当前位置： SCI文献检索 > CANCER RESEARCH期刊下所有文献 > Mouse mammary tumor virus p75 and p110 CUX1 transgenic mice develop mammary tumors of various histologic types.

Mouse mammary tumor virus p75 and p110 CUX1 transgenic mice develop mammary tumors of various histologic types.

Abstract：

:The p75 and p110 isoforms of the CUX1 homeodomain protein are overexpressed in breast tumors and cancer cell lines. To assess and compare the ability of these short CUX1 isoforms in driving mammary tumor development, we used site-specific transgenesis into the Hprt locus to generate transgenic mice expressing p75 or p110 CUX1 under the control of the mouse mammary tumor virus-long terminal repeat. We report that mammary tumors developed after a long latency period, and although various histopathologies were observed, the proportion of adenosquamous carcinomas was significantly higher in p75 CUX1 than in p110 CUX1 transgenic mice. Metastasis to the lung was observed in three p75 CUX1 transgenic mice. Comparisons between tumors and adjacent normal mammary glands revealed that transgenes were overexpressed in most but not all tumors, yet in all cases tested, CUX1 DNA binding was increased, suggesting that both higher expression and changes in post-translational modifications can contribute to stimulate transgene activity. Interestingly, higher expression of erbB2 mRNA was seen in most tumors, not only solid carcinomas but also adenosquamous carcinomas, whereas higher expression of various Wnt genes and activation of the beta-catenin pathway was observed primarily in adenosquamous carcinomas. Activation of erbB2 expression appeared to represent a cooperating event that occurred independently of CUX1. In contrast, chromatin immunoprecipitation, short hairpin RNA-mediated knockdown, and reporter assays established that CUX1 is involved in the transcriptional regulation of several Wnt genes. Together, these results support the notion that oncogenic activity of CUX1 can facilitate the establishment of a Wnt/beta-catenin autocrine loop.

journal_name

Cancer Res

journal_title

Cancer research

authors

Cadieux C,Kedinger V,Yao L,Vadnais C,Drossos M,Paquet M,Nepveu A

doi

10.1158/0008-5472.CAN-08-4899

subject

Has Abstract

pub_date

2009-09-15 00:00:00

pages

7188-97

issue

18

eissn

0008-5472

issn

1538-7445

pii

0008-5472.CAN-08-4899

journal_volume

69

pub_type

杂志文章

相关文献

CANCER RESEARCH文献大全
  • Progesterone receptor in non-small cell lung cancer--a potent prognostic factor and possible target for endocrine therapy.

    abstract：:A possible involvement of gender-dependent factors has been postulated in development of human non-small-cell lung cancers (NSCLC), but its details remain unclear. In this study, we examined biological significance of progesterone receptor in NSCLCs. Progesterone receptor immunoreactivity was detected in 106 of 228 NS...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-04-3087

    authors： Ishibashi H,Suzuki T,Suzuki S,Niikawa H,Lu L,Miki Y,Moriya T,Hayashi S,Handa M,Kondo T,Sasano H

    更新日期：2005-07-15 00:00:00

  • Genetic variants in oxidative stress-related genes predict chemoresistance in primary breast cancer: a prospective observational study and validation.

    abstract：:Chemotherapy response in patients with primary breast cancer is difficult to predict and the role of host genetic factors has not been thoroughly investigated. We hypothesized that polymorphisms in oxidative stress (OS)-related genes, including estrogen-quinone metabolizing enzymes NQO2 and GSTM1-5, may influence dise...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-11-2998

    authors： Yu KD,Huang AJ,Fan L,Li WF,Shao ZM

    更新日期：2012-01-15 00:00:00

  • Quantitative estimation of endogenous nitrosation in humans by monitoring N-nitrosoproline excreted in the urine.

    abstract：:Endogenous formation of N-nitrosoproline (NPRO) was demonstrated by monitoring its excretion in the urine of a male volunteer who had ingested vegetable juice, as a source of nitrate, and proline. The resulting NPRO was analyzed after derivatization by combined gas-liquid chromatography thermal energy analysis. The am...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Ohshima H,Bartsch H

