Altered TAB1:I kappaB kinase interaction promotes transforming growth factor beta-mediated nuclear factor-kappaB activation during breast cancer progression.

abstract：:An assay using a bimane derivative has been developed to detect free glutathione (GSH) in individual viable cells by flow cytometry. Monochlorobimane [syn-(ClCH2CH3)-1,5-diazabicycla[3.30]acta-3,6-diene-2,8-dio ne], itself nonfluorescent, reacts with GSH to form a highly fluorescent derivative. High pressure liquid ch...

journal_title：Cancer research

authors： Rice GC,Bump EA,Shrieve DC,Lee W,Kovacs M

更新日期：1986-12-01 00:00:00

abstract：:Tumor associated AUA1 monoclonal antibody and 11.4.1. nonspecific monoclonal antibody, which does not react with human tissues, were radiolabeled with 111In and administered intravesically to 23 patients undergoing cystoscopy for bladder carcinoma. The antibody solution remained in the bladder for 1 h and then was was...

journal_title：Cancer research

authors： Bamias A,Keane P,Krausz T,Williams G,Epenetos AA

更新日期：1991-01-15 00:00:00

abstract：:The MAGE-1 gene codes for a tumor-specific antigen, MZ2-E, that elicited a cytotoxic T-lymphocyte response in the melanoma patient from whom it was derived. We have developed a simplified method, using polymerase chain reaction amplification of exon 3 followed by restriction enzyme pattern analysis, to distinguish exp...

journal_title：Cancer research

authors： Zakut R,Topalian SL,Kawakami Y,Mancini M,Eliyahu S,Rosenberg SA

更新日期：1993-01-01 00:00:00

abstract：:Sixteen steroids with different endocrine activities were administered to female rats for 6 or 7 days, in a broad range of doses. Liver growth was recorded by measuring weight and DNA contents and monooxygenase activity by assaying the turnover of five different substrates. According to their effects on these paramete...

journal_title：Cancer research

authors： Schulte-Hermann R,Ochs H,Bursch W,Parzefall W

更新日期：1988-05-01 00:00:00

abstract：:Ascorbic acid (vitamin C) is known to act as an antimutagen and anticarcinogen in several test systems. However, there is no report of its effect on carcinogen-induced chromosomal damage in vivo in animals. The present study was performed to determine whether or not ascorbic acid affects sister chromatid exchanges (SC...

journal_title：Cancer research

authors： Krishna G,Nath J,Ong T

更新日期：1986-06-01 00:00:00

abstract：:Recent studies have demonstrated the presence of microsatellite instability (MSI) in tumors from patients with hereditary nonpolyposis colon cancer and in a subset of patients with sporadic colorectal cancer (CRC). In sporadic CRC, three tumor phenotypes have been defined: microsatellite stable (MSS), low-frequency MS...

journal_title：Cancer research

authors： Cunningham JM,Christensen ER,Tester DJ,Kim CY,Roche PC,Burgart LJ,Thibodeau SN

更新日期：1998-08-01 00:00:00

abstract：:Brain tumors such as medulloblastoma (MB) and glioblastoma multiforme (GBM) can derive from neural precursors. For instance, many MBs are thought to arise from the uncontrolled proliferation of cerebellar granule neuron precursors (GNP). GNPs normally proliferate in early postnatal stages in mice but then they become ...

journal_title：Cancer research

authors： Tatard VM,Xiang C,Biegel JA,Dahmane N

更新日期：2010-02-01 00:00:00

abstract：:Mutations in the NH(2)-terminal regulatory domain of the beta-catenin gene lead to aberrant stabilization and accumulation of the protein and increased TCF/LEF-dependent transcription. Although these mutations are common in some cancers, they are infrequent in prostate and breast cancer. We have found that metastatic ...

journal_title：Cancer research

authors： Rios-Doria J,Kuefer R,Ethier SP,Day ML

更新日期：2004-10-15 00:00:00

abstract：:Ovarian and testicular tumors were induced in the offspring (F1 generation) of MRC rats that received single or multiple doses of N-nitrosobis(2-oxopropyl)amine on the 14th, 18th, and/or 20th days of pregnancy. The ovarian tumor incidence was significantly higher (46%) in the F1 generation exposed to the carcinogen a ...

journal_title：Cancer research

authors： Pour PM

更新日期：1986-08-01 00:00:00

abstract：:Estrogen receptor (ER)-positive human breast cancer cells are hormonally regulated and are inhibited by retinoids, whereas most ER-negative breast cancer cells are not. Here, we compared retinoid-induced transcriptional activation and growth inhibition in the ER-negative breast cancer cell line MDA-MB-231, stably tran...

journal_title：Cancer research

authors： Rosenauer A,Nervi C,Davison K,Lamph WW,Mader S,Miller WH Jr

更新日期：1998-11-15 00:00:00

abstract：:The nuclear receptor PPAR-β/δ (PPARD) has essential roles in fatty acid catabolism and energy homeostasis as well as cell differentiation, inflammation, and metabolism. However, its contributions to tumorigenesis are uncertain and have been disputed. Here, we provide evidence of tumor suppressive activity of PPARD in ...

