Humanized Mouse Xenograft Models: Narrowing the Tumor-Microenvironment Gap.

abstract：:The possibility that the female sex steroid progesterone plays a role in meningioma proliferation has been suggested by a number of investigators; and it had been shown that many meningiomas have high affinity progesterone binding sites. The aim of this study was to examine the expression of progesterone receptor mRNA...

journal_title：Cancer research

authors： Carroll RS,Glowacka D,Dashner K,Black PM

更新日期：1993-03-15 00:00:00

abstract：:To determine whether the toxic effects and changes in many cell functions caused by antitumor 1-nitroacridines are related to their enzymatically mediated covalent interstrand DNA cross-linking (J. Konopa, J. W. Pawlak, and K. Pawlak. Chem.-Biol. Interact., 43: 175-197, 1983), the cross-linking potency of the derivati...

journal_title：Cancer research

authors： Pawlak K,Pawlak JW,Konopa J

更新日期：1984-10-01 00:00:00

abstract：:Isoprenoid inhibitors are being evaluated as agents for the treatment of cancer. Their antitumor activity is attributed to inhibition of post-translational modification of Ras, which is crucial for its translocation and attachment to the plasma membrane, and ultimate involvement in signal transduction. However, whethe...

journal_title：Cancer research

authors： Efuet ET,Keyomarsi K

更新日期：2006-01-15 00:00:00

abstract：:Hereditary nonpolyposis colorectal cancer (HNPCC) is commonly associated with at least three currently known DNA mismatch repair genes: (a) hMSH2; (b) hMLH1; and (c) hMSH6. A majority of HNPCC families has identifiable mutations in hMLH1 and hMSH2. When these mutations cause an inherited risk of colorectal cancer, the...

journal_title：Cancer research

authors： Liu HX,Zhou XL,Liu T,Werelius B,Lindmark G,Dahl N,Lindblom A

更新日期：2003-04-15 00:00:00

abstract：:Diffusion MRI (dMRI) is the only noninvasive method for mapping white matter connections in the brain. We describe SlicerDMRI, a software suite that enables visualization and analysis of dMRI for neuroscientific studies and patient-specific anatomic assessment. SlicerDMRI has been successfully applied in multiple stud...

journal_title：Cancer research

authors： Norton I,Essayed W,Zhang F,Pujol S,Yarmarkovich A,Golby AJ,Kindlmann G,Wassermann D,Estepar RSJ,Rathi Y,Pieper S,Kikinis R,Johnson HJ,Westin CF,O'Donnell LJ

更新日期：2017-11-01 00:00:00

abstract：:Patients diagnosed with leukemia approach their treatment with the hope of cure despite the effect on their quality of life. Some patients will be cured, others will die from treatment, and some will die of their disease. A common theme at the New Directions in Leukemia Research (NDLR 2012) meeting was that cure will ...

journal_title：Cancer research

authors： White DL,Brown AL,D'Andrea RJ,Rice AM

更新日期：2012-09-01 00:00:00

abstract：:To investigate the possible involvement of a tumor suppressor gene(s) on chromosome 8 in prostatic neoplasms, we performed a comprehensive loss of heterozygosity (LOH) study on 99 tumors from 97 prostate cancer patients. One of the carcinomas was a lymph node metastasis; the other 98 were primary carcinomas. Pure popu...

journal_title：Cancer research

authors： Vocke CD,Pozzatti RO,Bostwick DG,Florence CD,Jennings SB,Strup SE,Duray PH,Liotta LA,Emmert-Buck MR,Linehan WM

更新日期：1996-05-15 00:00:00

abstract：:Ribonucleotide reductase (RR) is responsible for the de novo conversion of the ribonucleoside diphosphates to deoxyribonucleoside diphosphates, which are essential for DNA synthesis and repair. RR consists of two subunits, hRRM1 and hRRM2. p53R2 is a new RR family member. Because the majority of human tumors possess m...

journal_title：Cancer research

authors： Zhou B,Liu X,Mo X,Xue L,Darwish D,Qiu W,Shih J,Hwu EB,Luh F,Yen Y

更新日期：2003-10-15 00:00:00

abstract：:Increased neovascularization and vascular hyperpermeability are integral processes in tumors, and various therapeutic strategies seek to reverse the angiogenic phenotype. Long-circulating liposomes extravasate in tumors such as the rat 9L gliosarcoma and accumulate in perivascular areas. Under such conditions, liposom...

journal_title：Cancer research

authors： Zhou R,Mazurchuk R,Straubinger RM

更新日期：2002-05-01 00:00:00

abstract：:Human CYP2A6 has been recognized as being involved in the mutagenic activation of promutagens such as the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Methoxsalen (8-methoxypsoralen) was reported to inhibit CYP2A6. In the present study, the inhibitory effects of methoxsalen on NN...

journal_title：Cancer research

authors： Takeuchi H,Saoo K,Yokohira M,Ikeda M,Maeta H,Miyazaki M,Yamazaki H,Kamataki T,Imaida K

