Nuclear factor-kappaB and manganese superoxide dismutase mediate adaptive radioresistance in low-dose irradiated mouse skin epithelial cells.

abstract：:The effects of an acidic condition (pH 6.5) on WAF1 gene expression and p53 accumulation was investigated in human glioblastoma cells with different p53 statuses. WAF1 and p53 accumulation after treatment in acidic conditions was observed in A-172 cells carrying the wild-type p53 gene but not in T98G cells carrying th...

journal_title：Cancer research

authors： Ohtsubo T,Wang X,Takahashi A,Ohnishi K,Saito H,Song CW,Ohnishi T

更新日期：1997-09-15 00:00:00

abstract：:In the diagnosis of non-Hodgkin's lymphomas, the ready characterization of the neoplastic cell lineage by analysis of cell surface markers is of great importance. We present evidence for the existence of a human B-leukemia-associated antigen recognized by a complement-fixing monoclonal antibody (anti-Y 29/55). A hybri...

journal_title：Cancer research

authors： Forster HK,Gudat FG,Girard MF,Albrecht R,Schmidt J,Ludwig C,Obrecht JP

更新日期：1982-05-01 00:00:00

abstract：:There is still insufficient knowledge of the distribution of drinking habits in human populations, and more descriptive surveys are needed. Both prospective and retrospective epidemiological studies indicate that alcohol consumption is a cancer hazard. Prospective studies on excessive drinkers have shown an increased ...

journal_title：Cancer research

authors： Tuyns AJ

更新日期：1979-07-01 00:00:00

abstract：:A patient with refractory acute myeloid leukemia was treated with tiazofurin, an agent that causes inhibition of tumor cell proliferation by depressing GTP concentrations in the malignant cells. The initial dose of 1100 mg/m2 was ineffective clinically and biochemically. Dose escalations to 1650, 2200, and finally 330...

journal_title：Cancer research

authors： Tricot GJ,Jayaram HN,Nichols CR,Pennington K,Lapis E,Weber G,Hoffman R

更新日期：1987-09-15 00:00:00

abstract：:Checkpoint inhibitors are relatively inefficacious in head and neck cancers, despite an abundance of genetic alterations and a T-cell-inflamed phenotype. One significant barrier to efficacy may be the recruitment of myeloid-derived suppressor cells (MDSC) into the tumor microenvironment. Here we demonstrate functional...

journal_title：Cancer research

authors： Davis RJ,Moore EC,Clavijo PE,Friedman J,Cash H,Chen Z,Silvin C,Van Waes C,Allen C

更新日期：2017-05-15 00:00:00

abstract：:Nonmyeloablative hematopoietic cell transplantation can cure patients with hematologic malignancies but has reported limited success against solid tumors. This is possibly because of profound peripheral tolerance mechanisms and/or suboptimal tumor recognition by effector T lymphocytes. We report that in mice developin...

journal_title：Cancer research

authors： Hess Michelini R,Freschi M,Manzo T,Jachetti E,Degl'Innocenti E,Grioni M,Basso V,Bonini C,Simpson E,Mondino A,Bellone M

更新日期：2010-05-01 00:00:00

abstract：:The cytotoxic, antimitotic, and growth inhibition properties of a photoactive analogue of vinblastine, N-(p-azidobenzoyl)-N'-beta-aminoethylvindesine (NABV), and vinblastine on P388 murine leukemia cells were compared. After 72-h exposure, the 50% drug-inhibitory concentrations for exponentially growing P388 leukemic ...

journal_title：Cancer research

authors： Safa AR,Glover CJ,Felsted RL

更新日期：1987-10-01 00:00:00

abstract：:Coded skin fibroblast cell strains from ataxia telangiectasia (AT) families and apparently normal individuals were obtained from two different sources. AT homozygous strains were clearly identified on the basis of marked hypersensitivity to cell killing by X-irradiation. AT heterozygotes were intermediate in their cyt...

journal_title：Cancer research

authors： Nagasawa H,Kraemer KH,Shiloh Y,Little JB

更新日期：1987-01-15 00:00:00

abstract：:Adult female rat urinary bladders were exposed to N-methyl-N-nitrosourea in vivo. After 12 weeks, urothelial hyperplasia was established. Ultrastructural changes of the luminal plasma membrane were studied with thin sectioning and freeze-fracturing techniques. The mosaic pattern which is a characteristic specializatio...

journal_title：Cancer research

authors： Hainau B

更新日期：1979-09-01 00:00:00

abstract：:This study investigated the ultrastructure and development of virus particles detected in a spontaneous mammary tumor of an 8 year old rhesus monkey. During a 3-month period of tumor growth, several biopsies were performed. Thin section electron microscopy of the tumor tissue revealed 2 types of particles: 1) an in...

journal_title：Cancer research

authors： Chopra HC,Mason MM

更新日期：1970-08-01 00:00:00

abstract：:Epidemiological and experimental carcinogenesis studies provide evidence that components of garlic (Allium sativum) have anticancer activity. We recently reported that the garlic derivative S-allylmercaptocysteine (SAMC) inhibits growth, arrests cells in G(2)-M, and induces apoptosis in human colon cancer cells (Shiri...

