Therapy of central nervous system leukemia in mice by liposome-entrapped 1-beta-D-arabinofuranosylcytosine.

abstract：:Dog and rat animal models have been developed for repeated intravascular administrations to the liver. However, mice have generally been considered too small to use for these models. This study describes the development of mouse models that permit the establishment of liver metastases that can be subsequently treated ...

journal_title：Cancer research

authors： Kasuya H,Kuruppu DK,Donahue JM,Choi EW,Kawasaki H,Tanabe KK

更新日期：2005-05-01 00:00:00

abstract：:The role of endogenous NO on cell survival was investigated in human melanoma cells and melanocytes. Inducible NO synthase (iNOS) was always expressed in a panel of melanoma cell lines from metastatic lesions and in normal adult melanocytes. iNOS was also detected by immunohistochemistry in melanoma cells from metasta...

journal_title：Cancer research

authors： Salvucci O,Carsana M,Bersani I,Tragni G,Anichini A

更新日期：2001-01-01 00:00:00

abstract：:MAPK signaling pathways are constitutively active in colon cancer and also promote acquired resistance to MEK1 inhibition. Here, we demonstrate that BRAFV600E -mutated colorectal cancers acquire resistance to MEK1 inhibition by inducing expression of the scaffold protein CEMIP through a β-catenin- and FRA-1-dependent ...

journal_title：Cancer research

authors： Duong HQ,Nemazanyy I,Rambow F,Tang SC,Delaunay S,Tharun L,Florin A,Büttner R,Vandaele D,Close P,Marine JC,Shostak K,Chariot A

更新日期：2018-08-15 00:00:00

abstract：:5'-Deoxy-5-fluorouridine (5'-dFUrd; Roche 21-9738) is a recently synthesized antineoplastic agent with therapeutic potential. The sensitivity of Ehrlich ascites tumor cells in CF-1 mice to 5'-dFUrd, as well as to 5-fluorouridine, was established. 5'-dFUrd was a more effective antitumor agent and was less toxic over a ...

journal_title：Cancer research

authors： Armstrong RD,Diasio RB

更新日期：1980-09-01 00:00:00

abstract：:Transcriptional regulator YAP is activated in multiple human cancers and plays critical roles in tumor initiation, progression, metastasis, and drug resistance. However, therapeutic targeting of the Hippo-YAP pathway has been challenging due to its low druggability and limited knowledge of YAP regulation in cancer. He...

journal_title：Cancer research

authors： Seo J,Kim MH,Hong H,Cho H,Park S,Kim SK,Kim J

更新日期：2019-12-15 00:00:00

abstract：:A new approach to selective photodynamic therapy (PDT) was developed by designing chlorin e6 (Ce6)-containing macromolecules, which are sensitive to tumor-associated proteases. The agents are nontoxic in their native state but become fluorescent and produce singlet oxygen on protease conversion. Coupled with optimized...

journal_title：Cancer research

authors： Choi Y,Weissleder R,Tung CH

更新日期：2006-07-15 00:00:00

abstract：:An animal lectin purified from loach (Misgurnus anguillicaudatus) eggs induced release of cytotoxin from fresh bone marrow cells from mice, although the other lectins tested, wheat germ agglutinin, concanavalin A, and phytohemagglutinin did not. The cytotoxin released from bone marrow cells was a heat-labile protein w...

journal_title：Cancer research

authors： Okutomi T,Nakajima Y,Sakakibara F,Kawauchi H,Yamazaki M

更新日期：1987-01-01 00:00:00

abstract：:The murine monoclonal antibodies TURP-27 and HNK-1 have been shown to detect antigens which are heavily expressed by benign prostatic hyperplasia and carcinoma of the prostate. Western blot analysis of prostate extracts showed that monoclonal antibodies TURP-27 and HNK-1 bound glycoproteins with molecular weights of 1...

journal_title：Cancer research

authors： Lipford GB,Wright GL Jr

更新日期：1991-05-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) cells with somatic mutations in K-ras recruit to the tumor a variety of cell types (hereafter collectively termed "stromal cells") that can promote or inhibit tumorigenesis by mechanisms that have not been fully elucidated. Here, we postulated that stromal cells in the tumor microenv...

