Hypoxic cervical cancers with low apoptotic index are highly aggressive.

abstract：:To determine the role of the transcription factor signal transducer and activator of transcription (STAT) 1 on endothelial cell function, human umbilical vein endothelial cells (HUVEC) were treated with IFN-gamma, a potent activator of STAT1. IFN-gamma inhibited cell growth and tube formation of HUVECs. Although the p...

journal_title：Cancer research

authors： Battle TE,Lynch RA,Frank DA

更新日期：2006-04-01 00:00:00

abstract：:Photodynamic therapy (PDT), an experimental cancer treatment employing a photosensitizer and visible light, is a highly efficient inducer of apoptosis (or programmed cell death) in mouse L5178Y lymphoma cells, resulting in extensive DNA fragmentation within 1-2 h. The major targets for PDT are in cellular membranes, a...

journal_title：Cancer research

authors： Agarwal ML,Larkin HE,Zaidi SI,Mukhtar H,Oleinick NL

更新日期：1993-12-15 00:00:00

abstract：:Human carcinoembryonic antigen (CEA), a widely used tumor marker, and CEACAM6 [formerly nonspecific cross-reacting antigen (NCA)] are up-regulated in many types of human cancers, whereas family member CEACAM1 [formerly biliary glycoprotein (BGP)] is usually down-regulated. Deregulated overexpression of CEA/CEACAM6 but...

journal_title：Cancer research

authors： Ordoñez C,Screaton RA,Ilantzis C,Stanners CP

更新日期：2000-07-01 00:00:00

abstract：:Twenty-eight cervicovaginal tracts from approximately 2-year-old female BALB/cCrgl mice neonatally exposed to ovarian steroids were cut into small segments and transplanted into syngeneic hosts. Within six months, six of 28 host animals developed tumors. Three tumors were from progesterone-exposed mice, two were from ...

journal_title：Cancer research

authors： Jones LA,Pacillas-Verjan R

更新日期：1979-07-01 00:00:00

abstract：:Thirteen variables were evaluated for their significance in predicting the survival of 148 patients in a retrospective study with clinical Stage I cutaneous malignant melanoma. The variables studied were histological type, tumor thickness, level of invasion, mitotic activity, pigmentation type, existence of ulceration...

journal_title：Cancer research

authors： Hacene K,Le Doussal V,Brunet M,Lemoine F,Guerin P,Hebert H

更新日期：1983-06-01 00:00:00

abstract：:We have reported previously that the PTEN COOH-terminal 33 amino acids play a role in the maintenance of PTEN protein stability (Tolkacheva and Chan, Oncogene, 19: 680-689, 2000). By site-directed mutagenesis, we identified two threonine residues within this COOH-terminal region at codon 382 and 383 that may be target...

journal_title：Cancer research

authors： Tolkacheva T,Boddapati M,Sanfiz A,Tsuchida K,Kimmelman AC,Chan AM

更新日期：2001-07-01 00:00:00

abstract：:L-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-beta]thiazole hydrochloride (LMS), when used in concert with 1,3-bis(2-chloroethyl)-1-nitrosourea, resulted in a significantly higher percentage of long-term leukemic-free survivors. The additive effect provided by LMS treatment was evident during the immunosuppressed period in...

journal_title：Cancer research

authors： Chirigos MA,Fuhrman F,Pryor J

更新日期：1975-04-01 00:00:00

abstract：:Estrogens are known to induce tumors in high frequency in orchiectomized Syrian golden hamsters, but the histogenesis of the tumors is controversial. In order to identify the earliest precursors of the tumors, animals were implanted with pellets of four different estrogens, sacrificed at times ranging up to 6.4 months...

journal_title：Cancer research

authors： Goldfarb S,Pugh TD

更新日期：1990-01-01 00:00:00

abstract：:Phosphoglycerate dehydrogenase (PHGDH) is the metabolic enzyme responsible for shunting the glycolytic intermediate 3-phosphoglycerate to the serine synthesis pathway. In breast cancer and several other types of cancer, increased PHGDH expression is associated with patient mortality. Early studies focused on the role ...

journal_title：Cancer research

authors： Samanta D,Semenza GL

更新日期：2016-11-15 00:00:00

abstract：:beta-Catenin is an ubiquitously expressed cytoplasmic protein that has a crucial role in both cadherin-mediated cell-cell adhesion and as a downstream signaling molecule in the wingless/Wnt pathway. Activating mutations in exon 3 of the beta-catenin gene, at the phosphorylation sites for ubiquitination and degradation...

journal_title：Cancer research

authors： Rashid A,Gao YT,Bhakta S,Shen MC,Wang BS,Deng J,Fraumeni JF Jr,Hsing AW

更新日期：2001-04-15 00:00:00

abstract：:Based on reports that both human and murine lymphoblastoid cell lines can effect lysis in antibody-dependent (ADCC) and mitogen-induced (MICC) cell-mediated cytotoxicity, 10 human lymphoblastoid cell lines were investigated for their ability to act as effector cells in these lytic reactions. Four cell lines promoted M...

