Roles of urinary sodium ion concentration and pH in promotion by ascorbic acid of urinary bladder carcinogenesis in rats.

abstract：:The distribution in human tissues has been determined of the new DNA polymerase activity designated DNA polymerase Cm, first isolated from the human melanoma cell line A-375. Tissue samples were fractionated by ion exchange chromatography on diethylaminoethyl cellulose and phosphocellulose and by affinity chromatograp...

journal_title：Cancer research

authors： Loewenstein PM,Lange GW,Gerard GF

更新日期：1980-12-01 00:00:00

abstract：:The proto-oncogene MET is aberrantly activated via overexpression or mutation in numerous cancers, making it a prime anticancer molecular target. However, the clinical success of MET-directed tyrosine kinase inhibitors (TKI) has been limited due, in part, to mutations in the MET kinase domain that confer therapeutic r...

journal_title：Cancer research

authors： Miyajima N,Tsutsumi S,Sourbier C,Beebe K,Mollapour M,Rivas C,Yoshida S,Trepel JB,Huang Y,Tatokoro M,Shinohara N,Nonomura K,Neckers L

更新日期：2013-12-01 00:00:00

abstract：:Data are presented indicating marked antineoplastic activity for cis-dichlorodiammineplatinum(II) in MOPC 104E myeloma. One-eighteenth of the dose that produced 100% cures can be combined with noncurative, low doses of cyclophosphamide and 1,3-bis(2-chloroethyl)-1-nitrosourea to produce antineoplastic activity of the ...

journal_title：Cancer research

authors： Ghanta VK,Jones MT,Woodard DA,Durant JR,Hiramoto RN

更新日期：1977-03-01 00:00:00

abstract：:A large number of studies have been carried out to identify the Friend leukemia virus (FV) target cell(s). In FV-infected mice, the kinetics of "primitive" erythroid burst-forming units (P-BFU-E) is perturbed, and their proliferative rate is enhanced. These results indirectly suggest, but do not prove, that cycling P-...

journal_title：Cancer research

authors： Colletta G,Di Fiore PP,Fusco A,Lettieri F,Covelli A,Peschle C

更新日期：1983-02-01 00:00:00

abstract：:General anesthesia was used to facilitate 259 whole-body hyperthermia treatments in 90 patients. These patients fell into American Society of Anesthesiologists Classifications 3 (moderate to severe systemic disease) and 4 (severe systemic disease with life-threatening potential). Whole-body hyperthermia imposes severe...

journal_title：Cancer research

authors： Cronau LH Jr,Bourke DL,Bull JM

更新日期：1984-10-01 00:00:00

abstract：:Creation of a nuclear export signal (NES) motif and loss of tryptophans (W) 288 and 290 (or 290 only) at the COOH terminus of nucleophosmin (NPM) are both crucial for NPM aberrant cytoplasmic accumulation in acute myelogenous leukemia (AML) carrying NPM1 mutations. Hereby, we clarify how these COOH-terminal alteration...

journal_title：Cancer research

authors： Bolli N,Nicoletti I,De Marco MF,Bigerna B,Pucciarini A,Mannucci R,Martelli MP,Liso A,Mecucci C,Fabbiano F,Martelli MF,Henderson BR,Falini B

更新日期：2007-07-01 00:00:00

abstract：:N4G3, a cell line that overexpresses translation initiation factor eIF4G, one of the components of eIF4F, was made by stable transfection of the human eIF4G cDNA into NIH3T3 cells. The cells expressed 80-100 times greater levels of eIF4G mRNA than did NIH3T3 cells. N4G3 cells formed transformed foci on a monolayer of ...

journal_title：Cancer research

authors： Fukuchi-Shimogori T,Ishii I,Kashiwagi K,Mashiba H,Ekimoto H,Igarashi K

更新日期：1997-11-15 00:00:00

abstract：:Groups of 6-wk-old male F344/NCr rats received a single i.v. injection of either vehicle or N-nitrosomethylurea (Cas: 684-93-5) (MNU) at a dose of 41.2 mg/kg body weight. Two wk later, groups of rats were placed on iodine-deficient, iodine-adequate, or commercial (Wayne Lab Blox) diets, or one of these diets and witho...

