Suppression of intracranial human glioma growth after intramuscular administration of an adeno-associated viral vector expressing angiostatin.

abstract：:We reported recently that medium conditioned with mouse lung microvessel endothelial cells possessed chemotactic activity for a highly lung-metastatic variant (L17) of the RAW117 murine large-cell lymphoma cell line but not for the poorly metastatic parental cells (P) or a liver-metastasizing variant (H10). The chemot...

journal_title：Cancer research

authors： Wakabayashi H,Cavanaugh PG,Nicolson GL

更新日期：1995-10-01 00:00:00

abstract：:Carcinoembryonic antigen (CEA)-related cell adhesion molecule 1 (CEACAM1) is a member of the CEA family of immunoglobulin-like adhesion molecules with two major splice variants, CEACAM1(a)-4L and CEACAM1(b)-4S, differing in the length of their COOH-terminal cytoplasmic tail. Both forms are down-regulated in prostate a...

journal_title：Cancer research

authors： Laurie NA,Comegys MM,Carreiro MP,Brown JF,Flanagan DL,Brilliant KE,Hixson DC

更新日期：2005-12-01 00:00:00

abstract：:When human tumor xenotransplants into nude mice are used as experimental models, it is important to know whether their microvascular anatomy is rather host or tumor specific. Therefore a morphometric comparison of the vascular network in human squamous cell carcinomas and their xenotransplants was carried out. Biopsie...

journal_title：Cancer research

authors： Lauk S,Zietman A,Skates S,Fabian R,Suit HD

更新日期：1989-08-15 00:00:00

abstract：:Merkel cell carcinoma (MCC) is a highly malignant neuroendocrine nonmelanoma skin cancer, which is associated with the Merkel cell polyoma virus (MCPyV). Recently, expression of the terminal deoxynucleotidyl transferase (TdT) and the paired box gene 5 (PAX 5) has been consistently reported in the majority of MCCs. We ...

journal_title：Cancer research

authors： Zur Hausen A,Rennspiess D,Winnepenninckx V,Speel EJ,Kurz AK

更新日期：2013-08-15 00:00:00

abstract：:Patients diagnosed with leukemia approach their treatment with the hope of cure despite the effect on their quality of life. Some patients will be cured, others will die from treatment, and some will die of their disease. A common theme at the New Directions in Leukemia Research (NDLR 2012) meeting was that cure will ...

journal_title：Cancer research

authors： White DL,Brown AL,D'Andrea RJ,Rice AM

更新日期：2012-09-01 00:00:00

abstract：:We have investigated the ability of tamoxifen to regulate members of the transforming growth factor beta (TGF-beta) family in human breast cancers in vivo. Using immunohistochemical techniques, we find that 3 months of tamoxifen treatment causes a consistent induction of extracellular TGF-beta 1 in breast cancer biops...

journal_title：Cancer research

authors： Butta A,MacLennan K,Flanders KC,Sacks NP,Smith I,McKinna A,Dowsett M,Wakefield LM,Sporn MB,Baum M

更新日期：1992-08-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) typically develops in cirrhosis, a condition characterized by Hedgehog (Hh) pathway activation and accumulation of Hh-responsive myofibroblasts. Although Hh signaling generally regulates stromal-epithelial interactions that support epithelial viability, the role of Hh-dependent myofibrob...

journal_title：Cancer research

authors： Chan IS,Guy CD,Chen Y,Lu J,Swiderska-Syn M,Michelotti GA,Karaca G,Xie G,Krüger L,Syn WK,Anderson BR,Pereira TA,Choi SS,Baldwin AS,Diehl AM

更新日期：2012-12-15 00:00:00

abstract：:Fluence response relationships for the induction of DNA damage in the skin of UV-irradiated Xiphophorus fish were obtained by quantitative gel electrophoresis of unlabeled DNA following extraction and treatment with an enzyme preparation that makes single strand breaks next to cyclobutane pyrimidine dimers. A buffer c...

journal_title：Cancer research

authors： Ahmed FE,Setlow RB

更新日期：1993-05-15 00:00:00

abstract：:The p75 and p110 isoforms of the CUX1 homeodomain protein are overexpressed in breast tumors and cancer cell lines. To assess and compare the ability of these short CUX1 isoforms in driving mammary tumor development, we used site-specific transgenesis into the Hprt locus to generate transgenic mice expressing p75 or p...

journal_title：Cancer research

authors： Cadieux C,Kedinger V,Yao L,Vadnais C,Drossos M,Paquet M,Nepveu A

更新日期：2009-09-15 00:00:00

abstract：:Interleukin 4, a T cell-derived 20-kDa glycoprotein, plays an important role in regulating the immune response of B cells, T cells, and macrophages against infections and malignant cells. For this reason recombinant human interleukin 4 (rhIL-4) has entered early clinical trials in cancer patients. In the present study...

journal_title：Cancer research

authors： Topp MS,Papadimitriou CA,Eitelbach F,Koenigsmann M,Oelmann E,Koehler B,Oberberg D,Reufi B,Stein H,Thiel E

