Mutagenesis and morphological transformation of mammalian cells by a non-bay-region polycyclic cyclopenta(cd)pyrene and its 3,4-oxide.

abstract：:The presence of metastases in the regional lymph nodes is the major prognostic factor in breast cancer in the absence of overt distant metastases and is also an important indicator of the need for adjuvant therapy in "early" breast cancer. Currently, the accurate assessment of axillary lymph node status requires axill...

journal_title：Cancer research

authors： Tjandra JJ,Russell IS,Collins JP,Andrews JT,Lichtenstein M,Binns D,McKenzie IF

更新日期：1989-03-15 00:00:00

abstract：:Reconstituted basement membrane matrix (Matrigel) has been utilized for in vitro assay of tumor cell invasion in recent years. In the conventional chamber for the invasion assay, however, a large number of cells passed easily through the center of the Matrigel-coated filter because the Matrigel layer could not be comp...

journal_title：Cancer research

authors： Imamura H,Takao S,Aikou T

更新日期：1994-07-01 00:00:00

abstract：:The Xeroderma pigmentosum group D (XPD) protein is an essential participant in nucleotide excision repair and basal transcription. There is evidence that three common polymorphisms of the XPD gene (C156A, Asp312Asn, and Lys751Gln) may be associated with differential DNA repair activity. Because increased DNA repair pl...

journal_title：Cancer research

authors： Park DJ,Stoehlmacher J,Zhang W,Tsao-Wei DD,Groshen S,Lenz HJ

更新日期：2001-12-15 00:00:00

abstract：:Malignant pleural mesothelioma is a relatively uncommon and yet incurable tumor. The pathogenesis of mesothelioma remains poorly understood. This study evaluated the role of Wnt signaling in mesothelioma. Western blot analysis was conducted to confirm the expression of Dishevelled (Dvl) and cytosolic beta-catenin in m...

journal_title：Cancer research

authors： Uematsu K,Kanazawa S,You L,He B,Xu Z,Li K,Peterlin BM,McCormick F,Jablons DM

更新日期：2003-08-01 00:00:00

abstract：:The expression and activities of epidermal growth factor (EGF) receptor and a highly related protein (Mr approximately 190,000 protein; p190) were characterized from a human glioma cell line, KE. p190 was specifically immunoprecipitated with a monoclonal antibody with specificity against the EGF receptor (Mr approxima...

journal_title：Cancer research

authors： Steck PA,Lee P,Hung MC,Yung WK

更新日期：1988-10-01 00:00:00

abstract：:In the present study, we assessed the susceptibility of freshly isolated neuroblastoma cells to killing mediated by normal human natural killer (NK) cells and analyzed the receptor-ligand interactions that regulate this event. We show that killing of freshly isolated neuroblasts, similar to neuroblastoma cell lines, i...

journal_title：Cancer research

authors： Castriconi R,Dondero A,Corrias MV,Lanino E,Pende D,Moretta L,Bottino C,Moretta A

更新日期：2004-12-15 00:00:00

abstract：:Metastatic cases of breast cancer pose the primary challenge in clinical management of this disease, demanding the identification of effective therapeutic strategies that remain wanting. In this study, we report that elevated levels of α-tubulin acetylation are a sufficient cause of metastatic potential in breast canc...

journal_title：Cancer research

authors： Boggs AE,Vitolo MI,Whipple RA,Charpentier MS,Goloubeva OG,Ioffe OB,Tuttle KC,Slovic J,Lu Y,Mills GB,Martin SS

更新日期：2015-01-01 00:00:00

abstract：:The Ral family of small G proteins has been implicated in tumorigenesis, invasion, and metastasis. However, little emphasis has been placed on clarifying the individual roles of the two Ral proteins, RalA and RalB, in these processes in view of their high sequence homology. Here we analyze the separate contributions o...

journal_title：Cancer research

authors： Oxford G,Owens CR,Titus BJ,Foreman TL,Herlevsen MC,Smith SC,Theodorescu D

更新日期：2005-08-15 00:00:00

abstract：:We have studied the effects of tamoxifen on the cell cycle kinetics of the endocrine-responsive MCF-7 human breast cancer cells. Tamoxifen inhibits proliferation of MCF-7 cells. The tritiated thymidine labeling index is markedly reduced by tamoxifen, indicating a reduction in the fraction of cells in S phase. Flow cyt...

journal_title：Cancer research

authors： Osborne CK,Boldt DH,Clark GM,Trent JM

更新日期：1983-08-01 00:00:00

abstract：:The ability of the phorbol ester tumor promoter 12-O-tetradecanoylphorbol- 13-acetate (TPA) to lead to the activation of cyclic adenosine 3':5'-monophosphate (cAMP)-dependent protein kinase was investigated in three cell lines. In the Reuber H35 hepatoma cells, TPA (1.6 microM) led to an increase in the protein kinase...