journal_title：Cancer research

authors： Martín-Martín N,Zabala-Letona A,Fernández-Ruiz S,Arreal L,Camacho L,Castillo-Martin M,Cortazar AR,Torrano V,Astobiza I,Zúñiga-García P,Ugalde-Olano A,Loizaga-Iriarte A,Unda M,Valcárcel-Jiménez L,Arruabarrena-Aristorena A,Pi

更新日期：2018-01-15 00:00:00

abstract：:Tumorigenesis in humans and experimental animals appears to involve the activation of ras protooncogenes for a number of organ systems and seems to be important to the development of the metastatic phenotype in several model systems. Clinically, the presence of activated ras protooncogenes has been reported to be a ne...

journal_title：Cancer research

authors： Mizuuchi H,Nasim S,Kudo R,Silverberg SG,Greenhouse S,Garrett CT

更新日期：1992-05-15 00:00:00

abstract：:The clinical effects and pharmacokinetics of high-dose uridine were determined in seven patients with advanced-stage cancer and in one healthy volunteer. Uridine was also examined for its effect on 5-fluorouracil toxicity in two patients. Uridine was administered as a 1-hr i.v. infusion at doses of 1 to 12 g/sq m. Pla...

journal_title：Cancer research

authors： Leyva A,van Groeningen CJ,Kraal I,Gall H,Peters GJ,Lankelma J,Pinedo HM

更新日期：1984-12-01 00:00:00

abstract：:Transcription factor PAX3 has seven isoforms of which PAX3c has been studied extensively whereas the functions of the other isoforms are less well known. Here, we found that PAX3 isoforms in a stable transfection system have different biological functions in mouse melanocytes in vitro. PAX3a and PAX3b had negative eff...

journal_title：Cancer research

authors： Wang Q,Kumar S,Slevin M,Kumar P

更新日期：2006-09-01 00:00:00

abstract：:Fibroblast growth factor (FGF) receptor (FGFR) substrate 2 (FRS2) is an adaptor protein that plays a critical role in FGFR signaling. FRS2 is located on chromosome 12q13-15 that is frequently amplified in liposarcomas. The significance of FRS2 and FGFR signaling in high-grade liposarcomas is unknown. Herein, we first ...

journal_title：Cancer research

authors： Zhang K,Chu K,Wu X,Gao H,Wang J,Yuan YC,Loera S,Ho K,Wang Y,Chow W,Un F,Chu P,Yen Y

更新日期：2013-02-15 00:00:00

abstract：:Fractalkine is a CX3C-type chemokine that induces chemotaxis of monocytes and cytotoxic T cells. Using the differential display method for examining gene expression in p53-defective cells transfected by adenovirus containing wild-type p53, we observed that fractalkine was induced by ectopic expression of p53. An elect...

journal_title：Cancer research

authors： Shiraishi K,Fukuda S,Mori T,Matsuda K,Yamaguchi T,Tanikawa C,Ogawa M,Nakamura Y,Arakawa H

更新日期：2000-07-15 00:00:00

abstract：:We established a cisplatin-resistant human ovarian cancer cell line (HAC2/0.1) from the parent cell line (HAC2/P) by continuous exposure of HAC2/P to 0.1 microgram of cisplatin/ml. Drug sensitivity determined by colony assay revealed that HAC2/0.1 was 2.4 times as resistant to cisplatin as the parental cell line. HAC2...

journal_title：Cancer research

authors： Niimi S,Nakagawa K,Sugimoto Y,Nishio K,Fujiwara Y,Yokoyama S,Terashima Y,Saijo N

更新日期：1992-01-15 00:00:00

abstract：:Phosphate ore mining and processing operations are associated with dusty conditions and potential exposure to gamma radiation and radon daughter products. Although most current measurements are within Occupational Safety and Health Administration (OSHA) guidelines, no measurements exist for the era preceding modern st...

journal_title：Cancer research

authors： Block G,Matanoski GM,Seltser R,Mitchell T

更新日期：1988-12-15 00:00:00

abstract：:Antibody titer to Bacillus Calmette-Guérin (BCG) was determined by complement fixation in 111 normal volunteers and 83 melanoma patients. In 43 of these melanoma patients, sequential determination of antibody titer was made and correlated with clinical course. Low titers of antibody to BCG were found frequently in nor...

journal_title：Cancer research

authors： Wile AG,Sparks FC,Morton DL

更新日期：1977-07-01 00:00:00

abstract：:p16Ink4 and p15Ink4B are cyclin-dependent kinase 4 inhibitors and link to the regulation of cell cycle in mammalian cells. The genes encoding these inhibitors are located at 9p21, which is a frequent site of allelic loss in various types of tumors. Twenty-five primary biliary tract cancers were examined for somatic mu...

journal_title：Cancer research

authors： Yoshida S,Todoroki T,Ichikawa Y,Hanai S,Suzuki H,Hori M,Fukao K,Miwa M,Uchida K

