Serum hormones and lipoproteins in benign breast disease.

abstract：:Sporadic colorectal cancer (CRC) is characterized by genetic and epigenetic changes such as regional DNA hypermethylation and global DNA hypomethylation. Epidemiological and animal studies suggest that aberrant DNA methylation is associated with low dietary folate intake, which is aggravated by high alcohol intake. Th...

journal_title：Cancer research

authors： van Engeland M,Weijenberg MP,Roemen GM,Brink M,de Bruïne AP,Goldbohm RA,van den Brandt PA,Baylin SB,de Goeij AF,Herman JG

更新日期：2003-06-15 00:00:00

abstract：:The alternative reading frame (ARF) tumor suppressor exerts both p53-dependent and p53-independent activities critical to the prevention of cancer in mice and humans. Recent evidence from mouse models suggests that when p53 is absent, further loss of ARF can widen the tumor spectrum, and potentiate invasion and metast...

journal_title：Cancer research

authors： Paliwal S,Kovi RC,Nath B,Chen YW,Lewis BC,Grossman SR

更新日期：2007-10-01 00:00:00

abstract：:Indomethacin, an inhibitor of prostaglandin (PG) synthesis, was investigated for its ability to increase radioresponse of two fibrosarcomas, FSA and NFSA, in C3Hf/Kam mice. In addition, the effect of indomethacin on radioresponse of hematopoietic tissue, jejunum, hair follicles, and tissues involved in the development...

journal_title：Cancer research

authors： Furuta Y,Hunter N,Barkley T Jr,Hall E,Milas L

更新日期：1988-06-01 00:00:00

abstract：:SOX9 is a member of the SOX [Sry-related high-mobility group (HMG) box] family of HMG DNA-binding domain transcription factors and is required for the development and differentiation of multiple cell lineages. This report shows that basal epithelial cells express SOX9 in normal prostate, with no detectable expression ...

journal_title：Cancer research

authors： Wang H,McKnight NC,Zhang T,Lu ML,Balk SP,Yuan X

更新日期：2007-01-15 00:00:00

abstract：:Complementary DNA (cDNA)-oligodeoxythmidylate-celluloses were prepared from cDNA copies of polysomal messenger RNA (mRNA) of Novikoff hepatoma, normal rat liver, and regenerating rat liver. cDNA synthesis with reverse transcriptase was approximately 46% with respect to input mRNA with oligodeoxythymidylate-cellulose p...

journal_title：Cancer research

authors： Hirsch FW,Nall KN,Hayes LC,Raju KS,Spohn WH,Busch H

更新日期：1977-10-01 00:00:00

abstract：:P-cadherin is normally expressed in the basal layer of squamous epithelia and absent from the healthy intestine and colon. We have previously shown it to be expressed in all inflamed, hyperplastic, and dysplastic intestinal and colonic mucosa. This study aimed to better understand the mechanisms controlling the expres...

journal_title：Cancer research

authors： Milicic A,Harrison LA,Goodlad RA,Hardy RG,Nicholson AM,Presz M,Sieber O,Santander S,Pringle JH,Mandir N,East P,Obszynska J,Sanders S,Piazuelo E,Shaw J,Harrison R,Tomlinson IP,McDonald SA,Wright NA,Jankowski JA

更新日期：2008-10-01 00:00:00

abstract：:We have previously identified amplification at 4q12 in testicular germ cell tumors of adolescents and adults centered around the KIT gene encoding a tyrosine kinase transmembrane receptor. Analysis of primary testicular germ cell tumors totaling 190 cases revealed 21% of the seminoma subtype with an increased copy num...

journal_title：Cancer research

authors： McIntyre A,Summersgill B,Grygalewicz B,Gillis AJ,Stoop J,van Gurp RJ,Dennis N,Fisher C,Huddart R,Cooper C,Clark J,Oosterhuis JW,Looijenga LH,Shipley J

更新日期：2005-09-15 00:00:00

abstract：:The conversion of transforming growth factor beta (TGF-beta) from a tumor suppressor to a tumor promoter occurs frequently during mammary tumorigenesis, yet the molecular mechanisms underlying this phenomenon remain undefined. We show herein that TGF-beta repressed nuclear factor-kappaB (NF-kappaB) activity in normal ...

journal_title：Cancer research

authors： Neil JR,Schiemann WP

更新日期：2008-03-01 00:00:00

abstract：:In this study, we identified 53 aberrantly hypermethylated DNA sequences in adult T-cell leukemia (ATL) cells using methylated CpG island amplification/representational difference analysis method. We also observed a proportionate increase in the methylation density of these regions with disease progression. Seven gene...

journal_title：Cancer research

authors： Yasunaga J,Taniguchi Y,Nosaka K,Yoshida M,Satou Y,Sakai T,Mitsuya H,Matsuoka M

更新日期：2004-09-01 00:00:00

abstract：:TNF-α, produced by most malignant cells, orchestrates the interplay between malignant cells and myeloid cells, which have been linked to tumor growth and metastasis. Although TNF-α can exist as one of two isoforms, a 26-kDa membrane tethered form (mTNF-α) or a soluble 17-kDa cytokine (sTNF-α), the vast majority of pub...

