DNA damage and repair in L1210 cells exposed to 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea.

abstract：:To identify molecular alterations involved in the initiation and progression of breast carcinomas, we analyzed the global gene expression profiles of normal mammary epithelial cells and in situ, invasive, and metastatic breast carcinomas using serial analysis of gene expression (SAGE). We identified sets of genes expr...

journal_title：Cancer research

authors： Porter DA,Krop IE,Nasser S,Sgroi D,Kaelin CM,Marks JR,Riggins G,Polyak K

更新日期：2001-08-01 00:00:00

abstract：:The sensitivity of mouse and human bone marrow hematopoietic precursor cells [colony-forming units committed to granulocyte-macrophage differentiatin (CFU-C)] was determined after in vitro incubation with chlorozotocin (2-[3-(2-chloroethyl)-3-nitrosoureido]-D-glucopyranose), or 1,3-bis(2-chloroethyl)-1-nitrosourea (BC...

journal_title：Cancer research

authors： Schein PS,Bull JM,Doukas D,Hoth D

更新日期：1978-02-01 00:00:00

abstract：:Thirty patients with lung cancer were studied using the leukocyte migration-inhibition assay. Cryostat sections of autologous and homologous carcinoma tissues and normal lung were used as antigens. Although no inhibition of migration was seen using autologous cancer tissues, seven of 30 patients (23%) demonstrated inh...

journal_title：Cancer research

authors： Erickson AD

更新日期：1980-10-01 00:00:00

abstract：:The activated RAS/RAF cascade plays a crucial role in lung cancer, but is also known to induce cellular senescence, a major barrier imposed on tumor cells early in tumorigenesis. MYC is a key factor in suppression of RAS/BRAF(V600E)-induced senescence in vitro. However, it is still unclear whether MYC has the same rol...

journal_title：Cancer research

authors： Tabor V,Bocci M,Alikhani N,Kuiper R,Larsson LG

更新日期：2014-08-15 00:00:00

abstract：:An unusual isozyme of lactate dehydrogenase, lactate dehydrogenase associated with Kirsten murine sarcoma virus (LDHk) was found in the sera of many patients with malignant tumors, while the sera of healthy persons had little or no such activity. This isozyme was detectable only when assayed in a nitrogen atmosphere, ...

journal_title：Cancer research

authors： Polonis VR,Anderson GR,Brzykcy J,Vladutiu AO,Manly KF

更新日期：1984-05-01 00:00:00

abstract：:Based on reports that both human and murine lymphoblastoid cell lines can effect lysis in antibody-dependent (ADCC) and mitogen-induced (MICC) cell-mediated cytotoxicity, 10 human lymphoblastoid cell lines were investigated for their ability to act as effector cells in these lytic reactions. Four cell lines promoted M...

journal_title：Cancer research

authors： Jordan TF,Ferrone S,Pellegrino MA,Dennert G

更新日期：1978-11-01 00:00:00

abstract：:The regulation of urokinase secretion and receptor display in a well-differentiated colon carcinoma cell line, GEO, adapted to serum-free conditions was examined. In protein-free medium, the cell line secreted 0.8 +/- 0.1 ng/ml/10(6) cells of urokinase in a 3-day period as determined by an enzyme-linked immunosorbent ...

journal_title：Cancer research

authors： Boyd D,Brattain M

更新日期：1989-04-15 00:00:00

abstract：:When human tumor xenotransplants into nude mice are used as experimental models, it is important to know whether their microvascular anatomy is rather host or tumor specific. Therefore a morphometric comparison of the vascular network in human squamous cell carcinomas and their xenotransplants was carried out. Biopsie...

journal_title：Cancer research

authors： Lauk S,Zietman A,Skates S,Fabian R,Suit HD

更新日期：1989-08-15 00:00:00

abstract：:Lymphoid cell subpopulations infiltrating into autografts of methylcholanthrene-induced sarcomas in rats immunized with autologous tumor cells were identified in terms of immunohistochemical and cytofluorographic techniques using various monoclonal antibodies raised against different classes of rat lymphohemopoietic c...

journal_title：Cancer research

authors： Ishii Y,Matsuura A,Takami T,Uede T,Ibayashi Y,Uede T,Imamura M,Kikuchi K,Kikuchi Y

更新日期：1984-09-01 00:00:00

abstract：:Cytogenetic analysis has not only provided important information on the pathogenesis of soft tissue tumors but, by disclosing distinct chromosomal rearrangements in different histopathological entities, has also come to serve as a valuable diagnostic tool. Little is known as yet about the potential prognostic impact o...

journal_title：Cancer research

authors： Mertens F,Strömberg U,Mandahl N,Dal Cin P,De Wever I,Fletcher CD,Mitelman F,Rosai J,Rydholm A,Sciot R,Tallini G,Van Den Berghe H,Vanni R,Willén H