journal_title：Cancer research

authors： Jordan TF,Ferrone S,Pellegrino MA,Dennert G

更新日期：1978-11-01 00:00:00

abstract：:Immunization to multiple defined tumor antigens for specific immune therapy of human cancer has thus far proven difficult. Eighteen HLA A*0201(+) patients with metastatic melanoma received injections s.c. of CD34(+)progenitor-derived autologous dendritic cells (DCs), which included Langerhans cells. DCs were pulsed wi...

journal_title：Cancer research

authors： Banchereau J,Palucka AK,Dhodapkar M,Burkeholder S,Taquet N,Rolland A,Taquet S,Coquery S,Wittkowski KM,Bhardwaj N,Pineiro L,Steinman R,Fay J

更新日期：2001-09-01 00:00:00

abstract：:A chimeric CYCLIN D1-TROP2 mRNA was isolated from human ovarian and mammary cancer cells. The CYCLIN D1-TROP2 mRNA was shown to be a potent oncogene as it transforms naïve, primary cells in vitro and induces aggressive tumor growth in vivo in cooperation with activated RAS. Silencing of the chimeric mRNA inhibits the ...

journal_title：Cancer research

authors： Guerra E,Trerotola M,Dell' Arciprete R,Bonasera V,Palombo B,El-Sewedy T,Ciccimarra T,Crescenzi C,Lorenzini F,Rossi C,Vacca G,Lattanzio R,Piantelli M,Alberti S

更新日期：2008-10-01 00:00:00

abstract：:Epidemiologic studies have reported the underrepresentation of cervical precancerous lesions caused by human papillomavirus (HPV) types 18 and 45 (HPV18/45) compared with the proportion of cervical cancers attributed to these HPV types. We investigated the timing of diagnosis of histologic cervical intraepithelial neo...

journal_title：Cancer research

authors： Safaeian M,Schiffman M,Gage J,Solomon D,Wheeler CM,Castle PE

更新日期：2009-04-15 00:00:00

abstract：:Antitumor type I T-cell responses involving IFN-γ production are critical to control cancer, but the efficacy of this response is limited by a variety of immunosuppressive mechanisms that promote tumoral immune escape. One critical mechanism involves the accumulation of FOXP3(+) T regulatory cells (Treg), a class of s...

journal_title：Cancer research

authors： Redjimi N,Raffin C,Raimbaud I,Pignon P,Matsuzaki J,Odunsi K,Valmori D,Ayyoub M

更新日期：2012-09-01 00:00:00

abstract：:Deoxycytidine kinase (DCK) is a key enzyme for the activation of a broad spectrum of nucleoside-based chemotherapy drugs (e.g., gemcitabine); low DCK activity is one of the most important causes of cancer drug-resistance. Noninvasive imaging methods that can quantify DCK activity are invaluable for assessing tumor res...

journal_title：Cancer research

authors： Han Z,Li Y,Zhang J,Liu J,Chen C,van Zijl PC,Liu G

更新日期：2019-05-15 00:00:00

abstract：:Neuroblastoma (NB), a common pediatric neoplasm, consists of two main cell populations: neuroblastic/ganglionic cells and Schwann cells. NB tumors with abundant Schwannian stroma display a more benign clinical behavior than stroma-poor tumors. Recent studies suggest that Schwann cells influence NB tumor growth via sec...

journal_title：Cancer research

authors： Chlenski A,Liu S,Crawford SE,Volpert OV,DeVries GH,Evangelista A,Yang Q,Salwen HR,Farrer R,Bray J,Cohn SL

更新日期：2002-12-15 00:00:00

abstract：:Cell culture studies have been performed to compare the mutagenic potential and the induction of sister chromatid exchanges for hematoporphyrin derivative photoradiation, ionizing radiation, and UV radiation. The mutation frequency in Chinese hamster ovary cells at the hypoxanthine-guanine phosphoribosyltransferase lo...

journal_title：Cancer research

authors： Gomer CJ,Rucker N,Banerjee A,Benedict WF

更新日期：1983-06-01 00:00:00

abstract：:Cisplatin (cis-diamminedichloroplatinum, CDDP) is one of the most used drugs for osteosarcoma chemotherapy. By using a series of CDDP-resistant variants, which were established from the U-2OS and Saos-2 human osteosarcoma cell lines, we found that CDDP resistance was mainly associated with the increase of both the int...

journal_title：Cancer research

authors： Pasello M,Michelacci F,Scionti I,Hattinger CM,Zuntini M,Caccuri AM,Scotlandi K,Picci P,Serra M

更新日期：2008-08-15 00:00:00

abstract：:Toll-like receptor (TLR) agonists are considered adjuvants in clinical trials of cancer immunotherapy. Here, we investigated the modulation of gammadelta T cell-mediated tumor cell lysis by TLR ligands. gammadelta T-cell cytotoxicity and granzyme A/B production were enhanced after pretreatment of tumor cells with TLR3...

journal_title：Cancer research

authors： Shojaei H,Oberg HH,Juricke M,Marischen L,Kunz M,Mundhenke C,Gieseler F,Kabelitz D,Wesch D

