Abstract：
:High speed (200 ms temporal resolution) functional computed tomography was used to demonstrate tumor vascular heterogeneity with 0.05 microliter spatial resolution. Vascular topologies were investigated in 2 human small cell lung cancer lines implanted either s.c. or as a tissue isolated preparation in immunocompromised mice. Peripheral versus central vascular topology was identified in the s.c. and tissue-isolated preparations, respectively. Pharmacokinetic analysis demonstrated that tumor physiology was influenced by cell line (P = 0.016) and not by location (P > 0.6). This new technique has the potential to characterize individual tumors in patients with minimal invasiveness, permitting more detailed prognosis and management.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Hamberg LM,Kristjansen PE,Hunter GJ,Wolf GL,Jain RKsubject
Has Abstractpub_date
1994-12-01 00:00:00pages
6032-6issue
23eissn
0008-5472issn
1538-7445journal_volume
54pub_type
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