journal_title：Cancer research

authors： Ardestani S,Li B,Deskins DL,Wu H,Massion PP,Young PP

更新日期：2013-07-01 00:00:00

abstract：:Pemetrexed is a novel antifolate effective in the treatment of mesothelioma. Studies were undertaken to characterize the transport of this antifolate in this tumor. We report the presence of a novel, concentrative high-affinity transport activity in three human mesothelioma cell lines, characterized in detail in the N...

journal_title：Cancer research

authors： Wang Y,Zhao R,Chattopadhyay S,Goldman ID

更新日期：2002-11-15 00:00:00

abstract：:Mutations in the parkin gene, which encodes a ubiquitin ligase, are a major genetic cause of parkinsonism. Interestingly, parkin also plays a role in cancer as a putative tumor suppressor, and the gene is frequently targeted by deletion and inactivation in human malignant tumors. Here, we investigated a potential tumo...

journal_title：Cancer research

authors： Yeo CW,Ng FS,Chai C,Tan JM,Koh GR,Chong YK,Koh LW,Foong CS,Sandanaraj E,Holbrook JD,Ang BT,Takahashi R,Tang C,Lim KL

更新日期：2012-05-15 00:00:00

abstract：:The human breast cancer (Br-10) serially transplanted to nude mice (BALB/c-nu/nu) grew well in female mice but very slowly or not at all in untreated male mice and female mice treated with 1 mg of testosterone i.m. twice a week. The growth in female mice was arrested by ovariectomy, and that in male mice was accelerat...

journal_title：Cancer research

authors： Hirohashi S,Shimosato Y,Kameya T,Nagai K,Tsunematsu R

更新日期：1977-09-01 00:00:00

abstract：:Various chemical compounds have been described to induce photosensitization of tumor cells resulting in cell death. We studied the effect of merocyanine-540 (MC-540) on both leukemic and normal bone marrow (BM) cells. Acute promyelocytic leukemia (HL-60) and common acute lymphoblastic leukemia antigen-positive non-T, ...

journal_title：Cancer research

authors： Atzpodien J,Gulati SC,Clarkson BD

更新日期：1986-10-01 00:00:00

abstract：:2'-Fluoro-5-iodo-1-beta-D-arabinofuranosylcytosine (FIAC) is a potent selective inhibitor of the replication of herpes simplex virus types 1 and 2 (HSV-1, HSV-2), varicella zoster virus, and cytomegalovirus in cell culture systems. FIAC produces an unequivocal therapeutic effect in mice that have been inoculated with ...

journal_title：Cancer research

authors： Young CW,Schneider R,Leyland-Jones B,Armstrong D,Tan CT,Lopez C,Watanabe KA,Fox JJ,Philips FS

更新日期：1983-10-01 00:00:00

abstract：:Surface-exposed proteins of vinblastine-sensitive human lymphoid cell line of leukemic origin (CCRF-CEM) were examined by the lactoperoxidase-catalyzed iodination and two-dimensional polyacrylamide gel electrophoresis methods. Spots which comigrate with bovine brain tubulin and rabbit muscle actin were prominently lab...

journal_title：Cancer research

authors： Rubin RW,Quillen M,Corcoran JJ,Ganapathi R,Krishan A

更新日期：1982-04-01 00:00:00

abstract：:Human mammary and other carcinoma cells secrete and express on their cell surfaces complex, mucin-like glycoproteins (Mr greater than 10(6] that are recognized as tumor-associated antigens by a variety of monoclonal antibodies (MAbs). One such MAb, B72.3, has been extensively studied as to range of reactivity for a va...

journal_title：Cancer research

authors： Sheer DG,Schlom J,Cooper HL

更新日期：1988-12-01 00:00:00

abstract：:An unusual isozyme of lactate dehydrogenase, lactate dehydrogenase associated with Kirsten murine sarcoma virus (LDHk) was found in the sera of many patients with malignant tumors, while the sera of healthy persons had little or no such activity. This isozyme was detectable only when assayed in a nitrogen atmosphere, ...

journal_title：Cancer research

authors： Polonis VR,Anderson GR,Brzykcy J,Vladutiu AO,Manly KF

更新日期：1984-05-01 00:00:00

abstract：:Suramin is a polyanionic agent which has been found to be an effective antineoplastic agent against various human tumors including adrenal, renal and prostatic cancer, and osteosarcoma. Recently, suramin has been shown to inhibit bone resorption in organ cultures of mouse calvarial bones. In the present study, we exam...

journal_title：Cancer research

authors： Yoneda T,Williams P,Rhine C,Boyce BF,Dunstan C,Mundy GR

更新日期：1995-05-01 00:00:00

abstract：:We have demonstrated previously that there is a marked decrease in the level of labeled fucose incorporated into an amino acid fucoside, i.e., fucosyl-N-acetylglucosaminylasparagine (FL4c) in SV40-transformed human embryonic lung cells (SV40-WI-38) as compared to WI-38 cells (Morton, P.A., Klinger, M. M., and Steiner,...