更新日期：1995-05-15 00:00:00

abstract：:Recently, the cDNA encoding a novel candidate for prostate cancer-specific antigen, named prostate-specific membrane antigen (PSM), was cloned from the LNCaP prostate cancer cell line (R. S. Israeli, C. T. Powell, W. R. Fair, and W. D. W. Heston, Cancer Res., 53: 227-230,1993). More recently, they also identified an a...

journal_title：Cancer research

authors： Kawakami M,Nakayama J

更新日期：1997-06-15 00:00:00

abstract：:Elucidating the mechanisms of prostate cancer (CaP) survival and metastasis are critical to the discovery of novel therapeutic targets. The monomeric G protein Rap1 has been implicated in cancer tumorigenesis. Rap1 signals to pathways involved in cell adhesion, migration, and survival, suggesting Rap1 may promote seve...

journal_title：Cancer research

authors： Bailey CL,Kelly P,Casey PJ

更新日期：2009-06-15 00:00:00

abstract：:Bleomycin treatment produced dose-dependent changes in lung collagen content and in several measurable histopathological parameters. NIH/Swiss mice were treated twice weekly for 6 weeks with bleomycin, 0, 1, 20, or 40 mg/kg s.c. The two highest doses produced mortalities of 35 and 100%, respectively, as well as loss o...

journal_title：Cancer research

authors： Sikic BI,Young DM,Mimnaugh EG,Gram TE

更新日期：1978-03-01 00:00:00

abstract：:Membrane-type matrix metalloproteinases (MT-MMP) constitute a subfamily of six distinct membrane-associated MMPs. Although the contribution of MT1-MMP during different steps of cancer progression has been well documented, the significance of other MT-MMPs is rather unknown. We have investigated the involvement of MT4-...

journal_title：Cancer research

authors： Chabottaux V,Sounni NE,Pennington CJ,English WR,van den Brûle F,Blacher S,Gilles C,Munaut C,Maquoi E,Lopez-Otin C,Murphy G,Edwards DR,Foidart JM,Noël A

更新日期：2006-05-15 00:00:00

abstract：:Most patients' prostate cancers respond to androgen deprivation but relapse after periods of several months to years. Only two prostate cancer xenografts, LNCaP and PC-346, have been reported to be responsive to androgen deprivation and to relapse subsequently. Both of these tumors shrink slightly, if at all, and rela...

journal_title：Cancer research

authors： Nagabhushan M,Miller CM,Pretlow TP,Giaconia JM,Edgehouse NL,Schwartz S,Kung HJ,de Vere White RW,Gumerlock PH,Resnick MI,Amini SB,Pretlow TG

更新日期：1996-07-01 00:00:00

abstract：:Physiological cell conditions, such as glucose deprivation and hypoxia, play a role in developing drug resistance in solid tumors. These tumor-specific conditions cause decreased expression of DNA topoisomerase IIalpha (topo IIalpha), rendering cells resistant to topo II-targeted drugs, such as etoposide and doxorubic...

journal_title：Cancer research

authors： Ogiso Y,Tomida A,Lei S,Omura S,Tsuruo T

更新日期：2000-05-01 00:00:00

abstract：:HsRec2/Rad51B is a 350-amino acid protein with a molecular mass of 38,300 Da that appears to be involved in cell cycle regulation and UV-induced apoptosis. The mouse and human genes were isolated based on their homology to a recombinational repair gene from Ustilago maydis and contain functional domains to hRAD51 and ...

journal_title：Cancer research

authors： Havre PA,Rice MC,Noe M,Kmiec EB

更新日期：1998-10-15 00:00:00

abstract：:Mutations of the p53 gene constitute one of the most frequent genetic alterations in squamous cell carcinoma of the head and neck (SCCHN). In this study, we introduced wild-type p53 into two separate SCCHN cell lines via a recombinant adenoviral vector, Ad5CMV-p53. Northern blotting showed that following infection by ...

journal_title：Cancer research

authors： Liu TJ,Zhang WW,Taylor DL,Roth JA,Goepfert H,Clayman GL

更新日期：1994-07-15 00:00:00

abstract：:Neuroblastomas often undergo spontaneous differentiation and/or regression in vivo, which is at least partly regulated by the signals through neurotrophins and their receptors. Recently, glial cell line-derived neurotrophic factor (GDNF) and a second family member, neurturin (NTN), have been found to mediate their sig...

journal_title：Cancer research

authors： Hishiki T,Nimura Y,Isogai E,Kondo K,Ichimiya S,Nakamura Y,Ozaki T,Sakiyama S,Hirose M,Seki N,Takahashi H,Ohnuma N,Tanabe M,Nakagawara A

更新日期：1998-05-15 00:00:00

abstract：:Cyclooxygenase-2 (Cox-2) expression can induce mammary tumorigenesis in transgenic mice, and selective Cox-2 inhibitors are both chemopreventive and chemotherapeutic in rat models of breast cancer. We analyzed the expression of Cox-2 protein by immunohistochemistry in tissue array specimens of 1576 invasive breast can...

