Neutralizing murine TGFβR2 promotes a differentiated tumor cell phenotype and inhibits pancreatic cancer metastasis.

abstract：:The effect of heat on 1,4-dihydroxy-5,8-bis[2-[(2-hydroxyethyl)amino]ethylamino]-9, 10-anthracenedione dihydrochloride (DHAD; mitoxantrone, NSC 301739) cytotoxicity was studied in V79 Chinese hamster cells. An overnight exposure to the drug at 40 degrees C enhanced drug damage in chromosome aberrations, culture growth...

journal_title：Cancer research

authors： Yang SJ,Rafla S

更新日期：1985-08-01 00:00:00

abstract：:Exposure of mice to total body irradiation induces nuclear factor kappaB (NFkappaB) activation in a tissue-specific manner. In addition to the spleen, lymph nodes, and bone marrow, the tissues that exhibit NFkappaB activation now include the newly identified site of the intestinal epithelial cells. NFkappaB activated ...

journal_title：Cancer research

authors： Wang Y,Meng A,Lang H,Brown SA,Konopa JL,Kindy MS,Schmiedt RA,Thompson JS,Zhou D

更新日期：2004-09-01 00:00:00

abstract：:Alkaline phosphatase was monitored in 17 mice with s.c.-implanted tumors to relate the total circulating alkaline phosphatase to the total number of tumor cells in each mouse. There was a semilogarithmic relationship between the alkaline phosphatase units and the number of tumor cells. A time-independent standard plot...

journal_title：Cancer research

authors： Hiramoto RN,Ghanta VK,Soong SJ,Hurst DC

更新日期：1977-02-01 00:00:00

abstract：:Hyaluronic acid (HA) binds to cell-surface receptors such as CD44, and seems to be involved in cell adhesion, motility, and tumor progression in brain. To identify gene expression changes that are initiated by HA, we explored human cytokine arrays in U87MG glioma cells and identified osteopontin, a secreted matrix pro...

journal_title：Cancer research

authors： Kim MS,Park MJ,Moon EJ,Kim SJ,Lee CH,Yoo H,Shin SH,Song ES,Lee SH

更新日期：2005-02-01 00:00:00

abstract：:Tumor necrosis factor (TNF) acts via a cell surface receptor to induce a variety of cellular events including cytolysis, differentiation, and mitogenesis. The mechanisms underlying the cell specific actions of TNF are not known. In the present study, postreceptor events associated with the autoinduction of TNF express...

journal_title：Cancer research

authors： Spriggs DR,Sherman ML,Imamura K,Mohri M,Rodriguez C,Robbins G,Kufe DW

更新日期：1990-11-15 00:00:00

abstract：:In this study, we show that rodent albumin is expressed by and cell surface localized on at least some murine tumor cells. We have been able to purify this tumor-expressed albumin from in vivo grown tumor masses. The tumor-expressed albumin, unlike normal serum albumin purified from blood, is capable of inhibiting T-c...

journal_title：Cancer research

authors： Graner MW,Likhacheva A,Davis J,Raymond A,Brandenberger J,Romanoski A,Thompson S,Akporiaye E,Katsanis E

更新日期：2004-11-01 00:00:00

abstract：:Tumor development is angiogenesis dependent, and vascular endothelial growth factor (VEGF) is a key growth factor in this process. We demonstrate that high expression of VEGF mRNA in 55 superficial bladder cancers was associated with earlier recurrence (P = 0.001; hazard ratio, 3.09) and progression to a more invasive...

journal_title：Cancer research

authors： Crew JP,O'Brien T,Bradburn M,Fuggle S,Bicknell R,Cranston D,Harris AL

更新日期：1997-12-01 00:00:00

abstract：:Gliomas are primary brain tumors with high mortality and heterogeneous biology that is insufficiently understood. In this study, we performed a systematic analysis of the intrinsic organization of complex glioma transcriptome to gain deeper knowledge of the tumor biology. Gene coexpression relationships were explored ...

journal_title：Cancer research

authors： Ivliev AE,'t Hoen PA,Sergeeva MG

更新日期：2010-12-15 00:00:00

abstract：:Because chronic intestinal inflammation is a risk factor for colorectal cancer, we hypothesized that genetic variants of inflammatory mediators, such as mannose-binding lectin 2 (MBL2), are associated with colon cancer susceptibility. Here, we report the association of 24 MBL2 single-nucleotide polymorphisms (SNP) and...

journal_title：Cancer research

authors： Zanetti KA,Haznadar M,Welsh JA,Robles AI,Ryan BM,McClary AC,Bowman ED,Goodman JE,Bernig T,Chanock SJ,Harris CC

更新日期：2012-03-15 00:00:00

abstract：:p63, a recently identified member of the p53 gene family, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. To explore the penetrance of p63 in bladder carcinogenesis, we performed expression and mutation analyses of two major isotypes, TAp63 and deltaNp63, in 63 bladder...