journal_title：Cancer research

authors： Zhong L,Roybal J,Chaerkady R,Zhang W,Choi K,Alvarez CA,Tran H,Creighton CJ,Yan S,Strieter RM,Pandey A,Kurie JM

更新日期：2008-09-01 00:00:00

abstract：:In the vascular system, circulating tumor cells interact with endothelial cells. Tumor-endothelial cross-talk transforms the intravascular milieu to a prothrombotic, proinflammatory, and cell-adhesive state called endothelial cell activation (ECA). In the present study, we analyze the potential of metastatic tumor-der...

journal_title：Cancer research

authors： Goerge T,Barg A,Schnaeker EM,Poppelmann B,Shpacovitch V,Rattenholl A,Maaser C,Luger TA,Steinhoff M,Schneider SW

更新日期：2006-08-01 00:00:00

abstract：:We have studied the effects of tamoxifen on the cell cycle kinetics of the endocrine-responsive MCF-7 human breast cancer cells. Tamoxifen inhibits proliferation of MCF-7 cells. The tritiated thymidine labeling index is markedly reduced by tamoxifen, indicating a reduction in the fraction of cells in S phase. Flow cyt...

journal_title：Cancer research

authors： Osborne CK,Boldt DH,Clark GM,Trent JM

更新日期：1983-08-01 00:00:00

abstract：:Two human B-cell lines carrying a 14;18 chromosome translocation [t(14;18)(q32;q21)], designated FL-218 and FL-318, were established from effusion cells of two Japanese patients manifesting the transformed histology of follicular lymphoma. The FL-218 and FL-318 cell lines were composed of cells in the hyperdiploid ran...

journal_title：Cancer research

authors： Amakawa R,Fukuhara S,Ohno H,Tanabe S,Horii M,Matsuyama F,Kato I,Kakita T,Nagauchi O

更新日期：1990-04-15 00:00:00

abstract：:Ependymomas and astrocytomas commonly have allelic losses of chromosome 22q, which suggests the presence of a glioma tumor suppressor gene on 22q. A candidate tumor suppressor gene on 22q is the neurofibromatosis 2 (NF2) gene since NF2 patients have an increased susceptibility to ependymomas and astrocytomas. Using si...

journal_title：Cancer research

authors： Rubio MP,Correa KM,Ramesh V,MacCollin MM,Jacoby LB,von Deimling A,Gusella JF,Louis DN

更新日期：1994-01-01 00:00:00

abstract：:Recent studies have shown that the Bcl-2 protein suppresses programmed cell death or apoptosis induced by a variety of stimuli including chemotherapeutic drugs. Because estrogen promotes the survival of estrogen-dependent breast cancer cells in vivo, we investigated whether estrogen might regulate levels of Bcl-2 gene...

journal_title：Cancer research

authors： Teixeira C,Reed JC,Pratt MA

更新日期：1995-09-01 00:00:00

abstract：:Fusarium moniliforme (FM) is a major fungal pathogen of corn and is involved with stalk rot disease. FM is widely spread throughout the world, including the United States. Most strains of FM produce several mycotoxins, the most prominent of which is called fumonisin. Recent epidemiological studies indicated that inges...

journal_title：Cancer research

authors： Huang C,Dickman M,Henderson G,Jones C

更新日期：1995-04-15 00:00:00

abstract：:The Notch ligand Dll4 has a recognized role during both physiologic and tumor angiogenesis, as it contributes to regulate Notch activity in endothelial cells (EC). The effects of Dll4 on Notch signaling in tumor cells expressing Notch receptors remain, however, largely unknown. Here, we report that escape of human T-c...

journal_title：Cancer research

authors： Indraccolo S,Minuzzo S,Masiero M,Pusceddu I,Persano L,Moserle L,Reboldi A,Favaro E,Mecarozzi M,Di Mario G,Screpanti I,Ponzoni M,Doglioni C,Amadori A