journal_title：Cancer research

authors： Xiao D,Pinto JT,Soh JW,Deguchi A,Gundersen GG,Palazzo AF,Yoon JT,Shirin H,Weinstein IB

更新日期：2003-10-15 00:00:00

abstract：:Of 20,000 plant extracts submitted to the National Cancer Institute antitumor screens from 1960 to 1980, over 95% exhibited inadequate tumor-inhibiting activity or promoted tumor growth. Of these, 50 extracts representing 42 species showed significant levels of tumor growth enhancement compared to controls on the basi...

journal_title：Cancer research

authors： Caldwell ME,Brewer WR

更新日期：1983-12-01 00:00:00

abstract：:Sulindac is the most extensively investigated clinically relevant chemopreventive nonsteroidal anti-inflammatory drug. Sulindac sulfide is one of the major metabolites of sulindac that is believed to mediate its antitumorigenic effects by inducing apoptosis. Recent evidence suggests that sulindac sulfide engages the m...

journal_title：Cancer research

authors： Huang Y,He Q,Hillman MJ,Rong R,Sheikh MS

更新日期：2001-09-15 00:00:00

abstract：:p51/p63 is a novel p53 homologue that has been shown to act as a transcriptional activator through the p53-binding sequence of the p21/WAF1 promoter and to induce apoptosis when it is expressed transiently in a human tumor cell line. We developed transcription assay systems for these two related genes in both Saccharo...

journal_title：Cancer research

authors： Shimada A,Kato S,Enjo K,Osada M,Ikawa Y,Kohno K,Obinata M,Kanamaru R,Ikawa S,Ishioka C

更新日期：1999-06-15 00:00:00

abstract：:Lung carcinoma cell lines were analyzed in culture and in nude mouse xenograft for both morphological appearance and expression of specific proteins that participate in cross-linked envelope formation during normal squamous cell terminal differentiation. Cross-linked envelope formation, induced by artificial influx of...

journal_title：Cancer research

authors： Levitt ML,Gazdar AF,Oie HK,Schuller H,Thacher SM

更新日期：1990-01-01 00:00:00

abstract：:Targeted therapies for cancer are inherently limited by the inevitable recurrence of resistant disease after initial responses. To define early molecular changes within residual tumor cells that persist after treatment, we analyzed drug-sensitive lung adenocarcinoma cell lines exposed to reversible or irreversible epi...

journal_title：Cancer research

authors： Fan W,Tang Z,Yin L,Morrison B,Hafez-Khayyata S,Fu P,Huang H,Bagai R,Jiang S,Kresak A,Howell S,Vasanji A,Flask CA,Halmos B,Koon H,Ma PC

更新日期：2011-07-01 00:00:00

abstract：:Telomerase is essential for immortalization of most human cancer cells. Expression of the core telomerase RNA (hTR) and reverse transcriptase (hTERT) subunits is mainly regulated by transcription. However, hTR transcriptional regulation remains poorly understood. We previously showed that the core hTR promoter is acti...

journal_title：Cancer research

authors： Bilsland AE,Stevenson K,Atkinson S,Kolch W,Keith WN

更新日期：2006-02-01 00:00:00

abstract：:Dissemination to draining lymph nodes is a frequent first step in prostate cancer metastasis. Although tumors metastasize to lymph nodes via the lymphatics, the importance of lymphangiogenesis in mediating the process remains controversial. Here, we inhibit intratumoral lymphangiogenesis in s.c. and surgical orthotopi...

journal_title：Cancer research

authors： Wong SY,Haack H,Crowley D,Barry M,Bronson RT,Hynes RO

更新日期：2005-11-01 00:00:00

abstract：:Three groups of 6 to 8-week-old male mice with transplanted C57BL/6 X DBA/2F1 tumor were irradiated by a single dose of 60Co localized on the tumor in association with i.p. injections of lyophilized Bacillus Calmette-Guérin. When the animals were sacrificed, tumor parameters (weight, surface area, and volume) were det...

journal_title：Cancer research

authors： Dubois JB,Serrou B

更新日期：1976-05-01 00:00:00

abstract：:Previous studies have shown dose-dependent growth inhibition of the human mammary carcinoma cell line MDA-MB-231 xenotransplanted in athymic mice using retinol. In this study, the growth inhibitory effect of retinoic acid (RA) and 13-cis-retinoic acid (13-cis-RA) was examined in vitro and in vivo. With both agents the...

journal_title：Cancer research

authors： Halter SA,Fraker LD,Adcock D,Vick S

更新日期：1988-07-01 00:00:00

abstract：:Similarly to p53, p73alpha and p73beta induce growth arrest and/or apoptosis in response to DNA damage or when exogenously expressed. However, how they trigger apoptosis remains unresolved. After stable transduction of either p73alpha or p73beta, a greater apoptotic response was observed for p73beta in both primary an...

