Establishment of an HLA-A*0201 human papillomavirus type 16 tumor model to determine the efficacy of vaccination strategies in HLA-A*0201 transgenic mice.

abstract：:Triple-negative breast cancer (TNBC) commonly develops resistance to chemotherapy, yet markers predictive of chemoresistance in this disease are lacking. Here, we define WNT10B-dependent biomarkers for β-CATENIN/HMGA2/EZH2 signaling predictive of reduced relapse-free survival. Concordant expression of HMGA2 and EZH2 p...

journal_title：Cancer research

authors： El Ayachi I,Fatima I,Wend P,Alva-Ornelas JA,Runke S,Kuenzinger WL,Silva J,Silva W,Gray JK,Lehr S,Barch HC,Krutilina RI,White AC,Cardiff R,Yee LD,Yang L,O'Regan RM,Lowry WE,Seagroves TN,Seewaldt V,Krum SA,Miranda

更新日期：2019-03-01 00:00:00

abstract：:Although numerous studies have implicated vitamin D in preventing prostate cancer, the underlying mechanism(s) remains unclear. Using normal human prostatic epithelial cells, we examined the role of mitogen-activated protein kinase phosphatase 5 (MKP5) in mediating cancer preventive activities of vitamin D. Up-regulat...

journal_title：Cancer research

authors： Nonn L,Peng L,Feldman D,Peehl DM

更新日期：2006-04-15 00:00:00

abstract：:The molecular pathways driving mesenchymal glioblastoma (GBM) are still not well understood. We report here that truncated glioma-associated oncogene homolog 1 (tGLI1) is a tumor-specific transcription factor that facilitates GBM growth, is enriched in the mesenchymal subtype of GBM and glioma stem cells (GSC), and pr...

journal_title：Cancer research

authors： Rimkus TK,Carpenter RL,Sirkisoon S,Zhu D,Pasche BC,Chan MD,Lesser GJ,Tatter SB,Watabe K,Debinski W,Lo HW

更新日期：2018-05-15 00:00:00

abstract：:p16Ink4 and p15Ink4B are cyclin-dependent kinase 4 inhibitors and link to the regulation of cell cycle in mammalian cells. The genes encoding these inhibitors are located at 9p21, which is a frequent site of allelic loss in various types of tumors. Twenty-five primary biliary tract cancers were examined for somatic mu...

journal_title：Cancer research

authors： Yoshida S,Todoroki T,Ichikawa Y,Hanai S,Suzuki H,Hori M,Fukao K,Miwa M,Uchida K

更新日期：1995-07-01 00:00:00

abstract：:Arzoxifene ([6-hydroxy-3-[4-[2-(1-piperidinyl)-ethoxy]phenoxy]-2-(4-methoxyphenyl)]benzo[b]thiophene) is a selective estrogen receptor modulator (SERM) that is a potent estrogen antagonist in mammary and uterine tissue while acting as an estrogen agonist to maintain bone density and lower serum cholesterol. Arzoxifene...

journal_title：Cancer research

authors： Suh N,Glasebrook AL,Palkowitz AD,Bryant HU,Burris LL,Starling JJ,Pearce HL,Williams C,Peer C,Wang Y,Sporn MB

更新日期：2001-12-01 00:00:00

abstract：:Infection by human papillomaviruses (HPV) leads to the formation of benign lesions, warts, and in some cases, cervical cancer. The formation of these lesions is dependent upon increased expression of proangiogenic factors. Angiogenesis is linked to tissue hypoxia through the activity of the oxygen-sensitive hypoxia-in...

journal_title：Cancer research

authors： Bodily JM,Mehta KP,Laimins LA

更新日期：2011-02-01 00:00:00

abstract：:Seventeen young women with clinically confirmed mammary dysplasia and six age-matched controls were treated with alpha-tocopherol. Serum samples collected during the luteal phase of each woman at monthly intervals for the 4-month duration of the study were analyzed for serum luteinizing hormone, follicle-stimulating h...

