Abstract:
:We have investigated the ability of tamoxifen to regulate members of the transforming growth factor beta (TGF-beta) family in human breast cancers in vivo. Using immunohistochemical techniques, we find that 3 months of tamoxifen treatment causes a consistent induction of extracellular TGF-beta 1 in breast cancer biopsies, compared with matched pretreatment samples from the same patient. The induced TGF-beta is localized between and around stromal fibroblasts and appears to be derived from these cells. Lower levels of TGF-beta 1,-beta 2, and -beta 3 seen in epithelial cells were not altered by tamoxifen treatment. The increased stromal staining of TGF-beta 1 occurred in estrogen receptor-negative as well as estrogen receptor-positive tumors. These results provide in vivo evidence for a novel, estrogen receptor-independent mechanism of action for tamoxifen, involving the stromal induction of a potent growth inhibitor for epithelial cells.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Butta A,MacLennan K,Flanders KC,Sacks NP,Smith I,McKinna A,Dowsett M,Wakefield LM,Sporn MB,Baum Msubject
Has Abstract,Author List Incompletepub_date
1992-08-01 00:00:00pages
4261-4issue
15eissn
0008-5472issn
1538-7445journal_volume
52pub_type
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