Soluble tumor necrosis factor-like weak inducer of apoptosis overexpression in HEK293 cells promotes tumor growth and angiogenesis in athymic nude mice.

abstract：:While colony formation assays provide sensitive indices of tumor cell proliferation and growth inhibition imposed by many chemotherapeutic agents, drugs which require metabolic activation lack activity in such assays. In the present study, we have utilized freshly isolated rat hepatocytes for the activation of drugs w...

journal_title：Cancer research

authors： Alley MC,Powis G,Appel PL,Kooistra KL,Lieber MM

更新日期：1984-02-01 00:00:00

abstract：:Microbial carboxyl and catechol siderophores have been shown to have natural iron-chelating abilities, suggesting that hyaluronic acid (HA) and the catechol compound, gallic acid (GA), may have iron-coordinating activities. Here, a photoresponsive self-gelling hydrogel that was both injectable and could be applied to ...

journal_title：Cancer research

authors： Ko S,Park JY,Oh YK

更新日期：2019-12-15 00:00:00

abstract：:A dose-response study was conducted in Fischer rats with nitrosodiethylamine, which was administered in regulated amounts as a solution in drinking water. Groups of 20 female rats each received a different treatment, one group consisted of 12 animals; one of the groups was untreated. The concentrations of the solution...

journal_title：Cancer research

authors： Lijinsky W,Reuber MD,Riggs CW

更新日期：1981-12-01 00:00:00

abstract：:We clarified the role of mold exposure in pituitary tumor induction using 53 germ-free Wistar rats exposed before birth and continually exposed thereafter, to Aspergillus versicolor alone. Rats were autopsied at 540 to 730 days. Untreated germ-free controls were autopsied on day 730. Thirty-three of the 53 monoassocia...

journal_title：Cancer research

authors： Sumi Y,Nagura H,Miyakawa M

更新日期：1990-01-15 00:00:00

abstract：:For two decades, the antigen recognized by the Pathologische Anatomie Leiden-Endothelium (PAL-E) monoclonal antibody, a standard vascular endothelial cell marker, has remained elusive. Here, we used a combinatorial phage display-based approach ("epitope mapping") to select peptides binding to the original PAL-E antibo...

journal_title：Cancer research

authors： Jaalouk DE,Ozawa MG,Sun J,Lahdenranta J,Schlingemann RO,Pasqualini R,Arap W

更新日期：2007-10-15 00:00:00

abstract：:Chimeric antigen receptor (CAR) T-cell therapy is an emerging immunotherapy against several malignancies including glioblastoma, the most common and most aggressive malignant primary brain tumor in adults. The challenges in solid tumor immunotherapy comprise heterogenously expressed tumor target antigens and restricte...

journal_title：Cancer research

authors： Weiss T,Weller M,Guckenberger M,Sentman CL,Roth P

更新日期：2018-02-15 00:00:00

abstract：:The ability of the in vitro sister chromatid exchange (SCE) assay to predict in vivo tumor drug sensitivity was investigated using a spontaneous hepatocarcinoma in C3Hf/Kam mice and 3 chemotherapeutic agents: melphalan; cis-platinum; and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). For hepatocarcinoma cells grown in m...

journal_title：Cancer research

authors： Tofilon PJ,Basic I,Milas L

更新日期：1985-05-01 00:00:00

abstract：:Between June 1977 and December 1979, 72 evaluable patients with childhood non-T-cell acute lymphoblastic leukemia were induced into complete remission using vincristine, prednisone, and doxorubicin. All received asparaginase consolidation and central nervous system prophylaxis with cranial irradiation and intrathecal ...

journal_title：Cancer research

authors： Sallan SE,Hitchcock-Bryan S,Gelber R,Cassady JR,Frei E 3rd,Nathan DG

更新日期：1983-11-01 00:00:00

abstract：:A series of linkage studies was previously conducted to identify quantitative trait loci associated with chemically induced lung tumors. However, little is known of genetic susceptibility to spontaneously occurring lung tumorigenesis (SLT) in mice. In this study, we did a whole-genome linkage disequilibrium analysis f...

journal_title：Cancer research

authors： Wang D,You M

更新日期：2005-09-15 00:00:00

abstract：:Cyclooxygenase-2 (Cox-2) expression can induce mammary tumorigenesis in transgenic mice, and selective Cox-2 inhibitors are both chemopreventive and chemotherapeutic in rat models of breast cancer. We analyzed the expression of Cox-2 protein by immunohistochemistry in tissue array specimens of 1576 invasive breast can...

journal_title：Cancer research

authors： Ristimäki A,Sivula A,Lundin J,Lundin M,Salminen T,Haglund C,Joensuu H,Isola J

更新日期：2002-02-01 00:00:00

abstract：:The effects of the protein kinase C (PKC) activators, phorbol ester 12-O-tetradecanoyl-13-phorbol acetate (TPA) and the marine natural product, bryostatin 1, on the growth and morphology of human breast cancer cell lines were examined. TPA (1 to 100 nM) inhibited growth of four of six cell lines by up to 75% in 5-day ...

