Molecular properties of F9 embryoglycan recognized by a unique antibody in sera from patients with germ cell tumors.

abstract：:A rational monoclonal antibody (mAb)-based antitumor therapy approach has previously been shown to eradicate various established experimental and carcinogen-induced tumors in a majority of mice. This therapy comprised an agonistic mAb reactive with tumor necrosis factor-related apoptosis-inducing ligand receptor (DR5)...

journal_title：Cancer research

authors： Teng MW,Westwood JA,Darcy PK,Sharkey J,Tsuji M,Franck RW,Porcelli SA,Besra GS,Takeda K,Yagita H,Kershaw MH,Smyth MJ

更新日期：2007-08-01 00:00:00

abstract：:Whereas transplantable tumors can be readily cured with immunotherapeutic approaches, similar therapies in cancer patients have been less effective. This difference may be explained by an immunosuppression resulting from the presence of a slowly growing primary tumor in the patient, whereas the immune system in a mous...

journal_title：Cancer research

authors： Horiguchi S,Petersson M,Nakazawa T,Kanda M,Zea AH,Ochoa AC,Kiessling R

更新日期：1999-06-15 00:00:00

abstract：:We investigated the production of hyaluronan and the presence of hyaluronan receptors in a panel of human lung carcinoma cell lines, consisting of small cell carcinomas (SCLC) and non-small cell carcinomas (non-SCLC). These transformed cell lines produced only minute amounts of hyaluronan, whereas normal lung fibrobla...

journal_title：Cancer research

authors： Teder P,Bergh J,Heldin P

更新日期：1995-09-01 00:00:00

abstract：:15-Lipoxygenase (15-LOX)-2 is expressed in benign prostate secretory cells and benign prostate produces 15S-hydroxyeicosatetraenoic acid (15S-HETE) from exogenous arachidonic acid (AA). In contrast, 15S-LOX-2 and 15S-HETE formation are reduced in prostate carcinoma (Pca). The mechanisms whereby reduced 15-LOX-2 may co...

journal_title：Cancer research

authors： Shappell SB,Gupta RA,Manning S,Whitehead R,Boeglin WE,Schneider C,Case T,Price J,Jack GS,Wheeler TM,Matusik RJ,Brash AR,Dubois RN

更新日期：2001-01-15 00:00:00

abstract：:We have shown that cyclophosphamide (CY) can augment the development of delayed-type hypersensitivity to a primary antigen in patients with advanced cancer. In the present study, we administered CY (1000 mg/sq m) to 19 patients with advanced, metastatic cancer and monitored the compositional and functional changes in ...

journal_title：Cancer research

authors： Berd D,Maguire HC Jr,Mastrangelo MJ

更新日期：1984-03-01 00:00:00

abstract：:The effect of dietary intake of different levels of Menhaden fish oil on azoxymethane-induced carcinogenesis was examined in male F344 rats fed the semipurified diets. Starting at 5 weeks of age, groups of animals were fed the 5% corn oil (low corn oil) diet. At 7 weeks of age, all animals except the vehicle-treated c...

journal_title：Cancer research

authors： Reddy BS,Maruyama H

更新日期：1986-07-01 00:00:00

abstract：:This study investigates possible alterations in exons 5 through 8 of the p53 gene and altered p53 protein expression in the Syrian golden hamster model of pancreatic ductal adenocarcinoma. In the Syrian hamster p53 sequence, 1469 base pairs are presented for the genomic regions surrounding exons 5 through 8, along wit...

journal_title：Cancer research

authors： Chang KW,Mangold KA,Hubchak S,Laconi S,Scarpelli DG

更新日期：1994-07-15 00:00:00

abstract：:Previous studies have shown that treatment of rats with gonadotropin-releasing hormone (GnRH) analogues or steroids either before exposure to procarbazine or radiation or after irradiation enhances subsequent levels of spermatogenesis. We demonstrate here that giving a GnRH agonist after procarbazine injection also en...

journal_title：Cancer research

authors： Meistrich ML,Wilson G,Huhtaniemi I

更新日期：1999-08-01 00:00:00

abstract：:Contrary to a recent suggestion, new and useful drugs for the treatment of human cancer continue to be developed although clinical trials today are more difficult and the chances for success are diminished. In the past, research at Southern Research Institute led to the development of two new classes of clinically use...

journal_title：Cancer research

authors： Montgomery JA

更新日期：1982-10-01 00:00:00

abstract：:The majority of advanced prostate cancer therapies aim to inhibit androgen receptor (AR) signaling. However, AR reactivation inevitably drives disease progression to castration-resistant prostate cancer (CRPC). Here we demonstrate that protein arginine methyltransferase 5 (PRMT5) functions as an epigenetic activator o...

journal_title：Cancer research

authors： Beketova E,Fang S,Owens JL,Liu S,Chen X,Zhang Q,Asberry AM,Deng X,Malola J,Huang J,Li C,Pili R,Elzey BD,Ratliff TL,Wan J,Hu CD

