Abstract:
:Chemotherapy-induced peripheral neuropathy is a common, dose-limiting side effect of cancer treatment. This conference was the first of its kind to bring together a wide range of clinicians, researchers, and industry professionals to address the potential causes, preventions, and treatments for this drug toxicity. Intraepidermal nerve fiber loss, axonal degeneration, immune cell infiltration, alterations in tubulin protein expression and microtubule stability, axonal transport, and mitochondrial dysfunction were addressed as possible mechanisms. Problems with animal models of the disease were discussed, as well as the potential of patient-derived induced sensory neurons to serve as a novel in vitro model.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Smith JA,Benbow SJdoi
10.1158/0008-5472.CAN-15-1145subject
Has Abstractpub_date
2015-09-15 00:00:00pages
3696-8issue
18eissn
0008-5472issn
1538-7445pii
0008-5472.CAN-15-1145journal_volume
75pub_type
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