journal_title：Cancer research

authors： Sundaram GS,London R,Margolis S,Wenk R,Lustgarten J,Nair PP,Goldstein P

更新日期：1981-09-01 00:00:00

abstract：:A historical cohort of 68 female breast cancer patients from one institution who were enrolled in a multicenter randomized controlled trial between 1971 and 1973 were followed up to the beginning of 1986. Weight and height at the time of mastectomy were transformed into two indices of body size, namely the Quetelet In...

journal_title：Cancer research

authors： Suissa S,Pollak M,Spitzer WO,Margolese R

更新日期：1989-06-01 00:00:00

abstract：:Although interleukin-15 (IL-15) is a powerful immunomodulatory factor that has been proposed for cancer immunotherapy, its intratumoral expression may be correlated with tumor progression and/or poor clinical outcome. Therefore, neoplasias potentially sensitive to immunotherapy should be checked for their IL-15 expres...

journal_title：Cancer research

authors： Khawam K,Giron-Michel J,Gu Y,Perier A,Giuliani M,Caignard A,Devocelle A,Ferrini S,Fabbi M,Charpentier B,Ludwig A,Chouaib S,Azzarone B,Eid P

更新日期：2009-02-15 00:00:00

abstract：:In cancer chemoprevention studies, the identification of better antitumor-promoting agents is highly desired because they may have a wider applicability against the development of clinical cancers. Both epidemiological and animal studies have suggested that microchemicals present in the diet and several herbs and plan...

journal_title：Cancer research

authors： Lahiri-Chatterjee M,Katiyar SK,Mohan RR,Agarwal R

更新日期：1999-02-01 00:00:00

abstract：:Southern blot-hybridization analysis of DNAs from human tumors demonstrated amplification of the epidermal growth factor (EGF) receptor gene in 10 of 12 squamous cell carcinoma cell lines tested and in none of 18 tumor cell lines of nonsquamous cell carcinomas. The degree of amplification in the squamous cells varied ...

journal_title：Cancer research

authors： Yamamoto T,Kamata N,Kawano H,Shimizu S,Kuroki T,Toyoshima K,Rikimaru K,Nomura N,Ishizaki R,Pastan I

更新日期：1986-01-01 00:00:00

abstract：:Disease recurrence and metastasis are frequently observed in many successfullytreated localized cancers, including hepatocellular carcinoma in which intrahepatic and extrahepatic recurrence (metastasis) are frequently observed after curative resection. The present study aimed at identifying metastasis-associated genes...

journal_title：Cancer research

authors： Cheung ST,Chen X,Guan XY,Wong SY,Tai LS,Ng IO,So S,Fan ST

更新日期：2002-08-15 00:00:00

abstract：:Several properties of four 1-deaza-7,8-dihydropteridines were compared with those of each other and with those of colchicine, nocodazole, podophyllotoxin, and vincristine. Compound NSC 370147 was more active than the other compounds of this type with respect to inhibition of proliferation of cultured L1210 cells and t...

journal_title：Cancer research

authors： Bowdon BJ,Waud WR,Wheeler GP,Hain R,Dansby L,Temple C Jr

更新日期：1987-03-15 00:00:00

abstract：:Cloned lines of Adriamycin (ADR)-sensitive and -resistant P388 leukemia have been established from single cell cultures. A marker chromosome M1 was found in all cells in the heterogeneous resistant P388/ADR parental line as well as in the cloned resistant lines P388/ADR/3 and P388/ADR/7; a different marker chromosome ...

journal_title：Cancer research

authors： Goldenberg GJ,Wang H,Blair GW

更新日期：1986-06-01 00:00:00

abstract：:Preclinical and clinical development of agents that inhibit cell-cycle progression have brought an understanding of the feasibility of targeting various cell-cycle regulators in patients with cancer. Small molecule inhibitors targeting key proteins that participate in cell-cycle progression including the cyclin-depend...

