Growth suppression of human head and neck cancer cells by the introduction of a wild-type p53 gene via a recombinant adenovirus.

abstract：:Peroxisome proliferator-activated receptor-gamma (PPARgamma) is a member of the nuclear receptor (NR) family of transcription factors with important regulatory roles in cellular growth, differentiation, and apoptosis. Using proteomic analysis, we showed expression of PPARgamma protein in a series of 260 newly diagnose...

journal_title：Cancer research

authors： Tsao T,Kornblau S,Safe S,Watt JC,Ruvolo V,Chen W,Qiu Y,Coombes KR,Ju Z,Abdelrahim M,Schober W,Ling X,Kardassis D,Meyer C,Schimmer A,Kantarjian H,Andreeff M,Konopleva M

更新日期：2010-06-15 00:00:00

abstract：:Morris 7777 hepatoma cells, maintained in culture for 5 days in Lewis medium supplemented with 0.1 to 0.35 mM cis-unsaturated fatty acid of the oleic (number of carbon atoms: number of double bonds, 18:1), linoleic (18:2), or arachidonic (20:4) type, were compared to similarly maintained, unsupplemented cells as to ul...

journal_title：Cancer research

authors： Abbas MK,Yoo TJ,Viles J

更新日期：1982-11-01 00:00:00

abstract：:Epidemiological and experimental carcinogenesis studies provide evidence that components of garlic (Allium sativum) have anticancer activity. We recently reported that the garlic derivative S-allylmercaptocysteine (SAMC) inhibits growth, arrests cells in G(2)-M, and induces apoptosis in human colon cancer cells (Shiri...

journal_title：Cancer research

authors： Xiao D,Pinto JT,Soh JW,Deguchi A,Gundersen GG,Palazzo AF,Yoon JT,Shirin H,Weinstein IB

更新日期：2003-10-15 00:00:00

abstract：:Acute lymphoblastic leukemia (ALL) with 11q23 translocations is usually associated with MLL gene rearrangement, but little is known about its leukemogenesis. We analyzed the gene expression profiles of pediatric ALL samples according to their translocations. Using oligonucleotide microarray analysis, we identified dis...

journal_title：Cancer research

authors： Tsutsumi S,Taketani T,Nishimura K,Ge X,Taki T,Sugita K,Ishii E,Hanada R,Ohki M,Aburatani H,Hayashi Y

更新日期：2003-08-15 00:00:00

abstract：:The von Hippel-Lindau (VHL) tumor suppressor gene is mutated in patients with VHL disease and in the majority of patients with sporadic clear cell renal carcinoma (RCC). Overexpression of transforming growth factor (TGF) beta1 has been observed in patients with several cancers, including RCCs, with serum and urine lev...

journal_title：Cancer research

authors： Ananth S,Knebelmann B,Grüning W,Dhanabal M,Walz G,Stillman IE,Sukhatme VP

更新日期：1999-05-01 00:00:00

abstract：:The steroid hormone 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] has potential to be used as an antitumor agent, but its clinical application is restricted by the strong calcemic activity. Therefore, new vitamin D3 analogues are developed with increased growth inhibitory and reduced calcemic activity. In the present study,...

journal_title：Cancer research

authors： Vink-van Wijngaarden T,Pols HA,Buurman CJ,van den Bemd GJ,Dorssers LC,Birkenhäger JC,van Leeuwen JP

更新日期：1994-11-01 00:00:00

abstract：:Heterozygous mutations in the BRCA1 gene predispose women to breast and ovarian cancer, while biallelic BRCA1 mutations are a cause of Fanconi anemia (FA), a rare genetic disorder characterized by developmental abnormalities, early-onset bone marrow failure, increased risk of cancers, and hypersensitivity to DNA-cross...

journal_title：Cancer research

authors： Park D,Bergin SM,Jones D,Ru P,Koivisto CS,Jeon YJ,Sizemore GM,Kladney RD,Hadjis A,Shakya R,Ludwig T