更新日期：2002-07-15 00:00:00

abstract：:The effect of Adriamycin on the invasive capacity of rat ascites hepatoma cells, W1, was studied. The invasive capacity of W1 cells was estimated in vitro by counting the number of penetrated single tumor cells and tumor cell colonies formed from the penetrated cells underneath a cultured mesothelial cell monolayer (H...

journal_title：Cancer research

authors： Imamura F,Horai T,Mukai M,Shinkai K,Akedo H

更新日期：1990-04-01 00:00:00

abstract：:Previous laboratory investigations, case reports, and a hospital-based case-control study have suggested that marijuana use may be a risk factor for squamous cell head and neck cancer. We conducted a population-based case-control study to determine whether marijuana use is associated with the development of oral squam...

journal_title：Cancer research

authors： Rosenblatt KA,Daling JR,Chen C,Sherman KJ,Schwartz SM

更新日期：2004-06-01 00:00:00

abstract：:In this study, we have exploited the power of insertional mutagenesis to elucidate tumor progression pathways in mice carrying two oncogenes (MYC/Runx2) that collaborate to drive early lymphoma development. Neonatal infection of these mice with Moloney murine leukemia virus resulted in accelerated tumor onset with ass...

journal_title：Cancer research

authors： Stewart M,Mackay N,Hanlon L,Blyth K,Scobie L,Cameron E,Neil JC

更新日期：2007-06-01 00:00:00

abstract：:The external pH of solid tumors is acidic as a consequence of increased metabolism of glucose and poor perfusion. Acid pH has been shown to stimulate tumor cell invasion and metastasis in vitro and in cells before tail vein injection in vivo. The present study investigates whether inhibition of this tumor acidity will...

journal_title：Cancer research

authors： Robey IF,Baggett BK,Kirkpatrick ND,Roe DJ,Dosescu J,Sloane BF,Hashim AI,Morse DL,Raghunand N,Gatenby RA,Gillies RJ

更新日期：2009-03-15 00:00:00

abstract：:Discovery of somatically mutated cells in human tissues has been less frequent than would be predicted by in vitro mutational rates. We analyzed the PTEN tumor suppressor gene as an early marker for endometrial carcinogenesis, and we show that 43% of histologically normal premenopausal endometria contain rare glands t...

journal_title：Cancer research

authors： Mutter GL,Ince TA,Baak JP,Kust GA,Zhou XP,Eng C

更新日期：2001-06-01 00:00:00

abstract：:The stability of several oncoproteins, including c-Myc, is regulated by ubiquitin-dependent degradation mediated by the SCF(Fbw7) ubiquitin ligase. This activity is antagonized by the deubiquitinase Usp28, which is highly expressed in murine and human intestinal cancers. Usp28 was previously shown to interact with its...

journal_title：Cancer research

authors： Diefenbacher ME,Chakraborty A,Blake SM,Mitter R,Popov N,Eilers M,Behrens A

更新日期：2015-04-01 00:00:00

abstract：:Earlier studies suggested that TSP50 is a testis-specific gene that encodes a protein, which is homologous to serine proteases but differs in that threonine replaces serine in its catalytic triad. Most importantly, it was abnormally reactivated in many breast cancer biopsies tested. While further investigating its bio...

journal_title：Cancer research

authors： Xu H,Shan J,Jurukovski V,Yuan L,Li J,Tian K

更新日期：2007-02-01 00:00:00

abstract：:Using Mth1 and Ogg1 knockout mice, we evaluated the roles of these enzymes to prevent tumorigenesis and the accumulation of 8-oxoguanine (8-oxoG) in DNA. We found that lung adenoma/carcinoma spontaneously developed in Ogg1 knockout mice approximately 1.5 years after birth in which 8-oxoG was found to accumulate in the...

journal_title：Cancer research

authors： Sakumi K,Tominaga Y,Furuichi M,Xu P,Tsuzuki T,Sekiguchi M,Nakabeppu Y

更新日期：2003-03-01 00:00:00

abstract：:Treatment of L1210 cells with glucose, 1-methyl-3-isobutylxanthine, theophylline, and prostaglandins E1 and E2 was used to increase to varying degrees the endogenous level of cyclic adenosine 3':5'-monophosphate (cAMP). In an inverse manner these agents decreased the rate of methotrexate (MTX) transport into the cells...

journal_title：Cancer research

authors： Henderson GB,Zevely EM,Huennekens FM

更新日期：1978-03-01 00:00:00

abstract：:Mounting evidence suggests a role for matrix metalloproteinase (MMP)-2 in the malignant progression of breast cancer cells. We showed previously that H-Ras, but not N-Ras, induced invasion of MCF10A human breast epithelial cells through Rac-MKK3/6-p38 pathway resulted in MMP-2 up-regulation. Activation of p38 pathway ...