    更新日期：1981-09-01 00:00:00

  • Association of APC gene mutations and histological characteristics of colorectal adenomas.

    abstract：:Fifty-nine colonic adenomas and 6 hyperplastic colonic polyps were analyzed by single-strand conformation polymorphism analysis for mutations in the adenomatous polyposis coli gene (APC). Frameshifts and premature stop codons in at least one copy of APC were detected in 25 of these adenomas. Five adenomas carried 2 AP...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： De Benedetti L,Sciallero S,Gismondi V,James R,Bafico A,Biticchi R,Masetti E,Bonelli L,Heouaine A,Picasso M

    更新日期：1994-07-01 00:00:00

  • DNA methylation alterations in the pancreatic juice of patients with suspected pancreatic disease.

    abstract：:Molecular markers of pancreatic neoplasia could aid in the evaluation of visible pancreatic lesions and indicate neoplasia invisible to imaging. We evaluated methylation-specific PCR (MSP) assays that detect aberrantly methylated DNA for their use as markers of pancreatic neoplasia. Methylation analysis was done on pa...

    journal_title：Cancer research

    pub_type： 临床试验,杂志文章

    doi：10.1158/0008-5472.CAN-05-2664

    authors： Matsubayashi H,Canto M,Sato N,Klein A,Abe T,Yamashita K,Yeo CJ,Kalloo A,Hruban R,Goggins M

    更新日期：2006-01-15 00:00:00

  • Identification of leukocyte E-selectin ligands, P-selectin glycoprotein ligand-1 and E-selectin ligand-1, on human metastatic prostate tumor cells.

    abstract：:Prostate tumor cells, which characteristically metastasize to bone, initiate binding interactions with bone marrow endothelium under blood flow conditions through binding interactions with E-selectin. We hypothesized that E-selectin ligands on prostate tumor cells are directly associated with bone-metastatic potential...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-04-4653

    authors： Dimitroff CJ,Descheny L,Trujillo N,Kim R,Nguyen V,Huang W,Pienta KJ,Kutok JL,Rubin MA

    更新日期：2005-07-01 00:00:00

  • A novel method for the detection of necrotic lesions in human cancers.

    abstract：:Data are presented in support of the hypothesis that malignant tumors, containing abnormally permeable, degenerating cells, can be selectively detected using monoclonal antibodies to intracellular antigens. Biodistribution, imaging, and autoradiographic studies were performed in nude mice transplanted with four differ...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Epstein AL,Chen FM,Taylor CR

    更新日期：1988-10-15 00:00:00

  • LKB1/STK11 suppresses cyclooxygenase-2 induction and cellular invasion through PEA3 in lung cancer.

    abstract：:We showed that the PEA3 transcriptional factor interacted with LKB1, a serine/threonine kinase, which is somatically mutated in lung cancer. This interaction occurred through the ETS domain of PEA3 and the kinase domain of LKB1. Mutation of LKB1 in lung cancer cells stabilized PEA3. Reintroduction of wild-type (WT) LK...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-05-2902

    authors： Upadhyay S,Liu C,Chatterjee A,Hoque MO,Kim MS,Engles J,Westra W,Trink B,Ratovitski E,Sidransky D

    更新日期：2006-08-15 00:00:00

  • Motility of human carcinoma cells in response to thrombospondin: relationship to metastatic potential and thrombospondin structural domains.

    abstract：:The interactions of tumorigenic cells with the extracellular matrix play a critical role in the establishment of metastases. Thrombospondin (TSP) is prominent at sites of tissue injury and promotes the attachment, spreading, and motility of several cell types. We have investigated the relationship between human carcin...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Yabkowitz R,Mansfield PJ,Dixit VM,Suchard SJ

    更新日期：1993-01-15 00:00:00

  • Expression of Ca antigen in relation to cell cycle in cultured human tumor cells.

    abstract：:In order to explain the heterogeneity of Ca antigen (Ca) expression observed previously on human malignant cells, a relationship of antigen content with events in the cell cycle was studied by multiparameter flow cytometry on four continuous human cell lines, HeLaS3, C4l, HT29, and T24, grown exponentially in culture....