更新日期：2020-10-01 00:00:00

abstract：:Osteosarcoma is the most frequent primary bone tumor that develops mainly in the young, the median age of diagnosis being 18 years. Despite improvement in osteosarcoma treatment, survival rate is only 30% at 5 years for patients with pulmonary metastases at diagnosis. This warrants exploration of new therapeutic optio...

journal_title：Cancer research

authors： Lamoureux F,Richard P,Wittrant Y,Battaglia S,Pilet P,Trichet V,Blanchard F,Gouin F,Pitard B,Heymann D,Redini F

更新日期：2007-08-01 00:00:00

abstract：:A complex of polyinosinic-polycytidylic acid [poly(I) x poly(C)] and cationic liposome (LIC) inhibited the growth of many tumor cell lines at low concentration in vitro, but poly(I) x poly(C) alone had no such antiproliferative effect. The IC50 values of LIC against the tumor cells ranged from 0.1 to 1000 ng/ml. LIC h...

journal_title：Cancer research

authors： Hirabayashi K,Yano J,Inoue T,Yamaguchi T,Tanigawara K,Smyth GE,Ishiyama K,Ohgi T,Kimura K,Irimura T

更新日期：1999-09-01 00:00:00

abstract：:Although many clinicians and researchers work to understand cancer, there has been limited success to effectively combine forces and collaborate over time, distance, data, and budget constraints. Here we present a workflow template for multidisciplinary cancer therapy that was developed during the 2nd Annual Workshop ...

journal_title：Cancer research

authors： McGuire MF,Enderling H,Wallace DI,Batra J,Jordan M,Kumar S,Panetta JC,Pasquier E

更新日期：2013-10-15 00:00:00

abstract：:The mechanisms underlying the progression of prostate cancer to a state of resistance to hormone ablation remain poorly understood. Here, we have investigated the relationship between androgen receptor (AR) and Her-2/neu in prostate cancer cells. Overexpression of Her-2/neu (c-ErbB2) activates the AR pathway and confe...

journal_title：Cancer research

authors： Berger R,Lin DI,Nieto M,Sicinska E,Garraway LA,Adams H,Signoretti S,Hahn WC,Loda M

更新日期：2006-06-01 00:00:00

abstract：:Despite descriptions of light-mediated therapy in ancient texts and the discovery of photodynamic therapy (PDT) in the early 1900s, the landmark article in 1978 in Cancer Research by Dougherty and his colleagues at the Roswell Park Cancer Institute remains rightly viewed as the starting point for clinical PDT in moder...

journal_title：Cancer research

authors： Cengel KA,Simone CB 2nd,Glatstein E

更新日期：2016-05-01 00:00:00

abstract：:The process of monoclonal antibody (MAb) binding to tumor cells is greatly influenced by the biology of the respective antigen. This was concluded from an analysis of binding and release of MAbs and MAb fragments to melanoma cells at different concentration levels and different temperatures. With an antigen known to b...

journal_title：Cancer research

authors： Matzku S,Bröcker EB,Brüggen J,Dippold WG,Tilgen W

更新日期：1986-08-01 00:00:00

abstract：:We tested the influence of recombinant human interleukin (rhIL)-l3 and rhIL-4 on clonal growth of human breast cancer cell lines. rhIL-13 and rhIL-4 inhibited clonal growth of three of nine lines to approximately 50% of controls (ED50, 0.5 ng/ml). rhIl-13 reduced [3H]thymidine incorporation in all three cell lines: tw...

journal_title：Cancer research

authors： Serve H,Oelmann E,Herweg A,Oberberg D,Serve S,Reufi B,Mücke C,Minty A,Thiel E,Berdel WE

更新日期：1996-08-01 00:00:00

abstract：:The ether lipid analogue 1-octadecyl-2-methyl-rac-glycero-3-phosphocholine (ET-18-OCH3) has been shown to be a direct inhibitor of Swiss 3T3 fibroblast and BG1 ovarian adenocarcinoma cell cytosolic phosphoinositide selective phospholipase C (PIPLC) using [3H]-phosphatidylinositol-(4, 5)-bisphosphate ([3H]PIP2) as the ...