更新日期：2003-11-15 00:00:00

abstract：:Hereditary ovarian cancers associated with germline mutations in either BRCA1 or BRCA2 were studied to determine whether somatic mutation of the P53 gene is required for BRCA-linked ovarian tumorigenesis and further, whether the spectrum of additional somatic molecular genetic alterations present in these tumors diffe...

journal_title：Cancer research

authors： Rhei E,Bogomolniy F,Federici MG,Maresco DL,Offit K,Robson ME,Saigo PE,Boyd J

更新日期：1998-08-01 00:00:00

abstract：:Kaposi's sarcoma-associated herpes virus (KSHV) contributes to the pathogenesis of Kaposi's sarcoma and primary effusion lymphomas. KSHV encodes a G protein-coupled receptor (KSHV-GPCR) that signals constitutively and transforms NIH3T3 cells. Here, we show that KSHV-GPCR transformation requires activation of the small...

journal_title：Cancer research

authors： Dadke D,Fryer BH,Golemis EA,Field J

更新日期：2003-12-15 00:00:00

abstract：:The forkhead transcription factor Foxp3 is highly expressed in CD4+CD25+ regulatory T cells (Treg) and was recently identified as a key player in mediating their inhibitory functions. Here, we describe for the first time the expression and function of Foxp3 in pancreatic ductal adenocarcinoma cells and tumors. Foxp3 e...

journal_title：Cancer research

authors： Hinz S,Pagerols-Raluy L,Oberg HH,Ammerpohl O,Grüssel S,Sipos B,Grützmann R,Pilarsky C,Ungefroren H,Saeger HD,Klöppel G,Kabelitz D,Kalthoff H

更新日期：2007-09-01 00:00:00

abstract：:VEGF/vascular permeability factor (VEGF/VPF or VEGF-A) is a pivotal driver of cancer angiogenesis that is a central therapeutic target in the treatment of malignancy. However, little work has been devoted to investigating functions of VEGF that are independent of its proangiogenic activity. Here, we report that VEGF p...

journal_title：Cancer research

authors： Cao Y,E G,Wang E,Pal K,Dutta SK,Bar-Sagi D,Mukhopadhyay D

更新日期：2012-08-15 00:00:00

abstract：:O(6)-Alkylguanine-DNA alkyltransferase (AGT) plays a critical role in protection from the carcinogenic effects of simple alkylating agents by repairing O(6)-alkylguanine adducts via a direct transfer reaction. Nitric oxide (NO) or species derived from it are known to be able to initiate neoplastic growth and cannot on...

journal_title：Cancer research

authors： Liu L,Xu-Welliver M,Kanugula S,Pegg AE

更新日期：2002-06-01 00:00:00

abstract：:In previous studies a clone of the gynogenetic fish, Poecilia formosa (the Amazon molly), was successfully used as a test animal to identify ultraviolet-induced damage. This work has been extended, and the fish system was used to detect damage caused byionizing radiation. Fish cells, exposed in vitro to 250 and 500 ra...

journal_title：Cancer research

authors： Woodhead D,Setlow RB,Hart RW

更新日期：1977-12-01 00:00:00

abstract：:Recent in vitro studies of the epidermal growth factor receptor (EGFR) family have revealed complex signaling interactions involving the production of ligand-mediated heterodimers synergistic for the transformation of cells in vitro. In a series of 70 patients with childhood medulloblastoma, we have used immunohistoch...

journal_title：Cancer research

authors： Gilbertson RJ,Perry RH,Kelly PJ,Pearson AD,Lunec J

更新日期：1997-08-01 00:00:00

abstract：:Here, we report the molecular regulation of interleukin (IL)-8 expression in human melanoma cells. The inflammatory cytokines IL-1beta and tumor necrosis factor-alpha (TNF-alpha) up-regulated IL-8 expression, in a time- and concentration-dependent manner, in three metastatic melanoma variants, SBC-2 (nonmetastatic), A...

journal_title：Cancer research

authors： Singh RK,Varney ML

更新日期：1998-04-01 00:00:00

abstract：:Although the ability of Taxol to stabilize cellular microtubules is well accepted, the mechanisms by which Taxol induces growth arrest and cell death remain unclear. Recent evidence indicates that Taxol alters specific intracellular signal transduction events, such as the activation of Raf-1 kinase, that may be essent...

journal_title：Cancer research

authors： Torres K,Horwitz SB

更新日期：1998-08-15 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) inhibitors reduce angiogenic responses to a variety of stimuli, suggesting that products of COX-2 may mediate critical steps. Here, we show that thromboxane A2 (TXA2) is one of several eicosanoid products generated by activated human microvascular endothelial cells. Selective COX-2 antagonists...

