High frequency of fibroblast growth factor (FGF) 8 expression in clinical prostate cancers and breast tissues, immunohistochemically demonstrated by a newly established neutralizing monoclonal antibody against FGF 8.

abstract：:The insulin-like growth factor receptor (IGF-IR) and insulin receptor are either overactivated and/or overexpressed in a wide range of tumor types and contribute to tumorigenicity, proliferation, metastasis, and drug resistance. Here, we show that BMS-554417, a novel small molecule developed as an inhibitor of IGF-IR,...

journal_title：Cancer research

authors： Haluska P,Carboni JM,Loegering DA,Lee FY,Wittman M,Saulnier MG,Frennesson DB,Kalli KR,Conover CA,Attar RM,Kaufmann SH,Gottardis M,Erlichman C

更新日期：2006-01-01 00:00:00

abstract：:The nonspecific accumulation of radioactivity in bone marrow, liver, and spleen in patients with melanoma injected with radiolabeled whole IgG of anti-high molecular weight-melanoma associated antigen (HMW-MAA) monoclonal antibody (mAb) hampers the application of immunoscintigraphy to visualize melanoma lesions. This ...

journal_title：Cancer research

authors： Temponi M,Gold AM,Ferrone S

更新日期：1992-05-01 00:00:00

abstract：:The effects of four anti-GM2 monoclonal antibodies (DMAb-1, DMAb-2, DMAb-3, and DMAb-5) were studied on spheroid cultures from a human glioma cell line (D-54 MG) that is known to express high levels of GM2. The spheroids developed central necrosis 48 h after antibody exposures at concentrations greater than 6 microgra...

journal_title：Cancer research

authors： Bjerkvig R,Engebraaten O,Laerum OD,Fredman P,Svennerholm L,Vrionis FD,Wikstrand CJ,Bigner DD

更新日期：1991-09-01 00:00:00

abstract：:HER2/Neu/ERBB2 is a receptor tyrosine kinase overexpressed in approximately 20% of human breast tumors. Truncated or mutant isoforms that show increased oncogenicity compared with the wild-type receptor are found in many breast tumors. Here, we report that constitutively active ERBB2 sensitizes human breast epithelial...

journal_title：Cancer research

authors： Martín-Pérez R,Palacios C,Yerbes R,Cano-González A,Iglesias-Serret D,Gil J,Reginato MJ,López-Rivas A

更新日期：2014-03-15 00:00:00

abstract：:It has been well established that overexpression of Cyclooxygenase-2 (Cox-2) in epithelial cells inhibits apoptosis and increases the invasiveness of malignant cells, favoring tumorigenesis and metastasis. However, the molecular mechanism that regulates Cox-2 expression has not been well defined in gastric carcinoma. ...

journal_title：Cancer research

authors： Song SH,Jong HS,Choi HH,Inoue H,Tanabe T,Kim NK,Bang YJ

更新日期：2001-06-01 00:00:00

abstract：:We know that the Yin Yang 1 protein (YY1) overexpression is positively and strongly correlated with the degree of malignancy of bone tumors. Therefore, we questioned whether we could influence cell invasiveness by deleting YY1 in human osteosarcoma cells (SaOs-2), as tested in Matrigel-coated filters and metastasis im...

journal_title：Cancer research

authors： de Nigris F,Rossiello R,Schiano C,Arra C,Williams-Ignarro S,Barbieri A,Lanza A,Balestrieri A,Giuliano MT,Ignarro LJ,Napoli C

更新日期：2008-03-15 00:00:00

abstract：:Unlike the growth factor dependence of normal cells, cancer cells can maintain growth factor-independent glycolysis and survival through expression of oncogenic kinases, such as BCR-Abl. Although targeted kinase inhibition can promote cancer cell death, therapeutic resistance develops frequently, and further mechanist...

journal_title：Cancer research

authors： Mason EF,Zhao Y,Goraksha-Hicks P,Coloff JL,Gannon H,Jones SN,Rathmell JC