journal_title：Cancer research

authors： Song H,Ki SH,Kim SG,Moon A

更新日期：2006-11-01 00:00:00

abstract：:Chemotherapeutic agents may damage gastrointestinal epithelium and thereby impair the mucosal barrier to bacteria and their products. In order to obtain an objective measurement of gastrointestinal permeability to large molecules, we measured urinary excretion of [14C]polyvinylpyrrolidone administered p.o. (mean molec...

journal_title：Cancer research

authors： Siber GR,Mayer RJ,Levin MJ

更新日期：1980-10-01 00:00:00

abstract：:O6-Alkylguanine, a DNA adduct formed by nitrosoureas, becomes the site of a point mutation during DNA synthesis by preferentially base mispairing with thymine rather than correctly base pairing with cytosine. To repair this adduct, cells contain a limited amount of O6-alkylguanine-DNA alkyltransferase (alkyltransferas...

journal_title：Cancer research

authors： Gerson SL,Trey JE,Miller K,Benjamin E

更新日期：1987-01-01 00:00:00

abstract：:Human CYP2A6 has been recognized as being involved in the mutagenic activation of promutagens such as the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Methoxsalen (8-methoxypsoralen) was reported to inhibit CYP2A6. In the present study, the inhibitory effects of methoxsalen on NN...

journal_title：Cancer research

authors： Takeuchi H,Saoo K,Yokohira M,Ikeda M,Maeta H,Miyazaki M,Yamazaki H,Kamataki T,Imaida K

更新日期：2003-11-15 00:00:00

abstract：:Metastasis is the primary cause of death from breast cancer. A xenograft model was used to identify genes potentially involved with metastasis, comparing expression in the poorly metastatic GI101A human breast cancer cell line and a highly metastatic variant, GILM2. cDNA microarray analyses of these isogenic variants ...

journal_title：Cancer research

authors： Kluger HM,Chelouche Lev D,Kluger Y,McCarthy MM,Kiriakova G,Camp RL,Rimm DL,Price JE

更新日期：2005-07-01 00:00:00

abstract：:Endogenous formation of N-nitrosoproline (NPRO) was demonstrated by monitoring its excretion in the urine of a male volunteer who had ingested vegetable juice, as a source of nitrate, and proline. The resulting NPRO was analyzed after derivatization by combined gas-liquid chromatography thermal energy analysis. The am...

journal_title：Cancer research

authors： Ohshima H,Bartsch H

更新日期：1981-09-01 00:00:00

abstract：:There is evidence from experimental work that hypoxia induces apoptosis in apoptosis-sensitive neoplastic cells and that this apoptotic sensitivity is lost during malignant progression. Oxygenation profiles and apoptotic indices in human squamous cell cancer of the uterine cervix have been determined, and a subgroup o...

journal_title：Cancer research

authors： Höckel M,Schlenger K,Höckel S,Vaupel P

更新日期：1999-09-15 00:00:00

abstract：:In breast cancer bone metastasis, tumor cells stimulate osteoclast-mediated bone resorption, and bone-derived growth factors released from resorbed bone stimulate tumor growth. The alphavbeta3 integrin is an adhesion receptor expressed by breast cancer cells and osteoclasts. It is implicated in tumor cell invasion and...

journal_title：Cancer research

authors： Zhao Y,Bachelier R,Treilleux I,Pujuguet P,Peyruchaud O,Baron R,Clément-Lacroix P,Clézardin P

更新日期：2007-06-15 00:00:00

abstract：:A balanced lipid metabolism is crucial for all cells. Disturbance of this homeostasis by nonphysiological intracellular accumulation of fatty acids can result in apoptosis. This was proven in animal studies and was correlated to some human diseases, like lipotoxic cardiomyopathy. Some metabolic mechanisms of lipo-apop...

journal_title：Cancer research

authors： Pohle T,Brändlein S,Ruoff N,Müller-Hermelink HK,Vollmers HP

更新日期：2004-06-01 00:00:00

abstract：:Previous cytogenetic analysis has revealed frequent losses of chromosome 1p21-22 in human malignant mesothelioma, suggesting that the loss or inactivation of a tumor suppressor gene's) residing at this site may contribute to the tumorigenic conversion of mesothelial cells. To more precisely define the location of the ...

journal_title：Cancer research

authors： Lee WC,Balsara B,Liu Z,Jhanwar SC,Testa JR

更新日期：1996-10-01 00:00:00

abstract：:Notch signaling is an area of great interest in oncology. RO4929097 is a potent and selective inhibitor of gamma-secretase, producing inhibitory activity of Notch signaling in tumor cells. The RO4929097 IC50 in cell-free and cellular assays is in the low nanomolar range with >100-fold selectivity with respect to 75 ot...

journal_title：Cancer research

authors： Luistro L,He W,Smith M,Packman K,Vilenchik M,Carvajal D,Roberts J,Cai J,Berkofsky-Fessler W,Hilton H,Linn M,Flohr A,Jakob-Røtne R,Jacobsen H,Glenn K,Heimbrook D,Boylan JF

更新日期：2009-10-01 00:00:00