journal_title：Cancer research

authors： Daniel TO,Liu H,Morrow JD,Crews BC,Marnett LJ

更新日期：1999-09-15 00:00:00

abstract：:In acute promyelocytic leukemia (APL), all-trans retinoic acid (ATRA) treatment induces granulocytic maturation and complete remission of leukemia. microRNAs are known to be critical players in the formation of the leukemic phenotype. In this study, we report downregulation of the miR-181a/b gene cluster in APL blasts...

journal_title：Cancer research

authors： Bräuer-Hartmann D,Hartmann JU,Wurm AA,Gerloff D,Katzerke C,Verga Falzacappa MV,Pelicci PG,Müller-Tidow C,Tenen DG,Niederwieser D,Behre G

更新日期：2015-08-15 00:00:00

abstract：:Glioblastomas display cellular hierarchies with self-renewing tumor-initiating cells (TIC), also known as cancer stem cells, at the apex. Although the TIC hypothesis remains controversial and the functional assays to define the TIC phenotype are evolving, we and others have shown that TICs may contribute to therapeuti...

journal_title：Cancer research

authors： Kim Y,Wu Q,Hamerlik P,Hitomi M,Sloan AE,Barnett GH,Weil RJ,Leahy P,Hjelmeland AB,Rich JN

更新日期：2013-08-01 00:00:00

abstract：:The effects of 5-fluoro-2'-deoxyuridine (FdUrd) and 5,8-dideazaisofolic acid on the coordination of thymidylate synthase activity and DNA synthesis were examined in human CCRF-CEM leukemic cells following a continuous exposure to these agents. In logarithmically growing control tumor cells, the rate of in situ thymidy...

journal_title：Cancer research

authors： Fernandes DJ,Cranford SK

更新日期：1986-04-01 00:00:00

abstract：:Breast cancer progresses in a multistep process from primary tumor growth and stroma invasion to metastasis. Nutrient-limiting environments promote chemotaxis with aggressive morphologies characteristic of invasion. It is unknown how coexisting cells differ in their response to nutrient limitations and how this impact...

journal_title：Cancer research

authors： Kimmel GJ,Dane M,Heiser LM,Altrock PM,Andor N

更新日期：2020-11-15 00:00:00

abstract：:Adrenocortical carcinoma (ACC) is a rare disease with an overall poor but heterogeneous prognosis. This heterogeneity could reflect different mechanisms of tumor development. Gene expression profiling by transcriptome analysis led to ACC being divided into two groups of tumors with very different outcomes. Somatic ina...

journal_title：Cancer research

authors： Ragazzon B,Libé R,Gaujoux S,Assié G,Fratticci A,Launay P,Clauser E,Bertagna X,Tissier F,de Reyniès A,Bertherat J

更新日期：2010-11-01 00:00:00

abstract：:Monocytes and dendritic cells are key players in the immune response. Because dendritic cells drive the tumor host defense, it is important that monocytes and dendritic cells survive cytotoxic tumor therapy. Although most of the anticancer drugs target DNA, the DNA repair capacity of monocytes and dendritic cells has ...

journal_title：Cancer research

authors： Briegert M,Kaina B

更新日期：2007-01-01 00:00:00

abstract：:Genomic imprinting is an epigenetic modification of the gamete or zygote leading to parental origin-specific gene expression in somatic cells of the offspring. We have previously identified a cluster of imprinted genes on human chromosome 11p15.5, a region involved in Beckwith-Wiedemann syndrome, Wilms' tumor, and ova...

journal_title：Cancer research

authors： Lee MP,Feinberg AP

更新日期：1998-03-01 00:00:00

abstract：:Activation of the matrix metalloproteinase 2 (MMP-2) has been shown to play a major role in the proteolysis of extracellular matrix (ECM) associated with tumor invasion. Although the precise mechanism of this activation remains elusive, levels of the membrane type 1-MMP (MT1-MMP) at the cell surface and of the tissue ...

journal_title：Cancer research

authors： Gilles C,Bassuk JA,Pulyaeva H,Sage EH,Foidart JM,Thompson EW

更新日期：1998-12-01 00:00:00

abstract：:The tumor microenvironment is characterized by regions of fluctuating and chronic hypoxia, low pH, and nutrient deprivation. It has been proposed that this unique tissue environment itself may constitute a major cause of the genetic instability seen in cancer. To investigate possible mechanisms by which the tumor micr...

journal_title：Cancer research

authors： Yuan J,Narayanan L,Rockwell S,Glazer PM

更新日期：2000-08-15 00:00:00

abstract：:In the vascular system, circulating tumor cells interact with endothelial cells. Tumor-endothelial cross-talk transforms the intravascular milieu to a prothrombotic, proinflammatory, and cell-adhesive state called endothelial cell activation (ECA). In the present study, we analyze the potential of metastatic tumor-der...

journal_title：Cancer research

authors： Goerge T,Barg A,Schnaeker EM,Poppelmann B,Shpacovitch V,Rattenholl A,Maaser C,Luger TA,Steinhoff M,Schneider SW

更新日期：2006-08-01 00:00:00