更新日期：2010-10-15 00:00:00

abstract：:The tachykinin family of neuropeptides, including substance P and neurokinins A and B, induce a transient increase in intracellular free calcium concentration in human small cell lung carcinoma (SCLC) cells, as measured with a calcium indicator fura-2. The effects are dose dependent and even greater than that of bombe...

journal_title：Cancer research

authors： Takuwa N,Takuwa Y,Ohue Y,Mukai H,Endoh K,Yamashita K,Kumada M,Munekata E

更新日期：1990-01-15 00:00:00

abstract：:Thrombospondin-1 (TSP-1) is a potent inhibitor of tumor growth and angiogenesis. The antiangiogenic activity of TSP-1 has been mapped to the procollagen homology region and the type 1 repeats (TSR) using synthetic peptides. To elucidate the molecular mechanisms that are involved in the inhibition of tumor growth by th...

journal_title：Cancer research

authors： Miao WM,Seng WL,Duquette M,Lawler P,Laus C,Lawler J

更新日期：2001-11-01 00:00:00

abstract：:The ability of cancer cells to evade apoptosis is dictated by a shift in the balance between proapoptotic and antiapoptotic gene expression programs. Monocyte chemotactic protein-induced protein 1 (MCPIP1) is a zinc-finger RNA binding protein with important roles in mediating inflammatory responses. Overexpression of ...

journal_title：Cancer research

authors： Lu W,Ning H,Gu L,Peng H,Wang Q,Hou R,Fu M,Hoft DF,Liu J

更新日期：2016-03-15 00:00:00

abstract：:Cytogenetic analysis has not only provided important information on the pathogenesis of soft tissue tumors but, by disclosing distinct chromosomal rearrangements in different histopathological entities, has also come to serve as a valuable diagnostic tool. Little is known as yet about the potential prognostic impact o...

journal_title：Cancer research

authors： Mertens F,Strömberg U,Mandahl N,Dal Cin P,De Wever I,Fletcher CD,Mitelman F,Rosai J,Rydholm A,Sciot R,Tallini G,Van Den Berghe H,Vanni R,Willén H

更新日期：2002-07-15 00:00:00

abstract：:Fatigue is the most common symptom of cancer at diagnosis, yet causes and effective treatments remain elusive. As tumors can be highly inflammatory, it is generally accepted that inflammation mediates cancer-related fatigue. However, evidence to support this assertion is mostly correlational. In this study, we directl...

journal_title：Cancer research

authors： Grossberg AJ,Vichaya EG,Christian DL,Molkentine JM,Vermeer DW,Gross PS,Vermeer PD,Lee JH,Dantzer R

更新日期：2018-02-01 00:00:00

abstract：:Mortality or incidence rates of ten major neoplasms in migrants from several countries, their respective countries of origin, their American-born offspring, and United States whites were compared. Rates in succeeding generations of Americans increased most rapidly for colon cancer and most slowly for breast cancer, wi...

journal_title：Cancer research

authors： Thomas DB,Karagas MR

更新日期：1987-11-01 00:00:00

abstract：:Calorie restriction has been shown to inhibit epithelial carcinogenesis and this method of dietary restriction reduces many circulating proteins, including insulin-like growth factor I (IGF-I). Previously, we identified a relationship between elevated tissue IGF-I levels and enhanced susceptibility to chemically induc...

journal_title：Cancer research

authors： Moore T,Carbajal S,Beltran L,Perkins SN,Yakar S,Leroith D,Hursting SD,Digiovanni J

更新日期：2008-05-15 00:00:00

abstract：:Radiolabeled first-generation anti-tumor-associated glycoprotein-72 (TAG-72) monoclonal antibody (MAb), B72.3, has proven useful in detecting primary and secondary colorectal carcinoma. It has been anticipated that the development of second-generation, higher affinity, anti-TAG-72 MAbs, CC49 and CC83, would be of grea...