journal_title：Cancer research

authors： Kennedy MJ,Prestigiacomo LJ,Tyler G,May WS,Davidson NE

更新日期：1992-03-01 00:00:00

abstract：:Vaccine strategies for treatment of human papillomavirus-induced cervical cancer are based on either the recombinant E7 fusion oncoprotein or E7 CTL peptides. The therapeutic potential of the E7-based vaccine depends on the use of different adjuvants. In this study, we describe for the first time the expression of the...

journal_title：Cancer research

authors： Franconi R,Di Bonito P,Dibello F,Accardi L,Muller A,Cirilli A,Simeone P,Donà MG,Venuti A,Giorgi C

更新日期：2002-07-01 00:00:00

abstract：:Alpha-particle immunotherapy by targeted alpha-emitters or alpha-emitting isotope generators is a novel form of extraordinarily potent cancer therapy. A major impediment to the clinical use of targeted actinium-225 (225Ac) in vivo generators may be the radiotoxicity of the systemically released daughter radionuclides....

journal_title：Cancer research

authors： Jaggi JS,Kappel BJ,McDevitt MR,Sgouros G,Flombaum CD,Cabassa C,Scheinberg DA

更新日期：2005-06-01 00:00:00

abstract：:Despite the impressive results obtained in animal models, the clinical use of tumor necrosis factor-alpha (TNF) as an anticancer drug is limited by severe toxicity. We have shown previously that targeted delivery of TNF to aminopeptidase N (CD13), a marker of angiogenic vessels, improved the therapeutic index of this ...

journal_title：Cancer research

authors： Curnis F,Gasparri A,Sacchi A,Longhi R,Corti A

更新日期：2004-01-15 00:00:00

abstract：:Peroxisome proliferators (PPs) act as nongenotoxic tumor promoters in rodents. Their hepatocarcinogenicity requires the presence of the PP-activated receptor alpha (PPARalpha); however, the exact role played by this transcription factor in the liver, more precisely in liver cell growth and differentiation, is not know...

journal_title：Cancer research

authors： Kaplanski C,Pauley CJ,Griffiths TG,Kawabata TT,Ledwith BJ

更新日期：2000-02-01 00:00:00

abstract：:Positive therapeutic effects of interferons (IFNs) in combination with other therapies will depend on defining modalities, doses, and timing of treatment in the setting of varied tumor burdens. When 10(4) P388 leukemia cells were inoculated i.p. on day 0 in BALB/c x DBA/2 F1 mice, all mice died within 18 days if left ...

journal_title：Cancer research

authors： Borden EC,Sidky YA,Hatcher JF,Bryan GT

更新日期：1988-05-01 00:00:00

abstract：:Topotecan (SK&F 104864, hycamptamine, NSC 609699) is believed to exert its cytotoxic effects through inhibition of topoisomerase I, the activity of which recovers rapidly on removal of the drug in vitro. In vivo studies show that the activity of topotecan is schedule dependent, favoring repeated doses. Early human stu...

journal_title：Cancer research

authors： Haas NB,LaCreta FP,Walczak J,Hudes GR,Brennan JM,Ozols RF,O'Dwyer PJ

更新日期：1994-03-01 00:00:00

abstract：:MSN-1 is a monoclonal antibody, which was raised by immunizing mice with a human endometrial cancer cell line, SNG-II. The MSN-1 specifically recognizes a blood group carbohydrate antigen, Leb. We investigated the subcellular and suborganellar localization of the MSN-1-reactive carbohydrate antigens in the endometrial...

journal_title：Cancer research

authors： Susumu N,Kawakami H,Aoki D,Hirano H,Nozawa S

更新日期：1993-08-01 00:00:00

abstract：:The role of Janus-activated kinase (JAK) signaling in cell cycle transit and maintenance of genomic stability was determined in HL-60 myeloblastic leukemia cells. Inhibition of JAKs, all JAKs (JAK1, JAK2, JAK3, and tyrosine kinase 2), JAK2, or JAK3, caused a significant reduction in cell growth with a major G2-M arres...

journal_title：Cancer research

authors： Reiterer G,Yen A

更新日期：2006-09-15 00:00:00

abstract：:BALB/c mice were hyperimmunized against a membrane preparation derived from a pool of transurethral resection specimens which included three benign prostatic hyperplasia and one prostate adenocarcinoma tissue samples. The activated lymphocytes were fused with the NS-1 mouse myeloma cell line, and supernatants from imm...

journal_title：Cancer research

authors： Starling JJ,Sieg SM,Beckett ML,Wirth PR,Wahab Z,Schellhammer PF,Ladaga LE,Poleskic S,Wright GL Jr

更新日期：1986-01-01 00:00:00

abstract：:Cetuximab, the FDA-approved anti-EGFR antibody for head and neck squamous cell carcinoma (HNSCC), has displayed limited efficacy due to the emergence of intrinsic and acquired resistance. We and others have demonstrated that cetuximab resistance in HNSCC is driven by alternative receptor tyrosine kinases (RTK), includ...