journal_title：Cancer research

authors： Ristimäki A,Sivula A,Lundin J,Lundin M,Salminen T,Haglund C,Joensuu H,Isola J

更新日期：2002-02-01 00:00:00

abstract：:Current awareness of the importance of environmental factors such as diet in the etiology of human cancer has stimulated renewed interest in animal models for studying effects of diet on tumorigenesis. Diet can influence cancer in animals by affecting the initiation or subsequent preneoplastic stage of tumorigenesis, ...

journal_title：Cancer research

authors： Carroll KK

更新日期：1975-11-01 00:00:00

abstract：:In an attempt to identify phytochemicals contributing to the well-documented preventive effect of plant-based diets on cancer incidence and mortality, we have previously shown that certain flavonoids inhibit in vitro angiogenesis. Here, we show that the flavonoid luteolin inhibited tumor growth and angiogenesis in a m...

journal_title：Cancer research

authors： Bagli E,Stefaniotou M,Morbidelli L,Ziche M,Psillas K,Murphy C,Fotsis T

更新日期：2004-11-01 00:00:00

abstract：:Glucuronidation is an important pathway in the metabolism of nicotine, with previous studies suggesting that ∼22% of urinary nicotine metabolites are in the form of glucuronidated compounds. Recent in vitro studies have suggested that the UDP-glucuronosyltransferases (UGT) 2B10 and 2B17 play major roles in nicotine gl...

journal_title：Cancer research

authors： Chen G,Giambrone NE Jr,Dluzen DF,Muscat JE,Berg A,Gallagher CJ,Lazarus P

更新日期：2010-10-01 00:00:00

abstract：:Fatty acid synthase (FASN) is the terminal enzyme in de novo lipogenesis and plays a key role in cell proliferation. Pharmacologic inhibitors of FASN are being evaluated in clinical trials for treatment of cancer, obesity, and other diseases. Here, we report a previously unknown mechanism of FASN regulation involving ...

journal_title：Cancer research

authors： Lin HP,Cheng ZL,He RY,Song L,Tian MX,Zhou LS,Groh BS,Liu WR,Ji MB,Ding C,Shi YH,Guan KL,Ye D,Xiong Y

更新日期：2016-12-01 00:00:00

abstract：:Bik was initially identified as a BH3-domain-only protein that interacts with E1B 19K. Although systemically administered wild-type Bik significantly inhibited tumor growth and metastasis in an orthotopic nude mouse model, the proapoptotic potency of Bik can be modulated by posttranslational phosphorylation. Here, we ...

journal_title：Cancer research

authors： Li YM,Wen Y,Zhou BP,Kuo HP,Ding Q,Hung MC

更新日期：2003-11-15 00:00:00

abstract：:Nkx2.8, a homeodomain transcription factor, has been characterized in liver cancer and in the developing central nervous system. We now show that this factor is also expressed in the lung, where it localizes in adults to a discrete population of tracheobronchial basal cells. To target the mouse gene, the first exon wa...

journal_title：Cancer research

authors： Tian J,Mahmood R,Hnasko R,Locker J

更新日期：2006-11-01 00:00:00

abstract：:Sputum samples obtained during the screening phase of a chemoprevention trial in heavy smokers were evaluated independently by trained cytotechnologists and classified for degree of cellular atypia according to the method of Saccommano et al. (G. Saccommano et al., Cancer (Phila.), 33: 256-270, 1974). The level of agr...

journal_title：Cancer research

authors： Browman GP,Arnold A,Levine MN,D'Souza T,Turner-Smith LM,Cayco R,Johnstone B,Birse R

更新日期：1990-02-15 00:00:00

abstract：:p21(Cip1) is a cyclin-dependent kinase inhibitor whose abundance increases in cells exposed to radiation or other DNA-damaging agents. Such increases activate a G1 checkpoint, which allows time for DNA repair before S phase entry. By inhibiting cell cycle progression, p21(Cip1) potentially suppresses tumorigenesis, an...

journal_title：Cancer research

authors： Jackson RJ,Engelman RW,Coppola D,Cantor AB,Wharton W,Pledger WJ

更新日期：2003-06-15 00:00:00

abstract：:Vinblastine (VLB) is moderately active clinically against advanced breast cancer. Since VLB is extensively taken up by platelets and thus only partially available to tumor cells, to enhance the therapeutic index of VLB we have therefore administered this agent by continuous i.v. infusion to patients with advanced brea...

journal_title：Cancer research

authors： Lu K,Yap HY,Loo TL

更新日期：1983-03-01 00:00:00

abstract：:The carcinogenicities of a choline deficient L-amino acid defined (CDAA) diet and a semipurified choline deficient diet were comparatively examined. A total of 60 male Fischer 344 rats, 6 weeks old, were divided into 5 experimental groups each consisting of 12 rats. Group 1 received the CDAA diet chronically to the en...

journal_title：Cancer research

authors： Nakae D,Yoshiji H,Mizumoto Y,Horiguchi K,Shiraiwa K,Tamura K,Denda A,Konishi Y

更新日期：1992-09-15 00:00:00