Analysis of lipophilic carcinogen-membrane interactions using a model human erythrocyte membrane system.

abstract：:These studies explore the effects of an epipodophyllotoxin on the membrane transport and metabolism of thymidine in Ehrlich ascites tumor cells. Uptake of 3H after exposure of cells to [3H]-thymidine is characterized by a rapid initial velocity that approximates membrane transport followed by a slower rate of uptake t...

journal_title：Cancer research

authors： Yalowich JC,Goldman ID

更新日期：1984-03-01 00:00:00

abstract：:Primary central nervous system lymphoma (PCNSL) that arises in immune-deficient patients is an aggressive B-cell neoplasm that is universally associated with the EBV. Patients with EBV(+) PCNSL face a particularly poor prognosis with median survival times of 2-12 months despite aggressive management with radiation the...

journal_title：Cancer research

authors： Roychowdhury S,Peng R,Baiocchi RA,Bhatt D,Vourganti S,Grecula J,Gupta N,Eisenbeis CF,Nuovo GJ,Yang W,Schmalbrock P,Ferketich A,Moeschberger M,Porcu P,Barth RF,Caligiuri MA

更新日期：2003-03-01 00:00:00

abstract：:A new human myeloma cell line, OPM-6, was established from the peripheral blood of a patient with advanced IgG-kappa plasma cell leukemia. Cytogenetic and phenotypic analysis confirmed that the cells were derived from the patient's leukemic cells. Insulin-like growth factor-1 (IGF-1) acts as an autocrine growth factor...

journal_title：Cancer research

authors： Ogawa M,Nishiura T,Oritani K,Yoshida H,Yoshimura M,Okajima Y,Ishikawa J,Hashimoto K,Matsumura I,Tomiyama Y,Matsuzawa Y

更新日期：2000-08-01 00:00:00

abstract：:The majority of patients with colon cancer will develop advanced disease, with the liver being the most common site of metastatic disease. Patients with increased numbers of tumor-infiltrating lymphocytes in primary colon tumors and liver metastases have improved outcomes. However, the molecular factors that could emp...

journal_title：Cancer research

authors： Qiao G,Qin J,Kunda N,Calata JF,Mahmud DL,Gann P,Fu YX,Rosenberg SA,Prabhakar BS,Maker AV

更新日期：2017-04-15 00:00:00

abstract：:Overexpression of PRL-3, an oncogenic phosphatase, was identified as a novel cluster in patients with newly diagnosed multiple myeloma. However, the regulation and oncogenic activities of PRL-3 in multiple myeloma warrant further investigation. Here, we report that IL6 activates STAT3, which acts as a direct transcrip...

journal_title：Cancer research

authors： Chong PSY,Zhou J,Lim JSL,Hee YT,Chooi JY,Chung TH,Tan ZT,Zeng Q,Waller DD,Sebag M,Chng WJ

更新日期：2019-09-15 00:00:00

abstract：:When newly hatched chicks are given injections of Rous sarcoma virus, a tumor develops at the site of injection. In spite of the presence of the virus in the blood, no other tumors are found distant from the site of inoculation during the life span of the animal (4-6 weeks). However, if a wound is made away from the p...

journal_title：Cancer research

authors： Martins-Green M,Boudreau N,Bissell MJ

更新日期：1994-08-15 00:00:00

abstract：:The inhibitor of apoptosis proteins (IAPs) are a family of antiapoptotic proteins that bind and inhibit caspases 3, 7, and/or 9, but not caspase 8. Growing evidence also indicates that IAPs also modulate cell division, cell cycle progression, and signal transduction pathways. As our basic understanding of IAPs has inc...

journal_title：Cancer research

authors： Schimmer AD

更新日期：2004-10-15 00:00:00

abstract：:Non-P-glycoprotein multidrug resistance of HL60/ADR cells appears to be related to overexpression of the MRP gene. Recent studies suggest that this gene may play an important role in a new form of cell resistance to certain chemotherapeutic agents. To examine mechanisms regulating transcriptional activity of this gene...

journal_title：Cancer research

authors： Zhu Q,Center MS

更新日期：1994-08-15 00:00:00

abstract：:Overexpression of the adverse prognostic marker ERBB2 occurs in 30% of breast cancers; however, therapies targeting this gene have not proved to be as effective as was initially hoped. Transcriptional profiling meta-analyses have shown that there are approximately 150 genes co-overexpressed with ERBB2, suggesting that...

journal_title：Cancer research

authors： Kourtidis A,Jain R,Carkner RD,Eifert C,Brosnan MJ,Conklin DS

更新日期：2010-03-01 00:00:00

abstract：:We demonstrate that a mouse-human chimeric anti-ganglioside GD2-interleukin (IL)-2 fusion protein (ch14.18-IL2) substantially amplifies tumor-protective immunity against murine melanoma induced by an autologous oral DNA vaccine containing the murine ubiquitin gene fused to murine melanoma peptide epitopes gp100(25-35)...