journal_title：Cancer research

authors： Gallinger S,Reilly RM,Kirsh JC,Odze RD,Schmocker BJ,Hay K,Polihronis J,Damani MT,Shpitz B,Stern HS

更新日期：1993-01-15 00:00:00

abstract：:We have used genome-wide allelotyping with 348 polymorphic autosomal markers spaced, on average, 10 cM apart to quantitate the extent of intrachromosomal instability in 59 human sporadic colorectal carcinomas. We have compared instability measured by this method with that measured by inter-(simple sequence repeat) PCR...

journal_title：Cancer research

authors： Anderson GR,Brenner BM,Swede H,Chen N,Henry WM,Conroy JM,Karpenko MJ,Issa JP,Bartos JD,Brunelle JK,Jahreis GP,Kahlenberg MS,Basik M,Sait S,Rodriguez-Bigas MA,Nowak NJ,Petrelli NJ,Shows TB,Stoler DL

更新日期：2001-11-15 00:00:00

abstract：:The potential to heighten the efficacy of antiangiogenic agents was explored in this study based on active targeting of tumor cells overexpressing the gonadotropin-releasing hormone receptor (GnRH-R). The rational design pursued focused on five analogues of a clinically established antiangiogenic compound (sunitinib),...

journal_title：Cancer research

authors： Argyros O,Karampelas T,Asvos X,Varela A,Sayyad N,Papakyriakou A,Davos CH,Tzakos AG,Fokas D,Tamvakopoulos C

更新日期：2016-03-01 00:00:00

abstract：:We have investigated the behavior of dissociated cells of a moderately differentiated Longnecker transplantable pancreatic acinar carcinoma (Longnecker et al., Cancer Lett., 7: 197-202, 1979) maintained in vitro on acellular seminiferous tubular basement membranes of rat testis. The tumor cells, which grow as solid ma...

journal_title：Cancer research

authors： Reddy JK,Kanwar YS,Rao MS,Watanabe TK,Reddy MK,Parsa I,Longnecker DS,Tafuri S

更新日期：1986-01-01 00:00:00

abstract：:Antiangiogenic tumor therapies have recently attracted intense interest for their broad-spectrum action, low toxicity, and, in the case of direct endothelial targeting, an absence of drug resistance. To promote tumor regression and to maintain dormancy, antiangiogenic agents need to be chronically administered. Gene t...

journal_title：Cancer research

authors： Nguyen JT,Wu P,Clouse ME,Hlatky L,Terwilliger EF

更新日期：1998-12-15 00:00:00

abstract：:We previously showed that introduction of a normal, neomycin-tagged human chromosome 11 reduces the metastatic capacity of MDA-MB-435 (435) human breast carcinoma cells by 70-90% without affecting tumorigenicity, suggesting the presence of one or more metastasis suppressor genes encoded on human chromosome 11. To iden...

journal_title：Cancer research

authors： Seraj MJ,Samant RS,Verderame MF,Welch DR

更新日期：2000-06-01 00:00:00

abstract：:A two-stage genome-wide association study (GWAS) of the Cancer Genetic Markers of Susceptibility (CGEMS) initiative identified single nucleotide polymorphisms (SNP) in 150 regions across the genome that may be associated with prostate cancer (PCa) risk. We filtered these results to identify 43 independent SNPs where t...

journal_title：Cancer research

authors： Hsu FC,Sun J,Wiklund F,Isaacs SD,Wiley KE,Purcell LD,Gao Z,Stattin P,Zhu Y,Kim ST,Zhang Z,Liu W,Chang BL,Walsh PC,Duggan D,Carpten JD,Isaacs WB,Grönberg H,Xu J,Zheng SL

更新日期：2009-04-01 00:00:00

abstract：:Infection of tumor cells by herpes simplex virus 1 (HSV-1) results in cell destruction and production of progeny virion in a process referred to as viral oncolysis. In this study, an HSV-1 mutant (HSV1yCD) was engineered such that the viral ribonucleotide reductase gene is disrupted by sequences encoding yeast cytosin...