journal_title：Cancer research

authors： Steiner SM,Morton PA

更新日期：1984-10-01 00:00:00

abstract：:Pleural fluid from a child previously treated for rhabdomyosarcoma produced colonies in vitro. Cells from these colonies appeared to have the light and electron microscopic appearance of rhabdomyosarcoma cells. In this case, the malignant nature of the effusion had been suspected because of the patient's previous hist...

journal_title：Cancer research

authors： Altman AJ,Crussi FG,Rierden WJ,Baehner RL

更新日期：1975-07-01 00:00:00

abstract：:Combination treatment of SKCO1 human colon carcinoma cells with beta ser-interferon (IFN-beta ser) and gamma-interferon (IFN-gamma) results in a synergistic antiproliferative effect. The role of IFN-beta ser and IFN-gamma receptor modulation was investigated as a possible mechanism for this response. IFN-gamma (0.05-5...

journal_title：Cancer research

authors： Schiller JH,Bushmeyer SM,Ruzicka FJ,Princler GL,Faltynek CR,Borden EC

更新日期：1990-01-01 00:00:00

abstract：:In the last decade, large-scale genomic studies in patients with hematologic malignancies identified recurrent somatic alterations in epigenetic modifier genes. Among these, the de novo DNA methyltransferase DNMT3A has emerged as one of the most frequently mutated genes in adult myeloid as well as lymphoid malignancie...

journal_title：Cancer research

authors： Venugopal K,Feng Y,Shabashvili D,Guryanova OA

更新日期：2021-01-15 00:00:00

abstract：:Brain tumors are thought to originate from stem/progenitor cell populations that acquire specific genetic mutations. Although current preclinical models have relevance to human pathogenesis, most do not recapitulate the histogenesis of the human disease. Recently, a large series of human gliomas and medulloblastomas w...

journal_title：Cancer research

authors： Henriquez NV,Forshew T,Tatevossian R,Ellis M,Richard-Loendt A,Rogers H,Jacques TS,Reitboeck PG,Pearce K,Sheer D,Grundy RG,Brandner S

更新日期：2013-09-15 00:00:00

abstract：:The amino acid fucosides of tumorigenic and nontumorigenic mouse mammary gland-derived cells were studied. The cells examined included tumorigenic cell lines derived from mammary carcinomas of the following etiologies: induction by hormone; virus; and chemical carcinogen. Also studied were cells derived from normal ma...

journal_title：Cancer research

authors： Steiner MR,Richards CS,Butel JS,Medina D

更新日期：1983-06-01 00:00:00

abstract：:Prostate cancer is highly sensitive to hormone therapy because androgens are essential for prostate cancer cell growth. However, with the nearly invariable progression of this disease to androgen independence, endocrine therapy ultimately fails to control prostate cancer in most patients. Androgen-independent acquisit...

journal_title：Cancer research

authors： Cerasuolo M,Paris D,Iannotti FA,Melck D,Verde R,Mazzarella E,Motta A,Ligresti A

更新日期：2015-08-01 00:00:00

abstract：:Prostate cancer subtypes are poorly defined and functional validation of drivers of ETS rearrangement-negative prostate cancer has not been conducted. Here, we identified an ETS(-) subtype of aggressive prostate cancer (ERG(-)MAP3K7(del)CHD1(del)) and used a novel developmental model and a cell line xenograft model to...

journal_title：Cancer research

authors： Rodrigues LU,Rider L,Nieto C,Romero L,Karimpour-Fard A,Loda M,Lucia MS,Wu M,Shi L,Cimic A,Sirintrapun SJ,Nolley R,Pac C,Chen H,Peehl DM,Xu J,Liu W,Costello JC,Cramer SD

更新日期：2015-03-15 00:00:00

abstract：:The effect of the AC33 tumor on protein synthesis in Lewis-Wistar rats was investigated under four different dietary regimens. The four diets used were: (a) 1.25 g amino acids plus 12.5 g glucose per day, (b) 1.25 g amino acids, (c) 1.25 g glucose per day, and (d) 12.5 g glucose per day. The rats were maintained on th...

journal_title：Cancer research

authors： Stein TP,Oram-Smith JC,Leskiw MJ,Wallace HW,Miller EE

更新日期：1976-11-01 00:00:00

abstract：:Analysis of human fibrosarcoma cells exposed to radiolabeled monoclonal antibody 19-24, which recognizes sarcoma-associated antigen p102, revealed that over 54% of the cell surface-bound radioactivity was internalized. No modulation of cell surface p102 antigen by monoclonal antibody 19-24 was observed in human fibros...

journal_title：Cancer research

authors： Stastny JJ,Das Gupta TK

更新日期：1993-12-01 00:00:00

abstract：:The formation and persistence of O6-ethylguanine, O4-ethylthymine, and O2-ethylthymine were quantitated in the genomic DNA of human lymphoblasts exposed to 1.0 mM N-ethyl-N-nitrosourea using immunoslot-blot. The three cell lines used included one which lacks O6-alkylguanine-DNA alkyltransferase, one deficient in nucle...

journal_title：Cancer research

authors： Bronstein SM,Skopek TR,Swenberg JA

更新日期：1992-04-01 00:00:00