Abstract:
:Spontaneous tumorigenesis was evaluated in male p53-knockout (p53-/-) mice treated with dehydroepiandrosterone (DHEA), quercetin, d-limonene, or all-trans retinoic acid to determine whether tumor development in these mice can be modulated by cancer-chemopreventive agents. DHEA-treated mice experienced a delay in tumorigenesis (particularly lymphomas) and subsequent mortality (P < 0.01) relative to untreated control mice. Quercetin, d-limonene, and all-trans retinoic acid each had no effect on spontaneous tumor development in p53-/- mice. These data demonstrate that tumor development in p53-/- mice can be delayed by DHEA and suggest that p53-/- mice provide a useful model for evaluating strategies to offset the increased risk of tumorigenesis resulting from loss of p53 tumor suppressor function.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Hursting SD,Perkins SN,Haines DC,Ward JM,Phang JMsubject
Has Abstractpub_date
1995-09-15 00:00:00pages
3949-53issue
18eissn
0008-5472issn
1538-7445journal_volume
55pub_type
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