Transplantability and sex steroid hormone responsiveness of cervicovaginal tumors derived from female BALB/cCrgl mice neonatally treated with ovarian steroids.

abstract：:It has been hypothesized that complement inhibitors expressed on the surface of tumor cells prevent effective immune-mediated clearance. Whereas there are in vitro data to support this hypothesis, the species-selective activity of complement inhibitors has been a hindrance to investigating the role of membrane-bound c...

journal_title：Cancer research

authors： Chen S,Caragine T,Cheung NK,Tomlinson S

更新日期：2000-06-01 00:00:00

abstract：:Drug resistance is a major problem in the successful treatment of cancer. Resistance to one drug is often associated with cross-resistance to other anticancer agents. This is commonly seen with the "natural product" anticancer drugs such as the Vinca alkaloids and anthracyclines. In experimental systems, specific chan...

journal_title：Cancer research

authors： Danks MK,Metzger DW,Ashmun RA,Beck WT

更新日期：1985-07-01 00:00:00

abstract：:Inherent and acquired therapeutic resistance in breast cancer remains a major clinical challenge. In human breast cancer samples, overexpression of the oncogenic transcription factor FoxM1 has been suggested to be a marker of poor prognosis. In this study, we report that FoxM1 overexpression confers resistance to the ...

journal_title：Cancer research

authors： Carr JR,Park HJ,Wang Z,Kiefer MM,Raychaudhuri P

更新日期：2010-06-15 00:00:00

abstract：:The aldehyde reagent methoxyamine is able to interact with apurinic/apyrimidinic sites formed in vivo within cells and displays both an anti-cytotoxic and an antimutagenic activity on N-ethyl-N'-nitro-N-nitrosoguanidine-induced DNA damage in Chinese hamster ovary cells. To clarify the underlying mechanism we have exam...

journal_title：Cancer research

authors： Fortini P,Calcagnile A,Vrieling H,van Zeeland AA,Bignami M,Dogliotti E

更新日期：1993-03-01 00:00:00

abstract：:Metastasis is the primary cause of death from breast cancer. A xenograft model was used to identify genes potentially involved with metastasis, comparing expression in the poorly metastatic GI101A human breast cancer cell line and a highly metastatic variant, GILM2. cDNA microarray analyses of these isogenic variants ...

journal_title：Cancer research

authors： Kluger HM,Chelouche Lev D,Kluger Y,McCarthy MM,Kiriakova G,Camp RL,Rimm DL,Price JE

更新日期：2005-07-01 00:00:00

abstract：:Androgens via their receptor (AR) may play a role in prostate cancer etiology. This study focuses on the inhibitory effects of resveratrol on androgen action in the LNCaP prostate cancer cell line. We found that resveratrol represses different classes of androgen up-regulated genes at the protein or mRNA level includi...

journal_title：Cancer research

authors： Mitchell SH,Zhu W,Young CY

更新日期：1999-12-01 00:00:00

abstract：:Tetracyclines, a class of antibiotics that target bacterial translation, are commonly used in research for inducible gene expression using Tet-ON/Tet-OFF systems. However, such tetracycline-inducible systems carry a risk. Given that mitochondria have a "bacterial" ancestry, these antibiotics also target mitochondrial ...

journal_title：Cancer research

authors： Chatzispyrou IA,Held NM,Mouchiroud L,Auwerx J,Houtkooper RH

更新日期：2015-11-01 00:00:00

abstract：:Vascular endothelial growth factor D has recently been linked to the control of lymphangiogenesis and lymphatic metastasis. The molecular determinants regulating vegf-D gene transcription, however, have not yet been identified. After isolation of 2 kb of 5'-flanking DNA of the human vegf-D gene, we identified a novel,...

journal_title：Cancer research

authors： Schäfer G,Wissmann C,Hertel J,Lunyak V,Höcker M

更新日期：2008-01-15 00:00:00

abstract：:Gene expression signatures generated from DNA microarray analyses have shown promise as predictive biomarkers of clinical outcome. In this study, we determined a high-risk signature for disease recurrence using formalin-fixed head and neck squamous cell carcinoma (HNSCC) tumors and compared the results with an indepen...

journal_title：Cancer research

authors： Chung CH,Parker JS,Ely K,Carter J,Yi Y,Murphy BA,Ang KK,El-Naggar AK,Zanation AM,Cmelak AJ,Levy S,Slebos RJ,Yarbrough WG

更新日期：2006-08-15 00:00:00

abstract：:The flux activities of de novo and salvage purine synthesis were compared in rat hepatoma 3924A cells in various growth phases. The initial rate assays of [14C]adenine, [14C]hypoxanthine, and [14C]guanine incorporation yielded Michaelis-Menten kinetics with Kms of 5, 7, and 7 microM, respectively. After replating plat...