journal_title：Cancer research

authors： Powis G,Seewald MJ,Gratas C,Melder D,Riebow J,Modest EJ

更新日期：1992-05-15 00:00:00

abstract：:Cytochrome P4501B1 is highly active in the bioactivation of polycyclic aromatic hydrocarbons (PAHs) to mutagenic metabolites. The C3H mouse embryo fibroblast cell line, C3H10T1/2, and primary mouse embryo fibroblasts (MEFs) express CYP1B1 as the predominant cytochrome P-450 form. This is constitutively expressed and i...

journal_title：Cancer research

authors： Alexander DL,Eltom SE,Jefcoate CR

更新日期：1997-10-15 00:00:00

abstract：:p21(Cip1) is a cyclin-dependent kinase inhibitor whose abundance increases in cells exposed to radiation or other DNA-damaging agents. Such increases activate a G1 checkpoint, which allows time for DNA repair before S phase entry. By inhibiting cell cycle progression, p21(Cip1) potentially suppresses tumorigenesis, an...

journal_title：Cancer research

authors： Jackson RJ,Engelman RW,Coppola D,Cantor AB,Wharton W,Pledger WJ

更新日期：2003-06-15 00:00:00

abstract：:The single-dose toxicokinetics of N-nitrosomethyl(2-hydroxyethyl)amine (NMHA) has been characterized in 8-week-old Fischer 344 rats by analysis using high-performance liquid chromatography of serial blood samples. An i.v. bolus dose of 0.6 mumol/kg to male rats revealed biphasic first-order elimination with a terminal...

journal_title：Cancer research

authors： Streeter AJ,Nims RW,Hrabie JA,Heur YH,Keefer LK

更新日期：1989-04-01 00:00:00

abstract：:Neuroblastoma is the most common childhood solid tumor, yet the prognosis for high-risk disease remains poor. We demonstrate here that arginase 2 (ARG2) drives neuroblastoma cell proliferation via regulation of arginine metabolism. Targeting arginine metabolism, either by blocking cationic amino acid transporter 1 (CA...

journal_title：Cancer research

authors： Fultang L,Gamble LD,Gneo L,Berry AM,Egan SA,De Bie F,Yogev O,Eden GL,Booth S,Brownhill S,Vardon A,McConville CM,Cheng PN,Norris MD,Etchevers HC,Murray J,Ziegler DS,Chesler L,Schmidt R,Burchill SA,Haber M,De Sant

更新日期：2019-02-01 00:00:00

abstract：:N-2-(Diethylaminoethyl)-9-hydroxyellipticinium chloride (DHE) is a structural analogue of ellipticine that is currently a leading compound for clinical trials. We have investigated the mechanism of DNA damage by this compound in murine L1210 leukemia cells using the method of alkaline elution. Although DHE was about 1...

journal_title：Cancer research

authors： Djuric Z,Everett CK,Valeriote FA

更新日期：1992-03-15 00:00:00

abstract：:Natural killer (NK) cells are cytotoxic lymphocytes involved in innate immunity. NK-92, a human NK cell line, may be targeted to tumor-associated antigens in solid malignancies where it exhibits antitumor efficacy, but its clinical utility for treating brain tumors is limited by an inability to cross the blood-brain b...

journal_title：Cancer research

authors： Alkins R,Burgess A,Ganguly M,Francia G,Kerbel R,Wels WS,Hynynen K

更新日期：2013-03-15 00:00:00

abstract：:Translocation of the bcl-2 gene to the immunoglobulin heavy chain gene is the most common alteration in follicular lymphoma. The result is the deregulated expression of bcl-2 and increased resistance to cell death. Regulation of the immunoglobulin heavy chain gene is controlled in part by four DNase I-hypersensitive r...

journal_title：Cancer research

authors： Heckman CA,Cao T,Somsouk L,Duan H,Mehew JW,Zhang CY,Boxer LM

更新日期：2003-10-15 00:00:00

abstract：:Cisplatin (cis-diamminedichloroplatinum, CDDP) is one of the most used drugs for osteosarcoma chemotherapy. By using a series of CDDP-resistant variants, which were established from the U-2OS and Saos-2 human osteosarcoma cell lines, we found that CDDP resistance was mainly associated with the increase of both the int...

