypothesizing that SR-B1 expression may help facil...

journal_title：Cancer research

authors： Gordon JA,Noble JW,Midha A,Derakhshan F,Wang G,Adomat HH,Tomlinson Guns ES,Lin YY,Ren S,Collins CC,Nelson PS,Morrissey C,Wasan KM,Cox ME

更新日期：2019-07-01 00:00:00

abstract：:Gamma-aminobutyric acid (GABA) functions primarily as an inhibitory neurotransmitter in the mature central nervous system, and GABA/GABA receptors are also present in nonneural tissues, including cancer, but their precise function in nonneuronal or cancerous cells has thus far been poorly defined. Through the genome-w...

journal_title：Cancer research

authors： Takehara A,Hosokawa M,Eguchi H,Ohigashi H,Ishikawa O,Nakamura Y,Nakagawa H

更新日期：2007-10-15 00:00:00

abstract：:Replicative senescence limits the number of times primary cells can divide and is therefore regarded as a potential checkpoint for cancer progression. The majority of studies examining changes of gene expression upon senescence have been made with stationary senescent cells. We wanted to study the transition from norm...

journal_title：Cancer research

authors： Larsson O,Scheele C,Liang Z,Moll J,Karlsson C,Wahlestedt C

更新日期：2004-01-15 00:00:00

abstract：:Transcription factor p53 and phosphatase PTEN are two tumor suppressors that play essential roles in suppression of carcinogenesis. However, the mechanisms by which p53 mediates anticancer activity and the relationship between p53 and PTEN are not well understood. In the present study, we found that pretreatment of mo...

journal_title：Cancer research

authors： Wang J,Ouyang W,Li J,Wei L,Ma Q,Zhang Z,Tong Q,He J,Huang C

更新日期：2005-08-01 00:00:00

abstract：:A sound rationale exists for antibody targeting of the MET receptor tyrosine kinase, but therapeutic agents that can broadly block HGF ligand binding and exon 14-mutated or amplified MET to induce receptor degradation have yet to be reported. Here we report the identification of several MET monoclonal antibodies (mAb)...

journal_title：Cancer research

authors： Yang Y,Mandiyan S,Robinson BS,McMahon G

更新日期：2016-10-01 00:00:00