journal_title：Cancer research

authors： Natsumeda Y,Ikegami T,Olah E,Weber G

更新日期：1989-01-01 00:00:00

abstract：:Repurposing "old" drugs can facilitate rapid clinical translation but necessitates novel mechanistic insight. Warfarin, a vitamin K "antagonist" used clinically for the prevention of thrombosis for more than 50 years, has been shown to have anticancer effects. We hypothesized that the molecular mechanism underlying it...

journal_title：Cancer research

authors： Kirane A,Ludwig KF,Sorrelle N,Haaland G,Sandal T,Ranaweera R,Toombs JE,Wang M,Dineen SP,Micklem D,Dellinger MT,Lorens JB,Brekken RA

更新日期：2015-09-15 00:00:00

abstract：:Silybin, a main component of the milk thistle of Silybum marianum, has been reported to possess anticancer activity. We investigated the effects of IdB 1016, a complex of silybin with phosphatidylcholine, on the development of mammary tumors appearing spontaneously in HER-2/neu transgenic mice. The mechanisms involved...

journal_title：Cancer research

authors： Provinciali M,Papalini F,Orlando F,Pierpaoli S,Donnini A,Morazzoni P,Riva A,Smorlesi A

更新日期：2007-03-01 00:00:00

abstract：:We are developing a noninvasive approach for targeting imaging and therapeutic radionuclides to prostate cancer. Our method, Enzyme-Mediated Cancer Imaging and Therapy (EMCIT), aims to use enzyme-dependent, site-specific, in vivo precipitation of a radioactive molecule within the extracellular space of solid tumors. A...

journal_title：Cancer research

authors： Pospisil P,Wang K,Al Aowad AF,Iyer LK,Adelstein SJ,Kassis AI

更新日期：2007-03-01 00:00:00

abstract：:Certain ductal carcinoma in situ (DCIS) lesions overexpress the HER-2/neu receptor at this early stage of breast cancer development. Recently, we showed that a HER-2-targeted dendritic cell vaccine could be used to eliminate HER-2-overexpressing cells in patients that harbor these high-risk DCIS lesions. Our findings ...

journal_title：Cancer research

authors： Czerniecki BJ,Roses RE,Koski GK

更新日期：2007-07-15 00:00:00

abstract：:Pancreatic cancers with aberrant expression of macrophage migration inhibitory factor (MIF) are particularly aggressive. To identify key signaling pathways that drive disease aggressiveness in tumors with high MIF expression, we analyzed the expression of coding and noncoding genes in high and low MIF-expressing tumor...

journal_title：Cancer research

authors： Yang S,He P,Wang J,Schetter A,Tang W,Funamizu N,Yanaga K,Uwagawa T,Satoskar AR,Gaedcke J,Bernhardt M,Ghadimi BM,Gaida MM,Bergmann F,Werner J,Ried T,Hanna N,Alexander HR,Hussain SP

更新日期：2016-07-01 00:00:00

abstract：:4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and its glucuronides (sum of which is denoted as total NNAL) are metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). NNK and NNAL can induce lung cancer in laboratory animals but human data are limited. The association between prediagnostic levels o...

journal_title：Cancer research

authors： Yuan JM,Koh WP,Murphy SE,Fan Y,Wang R,Carmella SG,Han S,Wickham K,Gao YT,Yu MC,Hecht SS

更新日期：2009-04-01 00:00:00

abstract：:Metronomic chemotherapy refers to the close, regular administration of comparatively low doses of cytotoxic drugs, with minimal or no drug-free breaks, over prolonged periods. It is thought to have an antiangiogenic basis. However, whereas surprisingly durable and potent tumor responses have been observed in a number ...

journal_title：Cancer research

authors： Shaked Y,Emmenegger U,Francia G,Chen L,Lee CR,Man S,Paraghamian A,Ben-David Y,Kerbel RS

更新日期：2005-08-15 00:00:00

abstract：:Estrogen receptor-related receptors (ERR) are orphan nuclear receptors, which are constitutively activated without estrogen binding. Recent evidence indicates that the ligand-independent ERRs may be involved in similar ER-mediated regulatory pathways and modulate estrogen responsiveness in certain target cells. We rec...

journal_title：Cancer research

authors： Yu S,Wang X,Ng CF,Chen S,Chan FL

更新日期：2007-05-15 00:00:00

abstract：:We are in an era where the potential exists for deriving comprehensive profiles of DNA alterations characterizing each form of human cancer. Such profiles would provide invaluable insight into mechanisms underlying the evolution of each tumor type and will provide molecular markers, which could radically improve cance...

journal_title：Cancer research

authors： Esteller M,Corn PG,Baylin SB,Herman JG

更新日期：2001-04-15 00:00:00

abstract：:A case-control study of 229 ovarian cancer cases (including 172 epithelial tumors) and an equal number of population-based controls was conducted during 1984 to 1986 in Shanghai, China, a low-risk area for ovarian cancer. Similar to studies in high-risk areas, the risk of epithelial tumors was high for nulliparous wom...