journal_title：Cancer research

authors： Park BJ,Lee SJ,Kim JI,Lee SJ,Lee CH,Chang SG,Park JH,Chi SG

更新日期：2000-07-01 00:00:00

abstract：:4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and its glucuronides (sum of which is denoted as total NNAL) are metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). NNK and NNAL can induce lung cancer in laboratory animals but human data are limited. The association between prediagnostic levels o...

journal_title：Cancer research

authors： Yuan JM,Koh WP,Murphy SE,Fan Y,Wang R,Carmella SG,Han S,Wickham K,Gao YT,Yu MC,Hecht SS

更新日期：2009-04-01 00:00:00

abstract：:The Ral family of small G proteins has been implicated in tumorigenesis, invasion, and metastasis. However, little emphasis has been placed on clarifying the individual roles of the two Ral proteins, RalA and RalB, in these processes in view of their high sequence homology. Here we analyze the separate contributions o...

journal_title：Cancer research

authors： Oxford G,Owens CR,Titus BJ,Foreman TL,Herlevsen MC,Smith SC,Theodorescu D

更新日期：2005-08-15 00:00:00

abstract：:Structural alterations of the p53 gene were investigated in tissue specimens of gastric and cervical cancers and in cell lines of gastric, esophageal, and cervical cancers, by polymerase chain reaction-single-strand conformation polymorphism analysis. Two of the four gastric cancer metastases and four of the eight cel...

journal_title：Cancer research

authors： Yamada Y,Yoshida T,Hayashi K,Sekiya T,Yokota J,Hirohashi S,Nakatani K,Nakano H,Sugimura T,Terada M

更新日期：1991-11-01 00:00:00

abstract：:The process of monoclonal antibody (MAb) binding to tumor cells is greatly influenced by the biology of the respective antigen. This was concluded from an analysis of binding and release of MAbs and MAb fragments to melanoma cells at different concentration levels and different temperatures. With an antigen known to b...

journal_title：Cancer research

authors： Matzku S,Bröcker EB,Brüggen J,Dippold WG,Tilgen W

更新日期：1986-08-01 00:00:00

abstract：:Pheochromocytomas are tumors originating from chromaffin cells, the large majority of which are sporadic neoplasms. The genetic and molecular events determining their tumorigenesis continue to remain unknown. On the other hand, RET germ-line mutations cause the inheritance of familial tumors in multiple endocrine neop...

journal_title：Cancer research

authors： Le Hir H,Colucci-D'Amato LG,Charlet-Berguerand N,Plouin PF,Bertagna X,de Franciscis V,Thermes C

更新日期：2000-03-01 00:00:00

abstract：:Ras is frequently mutated in cancer, however, there is a lack of consensus in the literature regarding the cancer mutation frequency of Ras, with quoted values varying from 10%-30%. This variability is at least in part due to the selective aggregation of data from different databases and the dominant influence of part...

journal_title：Cancer research

authors： Prior IA,Hood FE,Hartley JL

更新日期：2020-07-15 00:00:00

abstract：:Mandibular condyles of late embryonic NMRI mice were used to study the effect of the FBR murine osteosarcoma virus in an in vitro tissue culture system. Chondroprogenitor cells and chondroblastic cells present in the condylar tissue normally undergo rapid differentiation in vitro which results in an advanced stage of ...

journal_title：Cancer research

authors： Schmidt J,Livne E,Erfle V,Gössner W,Silbermann M

更新日期：1986-06-01 00:00:00

abstract：:Prior investigations on the beneficial effect of dietary processed tomato products and lycopene on prostate cancer risk suggested that lycopene may require the presence of other constituents to exert its chemopreventive potential. We investigated whether ketosamines, a group of carbohydrate derivatives present in dehy...

journal_title：Cancer research

authors： Mossine VV,Chopra P,Mawhinney TP

更新日期：2008-06-01 00:00:00

abstract：:Neuroblastoma (NB), a tumor originating from the sympathetic nervous system, is the most common extracranial neurological tumor of childhood. Human NB cells may differentiate in vitro under treatment with biological agents, as gamma-interferon (IFN-gamma) and tumor necrosis factor (TNF). Unfortunately, NB cell lines r...

journal_title：Cancer research

authors： Ponzoni M,Casalaro A,Lanciotti M,Montaldo PG,Cornaglia-Ferraris P

更新日期：1992-02-15 00:00:00

abstract：:Compelling evidences indicate a key role for regulatory T cells (T(reg)) on the host response to cancer. The Wilms' tumor antigen (WT1) is overexpressed in several human leukemias and thus considered as promising target for development of leukemia vaccine. However, recent studies indicated that the generation of effec...

journal_title：Cancer research

authors： Lehe C,Ghebeh H,Al-Sulaiman A,Al Qudaihi G,Al-Hussein K,Almohareb F,Chaudhri N,Alsharif F,Al-Zahrani H,Tbakhi A,Aljurf M,Dermime S