journal_title：Cancer research

authors： Leonard B,Brand TM,O'Keefe RA,Lee ED,Zeng Y,Kemmer JD,Li H,Grandis JR,Bhola NE

更新日期：2018-08-01 00:00:00

abstract：:Aggressive tumor growth, diffuse tissue invasion, and neurodegeneration are hallmarks of malignant glioma. Although glutamate excitotoxicity is considered to play a key role in glioma-induced neurodegeneration, the mechanism(s) controlling this process is poorly understood. Astrocyte elevated gene-1 (AEG-1) is an onco...

journal_title：Cancer research

authors： Lee SG,Kim K,Kegelman TP,Dash R,Das SK,Choi JK,Emdad L,Howlett EL,Jeon HY,Su ZZ,Yoo BK,Sarkar D,Kim SH,Kang DC,Fisher PB

更新日期：2011-10-15 00:00:00

abstract：:The receptor-interacting protein kinase 1 (RIPK1) is an essential signaling molecule in pathways for cell survival, apoptosis, and necroptosis. We report here that RIPK1 is upregulated in human colorectal cancer and promotes cell proliferation when overexpressed in a colon cancer cell line. RIPK1 interacts with mitoch...

journal_title：Cancer research

authors： Zeng F,Chen X,Cui W,Wen W,Lu F,Sun X,Ma D,Yuan Y,Li Z,Hou N,Zhao H,Bi X,Zhao J,Zhou J,Zhang Y,Xiao RP,Cai J,Zhang X

更新日期：2018-06-01 00:00:00

abstract：:Human polymorphic N-acetyltransferase (NAT2) catalyzes the N-acetylation of arylamine carcinogens and the metabolic activation of N-hydroxyarylamine and N-hydroxyarylamide carcinogens by O- and N,O-acetylation, respectively. Rapid and slow acetylator phenotype is regulated at the NAT2 locus, and each has been associat...

journal_title：Cancer research

authors： Hein DW,Doll MA,Rustan TD,Ferguson RJ

更新日期：1995-08-15 00:00:00

abstract：:Donor lymphocyte infusions (DLI) provide effective therapy for patients with multiple myeloma who have relapsed after allogeneic bone marrow transplantation. However, the immunological mechanisms of the graft-versus-myeloma (GVM) effect have not been defined, and the target antigens of this response have not been iden...

journal_title：Cancer research

authors： Orsini E,Bellucci R,Alyea EP,Schlossman R,Canning C,McLaughlin S,Ghia P,Anderson KC,Ritz J

更新日期：2003-05-15 00:00:00

abstract：:Hypoxia in solid tumors is associated with treatment resistance and increased metastatic potential. Although hypoxia has been reported in pancreatic cancer patients, there is little direct evidence that this contributes to their overall poor prognosis. To address this, we examined the associations between hypoxia and ...

journal_title：Cancer research

authors： Chang Q,Jurisica I,Do T,Hedley DW

更新日期：2011-04-15 00:00:00

abstract：:Primary and metastatic bone cancers are difficult to eradicate and novel approaches are needed to improve treatment and extend life. As bone cancer grows, osteoclasts, the principal bone-resorbing cells of the body, are recruited to and activated at sites of cancer. In this investigation, we determined if osteoclast l...

journal_title：Cancer research

authors： Ramnaraine ML,Mathews WE,Donohue JM,Lynch CM,Goblirsch MJ,Clohisy DR

更新日期：2006-11-15 00:00:00

abstract：:Although there is considerable knowledge of how DNA damage triggers cell cycle arrest, DNA repair, and apoptosis, little was known about its potential role in immune responses. Recently, we showed that genotoxic stress and stalled DNA replication forks induce the expression of ligands for the NKG2D receptor found in n...

journal_title：Cancer research

authors： Gasser S,Raulet DH

更新日期：2006-04-15 00:00:00

abstract：:We reported previously that 1 alpha,25-dihydroxyvitamin D3 [1 alpha,25(OH)2D3], a hormonally active form of vitamin D3, markedly enhanced methylcholanthrene-induced transformation of BALB 3T3 A31-1-1 cells. When the cells were treated with methylcholanthrene (1 microgram/ml) for 72 h and then with 1 alpha,25(OH)2D3 (5...

journal_title：Cancer research

authors： Sasaki K,Chida K,Hashiba H,Kamata N,Abe E,Suda T,Kuroki T

更新日期：1986-02-01 00:00:00

abstract：:Neuroblastoma is a common solid tumor of childhood that is derived from the neural crest. Expression of epidermal growth factor (EGF) receptors (EGFRs) has been associated with enhanced cell growth and aggressive behavior in other tumors. Here, we examined the expression profile of EGFRs in neuroblastoma cell lines an...

journal_title：Cancer research

authors： Ho R,Minturn JE,Hishiki T,Zhao H,Wang Q,Cnaan A,Maris J,Evans AE,Brodeur GM

更新日期：2005-11-01 00:00:00