journal_title：Cancer research

authors： Shu XO,Brinton LA,Gao YT,Yuan JM

更新日期：1989-07-01 00:00:00

abstract：:Bifunctional alkylating agents are known to produce cross-links between DNA and protein and between paired DNA strands. The possibility of discriminating these two classes of cross-links in L1210 cells treated with haloethylnitrosoureas or nitrogen mustard was explored with the alkaline elution technique. Two classes ...

journal_title：Cancer research

authors： Ewig RA,Kohn KW

更新日期：1978-10-01 00:00:00

abstract：:We studied the distribution of transcripts encoding the cytoplasmic domain of the membrane-anchored precursor epidermal growth factor (proEGFcyt) and a novel cytoplasmic proEGF splice isoform with a deleted exon 23 and an out-of-frame fusion of exon 24 (proEGFdel23) in human normal and neoplastic thyroid tissues. In p...

journal_title：Cancer research

authors： Pyka J,Glogowska A,Dralle H,Hoang-Vu C,Klonisch T

更新日期：2005-02-15 00:00:00

abstract：:We reported recently that medium conditioned with mouse lung microvessel endothelial cells possessed chemotactic activity for a highly lung-metastatic variant (L17) of the RAW117 murine large-cell lymphoma cell line but not for the poorly metastatic parental cells (P) or a liver-metastasizing variant (H10). The chemot...

journal_title：Cancer research

authors： Wakabayashi H,Cavanaugh PG,Nicolson GL

更新日期：1995-10-01 00:00:00

abstract：:Thymidine phosphorylase (dThdPase)/platelet-derived endothelial cell growth factor is expressed at higher levels in a variety of human carcinomas than it is in adjacent normal tissue. The higher expression is associated with an increase of intratumoral microvessel density (IMVD) and an unfavorable patient prognosis. W...

journal_title：Cancer research

authors： Matsuura T,Kuratate I,Teramachi K,Osaki M,Fukuda Y,Ito H

更新日期：1999-10-01 00:00:00

abstract：:The aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 (AIMP2) splice variant designated DX2 is induced by cigarette smoke carcinogens and is often detected in human lung cancer specimens. However, the function of DX2 in lung carcinogenesis is obscure. In this study, we found that DX2 expression w...

journal_title：Cancer research

authors： Oh AY,Jung YS,Kim J,Lee JH,Cho JH,Chun HY,Park S,Park H,Lim S,Ha NC,Park JS,Park CS,Song GY,Park BJ

更新日期：2016-08-15 00:00:00

abstract：:The tachykinin family of neuropeptides, including substance P and neurokinins A and B, induce a transient increase in intracellular free calcium concentration in human small cell lung carcinoma (SCLC) cells, as measured with a calcium indicator fura-2. The effects are dose dependent and even greater than that of bombe...

journal_title：Cancer research

authors： Takuwa N,Takuwa Y,Ohue Y,Mukai H,Endoh K,Yamashita K,Kumada M,Munekata E

更新日期：1990-01-15 00:00:00

abstract：:The ability of polyribosomes, obtained from several bacterial species, to suppress the development of cutaneous SaD2 fibrosarcomas in DBA/2 mice were evaluated. Suppression of tumor appearance depended upon the tumor load at the time of treatment, dose of polyribosomes, and species source of polyribosomes, with Serrat...

journal_title：Cancer research

authors： Urban RW,Edwards BS,Segal W

更新日期：1980-05-01 00:00:00

abstract：:Studies were undertaken to determine the therapeutic effects of liposome-encapsulated 1-beta-D-arabinofuranosylcytosine (lip-ara-C) against intracranial L1210 leukemia. The effects of administration route, drug dosage, liposome type, and tumor load on therapeutic efficacy were also studied. One hundred % mice were cur...

journal_title：Cancer research

authors： Hong F,Mayhew E

更新日期：1989-09-15 00:00:00

abstract：:Two lines of human colonic carcinoma cells have different sensitivities to 5-fluorouracil and 1-(2-chlorethyl)-3-(4-methylcyclohexyl)-1-nitrosourea (methyl-CCNU). The growth of the BE line is 50% inhibited by 330 microM 5-fluorouracil and 15 microM methyl-CCNU, and the HT-29 line is 50% inhibited by 85 and 140 microM,...

journal_title：Cancer research

authors： Sutton JE,Roos IA,Hillcoat BL

更新日期：1982-12-01 00:00:00

abstract：:Multiple copies of N-myc proto-oncogene are only rarely detected in localized neuroblastomas (NBs), and the prognostic relevance of amplification in this subset of patients is not clear. We analyzed a series of 850 children with NB admitted to a Pediatric Oncology Group NB Biology Study and identified six patients wit...

journal_title：Cancer research

authors： Cohn SL,Look AT,Joshi VV,Holbrook T,Salwen H,Chagnovich D,Chesler L,Rowe ST,Valentine MB,Komuro H

更新日期：1995-02-15 00:00:00