更新日期：2008-08-01 00:00:00

abstract：:Transcription factor p53 and phosphatase PTEN are two tumor suppressors that play essential roles in suppression of carcinogenesis. However, the mechanisms by which p53 mediates anticancer activity and the relationship between p53 and PTEN are not well understood. In the present study, we found that pretreatment of mo...

journal_title：Cancer research

authors： Wang J,Ouyang W,Li J,Wei L,Ma Q,Zhang Z,Tong Q,He J,Huang C

更新日期：2005-08-01 00:00:00

abstract：:Expression of resistance to cis-diamminedichloroplatinum(II) (CDDP), one of the most effective chemotherapeutic drugs used to treat a variety of malignancies, remains a serious obstacle for improving cancer treatment. To study possible genetic mechanisms underlying the development of CDDP resistance, we have adopted t...

journal_title：Cancer research

authors： Lu SJ,Man S,Bani MR,Adachi D,Hawley RG,Kerbel RS,Ben-David Y

更新日期：1995-03-01 00:00:00

abstract：:In previous studies, we have demonstrated that transferrin-gallium inhibits cellular proliferation by a mechanism whereby cellular iron utilization is impaired. Since indium, a similar class 3A metal, has not been well studied, we examined its effects on cellular iron uptake and cellular proliferation. In these studie...

journal_title：Cancer research

authors： Moran PL,Seligman PA

更新日期：1989-08-01 00:00:00

abstract：:The cancer metastasis suppressor protein KAI1/CD82 is a member of the tetraspanin superfamily. Recent studies have demonstrated that tetraspanins are palmitoylated and that palmitoylation contributes to the organization of tetraspanin webs or tetraspanin-enriched microdomains. However, the effect of palmitoylation on ...

journal_title：Cancer research

authors： Zhou B,Liu L,Reddivari M,Zhang XA

更新日期：2004-10-15 00:00:00

abstract：:Colorectal cancers from the mutator phenotype pathway display distinctive pathological features and confer a lesser aggressiveness than colorectal adenocarcinomas originated by the suppressor pathway. The goal of this work was to test whether tumors developed through the mutator pathway could show a decrease in matrix...

journal_title：Cancer research

authors： Morán A,Iniesta P,de Juan C,González-Quevedo R,Sánchez-Pernaute A,Díaz-Rubio E,Ramón y Cajal S,Torres A,Balibrea JL,Benito M

更新日期：2002-07-01 00:00:00

abstract：:Mutations in the NH(2)-terminal regulatory domain of the beta-catenin gene lead to aberrant stabilization and accumulation of the protein and increased TCF/LEF-dependent transcription. Although these mutations are common in some cancers, they are infrequent in prostate and breast cancer. We have found that metastatic ...

journal_title：Cancer research

authors： Rios-Doria J,Kuefer R,Ethier SP,Day ML

更新日期：2004-10-15 00:00:00

abstract：:We analyzed the karyotype of 27 B-cell lymphomas of human origin that developed in mice with severe combined immunodeficiency disease following the injection of peripheral blood leukocytes from Epstein-Barr virus-seropositive donors. Three tumors had clonal abnormalities detected with conventional techniques, 2 had tr...

journal_title：Cancer research

authors： Thangavelu M,Snyder L,Anastasi J,Le Beau MM,Kirven M,Picchio G,Mosier DE,Rowley JD

更新日期：1992-09-01 00:00:00

abstract：:Mutation in either TSC1 or TSC2 causes the autosomal dominant disorder tuberous sclerosis, in which widespread hamartomas are seen, some of which have a high level of vascularization. Tuberous sclerosis complex (TSC) gene products negatively regulate mammalian target of rapamycin (mTOR) activity. We found that vascula...

journal_title：Cancer research

authors： El-Hashemite N,Walker V,Zhang H,Kwiatkowski DJ

更新日期：2003-09-01 00:00:00

abstract：:With the increasing generation of new cancer vaccine strategies, there is also an increasing demand for preclinical models that can carefully predict the efficacy of these vaccines in humans. However, the only tumor models available to study vaccines against human papillomavirus (HPV) 16 have been developed in C57BL/6...

journal_title：Cancer research

authors： Eiben GL,Velders MP,Schreiber H,Cassetti MC,Pullen JK,Smith LR,Kast WM

更新日期：2002-10-15 00:00:00

abstract：:Histopathological assessment of lymph node metastases (LNM) depends on subjective analysis of cellular morphology with inter-/intraobserver variability. In this study, LNM from esophageal adenocarcinoma was objectively detected using desorption electrospray ionization-mass spectrometry imaging (DESI-MSI). Ninety lymph...

journal_title：Cancer research

authors： Abbassi-Ghadi N,Golf O,Kumar S,Antonowicz S,McKenzie JS,Huang J,Strittmatter N,Kudo H,Jones EA,Veselkov K,Goldin R,Takats Z,Hanna GB

更新日期：2016-10-01 00:00:00