更新日期：1995-07-01 00:00:00

abstract：:The influences of pure human pluripotent colony-stimulating factor, highly purified pluripoietin alpha, pure recombinant human tumor necrosis factor alpha, pure recombinant human gamma-interferon, and natural prostaglandin E1 (PGE1) were evaluated on colony formation of multipotential and erythroid progenitor cells in...

journal_title：Cancer research

authors： Lu L,Welte K,Gabrilove JL,Hangoc G,Bruno E,Hoffman R,Broxmeyer HE

更新日期：1986-09-01 00:00:00

abstract：:We have recently identified a new gene, interleukin-17 receptor-like (IL-17RL), which is expressed in normal prostate and prostate cancer. This investigation is focused on the role of IL-17RL in prostate cancer. We found that IL-17RL was expressed at significantly higher levels in several androgen-independent prostate...

journal_title：Cancer research

authors： You Z,Shi XB,DuRaine G,Haudenschild D,Tepper CG,Lo SH,Gandour-Edwards R,de Vere White RW,Reddi AH

更新日期：2006-01-01 00:00:00

abstract：:Pancreatic cancer, one of the deadliest human malignancies, is almost invariably associated with the presence of an oncogenic form of Kras. Mice expressing oncogenic Kras in the pancreas recapitulate the stepwise progression of the human disease. The inflammatory cytokine interleukin (IL)-6 is often expressed by multi...

journal_title：Cancer research

authors： Zhang Y,Yan W,Collins MA,Bednar F,Rakshit S,Zetter BR,Stanger BZ,Chung I,Rhim AD,di Magliano MP

更新日期：2013-10-15 00:00:00

abstract：:Farnesol (FOH) and other isoprenoid alcohols induce apoptosis in various carcinoma cells and inhibit tumorigenesis in several in vivo models. However, the mechanisms by which they mediate their effects are not yet fully understood. In this study, we show that FOH is an effective inducer of apoptosis in several lung ca...

journal_title：Cancer research

authors： Joo JH,Liao G,Collins JB,Grissom SF,Jetten AM

更新日期：2007-08-15 00:00:00

abstract：:The insulin-like growth factor-1 receptor (IGF-1R) plays a pivotal role in transformation, growth, and survival of malignant cells, and has emerged as a general and promising target for cancer treatment. However, no fully selective IGF-1R inhibitors have thus far been found. This is explained by the fact that IGF-1R i...

journal_title：Cancer research

authors： Girnita A,Girnita L,del Prete F,Bartolazzi A,Larsson O,Axelson M

更新日期：2004-01-01 00:00:00

abstract：:Early diagnosis of lung cancer based on conventional screening procedures has been unable thus far to decrease lung cancer mortality. We explored the possibility of using microsatellite instability in the detection and screening of early phases of lung carcinogenesis. We studied tumor, histopathologically normal bronc...

journal_title：Cancer research

authors： Miozzo M,Sozzi G,Musso K,Pilotti S,Incarbone M,Pastorino U,Pierotti MA

更新日期：1996-05-15 00:00:00

abstract：:N'-[2-chloroethyl]-N[2-(methylsulfonyl) ethyl]-N'-nitrosourea (cystemustine),a chloroethylnitrosourea antineoplastic drug, provokes cellular proliferation inhibition and redifferentiation, but there was no cell death in B16 melanoma tumors. Because the phospholipid (Plp) metabolism is tightly involved in tumor growth ...

journal_title：Cancer research

authors： Morvan D,Demidem A,Papon J,De Latour M,Madelmont JC

更新日期：2002-03-15 00:00:00

abstract：:Genes regulated by androgenic hormones are of critical importance for the normal physiological function of the human prostate gland, and they contribute to the development and progression of prostate carcinoma. We used cDNA microarrays containing 1500 cDNAs to profile transcripts regulated by androgens in prostate can...

journal_title：Cancer research

authors： Lin B,Ferguson C,White JT,Wang S,Vessella R,True LD,Hood L,Nelson PS

更新日期：1999-09-01 00:00:00

abstract：:Pancreatic adenocarcinomas are among the most malignant forms of cancer and, therefore, it is of especial interest to set new strategies aimed at improving the prognostic of this deadly disease. The present study was undertaken to investigate the action of cannabinoids, a new family of potential antitumoral agents, in...

journal_title：Cancer research

authors： Carracedo A,Gironella M,Lorente M,Garcia S,Guzmán M,Velasco G,Iovanna JL

更新日期：2006-07-01 00:00:00

abstract：:In a search for the molecular basis of ABH status of tumors as correlated with malignancy, we studied various malignancy-related phenotypes of high H/Le(y)-expressing tumor cell lines in comparison with phenotypes of the same lines transfected with histo-blood group A or B genes. A and B gene transfectants, prepared i...

journal_title：Cancer research

authors： Ichikawa D,Handa K,Withers DA,Hakomori S

更新日期：1997-08-01 00:00:00