The reduction of N-hydroxy-4-acetylaminobiphenyl by the intestinal microflora of the rat.

abstract：:A common form of multidrug resistance in human cancer results from expression of the MDR1 gene which encodes a plasma membrane energy-dependent multidrug efflux pump. We have engineered transgenic mice which express this multidrug transporter in their bone marrow cells and demonstrated that peripheral WBC of these ani...

journal_title：Cancer research

authors： Mickisch GH,Licht T,Merlino GT,Gottesman MM,Pastan I

更新日期：1991-10-01 00:00:00

abstract：:The potentiation of monoclonal antibody/ligand toxin (immunotoxin) cytotoxicity by the ionophore monensin (Mo) or by human serum albumin-monensin (HSA-Mo) conjugates was investigated. Since disulfide cross-linked HSA-Mo (HSA-SPDP-Mo) is rapidly inactivated by human serum (M. Colombatti et al., Cancer Res., 50: 1385-13...

journal_title：Cancer research

authors： Candiani C,Franceschi A,Chignola R,Pasti M,Anselmi C,Benoni G,Tridente G,Colombatti M

更新日期：1992-02-01 00:00:00

abstract：:For two decades, the antigen recognized by the Pathologische Anatomie Leiden-Endothelium (PAL-E) monoclonal antibody, a standard vascular endothelial cell marker, has remained elusive. Here, we used a combinatorial phage display-based approach ("epitope mapping") to select peptides binding to the original PAL-E antibo...

journal_title：Cancer research

authors： Jaalouk DE,Ozawa MG,Sun J,Lahdenranta J,Schlingemann RO,Pasqualini R,Arap W

更新日期：2007-10-15 00:00:00

abstract：:The chemotherapeutic agent and vitamin A metabolite retinoic acid (RA) has been used to treat many tumor types. The effects of RA are mediated by a family of ligand-dependent transcription factors, the retinoic acid receptors (RAR) and the retinoid X receptors. Alterations in RAR expression have been implicated in tum...

journal_title：Cancer research

authors： Crowe DL

更新日期：1998-01-01 00:00:00

abstract：:Allelic loss of chromosome 9p21 is common in small cell lung cancer (SCLC), but inactivation of the tumor suppressor gene CDKN2a is rare, implying the existence of another target gene at 9p21. A recent deletion mapping study of chromosome 9p has also identified a site of deletion in non-small cell lung cancer (NSCLC) ...

journal_title：Cancer research

authors： Cairns P,Okami K,King P,Bonacum J,Ahrendt S,Wu L,Mao L,Jen J,Sidransky D

更新日期：1997-12-01 00:00:00

abstract：:Although chemoresistance remains a primary challenge in the treatment of pancreatic ductal adenocarcinoma (PDAC), exploiting oxidative stress might offer novel therapeutic clues. Here we explored the potential of targeting cystine/glutamate exchanger (SLC7A11/xCT), which contributes to the maintenance of intracellular...

journal_title：Cancer research

authors： Daher B,Parks SK,Durivault J,Cormerais Y,Baidarjad H,Tambutte E,Pouysségur J,Vučetić M

更新日期：2019-08-01 00:00:00

abstract：:Glioblastomas (GBM) are highly infiltrated by myeloid-derived innate immune cells that contribute to the immunosuppressive nature of the brain tumor microenvironment (TME). CD47 has been shown to mediate immune evasion, as the CD47-SIRPα axis prevents phagocytosis of tumor cells by macrophages and other myeloid cells....

journal_title：Cancer research

authors： Ma D,Liu S,Lal B,Wei S,Wang S,Zhan D,Zhang H,Lee RS,Gao P,Lopez-Bertoni H,Ying M,Li JJ,Laterra J,Wilson MA,Xia S

更新日期：2019-05-15 00:00:00

abstract：:The metabolism of both testosterone and dehydroepiandrosterone by 10 adenocarcinomas induced and grown in the presence of high prolactin (plasma prolactin greater than 220 ng/ml) was compared with the metabolism of 10 adenocarcinomas induced and grown in the presence of normal levels (plasma prolactin less than 60 ng/...

journal_title：Cancer research

authors： Miller WR

更新日期：1976-02-01 00:00:00

abstract：:It has recently been reported that the human myeloma cell line U266 proceeds to undergo apoptosis after cultivation with the antiestrogen tamoxifen, thus raising the possibility that antiestrogens may be candidates for use in myeloma therapy. To obtain basic information on the effects of antiestrogens on myeloma cells...

journal_title：Cancer research

authors： Otsuki T,Yamada O,Kurebayashi J,Moriya T,Sakaguchi H,Kunisue H,Yata K,Uno M,Yawata Y,Ueki A

更新日期：2000-03-01 00:00:00

abstract：:The tumorigenicities of 7-methylbenz[c]acridine (7MB[c]ACR) and its five metabolically possible trans-dihydrodiols were determined in two mouse tumor models. In initiation-promotion studies on mouse skin, a single topical application of 0.15 to 0.75 mumol of compound was followed 9 days later by twice weekly applicati...