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Czerniak B,Darzynkiewicz Z,Staiano-Coico L,Herz F,Koss LG

    更新日期：1984-10-01 00:00:00

  • Monocyte-Derived Leukemia-Associated Macrophages Facilitate Extramedullary Distribution of T-cell Acute Lymphoblastic Leukemia Cells.

    abstract：:Macrophages play important roles in both physiologic and pathologic processes and arise from successive waves of embryonic and adult hematopoiesis. Monocyte-derived macrophages (MOMF) exert distinct functions under pathologic conditions, and leukemia-associated macrophages (LAM) show considerable diversities in activa...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-20-0034

    authors： Yang F,Feng W,Wang H,Wang L,Liu X,Wang R,Chen C,Yang X,Zhang D,Ren Q,Zheng G

    更新日期：2020-09-01 00:00:00

  • Hepatitis B virus and cigarette smoking: risk factors for hepatocellular carcinoma in Hong Kong.

    abstract：:One hundred seven Chinese patients with primary hepatocellular carcinoma (PHC) were compared with 107 hospital controls for the presence of hepatitis B surface antigen and smoking, drinking, and dietary habits. Eighty-two % of PHC cases were hepatitis B surface antigen positive compared to 18% of controls (relative ri...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Lam KC,Yu MC,Leung JW,Henderson BE

    更新日期：1982-12-01 00:00:00

  • Effects of dietary folate and alcohol intake on promoter methylation in sporadic colorectal cancer: the Netherlands cohort study on diet and cancer.

    abstract：:Sporadic colorectal cancer (CRC) is characterized by genetic and epigenetic changes such as regional DNA hypermethylation and global DNA hypomethylation. Epidemiological and animal studies suggest that aberrant DNA methylation is associated with low dietary folate intake, which is aggravated by high alcohol intake. Th...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： van Engeland M,Weijenberg MP,Roemen GM,Brink M,de Bruïne AP,Goldbohm RA,van den Brandt PA,Baylin SB,de Goeij AF,Herman JG

    更新日期：2003-06-15 00:00:00

  • Inhibition of murine erythroleukemia cell differentiation by 3-deazaadenosine.

    abstract：:Recent studies have demonstrated that 5'-methylthioadenosine, an inhibitor of S-adenosylhomocysteine (AdoHcy) hydrolase, blocks induction of murine erythroleukemia cell (MEL) differentiation. The nucleoside analogue 3-deazaadenosine (c3Ado) is both an efficient substrate and a potent inhibitor of AdoHcy hydrolase. The...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Sherman ML,Shafman TD,Spriggs DR,Kufe DW

    更新日期：1985-11-01 00:00:00

  • Expression of differentiation melanoma-associated antigen genes is associated with favorable disease outcome in advanced-stage melanomas.

    abstract：:Cutaneous melanomas have been found to express several immunogenic differentiation melanoma-associated antigens (MAAs) that have been suggested to play an important role in disease outcome. Adaptive host immunity to MAAs has shown some level of control on melanoma progression. To date, there has been no definitive rep...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Takeuchi H,Kuo C,Morton DL,Wang HJ,Hoon DS

    更新日期：2003-01-15 00:00:00

  • Tumor Cell-Derived IL1β Promotes Desmoplasia and Immune Suppression in Pancreatic Cancer.

    abstract：:Pancreatic ductal adenocarcinoma (PDA) is an aggressive malignancy typified by a highly stromal and weakly immunogenic tumor microenvironment that promotes tumor evolution and contributes to therapeutic resistance. Here, we demonstrate that PDA tumor cell-derived proinflammatory cytokine IL1β is essential for the esta...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-19-2080

    authors： Das S,Shapiro B,Vucic EA,Vogt S,Bar-Sagi D

    更新日期：2020-03-01 00:00:00

  • Tumor progression in serial passages of the Dunning R3327-G rat prostatic adenocarcinoma: growth rate response to endocrine manipulation.