journal_title：Cancer research

authors： Niethammer AG,Xiang R,Ruehlmann JM,Lode HN,Dolman CS,Gillies SD,Reisfeld RA

更新日期：2001-08-15 00:00:00

abstract：:Fps/Fes proteins were among the first members of the protein tyrosine kinase family to be characterized as dominant-acting oncoproteins. Addition of retroviral GAG sequences or other experimentally induced mutations activated the latent transforming potential of Fps/Fes. However, activating mutations in fps/fes had no...

journal_title：Cancer research

authors： Sangrar W,Zirgnibl RA,Gao Y,Muller WJ,Jia Z,Greer PA

更新日期：2005-05-01 00:00:00

abstract：:O6-Benzylguanine is an inactivator of O6-alkylguanine-DNA alkyltransferases (AGT) which is currently entering clinical trials as an agent improving the cancer chemotherapeutic activity of chloroethylnitrosoureas and other alkylating agents. O6-Benzylguanine acts by virtue of its ability to serve as a substrate for the...

journal_title：Cancer research

authors： Crone TM,Goodtzova K,Edara S,Pegg AE

更新日期：1994-12-01 00:00:00

abstract：:Cancer cells with germline deleterious mutations of BRCA1 or BRCA2 are deficient in homologous recombination repair and therefore sensitive to PARP inhibitor treatment. However, wild-type BRCA1/2-expressing cells with defects in other DNA damage repair pathway components may also exhibit "BRCAness," which in combinati...

journal_title：Cancer research

authors： Cai C

更新日期：2020-07-15 00:00:00

abstract：:Phospholipase D (PLD) has emerged as a critical regulator of cell proliferation and survival signaling. We show for the first time that elevated expression of PLD isozymes attenuates expression of the tumor suppressors early growth response-1 (Egr-1) and the phosphatase and tensin homologue deleted on chromosome 10 (P...

journal_title：Cancer research

authors： Kim J,Lee YH,Kwon TK,Chang JS,Chung KC,Min DS

更新日期：2006-01-15 00:00:00

abstract：:The genetic and epigenetic effects of nutritional folate deficiency were studied in two Chinese hamster ovary (CHO) cell lines. The CHO-AA8 cell line (hemizygous at the aprt locus) and CHO-UV5 (DNA repair-deficient mutant of AA8) were cultured in Ham's F-12 medium or in custom-prepared Ham's F-12 medium lacking folic ...

journal_title：Cancer research

authors： James SJ,Basnakian AG,Miller BJ

更新日期：1994-10-01 00:00:00

abstract：:Glutamine supplementation has been advocated for patients requiring parenteral nutritional support. However, the direct effect of glutamine on neoplastic cells is poorly understood. We therefore investigated the effects of glutamine on the proliferation, differentiation, and cell-matrix interactions of two human colon...

journal_title：Cancer research

authors： Turowski GA,Rashid Z,Hong F,Madri JA,Basson MD

更新日期：1994-11-15 00:00:00

abstract：:The role of endogenous NO on cell survival was investigated in human melanoma cells and melanocytes. Inducible NO synthase (iNOS) was always expressed in a panel of melanoma cell lines from metastatic lesions and in normal adult melanocytes. iNOS was also detected by immunohistochemistry in melanoma cells from metasta...

journal_title：Cancer research

authors： Salvucci O,Carsana M,Bersani I,Tragni G,Anichini A

更新日期：2001-01-01 00:00:00

abstract：:NADPH-fortified human liver microsomes were examined with regard to ability to detoxicate several chemicals that do not require enzymatic oxidation to elicit a genotoxic response in a Salmonella typhimurium TA1535/pSK1002 system where umu response is used as an indicator of DNA damage. Microsomes did not affect the re...

journal_title：Cancer research

authors： Shimada T,Guengerich FP

更新日期：1990-04-01 00:00:00

abstract：:Insulin-like growth factor I action has been implicated in the pathogenesis of many different malignancies, including breast cancer. Insulin-like growth factor I receptors (IGF-IRs) are overexpressed in virtually all breast cancer cell lines, in which they are believed to enhance growth and inhibit apoptosis. In this ...

journal_title：Cancer research

authors： Resnik JL,Reichart DB,Huey K,Webster NJ,Seely BL

更新日期：1998-03-15 00:00:00

abstract：:The effects of vascular endothelial growth factor-A (VEGF-A/VEGF) and its receptors on endothelial cells function have been studied extensively, but their effects on tumor cells are less well defined. Studies of human colorectal cancer cells where the VEGF gene has been deleted suggest an intracellular role of VEGF as...

journal_title：Cancer research

authors： Bhattacharya R,Ye XC,Wang R,Ling X,McManus M,Fan F,Boulbes D,Ellis LM

更新日期：2016-05-15 00:00:00

abstract：:Active-specific immunotherapy with dendritic cells loaded with peptide derived from the melanoma antigen, gp100, failed to mediate regression of established B16F10 melanoma in normal mice. Dendritic cell vaccination induced activation and subsequent deletion of adoptively transferred naive CD8+ T-cell receptor transge...