journal_title：Cancer research

authors： Gonzalez S,Perez-Perez MM,Hernando E,Serrano M,Cordon-Cardo C

更新日期：2005-03-15 00:00:00

abstract：:Cell proliferation in 211 primary non-small cell lung carcinomas was assessed by using an immunostaining of proliferating cell nuclear antigen (PCNA) and a silver staining of argyrophilic nucleolar organizer region (Ag-NOR). More than 5% PCNA positive cells was designated PCNA(+), and less than 5% was PCNA(-). A mean ...

journal_title：Cancer research

authors： Ishida T,Kaneko S,Akazawa K,Tateishi M,Sugio K,Sugimachi K

更新日期：1993-10-15 00:00:00

abstract：:The capacity for tumor cells to metastasize efficiently is directly linked to their ability to colonize secondary sites. Here we identify Six2, a developmental transcription factor, as a critical regulator of a breast cancer stem cell program that enables metastatic colonization. In several triple-negative breast canc...

journal_title：Cancer research

authors： Oliphant MUJ,Vincent MY,Galbraith MD,Pandey A,Zaberezhnyy V,Rudra P,Johnson KR,Costello JC,Ghosh D,DeGregori J,Espinosa JM,Ford HL

更新日期：2019-02-15 00:00:00

abstract：:Angiogenesis is characteristic of solid tumor growth and a surrogate marker for metastasis in many human cancers. Inhibition of tumor angiogenesis using antiangiogenic drugs and gene transfer approaches has suggested the potential of this form of therapy in controlling tumor growth. However, for long-term tumor-free s...

journal_title：Cancer research

authors： Ponnazhagan S,Mahendra G,Kumar S,Shaw DR,Stockard CR,Grizzle WE,Meleth S

更新日期：2004-03-01 00:00:00

abstract：:Neuroblastomas often undergo spontaneous differentiation and/or regression in vivo, which is at least partly regulated by the signals through neurotrophins and their receptors. Recently, glial cell line-derived neurotrophic factor (GDNF) and a second family member, neurturin (NTN), have been found to mediate their sig...

journal_title：Cancer research

authors： Hishiki T,Nimura Y,Isogai E,Kondo K,Ichimiya S,Nakamura Y,Ozaki T,Sakiyama S,Hirose M,Seki N,Takahashi H,Ohnuma N,Tanabe M,Nakagawara A

更新日期：1998-05-15 00:00:00

abstract：:Upon MYC inactivation, tumors variously undergo proliferative arrest, cellular differentiation, and apoptosis and in some cases, apparently permanently revoking tumorigenesis. In liver tumor cells, we recently showed that MYC inactivation uncovers stem cell properties and triggers differentiation, but in this case, th...

journal_title：Cancer research

authors： Shachaf CM,Felsher DW

更新日期：2005-06-01 00:00:00

abstract：:Calf thymus DNA was modified in vitro by cis-diamminedichloroplatinum(II) (cisDDP), complexed with methylated bovine serum albumin and used to immunize rabbits. The anti-cisDDP-DNA antiserum obtained was applied in a double peroxidase-antiperoxidase staining procedure to localize cisDDP-DNA and cis-diammine(1,1-cyclob...

journal_title：Cancer research

authors： Terheggen PM,Floot BG,Scherer E,Begg AC,Fichtinger-Schepman AM,den Engelse L

更新日期：1987-12-15 00:00:00

abstract：:Estrogen independence and progression to a metastatic phenotype are hallmarks of therapeutic resistance and mortality in breast cancer patients. Metastasis has been associated with chemokine signaling through the SDF-1-CXCR4 axis. Thus, the development of estrogen independence and endocrine therapy resistance in breas...

journal_title：Cancer research

authors： Rhodes LV,Short SP,Neel NF,Salvo VA,Zhu Y,Elliott S,Wei Y,Yu D,Sun M,Muir SE,Fonseca JP,Bratton MR,Segar C,Tilghman SL,Sobolik-Delmaire T,Horton LW,Zaja-Milatovic S,Collins-Burow BM,Wadsworth S,Beckman BS,Wood CE

更新日期：2011-01-15 00:00:00

abstract：:BD-40, a pyridopyrroloisoquinoline analogue of ellipticines, has dose-dependent cytostatic and cytotoxic effects on cultures of Saccharomyces cerevisiae. These inhibitory effects take place only in growing cells and are enhanced in the presence of oxygen. Among the different repair-deficient mutants examined, a mutant...

journal_title：Cancer research

authors： Moustacchi E,Favaudon V,Bisagni E

更新日期：1983-08-01 00:00:00

abstract：:Monocytes and dendritic cells are key players in the immune response. Because dendritic cells drive the tumor host defense, it is important that monocytes and dendritic cells survive cytotoxic tumor therapy. Although most of the anticancer drugs target DNA, the DNA repair capacity of monocytes and dendritic cells has ...

journal_title：Cancer research

authors： Briegert M,Kaina B

更新日期：2007-01-01 00:00:00