    abstract：:Serial passages of the poorly differentiated, androgen-sensitive R3327-G prostatic adenocarcinoma were used to study the progressive changes that occur in tumor growth rate and androgen sensitivity. Different in vivo transplant generations (21st to 28th) were compared. The tumor doubling and animal survival times resu...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Pollack A,Block NL,Stover BJ,Irvin GL 3rd

    更新日期：1985-03-01 00:00:00

  • Positive correlation between calmodulin content and hepatoma growth rates.

    abstract：:Calmodulin contents of normal rat liver, host liver [bearing hepatoma 5123t.c.(h)], regenerating liver, and Morris hepatomas 7800, 5123t.c.(h), and 7794A were determined by phosphodiesterase assay and by radioimmunoassay. The calmodulin levels determined by both assays were significantly increased in three hepatomas w...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Wei JW,Morris HP,Hickie RA

    更新日期：1982-07-01 00:00:00

  • Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products.

    abstract：:Gemcitabine is currently the best treatment available for pancreatic cancer, but the disease develops resistance to the drug over time. Agents that can either enhance the effects of gemcitabine or overcome chemoresistance to the drug are needed for the treatment of pancreatic cancer. Curcumin, a component of turmeric ...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-06-4257

    authors： Kunnumakkara AB,Guha S,Krishnan S,Diagaradjane P,Gelovani J,Aggarwal BB

    更新日期：2007-04-15 00:00:00

  • Parkin pathway activation mitigates glioma cell proliferation and predicts patient survival.

    abstract：:Mutations in the parkin gene, which encodes a ubiquitin ligase, are a major genetic cause of parkinsonism. Interestingly, parkin also plays a role in cancer as a putative tumor suppressor, and the gene is frequently targeted by deletion and inactivation in human malignant tumors. Here, we investigated a potential tumo...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-11-3060

    authors： Yeo CW,Ng FS,Chai C,Tan JM,Koh GR,Chong YK,Koh LW,Foong CS,Sandanaraj E,Holbrook JD,Ang BT,Takahashi R,Tang C,Lim KL

    更新日期：2012-05-15 00:00:00

  • Ulcerative colitis-associated colorectal cancer arises in a field of short telomeres, senescence, and inflammation.

    abstract：:Inflammation plays a role in the progression to cancer and it is linked to the presence of senescent cells. Ulcerative colitis (UC) is a chronic inflammatory disease that predisposes to colorectal cancer. Tumorigenesis in this setting is associated with telomere shortening that can be observed in the nondysplastic epi...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-10-1966

    authors： Risques RA,Lai LA,Himmetoglu C,Ebaee A,Li L,Feng Z,Bronner MP,Al-Lahham B,Kowdley KV,Lindor KD,Rabinovitch PS,Brentnall TA

    更新日期：2011-03-01 00:00:00

  • Correlation of karyotype with clinical features in acute lymphoblastic leukemia.

    abstract：:We studied the clinical and karyotypic features of 50 patients with acute lymphoblastic leukemia, including 33 American and 17 Japanese patients, at two institutions. Clonal chromosome abnormalities were found in 39 of the 50 patients (78%) at diagnosis. Eleven patients had diploidy (N patients). Among the 39 aneuploi...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Kaneko Y,Rowley JD,Variakojis D,Chilcote RR,Check I,Sakurai M

    更新日期：1982-07-01 00:00:00

  • 3'-UTR and functional secretor haplotypes in mannose-binding lectin 2 are associated with increased colon cancer risk in African Americans.

    abstract：:Because chronic intestinal inflammation is a risk factor for colorectal cancer, we hypothesized that genetic variants of inflammatory mediators, such as mannose-binding lectin 2 (MBL2), are associated with colon cancer susceptibility. Here, we report the association of 24 MBL2 single-nucleotide polymorphisms (SNP) and...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-11-3073

    authors： Zanetti KA,Haznadar M,Welsh JA,Robles AI,Ryan BM,McClary AC,Bowman ED,Goodman JE,Bernig T,Chanock SJ,Harris CC