journal_title：Cancer research

authors： Mills CC,Kolb EA,Sampson VB

更新日期：2018-01-15 00:00:00

abstract：:Colony-stimulating factor-1 (CSF-1) and its receptor (CSF-1R) have been implicated in the pathogenesis and progression of various types of cancer, including breast cancer. This is based on high levels of circulating CSF-1 in patient sera with aggressive disease and increased CSF-1R staining in the tumor tissues. Howev...

journal_title：Cancer research

authors： Patsialou A,Wyckoff J,Wang Y,Goswami S,Stanley ER,Condeelis JS

更新日期：2009-12-15 00:00:00

abstract：:The evidence for tumor suppressor genes at 8p is well supported by many somatic deletion studies and genetic linkage studies. However, it remains a challenge to pinpoint the tumor suppressor genes at 8p primarily because the implicated regions are broad. In this study, we attempted to narrow down the implicated region...

journal_title：Cancer research

authors： Chang BL,Liu W,Sun J,Dimitrov L,Li T,Turner AR,Zheng SL,Isaacs WB,Xu J

更新日期：2007-05-01 00:00:00

abstract：:Nm23-H1 has been identified as a metastasis suppressor gene, but its protein interactions have yet to be understood with any mechanistic clarity. In this study, we evaluated the proteomic spectrum of interactions made by Nm23-H1 in 4T1 murine breast cancer cells derived from tissue culture, primary mammary tumors, and...

journal_title：Cancer research

authors： Marino N,Marshall JC,Collins JW,Zhou M,Qian Y,Veenstra T,Steeg PS

更新日期：2013-10-01 00:00:00

abstract：:The growth of human melanoma cells FO-1 in nude mice is strongly inhibited or even abrogated when the cells are stably transfected with a plasmid expressing an antisense RNA to the insulin-like growth factor 1 receptor (IGF-1R) RNA, which causes a marked reduction in the number of IGF-1 receptors. When a tumor arises ...

journal_title：Cancer research

authors： Resnicoff M,Coppola D,Sell C,Rubin R,Ferrone S,Baserga R

更新日期：1994-09-15 00:00:00

abstract：:Three loci have been implicated in the etiology of familial breast cancer; the BRCA1 locus on 17q, the p53 gene on 17p, and the androgen receptor gene on the X chromosome. However, it has been estimated that in approximately 50% of all breast cancer families the predisposing genetic defect is not linked to any of thes...

journal_title：Cancer research

authors： Lindblom A,Skoog L,Rotstein S,Werelius B,Larsson C,Nordenskjöld M

更新日期：1993-09-15 00:00:00

abstract：:Salmonella enterica and avirulent derivatives prefer solid tumors over normal tissue in animal models. The identification of endogenous Salmonella promoters that are preferentially activated in tumors could further our understanding of this phenomenon. Toward this goal, a random library of S. enterica typhimurium 1402...

journal_title：Cancer research

authors： Arrach N,Zhao M,Porwollik S,Hoffman RM,McClelland M

更新日期：2008-06-15 00:00:00

abstract：:We investigated the production of hyaluronan and the presence of hyaluronan receptors in a panel of human lung carcinoma cell lines, consisting of small cell carcinomas (SCLC) and non-small cell carcinomas (non-SCLC). These transformed cell lines produced only minute amounts of hyaluronan, whereas normal lung fibrobla...

journal_title：Cancer research

authors： Teder P,Bergh J,Heldin P

更新日期：1995-09-01 00:00:00

abstract：:The growth inhibitory effects of combinations of antifolates on hepatoma cells in culture have been examined. In these studies methotrexate or the lipophilic inhibitors of dihydrofolate reductase were used with the thymidylate synthase inhibitor N10-propargyl-5,8-dideazafolate (PDDF). Under certain conditions partial ...