journal_title：Cancer research

authors： Chang RL,Levin W,Wood AW,Shirai N,Ryan AJ,Duke CC,Jerina DM,Holder GM,Conney AH

更新日期：1986-09-01 00:00:00

abstract：:Diagnosis of hepatitis B virus (HBV)-positive hepatocellular carcinoma (HCC), particularly HCC independent of cirrhosis etiology, presents a great challenge because of a lack of biomarkers. Here we test the hypothesis that expression profiles of microRNAs (miRNAs) in serum can serve as biomarkers for diagnosis of HBV ...

journal_title：Cancer research

authors： Li LM,Hu ZB,Zhou ZX,Chen X,Liu FY,Zhang JF,Shen HB,Zhang CY,Zen K

更新日期：2010-12-01 00:00:00

abstract：:By applying a new and highly sensitive assay for measuring N-hydroxy metabolites, the biochemical properties of the microsomal N-hydroxylase from control and 3-methylcholanthrene-treated rat and hamster liver have been analyzed, and the following conclusions have been drawn. (a) Due to a difference in enzyme affinity,...

journal_title：Cancer research

authors： Razzouk C,Mercier M,Roberfroid M

更新日期：1980-10-01 00:00:00

abstract：:RhoC is a member of the Ras-homologous family of genes which have been implicated in tumorigenesis and tumor progression. However, the exact role of RhoC is controversial and is yet to be clarified. We have examined the effect of RhoC on prostate tumor cells and found that RhoC had no effect on cell proliferation in v...

journal_title：Cancer research

authors： Iiizumi M,Bandyopadhyay S,Pai SK,Watabe M,Hirota S,Hosobe S,Tsukada T,Miura K,Saito K,Furuta E,Liu W,Xing F,Okuda H,Kobayashi A,Watabe K

更新日期：2008-09-15 00:00:00

abstract：:Three mouse monoclonal antibodies to distinct cell surface antigens were derived from immunizations with cells of Tera-1, a human teratocarcinoma cell line, and a membrane preparation of placental tissue. The distribution of the antigens on 165 cultured lines of various human tumors and normal cells was determined by ...

journal_title：Cancer research

authors： Rettig WJ,Cordon-Cardo C,Ng JS,Oettgen HF,Old LJ,Lloyd KO

更新日期：1985-02-01 00:00:00

abstract：:Malignant astrocytoma is one of the most deadly primary central nervous system tumors. Although significant progress has been made in understanding the molecular pathways that lead to the development of these tumors in adults, comparatively little analysis has been done in childhood astrocytomas, which are less common...

journal_title：Cancer research

authors： Pollack IF,Finkelstein SD,Burnham J,Holmes EJ,Hamilton RL,Yates AJ,Finlay JL,Sposto R,Children's Cancer Group.

更新日期：2001-10-15 00:00:00

abstract：:We present a light scattering study using angle-resolved low coherence interferometry (a/LCI) to assess nuclear morphology and subcellular structure within MCF-7 cells at several time points after treatment with chemotherapeutic agents. Although the nuclear diameter and eccentricity are not observed to change, the lig...

journal_title：Cancer research

authors： Chalut KJ,Ostrander JH,Giacomelli MG,Wax A

更新日期：2009-02-01 00:00:00

abstract：:It has been reported that HLA-DR is a potent inducer of thrombin generation. Human colorectal cells (GEO, WiDr, DLD-1, and MIP) that lack the constitutive expression of HLA-DR cause platelet aggregation through a thrombin-dependent mechanism. Treatment with recombinant human gamma-interferon induced the expression of ...

journal_title：Cancer research

authors： Ferroni P,Guadagni F,Spila A,Martini F,Gazzaniga PP

更新日期：1994-02-01 00:00:00

abstract：:Isozymes of carbamyl phosphate synthetase (CPS), CPS I, a mitochondrial enzyme found exclusively in liver and involved in urea synthesis, and of CPS II, a soluble cytoplasmic enzyme widely distributed in animal tissues, were assayed in rat liver and in a series of rat liver neoplasms ranging widely in growth rate and ...

journal_title：Cancer research

authors： Lawson D,Paik WK,Morris HP,Weinhouse S

更新日期：1975-01-01 00:00:00

abstract：:Intracarotid infusion of bradykinin selectively increases the delivery of compounds into brain tumors. This study sought to determine the role of cyclic GMP in increased permeability across the blood-tumor barrier (BTB) after infusion of bradykinin. In permeability studies, 186 Wistar rats with RG2 gliomas and C6 glio...

journal_title：Cancer research

authors： Sugita M,Black KL

更新日期：1998-03-01 00:00:00

abstract：:Malignant ascites is a common complication in the late stages of epithelial ovarian cancer (EOC) that greatly diminishes the quality of life of patients. Malignant ascites is a known consequence of vascular dysfunction, but current approved treatments are not effective in preventing fluid accumulation. In this study, ...