journal_title：Cancer research

authors： Byus CV,Trevillyan JM,Cavit LJ,Fletcher WH

更新日期：1983-07-01 00:00:00

abstract：:miRNAs that translocate from the nucleus to mitochondria are referred to as mitochondrial microRNAs (mitomiR). mitomiRs have been shown to modulate the translational activity of the mitochondrial genome, yet their role in mitochondrial DNA (mtDNA) transcription remains to be determined. Here we report that the mitomiR...

journal_title：Cancer research

authors： Fan S,Tian T,Chen W,Lv X,Lei X,Zhang H,Sun S,Cai L,Pan G,He L,Ou Z,Lin X,Wang X,Perez MF,Tu Z,Ferrone S,Tannous BA,Li J

更新日期：2019-03-15 00:00:00

abstract：:The presence of estrogen-independent progesterone receptors (PgR) was demonstrated in a subline of a human endometrial cancer cell line, Ishikawa cells, although the original Ishikawa cells contained estrogen-inducible PgR. Scatchard plot analysis of cytoplasmic binding data in our subline (IK-90) revealed a high affi...

journal_title：Cancer research

authors： Terakawa N,Hayashida M,Shimizu I,Ikegami H,Wakimoto H,Aono T,Tanizawa O,Matsumoto K,Nishida M

更新日期：1987-04-01 00:00:00

abstract：:Variation in colorectal cancer rates between countries and within ethnic groups upon migration and/or Westernization suggests a role for some aspects of Western lifestyle in the etiology of this disease. We conducted a population-based case-control study in the multiethnic population of Hawaii to evaluate associations...

journal_title：Cancer research

authors： Le Marchand L,Wilkens LR,Kolonel LN,Hankin JH,Lyu LC

更新日期：1997-11-01 00:00:00

abstract：:The fibroblast growth factors (FGF) play diverse roles in development, wound healing, and angiogenesis. The intracellular signal transduction pathways, which mediate these pleiotropic activities, remain incompletely understood. We show here that the proangiogenic factors FGF2 and FGF8b can activate signal transducers ...

journal_title：Cancer research

authors： Yang X,Qiao D,Meyer K,Friedl A

更新日期：2009-02-15 00:00:00

abstract：:Antisense DNA has shown an ability to target specific oncogene transcripts and inhibit their expression in cells, but the degree to which sustained treatment can suppress total levels of an oncogenic product and alter tumorigenesis in vivo remains to be determined. In this study, NIH-3T3 cells transformed by the activ...

journal_title：Cancer research

authors： Gray GD,Hernandez OM,Hebel D,Root M,Pow-Sang JM,Wickstrom E

更新日期：1993-02-01 00:00:00

abstract：:Placenta growth factor (PlGF) is a mitogen for endothelial cells that can potentiate the growth and permeabilizing effects on endothelium of vascular endothelial growth factor. Here we report that hypoxia induces the expression of both PlGF mRNA and protein in immortalized/transformed mouse embryonic fibroblasts (mEFs...

journal_title：Cancer research

authors： Green CJ,Lichtlen P,Huynh NT,Yanovsky M,Laderoute KR,Schaffner W,Murphy BJ

更新日期：2001-03-15 00:00:00

abstract：:cis-Platinum, bleomycin, 5-fluorouracil, and cyclophosphamide were administered to rodent and canine models of osmotic blood-brain barrier modification to evaluate the relationship between tissue drug concentration in brain and the physiological and neuropathological effects of the drug. The toxicity studies were carr...

journal_title：Cancer research

authors： Neuwelt EA,Barnett PA,Glasberg M,Frenkel EP

更新日期：1983-11-01 00:00:00

abstract：:The ability of all-trans-retinoic acid (RA) to modulate the growth and squamous differentiation of four head and neck squamous cell carcinoma cell lines (183, 886, 1483, and SqCC/Y1) was examined, and the relationship of their state of squamous differentiation and RA responsiveness to the expression of cytosolic RA-bi...

journal_title：Cancer research

authors： Zou CP,Clifford JL,Xu XC,Sacks PG,Chambon P,Hong WK,Lotan R

更新日期：1994-10-15 00:00:00

abstract：:Glycerol and D2O can provide a protective effect to Chinese hamster V79 cells receiving heat treatment. The mechanism for this effect is assumed to be the ability of these agents to stabilize proteins which implies that one of the possible heat-killing mechanisms is the inactivation of a heat-sensitive molecule (prote...

journal_title：Cancer research

authors： Lin PS,Hefter K,Ho KC

更新日期：1984-12-01 00:00:00

abstract：:The progression from normal breast epithelium to a malignant phenotype may depend on changes in genetic events as well as failure of host mechanisms. Intermediate biomarkers are needed to more effectively identify malignant progression as well as to develop the potential for more specific treatments and prevention str...

journal_title：Cancer research

authors： Khanuja PS,Lehr JE,Soule HD,Gehani SK,Noto AC,Choudhury S,Chen R,Pienta KJ