journal_title：Cancer research

authors： Nakamura H,Mullen JT,Chandrasekhar S,Pawlik TM,Yoon SS,Tanabe KK

更新日期：2001-07-15 00:00:00

abstract：:Germ-line p53 mutations have been identified in most families with Li-Fraumeni syndrome (LFS). For germ-line p53 mutation carriers, there is considerable variability with respect to age of cancer onset and tumor type, suggesting that additional genetic effects influence the clinical severity and tumor spectrum. To ide...

journal_title：Cancer research

authors： Wu CC,Shete S,Amos CI,Strong LC

更新日期：2006-08-15 00:00:00

abstract：:The lymphoid tissue in the omentum, at the so-called milky spots, is known as an initial place for disseminated cancer cells to develop into solid tumors. In the present study, i.p. macrophages significantly took up oligomannose-coated liposomes (OMLs) that were injected into the peritoneal cavity, and then gradually ...

journal_title：Cancer research

authors： Ikehara Y,Niwa T,Biao L,Ikehara SK,Ohashi N,Kobayashi T,Shimizu Y,Kojima N,Nakanishi H

更新日期：2006-09-01 00:00:00

abstract：:Most cancer-associated single-nucleotide polymorphisms (SNP) identified using genome-wide association studies are located outside of protein-coding regions, and their significance and mode of action have been a source of continuing debate. One proposed mechanism of action of the SNPs is that they would affect the acti...

journal_title：Cancer research

authors： Sur I,Tuupanen S,Whitington T,Aaltonen LA,Taipale J

更新日期：2013-07-15 00:00:00

abstract：:Despite various therapeutic interventions, glioblastoma multiforme (GBM) is one of the most highly vascularized neoplasms in humans with poor prognosis. In this study, we show that a single i.m. injection of an adeno-associated viral (AAV) vector expressing angiostatin, a potent angiogenic inhibitor, effectively suppr...

journal_title：Cancer research

authors： Ma HI,Guo P,Li J,Lin SZ,Chiang YH,Xiao X,Cheng SY

更新日期：2002-02-01 00:00:00

abstract：:One of the major limitations of tumor-specific vaccination is the generation of antigen-loss variants that are able to escape the immune response elicited by a monoantigenic peptide epitope. Here, we report the identification of a new HLA-B*3701-restricted epitope shared by four different members of the MAGE family. P...

journal_title：Cancer research

authors： Tanzarella S,Russo V,Lionello I,Dalerba P,Rigatti D,Bordignon C,Traversari C

更新日期：1999-06-01 00:00:00

abstract：:Although the cyclooxygenase pathway of the arachidonic acid cascade has been suggested to play an important role in colon carcinogenesis, the molecular species of prostanoids and receptors involved have not been fully elucidated yet. We examined the development of aberrant crypt foci (ACFs), putative preneoplastic les...

journal_title：Cancer research

authors： Watanabe K,Kawamori T,Nakatsugi S,Ohta T,Ohuchida S,Yamamoto H,Maruyama T,Kondo K,Ushikubi F,Narumiya S,Sugimura T,Wakabayashi K

更新日期：1999-10-15 00:00:00

abstract：:The role of oxidative metabolism in the up-regulation/activation of stress-induciblesignaling pathways as well as induction of micronucleus formation in bystander cells was investigated. By immunoblotting and in situ immunofluorescence, active Cu-Zn superoxide dismutase (SOD) enzyme and active catalase enzyme were sho...

journal_title：Cancer research

authors： Azzam EI,De Toledo SM,Spitz DR,Little JB

更新日期：2002-10-01 00:00:00

abstract：:Fluence response relationships for the induction of DNA damage in the skin of UV-irradiated Xiphophorus fish were obtained by quantitative gel electrophoresis of unlabeled DNA following extraction and treatment with an enzyme preparation that makes single strand breaks next to cyclobutane pyrimidine dimers. A buffer c...

journal_title：Cancer research

authors： Ahmed FE,Setlow RB

更新日期：1993-05-15 00:00:00