journal_title：Cancer research

authors： Moughon DL,He H,Schokrpur S,Jiang ZK,Yaqoob M,David J,Lin C,Iruela-Arispe ML,Dorigo O,Wu L

更新日期：2015-11-15 00:00:00

abstract：:An accurate method of classification of the surface membrane characteristics of blast cells from patients with acute lymphoblastic leukemia would allow a more definitive study of the nature of this disease. Monoclonal antibodies have been produced to the surface antigens of leukemic blasts form a patient with high-ris...

journal_title：Cancer research

authors： Zipf TF,Fox RI,Dilley J,Levy R

更新日期：1981-11-01 00:00:00

abstract：:Monoclonal antibodies (mabs) have considerable potential for specific cancer treatment. However, due to the antigen heterogeneity and especially the low uptake in solid tumors, mabs have not been used successfully in most clinical trials to date. This study investigates the effects of a mab-cobra venom factor (CVF) co...

journal_title：Cancer research

authors： Juhl H,Sievers M,Baltzer K,Helmig F,Wolf H,Brenner W,Kalthoff H

更新日期：1995-12-01 00:00:00

abstract：:Animal models of human prostate cancer are very limited in number but are of obvious importance to develop. Dr. Morris Pollard (M. Pollard, J. Natl. Cancer Inst., 51: 1235-1241, 1973) has reported that Lobund-Wistar rats develop spontaneous metastatic prostatic cancer when they become old (approximately 25% incidence ...

journal_title：Cancer research

authors： Pugh TD,Chang C,Uemura H,Weindruch R

更新日期：1994-11-15 00:00:00

abstract：:Fps/Fes proteins were among the first members of the protein tyrosine kinase family to be characterized as dominant-acting oncoproteins. Addition of retroviral GAG sequences or other experimentally induced mutations activated the latent transforming potential of Fps/Fes. However, activating mutations in fps/fes had no...

journal_title：Cancer research

authors： Sangrar W,Zirgnibl RA,Gao Y,Muller WJ,Jia Z,Greer PA

更新日期：2005-05-01 00:00:00

abstract：:The Raf/mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase (MEK)/ERK signaling cascade enhances tumor cell proliferation in many cases. Here, we show that adenovirus type 5, a small DNA tumor virus used in experimental cancer therapy, strongly induces ERK phosphorylation during the late phase...

journal_title：Cancer research

authors： Schümann M,Dobbelstein M

更新日期：2006-02-01 00:00:00

abstract：:We recently reported the transcription patterns of human papillomavirus (HPV) type 18 sequences in human cervical carcinoma cell lines. The open reading frames (ORFs) E6* and E6 represent the 5'-terminal cistrons in HPV18 mRNAs. ORF E6* was assumed to be specific for HPV types associated with genital carcinomas. To id...

journal_title：Cancer research

authors： Schneider-Gädicke A,Kaul S,Schwarz E,Gausepohl H,Frank R,Bastert G

更新日期：1988-06-01 00:00:00

abstract：:The chemotherapeutic agent paclitaxel disrupts microtubule dynamics causing mitotic arrest, which leads to cell death. However, in paclitaxel-resistant tumor cells, treatment with paclitaxel induces abnormal progression through prophase resulting in a multimininucleated phenotype. Multimininucleation and subsequent po...

journal_title：Cancer research

authors： Panvichian R,Orth K,Day ML,Day KC,Pilat MJ,Pienta KJ

更新日期：1998-10-15 00:00:00

abstract：:Centrosome amplification is a hallmark of virtually all types of cancers, including solid tumors and hematologic malignancies. Cancer cells with extra centrosomes use centrosome clustering (CC) to allow for successful division. Because normal cells do not rely on this mechanism, CC is regarded as a promising target to...

journal_title：Cancer research

authors： Konotop G,Bausch E,Nagai T,Turchinovich A,Becker N,Benner A,Boutros M,Mizuno K,Krämer A,Raab MS

更新日期：2016-11-15 00:00:00

abstract：:HER2/Neu/ERBB2 is a receptor tyrosine kinase overexpressed in approximately 20% of human breast tumors. Truncated or mutant isoforms that show increased oncogenicity compared with the wild-type receptor are found in many breast tumors. Here, we report that constitutively active ERBB2 sensitizes human breast epithelial...

journal_title：Cancer research

authors： Martín-Pérez R,Palacios C,Yerbes R,Cano-González A,Iglesias-Serret D,Gil J,Reginato MJ,López-Rivas A

更新日期：2014-03-15 00:00:00

abstract：:The radionuclide of choice for use in diagnosis in most nuclear medicine diagnostic procedures is 99mTc. It is important, therefore, to establish whether there is potential clinical efficacy of an antitumor antigen directed monoclonal antibody labeled with 99mTc. We have investigated the potential use of a 99mTc label...

journal_title：Cancer research

authors： Brown BA,Dearborn CB,Drozynski CA,Sands H

更新日期：1990-02-01 00:00:00