journal_title：Cancer research

authors： Galivan J,Nimec Z,Rhee M

更新日期：1987-10-15 00:00:00

abstract：:Some, but not all, epidemiological studies have suggested that dichlorodiphenyltrichloroethane (DDT) may play a role in the development of breast cancer. These investigations have been conducted in countries where this substance has been banned for at least 20 years. We conducted a study in Mexico, a country in which ...

journal_title：Cancer research

authors： López-Carrillo L,Blair A,López-Cervantes M,Cebrián M,Rueda C,Reyes R,Mohar A,Bravo J

更新日期：1997-09-01 00:00:00

abstract：:Tn and sialylated Tn (sTn) are blood group-related epitopes expressed on mucins of colon carcinoma and other epithelial tumors and are, therefore, potential targets for immunological control. We have immunized 20 colorectal cancer patients at high risk for recurrence with a vaccine consisting of partially desialylated...

journal_title：Cancer research

authors： O'Boyle KP,Zamore R,Adluri S,Cohen A,Kemeny N,Welt S,Lloyd KO,Oettgen HF,Old LJ,Livingston PO

更新日期：1992-10-15 00:00:00

abstract：:The LeY determinant, a difucosylated type 2 blood group-related antigen, is a positional isomer of the Leb blood group antigen and a fucosylated derivative of the LeX antigen. The LeX antigen behaves like an oncodevelopmental tumor-associated antigen in human colon cancer, and extended polyfucosyl LeX antigens are mor...

journal_title：Cancer research

authors： Kim YS,Yuan M,Itzkowitz SH,Sun QB,Kaizu T,Palekar A,Trump BF,Hakomori S

更新日期：1986-11-01 00:00:00

abstract：:We have developed a new strain of rats (resistant rat) which exhibit resistance against the carcinogenic action of several carcinogenic compounds. In the present study, we compared the ability of resistant rat liver to activate 3'-methyl-4-dimethylaminoazobenzene and 2-acetylaminofluorene to highly reactive metabolite...

journal_title：Cancer research

authors： Yano M,Higashi T,Kano S,Tateishi N,Kido Y,Mori T,Higashi K,Sakamoto Y

更新日期：1989-10-01 00:00:00

abstract：:Fatty acid synthase (FASN) is the terminal enzyme in de novo lipogenesis and plays a key role in cell proliferation. Pharmacologic inhibitors of FASN are being evaluated in clinical trials for treatment of cancer, obesity, and other diseases. Here, we report a previously unknown mechanism of FASN regulation involving ...

journal_title：Cancer research

authors： Lin HP,Cheng ZL,He RY,Song L,Tian MX,Zhou LS,Groh BS,Liu WR,Ji MB,Ding C,Shi YH,Guan KL,Ye D,Xiong Y

更新日期：2016-12-01 00:00:00

abstract：:Multiple tobacco smoke-related premalignant and malignant lesions develop synchronously or metachronously in various organ sites, including the oral cavity. Both field cancerization and clonal migration seem to contribute to the occurrence of multiple tumors. Although the importance of endogenous factors (e.g., oncoge...

journal_title：Cancer research

authors： Du B,Leung H,Khan KM,Miller CG,Subbaramaiah K,Falcone DJ,Dannenberg AJ

更新日期：2007-09-15 00:00:00

abstract：:Because chronic intestinal inflammation is a risk factor for colorectal cancer, we hypothesized that genetic variants of inflammatory mediators, such as mannose-binding lectin 2 (MBL2), are associated with colon cancer susceptibility. Here, we report the association of 24 MBL2 single-nucleotide polymorphisms (SNP) and...

journal_title：Cancer research

authors： Zanetti KA,Haznadar M,Welsh JA,Robles AI,Ryan BM,McClary AC,Bowman ED,Goodman JE,Bernig T,Chanock SJ,Harris CC

更新日期：2012-03-15 00:00:00