Abstract:
:Frontline anticancer therapies such as chemotherapy and irradiation often slow tumor growth, but tumor regrowth and spread to distant sites usually occurs after the conclusion of treatment. We recently showed that macrophages could be used to deliver large quantities of a hypoxia-regulated, prostate-specific oncolytic virus (OV) to prostate tumors. In the current study, we show that administration of such OV-armed macrophages 48 hours after chemotherapy (docetaxel) or tumor irradiation abolished the posttreatment regrowth of primary prostate tumors in mice and their spread to the lungs for up to 27 or 40 days, respectively. It also significantly increased the lifespan of tumor-bearing mice compared with those given docetaxel or irradiation alone. These new findings suggest that such a novel, macrophage-based virotherapy could be used to markedly increase the efficacy of chemotherapy and irradiation in patients with prostate cancer.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Muthana M,Rodrigues S,Chen YY,Welford A,Hughes R,Tazzyman S,Essand M,Morrow F,Lewis CEdoi
10.1158/0008-5472.CAN-12-3056subject
Has Abstractpub_date
2013-01-15 00:00:00pages
490-5issue
2eissn
0008-5472issn
1538-7445pii
0008-5472.CAN-12-3056journal_volume
73pub_type
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