journal_title：Cancer research

authors： Pasello M,Michelacci F,Scionti I,Hattinger CM,Zuntini M,Caccuri AM,Scotlandi K,Picci P,Serra M

更新日期：2008-08-15 00:00:00

abstract：:The chemokine receptor CXCR4 plays a central role in organ-specific homing and tumor spreading and is induced by hypoxia. B lymphocytes are exposed to low oxygen tensions during their development, but the influence of hypoxia on their physiology is poorly understood. Here, we show that hypoxia is associated with up-re...

journal_title：Cancer research

authors： Piovan E,Tosello V,Indraccolo S,Masiero M,Persano L,Esposito G,Zamarchi R,Ponzoni M,Chieco-Bianchi L,Dalla-Favera R,Amadori A

更新日期：2007-09-15 00:00:00

abstract：:Aberrant crypt foci (ACF) are microscopic lesions which have been postulated to precede the development of adenomatous polyps, the precursors to colorectal cancer. APC and ras gene mutations have been shown to be important early molecular events in the development of colorectal neoplasms. The objective of this study w...

journal_title：Cancer research

authors： Smith AJ,Stern HS,Penner M,Hay K,Mitri A,Bapat BV,Gallinger S

更新日期：1994-11-01 00:00:00

abstract：:Discovery of somatically mutated cells in human tissues has been less frequent than would be predicted by in vitro mutational rates. We analyzed the PTEN tumor suppressor gene as an early marker for endometrial carcinogenesis, and we show that 43% of histologically normal premenopausal endometria contain rare glands t...

journal_title：Cancer research

authors： Mutter GL,Ince TA,Baak JP,Kust GA,Zhou XP,Eng C

更新日期：2001-06-01 00:00:00

abstract：:Sporadic prostate carcinoma is the most common male cancer in the Western world, yet many of the major genetic events involved in the progression of this often fatal cancer remain to be elucidated. Numerous cytogenetic and allelotype studies have reported frequent loss of heterozygosity on chromosomal arm 10q in spora...

journal_title：Cancer research

authors： Cairns P,Okami K,Halachmi S,Halachmi N,Esteller M,Herman JG,Jen J,Isaacs WB,Bova GS,Sidransky D

更新日期：1997-11-15 00:00:00

abstract：:Fibroblast growth factor (FGF) 8, also known as androgen-induced growth factor, was originally isolated from an androgen-dependent mouse mammary Shionogi carcinoma SC-3 cell line, in which it was shown to have androgen-regulated properties. We previously demonstrated that Fgf 8 transcripts were detected in several hum...

journal_title：Cancer research

authors： Tanaka A,Furuya A,Yamasaki M,Hanai N,Kuriki K,Kamiakito T,Kobayashi Y,Yoshida H,Koike M,Fukayama M

更新日期：1998-05-15 00:00:00

abstract：:The clinical effects and pharmacokinetics of high-dose uridine were determined in seven patients with advanced-stage cancer and in one healthy volunteer. Uridine was also examined for its effect on 5-fluorouracil toxicity in two patients. Uridine was administered as a 1-hr i.v. infusion at doses of 1 to 12 g/sq m. Pla...

journal_title：Cancer research

authors： Leyva A,van Groeningen CJ,Kraal I,Gall H,Peters GJ,Lankelma J,Pinedo HM

更新日期：1984-12-01 00:00:00

abstract：:Diethyldithiocarbamate (DDTC) has been shown to inhibit nephrotoxicity induced by cis-platinum (DDP) without inhibition of tumor response in the rat. We report here that DDTC at doses of 25-300 mg/kg inhibits DDP-induced nephrotoxicity and bone marrow toxicity in C57BL/6 X DBA/2F1 (hereafter called B6D2F1) mice, F344 ...

journal_title：Cancer research

authors： Bodenner DL,Dedon PC,Keng PC,Katz JC,Borch RF

更新日期：1986-06-01 00:00:00