journal_title：Cancer research

authors： Ohshima M,Ward JM

更新日期：1986-02-01 00:00:00

abstract：:Electron spin resonance (ESR) studies at -130 degrees have been made on frozen samples of normal human cervix and uterus and on frozen samples of various pathological conditions of the cervix and uterus including fibroleiomyoma and carcinoma. Fifty-five samples of normal cervix and endometrium, 40 samples of nonmalign...

journal_title：Cancer research

authors： Benedetto C,Bocci A,Dianzani MU,Ghiringhello B,Slater TF,Tomasi A,Vannini V

更新日期：1981-07-01 00:00:00

abstract：:Human osteosarcomas frequently show loss of alleles on chromosome 17 as well as those on chromosome 13 that harbors the retinoblastoma gene, indicating concerted operation of another tumor-suppressing gene on chromosome 17. To assign the affected gene to a defined region of chromosome 17, we performed mitotic recombin...

journal_title：Cancer research

authors： Toguchida J,Ishizaki K,Nakamura Y,Sasaki MS,Ikenaga M,Kato M,Sugimoto M,Kotoura Y,Yamamuro T

更新日期：1989-11-15 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSC) represent a primary mechanism of immune evasion in tumors and have emerged as a major obstacle for cancer immunotherapy. The immunoinhibitory activity of MDSC is tightly regulated by the tumor microenvironment and occurs through mechanistic mediators that remain unclear. Here, w...

journal_title：Cancer research

authors： Trillo-Tinoco J,Sierra RA,Mohamed E,Cao Y,de Mingo-Pulido Á,Gilvary DL,Anadon CM,Costich TL,Wei S,Flores ER,Ruffell B,Conejo-Garcia JR,Rodriguez PC

更新日期：2019-10-01 00:00:00

abstract：:DR-nm23 cDNA was cloned recently by differential screening of a cDNA library derived from chronic myelogenous leukemia-blast crisis primary cells. It is highly homologous to the putative metastasis suppressor nm23-H1 gene and the closely related nm23-H2 gene. When overexpressed in the myeloid precursor 32Dcl3 cell lin...

journal_title：Cancer research

authors： Martinez R,Venturelli D,Perrotti D,Veronese ML,Kastury K,Druck T,Huebner K,Calabretta B

更新日期：1997-03-15 00:00:00

abstract：:Animal models of human prostate cancer are very limited in number but are of obvious importance to develop. Dr. Morris Pollard (M. Pollard, J. Natl. Cancer Inst., 51: 1235-1241, 1973) has reported that Lobund-Wistar rats develop spontaneous metastatic prostatic cancer when they become old (approximately 25% incidence ...

journal_title：Cancer research

authors： Pugh TD,Chang C,Uemura H,Weindruch R

更新日期：1994-11-15 00:00:00

abstract：:We previously reported that intetumumab (CNTO 95), a fully human anti-αv integrin monoclonal antibody, is a radiosensitizer in mice with xenograft tumors. Because intetumumab does not cross-react with mouse integrins, but has cross-reactivity with rat integrins, we next studied the potential combined use of radiation ...

journal_title：Cancer research

authors： Ning S,Tian J,Marshall DJ,Knox SJ

更新日期：2010-10-01 00:00:00

abstract：:Herpesvirus saimiri (HVS) was propagated in vero cells for 3 passages at 39 degrees and cloned 3 times at 34 degrees. This virus was inoculated into cotton-topped marmoset and squirrel monkeys; all inoculated monkeys became infected as HVS was reisolated after their circulating lymphocytes were cultured with vero cell...

