Abstract：
:The papillomaviruses associated with human anogenital carcinomas encode two transforming genes, E6 and E7. The oncoprotein products of these two genes complex with the tumor suppressor gene products p53 and pRB, respectively. The loss of the normal function of these tumor suppressor gene products, either as a consequence of their association with E6 and E7 or by mutation, appears to be a common event in human cervical carcinogenesis.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Howley PMsubject
Has Abstractpub_date
1991-09-15 00:00:00pages
5019s-5022sissue
18 Suppleissn
0008-5472issn
1538-7445journal_volume
51pub_type
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