    更新日期：2012-03-15 00:00:00

  • Complete regression of experimental solid tumors by combination LEC/chTNT-3 immunotherapy and CD25(+) T-cell depletion.

    abstract：:LEC/chTNT-3, a chemokine fusion protein generated previously in our laboratory, produces a 40-60% reduction in well-established solid tumors of the BALB/c mouse. In this study, CD25(+) T-cell depletion was used in combination with LEC/chTNT-3 treatment to enhance the therapeutic value of this approach. In two tumor mo...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Li J,Hu P,Khawli LA,Epstein AL

    更新日期：2003-12-01 00:00:00

  • Multiple roles of p53-related pathways in somatic cell reprogramming and stem cell differentiation.

    abstract：:The inactivation of p53 functions enhances the efficiency and decreases the latency of producing induced pluripotent stem cells (iPSC) in culture. The formation of iPSCs in culture starts with a rapid set of cell divisions followed by an epigenetic reprogramming of the DNA and chromatin. The mechanisms by which the p5...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-12-1451

    authors： Yi L,Lu C,Hu W,Sun Y,Levine AJ

    更新日期：2012-11-01 00:00:00

  • CITED4 inhibits hypoxia-activated transcription in cancer cells, and its cytoplasmic location in breast cancer is associated with elevated expression of tumor cell hypoxia-inducible factor 1alpha.

    abstract：:The interaction of hypoxia-inducible factor 1alpha and the CH1 domain of the transcriptional coactivator p300/CBP is necessary for the expression of hypoxia responsive genes and tumor angiogenesis. The transcription factor CITED2 binds p300/CBP at the CH1 domain and functions as a negative regulator of hypoxia signali...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-04-0708

    authors： Fox SB,Bragança J,Turley H,Campo L,Han C,Gatter KC,Bhattacharya S,Harris AL

    更新日期：2004-09-01 00:00:00

  • Somatic APC and K-ras codon 12 mutations in aberrant crypt foci from human colons.

    abstract：:Aberrant crypt foci (ACF) are microscopic lesions which have been postulated to precede the development of adenomatous polyps, the precursors to colorectal cancer. APC and ras gene mutations have been shown to be important early molecular events in the development of colorectal neoplasms. The objective of this study w...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Smith AJ,Stern HS,Penner M,Hay K,Mitri A,Bapat BV,Gallinger S

    更新日期：1994-11-01 00:00:00

  • Prostate-localized and androgen-regulated expression of the membrane-bound serine protease TMPRSS2.

    abstract：:Genes regulated by androgenic hormones are of critical importance for the normal physiological function of the human prostate gland, and they contribute to the development and progression of prostate carcinoma. We used cDNA microarrays containing 1500 cDNAs to profile transcripts regulated by androgens in prostate can...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Lin B,Ferguson C,White JT,Wang S,Vessella R,True LD,Hood L,Nelson PS

    更新日期：1999-09-01 00:00:00

  • The quest for the 1p36 tumor suppressor.

    abstract：:Genomic analyses of late-stage human cancers have uncovered deletions encompassing 1p36, thereby providing an extensive body of literature supporting the idea that a potent tumor suppressor resides in this interval. Although several genes have been proposed as 1p36 candidate tumor suppressors, convincing evidence that...

    journal_title：Cancer research

    pub_type： 杂志文章,评审

    doi：10.1158/0008-5472.CAN-07-2095

    authors： Bagchi A,Mills AA

    更新日期：2008-04-15 00:00:00

  • Soluble tumor necrosis factor-like weak inducer of apoptosis overexpression in HEK293 cells promotes tumor growth and angiogenesis in athymic nude mice.

    abstract：:Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a member of the tumor necrosis factor superfamily of structurally related cytokines. TWEAK acts on responsive cells via binding to a cell surface receptor named Fn14. Recent studies have demonstrated that TWEAK can stimulate numerous cellular responses in...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-04-1879

    authors： Ho DH,Vu H,Brown SA,Donohue PJ,Hanscom HN,Winkles JA

    更新日期：2004-12-15 00:00:00