journal_title：Cancer research

authors： Falk L,Wright J,Deinhardt F,Wolfe L,Schaffer P,Benyesh-Melnick M

更新日期：1976-02-01 00:00:00

abstract：:S-2-(3-Aminopropylamino)ethylphosphorothioic acid (WR-2721) was shown to provide marked protection against development of radiation-induced leg contractures in C3Hf/Kam mice whose legs were exposed to single doses of gamma-radiation. The radiation doses ranged from 3300 to 6200 rads delivered to the right hind thighs ...

journal_title：Cancer research

authors： Hunter N,Milas L

更新日期：1983-04-01 00:00:00

abstract：:The term "Turcot's syndrome" has been used to describe approximatively 55 patients with an association of colonic polyposis and primary neuroepithelial tumors of the central nervous system. The p53 tumor suppressor gene is a possible candidate underlying the syndrome because (a) mutations in the p53 gene are ubiquitou...

journal_title：Cancer research

authors： Kikuchi T,Rempel SA,Rutz HP,de Tribolet N,Mulligan L,Cavenee WK,Jothy S,Leduy L,Van Meir EG

更新日期：1993-03-01 00:00:00

abstract：:That ferritin, an iron storage protein, can be produced by neuroblastoma cells raises the possibility that iron may have some role in promoting tumor cell growth. To explore this possibility, we studied the effects of desferoxamine, a compound which chelates iron, on viability of CHP 126 and CHP 100, two human neurobl...

journal_title：Cancer research

authors： Blatt J,Stitely S

更新日期：1987-04-01 00:00:00

abstract：:One limitation of autologous bone marrow transplantation for patients with cancer has been the presence of tumor cells in the bone marrow. Methods to eliminate tumor cells while preserving hematopoietic stem cells have been sought. The present study was performed to analyze the in vitro effectiveness of light-activate...

journal_title：Cancer research

authors： Meagher RC,Rothman SA,Paul P,Koberna P,Willmer C,Baucco PA

更新日期：1989-07-01 00:00:00

abstract：:A megakaryoblastic cell line, termed T-33, was established from the peripheral blood of a patient with Philadelphia chromosome-positive chronic myelogenous leukemia in megakaryoblastic crisis. T-33 cells have been maintained in RPMI 1640 medium containing 10% fetal calf serum in a single cell suspension with a doublin...

journal_title：Cancer research

authors： Tange T,Nakahara K,Mitani K,Yamasaki I,Yasuda H,Tanaka F,Mizuguchi M,Oda H,Yatomi Y,Takanashi R

更新日期：1988-11-01 00:00:00

abstract：:An approach to stimulating an immune response against tumors is to transduce tumor cells with bacterial genes, which represent a "danger signal" and can induce a wide immune response. Mycobacterium tuberculosis genes and their encoded proteins play a pivotal role in linking innate and cell-mediated adaptive immunity a...

journal_title：Cancer research

authors： Sfondrini L,Rodolfo M,Singh M,Colombo MP,Colnaghi MI,Ménard S,Balsari A

更新日期：2000-07-15 00:00:00

abstract：:Alkaline phosphatase activity in human endometrial cancer cells of the estrogen-responsive Ishikawa line was markedly stimulated (3-20-fold in 4 days) by estrogens, 5 alpha-dihydrotestosterone, and dehydroepiandrosterone but not by testosterone, medroxyprogesterone acetate, glucocorticoids, several peptide hormones, p...

journal_title：Cancer research

authors： Holinka CF,Hata H,Kuramoto H,Gurpide E

更新日期：1986-06-01 00:00:00

abstract：:Noninvasive, nonmetastatic BW5147 T-lymphoma cells were transfected with the activated human c-Ha-ras oncogene and were examined subsequently for the acquisition of invasive properties in vitro and of metastatic potential in vivo. It was found that several transfectants harboring the ras gene had become invasive in vi...

journal_title：Cancer research

authors： Collard JG,Schijven JF,Roos E

更新日期：1987-02-01 00:00:00

abstract：:Daunomycin was covalently bound to immunoglobulins by periodate oxidation as described in the preceding paper. Conjugates were prepared with immunoglobulins directed against either of two mouse lymphoid tumors or with nonspecific immunoglobulins. These conjugates were tested for their toxic effects on various tumor ta...