更新日期：2020-11-15 00:00:00

abstract：:Heparanase is overexpressed in many solid tumor cells and is capable of specifically cleaving heparan sulfate, and this activity is associated with the metastatic potential of tumor cells; however, the activation mechanism of heparanase has remained unknown. In this study, we investigated the link between disulfide bo...

journal_title：Cancer research

authors： Simizu S,Suzuki T,Muroi M,Lai NS,Takagi S,Dohmae N,Osada H

更新日期：2007-08-15 00:00:00

abstract：:Tumors of varying malignant potential arise from the complex epithelial lining of the nephron. Although the molecular characteristics of renal clear cell carcinomas, which arise from the proximal tubule, have been studied, little is known about tumors that develop from other parts of the renal tubular system. To eluci...

journal_title：Cancer research

authors： Polascik TJ,Cairns P,Epstein JI,Fuzesi L,Ro JY,Marshall FF,Sidransky D,Schoenberg M

更新日期：1996-04-15 00:00:00

abstract：:Our recent studies have shown that the FoxM1B transcription factor is overexpressed in human glioma tissues and that the level of its expression correlates directly with glioma grade. However, whether FoxM1B plays a role in the early development of glioma (i.e., in transformation) is unknown. In this study, we found t...

journal_title：Cancer research

authors： Dai B,Pieper RO,Li D,Wei P,Liu M,Woo SY,Aldape KD,Sawaya R,Xie K,Huang S

更新日期：2010-04-01 00:00:00

abstract：:More than 35 different partner genes with the mixed lineage leukemia (MLL) gene have been cloned from leukemia cells with translocations involving chromosome 11 band q23. In this study, we report on a novel fusion partner of the MLL gene, AF4p12, which we have identified as the human homologue to the furry gene of Dro...

journal_title：Cancer research

authors： Hayette S,Cornillet-Lefebvre P,Tigaud I,Struski S,Forissier S,Berchet A,Doll D,Gillot L,Brahim W,Delabesse E,Magaud JP,Rimokh R

更新日期：2005-08-01 00:00:00

abstract：:A human serum DNA-binding protein (C3DP) derived from complement component C3 has been found in elevated concentrations in the sera of individuals with malignant diseases. An assay system has been devised which reveals quantitative values of serum C3DP levels. Results obtained using this system indicate that normal hu...

journal_title：Cancer research

authors： Parsons RG,Longmire RL,Hoch SO,Hoch JA

更新日期：1977-03-01 00:00:00

abstract：:We have recently demonstrated that many cancer cell lines produce a novel trypsinogen isoenzyme called tumor-associated trypsinogen 2 (TAT-2). It was found during a search of the target protease for tumor-associated trypsin inhibitor (TATI). We now show that degradation of subendothelial cell extracellular matrix (ECM...

journal_title：Cancer research

authors： Koivunen E,Ristimäki A,Itkonen O,Osman S,Vuento M,Stenman UH

更新日期：1991-04-15 00:00:00

abstract：:The treatment of glioblastoma (GBM) remains challenging in part due to the presence of stem-like tumor-propagating cells that are resistant to standard therapies consisting of radiation and temozolomide. Among the novel and targeted agents under evaluation for the treatment of GBM are BRAF/MAPK inhibitors, but their e...

journal_title：Cancer research

authors： Lerner RG,Grossauer S,Kadkhodaei B,Meyers I,Sidorov M,Koeck K,Hashizume R,Ozawa T,Phillips JJ,Berger MS,Nicolaides T,James CD,Petritsch CK

更新日期：2015-12-15 00:00:00

abstract：:Detecting the presence and diversity of low-level mutations in human tumors undergoing genomic instability is desirable due to their potential prognostic value and their putative influence on the ability of tumors to resist drug treatment and/or metastasize. However, direct measurement of these genetic alterations in ...

journal_title：Cancer research

authors： Liu WH,Kaur M,Wang G,Zhu P,Zhang Y,Makrigiorgos GM

更新日期：2004-04-01 00:00:00

abstract：:Endocrine therapies effectively improve the outcomes of patients with estrogen receptor (ER)-positive breast cancer. However, the emergence of drug-resistant tumors creates a core clinical challenge. In breast cancer cells rendered resistant to the antiestrogen fulvestrant, we defined causative mechanistic roles for t...

journal_title：Cancer research

authors： Shibata T,Watari K,Izumi H,Kawahara A,Hattori S,Fukumitsu C,Murakami Y,Takahashi R,Toh U,Ito KI,Ohdo S,Tanaka M,Kage M,Kuwano M,Ono M

更新日期：2017-01-15 00:00:00

abstract：:The antiestrogen tamoxifen is used in the treatment of breast cancer and has recently been recommended as a chemopreventive drug for women at high risk for breast cancer. However, women treated with the drug have an increased incidence of endometrial cancer. It has been suggested that this endometrial cancer might res...

journal_title：Cancer research

authors： Shibutani S,Reardon JT,Suzuki N,Sancar A

更新日期：2000-05-15 00:00:00

abstract：:In this study, we identified 53 aberrantly hypermethylated DNA sequences in adult T-cell leukemia (ATL) cells using methylated CpG island amplification/representational difference analysis method. We also observed a proportionate increase in the methylation density of these regions with disease progression. Seven gene...

