Abstract：
:We report here the use of viral fusogenic membrane glycoproteins (FMGs) as a new class of therapeutic genes for the control of tumor growth. FMGs kill cells by fusing them into large multinucleated syncytia, which die by sequestration of cell nuclei and subsequent nuclear fusion by a mechanism that is nonapoptotic, as assessed by multiple criteria. Direct and bystander killing of three different FMGs were at least one log more potent than that of herpes simplex virus thymidine kinase or cytosine deaminase suicide genes. Transduction of human tumor xenografts with plasmid DNA prevented tumor outgrowth in vivo, and cytotoxicity could be regulated through transcriptional targeting. Syncytial formation is accompanied by the induction of immunostimulatory heat shock proteins, and tumor-associated FMG expression in immunocompetent animals generated specific antitumor immunity.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Bateman A,Bullough F,Murphy S,Emiliusen L,Lavillette D,Cosset FL,Cattaneo R,Russell SJ,Vile RGsubject
Has Abstractpub_date
2000-03-15 00:00:00pages
1492-7issue
6eissn
0008-5472issn
1538-7445journal_volume
60pub_type
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