更新日期：2009-11-15 00:00:00

abstract：:Hematogenous carcinoma metastasis is supported by aggregated platelets and leukocytes, forming tumor cell emboli. Early tumor cell-platelet interactions can be mediated by P-selectin binding to tumor cell surface ligands and this process is blocked by heparin. We previously showed that L-selectin deficiency also atten...

journal_title：Cancer research

authors： Läubli H,Stevenson JL,Varki A,Varki NM,Borsig L

更新日期：2006-02-01 00:00:00

abstract：:The cytotoxic, antimitotic, and growth inhibition properties of a photoactive analogue of vinblastine, N-(p-azidobenzoyl)-N'-beta-aminoethylvindesine (NABV), and vinblastine on P388 murine leukemia cells were compared. After 72-h exposure, the 50% drug-inhibitory concentrations for exponentially growing P388 leukemic ...

journal_title：Cancer research

authors： Safa AR,Glover CJ,Felsted RL

更新日期：1987-10-01 00:00:00

abstract：:The use of targeted therapeutics directed against BRAF(V600)-mutant metastatic melanoma improves progression-free survival in many patients; however, acquired drug resistance remains a major medical challenge. By far, the most common clinical resistance mechanism involves reactivation of the MAPK (RAF/MEK/ERK) pathway...

journal_title：Cancer research

authors： Goetz EM,Ghandi M,Treacy DJ,Wagle N,Garraway LA

更新日期：2014-12-01 00:00:00

abstract：:It has been hypothesized that complement inhibitors expressed on the surface of tumor cells prevent effective immune-mediated clearance. Whereas there are in vitro data to support this hypothesis, the species-selective activity of complement inhibitors has been a hindrance to investigating the role of membrane-bound c...

journal_title：Cancer research

authors： Chen S,Caragine T,Cheung NK,Tomlinson S

更新日期：2000-06-01 00:00:00

abstract：:Four bifunctional and one trifunctional alpha-chloro ethers were tested for carcinogenicity. These compounds were bis-1,2-(chloromethoxy)ethane (Compound I), bis-1,4-(chloromethoxy)butane (Compound II), bis-1,6-(chloromethoxy) hexane (Compound III), bis-1,4-(chloromethoxy)-p-xylene (Compound IV), and tris-1,2,3-(chlor...

journal_title：Cancer research

authors： Van Duuren BL,Goldschmidt BM,Seidman I

更新日期：1975-09-01 00:00:00

abstract：:Animal models, particularly mouse models, play a central role in the study of the etiology, prevention, and treatment of human prostate cancer. While tissue culture models are extremely useful in understanding the biology of prostate cancer, they cannot recapitulate the complex cellular interactions within the tumor m...

journal_title：Cancer research

authors： Ittmann M,Huang J,Radaelli E,Martin P,Signoretti S,Sullivan R,Simons BW,Ward JM,Robinson BD,Chu GC,Loda M,Thomas G,Borowsky A,Cardiff RD

更新日期：2013-05-01 00:00:00

abstract：:The activated RAS/RAF cascade plays a crucial role in lung cancer, but is also known to induce cellular senescence, a major barrier imposed on tumor cells early in tumorigenesis. MYC is a key factor in suppression of RAS/BRAF(V600E)-induced senescence in vitro. However, it is still unclear whether MYC has the same rol...

journal_title：Cancer research

authors： Tabor V,Bocci M,Alikhani N,Kuiper R,Larsson LG

更新日期：2014-08-15 00:00:00

abstract：:A method was elaborated for high-yield 125I-trap labeling of rat colon carcinoma cells using conjugates of dichlorotriazine aminofluorescein and bovine serum albumin substituted with either N-acetylgalactosamine or N-acetylglucosamine as vehicles. Fluorescence microscopy revealed that the ligands accumulated in perinu...

journal_title：Cancer research

authors： Rushfeldt C,Smedsrød B

更新日期：1993-02-01 00:00:00

abstract：:B7-H4 (VTCN1, B7x, B7s) is a ligand for inhibitory coreceptors on T cells implicated in antigenic tolerization. B7-H4 is expressed by tumor cells and tumor-associated macrophages (TAM), but its potential contributions to tumoral immune escape and therapeutic targeting have been less studied. To interrogate B7-H4 expre...

journal_title：Cancer research

authors： Dangaj D,Lanitis E,Zhao A,Joshi S,Cheng Y,Sandaltzopoulos R,Ra HJ,Danet-Desnoyers G,Powell DJ Jr,Scholler N

更新日期：2013-08-01 00:00:00

abstract：:Idoxifene, a novel antiestrogen with reduced estrogenic activity when compared to tamoxifen, has been given to 20 women with metastatic breast cancer, 19 of whom had received tamoxifen previously, in doses between 10-60 mg. Idoxifene had an initial half-life of 15 h and a terminal half-life of 23.3 days. At a maintena...

journal_title：Cancer research

authors： Coombes RC,Haynes BP,Dowsett M,Quigley M,English J,Judson IR,Griggs LJ,Potter GA,McCague R,Jarman M

更新日期：1995-03-01 00:00:00