journal_title：Cancer research

authors： Wang LX,Li R,Yang G,Lim M,O'Hara A,Chu Y,Fox BA,Restifo NP,Urba WJ,Hu HM

更新日期：2005-11-15 00:00:00

abstract：:Ligand-induced activation of peroxisome proliferator-activated receptor gamma (PPARgamma) inhibits proliferation in cancer cells in vitro and in vivo; however, the downstream targets remain undefined. We report the identification of a peroxisome proliferator response element in the promoter region of the Na(+)/H(+) tr...

journal_title：Cancer research

authors： Kumar AP,Quake AL,Chang MK,Zhou T,Lim KS,Singh R,Hewitt RE,Salto-Tellez M,Pervaiz S,Clément MV

更新日期：2009-11-15 00:00:00

abstract：:The use of rat testicular seminiferous tubular basement membrane (STBM) segments as a model substratum for the in vitro maintenance of tumor cells dissociated from a transplantable pancreatic acinar rat carcinoma (J. K. Reddy and M. S. Rao, Science (Wash. DC), 198: 78-80, 1977) is described. Ultrastructurally pure, ho...

journal_title：Cancer research

authors： Watanabe TK,Hansen LJ,Reddy NK,Kanwar YS,Reddy JK

更新日期：1984-11-01 00:00:00

abstract：:Immunotherapy based on adoptive transfer of tumor antigen-specific CD8(+) T cell (TC) is generally limited by poor in vivo expansion and tumor infiltration. In this study, we report that activated STAT5 transcription factors (STAT5CA) confer high efficiency on CD8(+) effector T cells (eTC) for host colonization after ...

journal_title：Cancer research

authors： Grange M,Buferne M,Verdeil G,Leserman L,Schmitt-Verhulst AM,Auphan-Anezin N

更新日期：2012-01-01 00:00:00

abstract：:A method for the preparation of biologically active [3H]- and [13C]bleomycin A2 is described. Demethyl Cu(II):bleomycin A2, isolated after pyrolysis of Cu(II):bleomycin A2, was methylated with either [3H]-or [13C]methyl iodide, which resulted in Cu(II):bleomycin A2 labeled in the dimethylsulfonium moiety. Copper was r...

journal_title：Cancer research

authors： Roy SN,Orr GA,Brewer CF,Horwitz SB

更新日期：1981-11-01 00:00:00

abstract：:cis-Diammine(1,1-cyclobutanedicarboxylato)platinum (CBDCA) is a nonnephrotoxic but myelosuppressive analogue of cisplatin (DDP) with greatly reduced protein binding and greatly increased renal excretion. Thus, CBDCA might produce undue toxicity in patients with decreased renal function. Twenty-two patients [14 females...

journal_title：Cancer research

authors： Egorin MJ,Van Echo DA,Tipping SJ,Olman EA,Whitacre MY,Thompson BW,Aisner J

更新日期：1984-11-01 00:00:00

abstract：:We previously reported (J. Galivan et al., Proc. Natl. Acad. Sci. USA, 82: 2598-2602, 1985) the synthesis and characterization of DL-erythro,threo-gamma-fluoromethotrexate (FMTX). The individual diastereomers, DL-erythro-FMTX (eFMTX) and DL-threo-FMTX (tFMTX), and their radiolabeled counterparts have now been prepared...

journal_title：Cancer research

authors： McGuire JJ,Graber M,Licato N,Vincenz C,Coward JK,Nimec Z,Galivan J

更新日期：1989-08-15 00:00:00

abstract：:The pathogenesis of choroid plexus papillomas, intraventricular papillary neoplasms most often occurring sporadically in children and young adults, remains poorly understood. To identify pathways operative in the development of choroid plexus papillomas, gene expression profiles obtained from laser-microdissected huma...

journal_title：Cancer research

authors： Hasselblatt M,Mertsch S,Koos B,Riesmeier B,Stegemann H,Jeibmann A,Tomm M,Schmitz N,Wrede B,Wolff JE,Zheng W,Paulus W

更新日期：2009-03-15 00:00:00

abstract：:Autologous hematopoietic stem cell transplantation after myelosuppressive chemotherapy is used for the treatment of high-risk breast cancer and other solid tumors. However, contamination of the autologous graft with tumor cells may adversely affect outcomes. Human hematopoietic bone marrow cells are resistant to herpe...

journal_title：Cancer research

authors： Wu A,Mazumder A,Martuza RL,Liu X,Thein M,Meehan KR,Rabkin SD

更新日期：2001-04-01 00:00:00

abstract：:The apolipoprotein B mRNA editing enzyme catalytic polypeptide-like APOBEC3A and APOBEC3B have emerged as key mutation drivers in cancer. Here, we show that APOBEC3A and APOBEC3B activities impose a unique type of replication stress by inducing abasic sites at replication forks. In contrast to cells under other types ...

journal_title：Cancer research

authors： Buisson R,Lawrence MS,Benes CH,Zou L

更新日期：2017-09-01 00:00:00