更新日期：1993-07-15 00:00:00

abstract：:To identify CpG islands differentially methylated in pancreatic adenocarcinoma, we used methylated CpG island amplification (MCA) coupled with representational difference analysis. Of 42 CpG islands identified by MCA/representational difference analysis, 7 CpG islands [methylated in carcinoma of the pancreas (MICP)] w...

journal_title：Cancer research

authors： Ueki T,Toyota M,Skinner H,Walter KM,Yeo CJ,Issa JP,Hruban RH,Goggins M

更新日期：2001-12-01 00:00:00

abstract：:Breast cancer is the second leading cause of cancer death for women in the United States. Of the different subtypes, estrogen receptor-negative (ER(-)) tumors, which are ErbB2+ or triple-negative, carry a relatively poor prognosis. In this study, we used system-wide analysis of breast cancer proteomes to identify prot...

journal_title：Cancer research

authors： Geiger T,Madden SF,Gallagher WM,Cox J,Mann M

更新日期：2012-05-01 00:00:00

abstract：:Although chrysotile asbestos is a proven human carcinogen, several studies have concluded that these fibers are not mutagenic to cultured mammalian cells. We show here, on the other hand, that when tested using the AL cell system that detects both intragenic and multilocus mutations, chrysotile is indeed mutagenic and...

journal_title：Cancer research

authors： Hei TK,Piao CQ,He ZY,Vannais D,Waldren CA

更新日期：1992-11-15 00:00:00

abstract：:High speed (200 ms temporal resolution) functional computed tomography was used to demonstrate tumor vascular heterogeneity with 0.05 microliter spatial resolution. Vascular topologies were investigated in 2 human small cell lung cancer lines implanted either s.c. or as a tissue isolated preparation in immunocompromis...

journal_title：Cancer research

authors： Hamberg LM,Kristjansen PE,Hunter GJ,Wolf GL,Jain RK

更新日期：1994-12-01 00:00:00

abstract：:A possible involvement of gender-dependent factors has been postulated in development of human non-small-cell lung cancers (NSCLC), but its details remain unclear. In this study, we examined biological significance of progesterone receptor in NSCLCs. Progesterone receptor immunoreactivity was detected in 106 of 228 NS...

journal_title：Cancer research

authors： Ishibashi H,Suzuki T,Suzuki S,Niikawa H,Lu L,Miki Y,Moriya T,Hayashi S,Handa M,Kondo T,Sasano H

更新日期：2005-07-15 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is a developmental program, which is associated with breast cancer progression and metastasis. Here, we report that ectopic overexpression of SOX4 in immortalized human mammary epithelial cells is sufficient for acquisition of mesenchymal traits, enhanced cell migration, and inv...

journal_title：Cancer research

authors： Zhang J,Liang Q,Lei Y,Yao M,Li L,Gao X,Feng J,Zhang Y,Gao H,Liu DX,Lu J,Huang B

更新日期：2012-09-01 00:00:00

abstract：:Cell division cycle 25B (Cdc25B) phosphatase controls entry into mitosis and regulates recovery from G2-M checkpoint-induced arrest. In the present study, we show that exposure of diploid mouse embryonic fibroblasts (MEF) to the ultimate carcinogen anti-benzo(a)pyrene (BP)-7,8-diol-9,10-epoxide (anti-BPDE) resulted in...

journal_title：Cancer research

authors： Srivastava SK,Bansal P,Oguri T,Lazo JS,Singh SV

更新日期：2007-10-01 00:00:00

abstract：:Thirty-seven consecutive patients with germ cell cancers (34 testicular, three extragonadal) and elevated serum levels of alpha-fetoprotein (AFP) and/or human chorionic gonadotropin (HCG) were treated with vinblastine, bleomycin, and cis-diamminedichloroplatinum induction chemotherapy. The AFP and/or HCG normalized in...

journal_title：Cancer research

authors： Vogelzang NJ,Lange PH,Goldman A,Vessela RH,Fraley EE,Kennedy BJ

更新日期：1982-11-01 00:00:00

abstract：:We have recently identified human epidermal growth factor-like immunoreactive factor synthesized and secreted by human breast cancer cells (MCF-7) as a secretory protein encoded by the pS2 gene, the transcription of which is directly induced by estrogen. We demonstrated in this paper that synthesis and secretion of pS...

journal_title：Cancer research

authors： Kida N,Yoshimura T,Mori K,Hayashi K

更新日期：1989-07-01 00:00:00

abstract：:: Cancer cells in quiescence (G0 phase) are resistant to death, and re-entry of quiescent cancer cells into the cell-cycle plays an important role in cancer recurrence. Here we show that two p53-responsive miRNAs utilize distinct but complementary mechanisms to promote cancer cell quiescence by facilitating stabilizat...

journal_title：Cancer research

authors： La T,Liu GZ,Farrelly M,Cole N,Feng YC,Zhang YY,Sherwin SK,Yari H,Tabatabaee H,Yan XG,Guo ST,Liu T,Thorne RF,Jin L,Zhang XD

更新日期：2018-12-01 00:00:00