journal_title：Cancer research

authors： Levy R,Hurwitz E,Maron R,Arnon R,Sela M

更新日期：1975-05-01 00:00:00

abstract：:Fifty-nine colonic adenomas and 6 hyperplastic colonic polyps were analyzed by single-strand conformation polymorphism analysis for mutations in the adenomatous polyposis coli gene (APC). Frameshifts and premature stop codons in at least one copy of APC were detected in 25 of these adenomas. Five adenomas carried 2 AP...

journal_title：Cancer research

authors： De Benedetti L,Sciallero S,Gismondi V,James R,Bafico A,Biticchi R,Masetti E,Bonelli L,Heouaine A,Picasso M

更新日期：1994-07-01 00:00:00

abstract：:Snail is a key regulator of epithelial-mesenchymal transition (EMT), which is a major step in tumor metastasis. Although the induction of Snail transcription precedes EMT, posttranslational regulation, especially phosphorylation of Snail, is critical for determining Snail protein levels or stability, subcellular local...

journal_title：Cancer research

authors： Ryu KJ,Park SM,Park SH,Kim IK,Han H,Kim HJ,Kim SH,Hong KS,Kim H,Kim M,Yoon SJ,Asaithambi K,Lee KH,Park JY,Hah YS,Cho HJ,Yook JI,Yang JW,Ko GH,Lee G,Kang YJ,Hwangbo C,Kim KD,Park YJ,Yoo J

更新日期：2019-08-15 00:00:00

abstract：:Aberrant cholesterol metabolism is increasingly appreciated to be essential for prostate cancer initiation and progression. Transcript expression of the high-density lipoprotein-cholesterol receptor scavenger receptor B1 (SR-B1) is elevated in primary prostate cancer. Hypothesizing that SR-B1 expression may help facil...

journal_title：Cancer research

authors： Gordon JA,Noble JW,Midha A,Derakhshan F,Wang G,Adomat HH,Tomlinson Guns ES,Lin YY,Ren S,Collins CC,Nelson PS,Morrissey C,Wasan KM,Cox ME

更新日期：2019-07-01 00:00:00

abstract：:Gene targeting studies in mice have shown that the transcription factor Ikaros plays an essential role in lymphoid development and as a tumor suppressor in T cells, whereas the related gene Aiolos functions as a tumor suppressor in B cells. We analyzed the expression levels of the Ikaros gene family, Ikaros and Aiolos...

journal_title：Cancer research

authors： Nakase K,Ishimaru F,Avitahl N,Dansako H,Matsuo K,Fujii K,Sezaki N,Nakayama H,Yano T,Fukuda S,Imajoh K,Takeuchi M,Miyata A,Hara M,Yasukawa M,Takahashi I,Taguchi H,Matsue K,Nakao S,Niho Y,Takenaka K,Shinagawa K,

更新日期：2000-08-01 00:00:00

abstract：:The liver represents a major and frequently sole site of metastases for many types of cancer, particularly gastrointestinal cancers. We showed previously that coadministration of an engineered hepatic-targeting Listeria monocytogenes (LM) with a cancer vaccine enhanced the antitumor effect of vaccine-induced T cells s...

journal_title：Cancer research

authors： Yoshimura K,Laird LS,Chia CY,Meckel KF,Slansky JE,Thompson JM,Jain A,Pardoll DM,Schulick RD

更新日期：2007-10-15 00:00:00

abstract：:Activation of the matrix metalloproteinase 2 (MMP-2) has been shown to play a major role in the proteolysis of extracellular matrix (ECM) associated with tumor invasion. Although the precise mechanism of this activation remains elusive, levels of the membrane type 1-MMP (MT1-MMP) at the cell surface and of the tissue ...

journal_title：Cancer research

authors： Gilles C,Bassuk JA,Pulyaeva H,Sage EH,Foidart JM,Thompson EW

更新日期：1998-12-01 00:00:00