journal_title：Cancer research

authors： Yasunaga J,Taniguchi Y,Nosaka K,Yoshida M,Satou Y,Sakai T,Mitsuya H,Matsuoka M

更新日期：2004-09-01 00:00:00

abstract：:Intravesical mitomycin C (MMC) therapy is used to treat superficial bladder cancer. This study was to establish the intra- and intersubject variabilities in the systemic (plasma) and target site (bladder) exposure to the drug and to identify the factors which contribute to these variabilities. The pharmacokinetics of ...

journal_title：Cancer research

authors： Dalton JT,Wientjes MG,Badalament RA,Drago JR,Au JL

更新日期：1991-10-01 00:00:00

abstract：:Antitumor responses can be induced in patients via active or adoptive immunotherapy, yet complete tumor eradication occurs infrequently. This paradox in tumor immunology led us to address two questions: (a) Does an antitumor response, which is intended to destroy the aberrant target population, also at the same time s...

journal_title：Cancer research

authors： Liu K,Caldwell SA,Abrams SI

更新日期：2005-05-15 00:00:00

abstract：:Genes encoding the four principal polypeptide domains (N, A1-B1, A2-B2, and A3-B3) of carcinoembryonic antigen (CEA) were synthesized and expressed in Escherichia coli as fusion products with bacterial CMP-KDO synthetase (CKS). The four synthetic fusion proteins were purified in high yield and used as targets in Weste...

journal_title：Cancer research

authors： Hass GM,Bolling TJ,Kinders RJ,Henslee JG,Mandecki W,Dorwin SA,Shively JE

更新日期：1991-04-01 00:00:00

abstract：:Human kallikrein 10 (hK10) is a secreted serine protease that is highly expressed in ovarian tissue. We hypothesized that hK10 might represent a novel serological marker for ovarian cancer. We quantified by immunoassay, hK10 in sera from 97 normal women (controls), 141 patients with benign gynecologic diseases, and 14...

journal_title：Cancer research

authors： Luo LY,Katsaros D,Scorilas A,Fracchioli S,Bellino R,van Gramberen M,de Bruijn H,Henrik A,Stenman UH,Massobrio M,van der Zee AG,Vergote I,Diamandis EP

更新日期：2003-02-15 00:00:00

abstract：:Oncogenic transformation has been induced in vitro in the C3H/10T1/2 clone 8 line of mouse cells by exposure to 5-fluoro-2'-deoxyuridine (FUdR) or 5-fluorouracil. This transformation is both dose and time dependent and can be markedly decreased by simultaneous exposure of the cells to thymidine. The transformation ind...

journal_title：Cancer research

authors： Jones PA,Benedict WF,Baker MS,Mondal S,Rapp U,Heidelberger C

更新日期：1976-01-01 00:00:00

abstract：:ERBB4/HER4 (referred to here as ERBB4) is a unique member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. In contrast to the other three members of the EGFR family (i.e., EGFR, ERBB2/HER2/NEU, and ERBB3), which are associated with aggressive forms of human cancers, ERBB4 expression ...

journal_title：Cancer research

authors： Naresh A,Long W,Vidal GA,Wimley WC,Marrero L,Sartor CI,Tovey S,Cooke TG,Bartlett JM,Jones FE

更新日期：2006-06-15 00:00:00

abstract：:Oncogene activation and loss of tumor suppressor function changes the metabolic activity of cancer cells to drive unrestricted proliferation. Moreover, cancer cells adapt their metabolism to sustain growth and survival when access to oxygen and nutrients is restricted, such as in poorly vascularized tumor areas. We sh...

journal_title：Cancer research

authors： Kaymak I,Maier CR,Schmitz W,Campbell AD,Dankworth B,Ade CP,Walz S,Paauwe M,Kalogirou C,Marouf H,Rosenfeldt MT,Gay DM,McGregor GH,Sansom OJ,Schulze A

更新日期：2020-01-15 00:00:00

abstract：:The signaling pathways that mediate the development of pancreatic ductal adenocarcinoma (PDAC) downstream of mutant Kras remain incompletely understood. Here, we focus on ribosomal protein S6 (rpS6), an mTOR effector not implicated previously in cancer. Phosphorylation of rpS6 was increased in pancreatic acinar cells ...

journal_title：Cancer research

authors： Khalaileh A,Dreazen A,Khatib A,Apel R,Swisa A,Kidess-Bassir N,Maitra A,Meyuhas O,Dor Y,Zamir G

更新日期：2013-03-15 00:00:00

abstract：:A unique electrophoretic form of lactate dehydrogenase (LDH-Z), formerly observed in a choriocarcinoma cell line (JEG-3) and first-trimester placenta, has been shown to be the same as that produced in hydatidiform mole and term placenta. We have also observed LDH-Z in second-trimester placenta, choriocarcinoma metasta...

journal_title：Cancer research

authors： Siciliano MJ,Bordelon-Riser ME,Freedman RS,Kohler PO

更新日期：1980-02-01 00:00:00