更新日期：2009-02-15 00:00:00

abstract：:CPT-11 [7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin ] is a prodrug that is converted to the active metabolite SN-38 by carboxylesterases. In its active form, the drug inhibits topoisomerase I, causes DNA damage, and induces apoptosis. Data in this study show metabolism of CPT-11 to SN-38 (7-ethyl...

journal_title：Cancer research

authors： Danks MK,Morton CL,Pawlik CA,Potter PM

更新日期：1998-01-01 00:00:00

abstract：:Cyclooxygenase-2-derived prostaglandin E(2) (PGE(2)) stimulates tumor cell growth and progression. However, the mechanisms by which PGE(2) increases tumor growth remain incompletely understood. In studies performed in non-small cell lung carcinoma (NSCLC) cells, we found that PGE(2) stimulates the expression of integr...

journal_title：Cancer research

authors： Zheng Y,Ritzenthaler JD,Sun X,Roman J,Han S

更新日期：2009-02-01 00:00:00

abstract：:The mammary carcinoma cell line MFM-223 is characterized by high androgen and low estrogen and progesterone receptor levels. With the dextran charcoal method, androgen binding was determined at 160 fmol/mg protein corresponding to approximately 100,000 binding sites per cell in whole cell binding assays. The estrogen ...

journal_title：Cancer research

authors： Hackenberg R,Lüttchens S,Hofmann J,Kunzmann R,Hölzel F,Schulz KD

更新日期：1991-10-15 00:00:00

abstract：:beta-Lapachone and certain of its derivatives directly bind and inhibit topoisomerase I (Topo I) DNA unwinding activity and form DNA-Topo I complexes, which are not resolvable by SDS-K+ assays. We show that beta-lapachone can induce apoptosis in certain cells, such as in human promyelocytic leukemia (HL-60) and human ...

journal_title：Cancer research

authors： Planchon SM,Wuerzberger S,Frydman B,Witiak DT,Hutson P,Church DR,Wilding G,Boothman DA

更新日期：1995-09-01 00:00:00

abstract：:Monoclonal antibodies (MABs) reactive with human renal cell carcinoma (RCC) were generated following immunization of mice with either RCC homogenates, RCC cell lines, or fetal kidney homogenates. The characteristics of four highly reactive immunoglobulin G1 MABs, designated UMVA-RCC-A6H, UMVA-RCC-A36, UMVA-RCC-C5H and...

journal_title：Cancer research

authors： Vessella RL,Moon TD,Chiou RK,Nowak JA,Arfman EW,Palme DF,Peterson GA,Lange PH

更新日期：1985-12-01 00:00:00

abstract：:Data are presented in support of the hypothesis that malignant tumors, containing abnormally permeable, degenerating cells, can be selectively detected using monoclonal antibodies to intracellular antigens. Biodistribution, imaging, and autoradiographic studies were performed in nude mice transplanted with four differ...

journal_title：Cancer research

authors： Epstein AL,Chen FM,Taylor CR

更新日期：1988-10-15 00:00:00

abstract：:Osteoprotegerin (OPG), a novel, secreted tumor necrosis factor receptor family member that inhibits osteoclast formation and activity was examined for its activity in a syngeneic tumor model of humoral hypercalcemia of malignancy. Normal mice bearing Colon-26 tumors develop increases in both parathyroid hormone-relate...

journal_title：Cancer research

authors： Capparelli C,Kostenuik PJ,Morony S,Starnes C,Weimann B,Van G,Scully S,Qi M,Lacey DL,Dunstan CR

更新日期：2000-02-15 00:00:00

abstract：:About two thirds of laryngeal cancers originate at the vocal cords. Early-stage detection of malignant vocal fold alterations, including a discrimination of premalignant lesions, represents a major challenge in laryngology as precancerous vocal fold lesions and small carcinomas are difficult to distinguish by means of...

journal_title：Cancer research

authors： Unger J,Lohscheller J,Reiter M,Eder K,Betz CS,Schuster M

更新日期：2015-01-01 00:00:00

abstract：:Dysregulation of Wnt/β-catenin signaling is frequently observed in human gastric cancer. Elucidation of the tumor immune microenvironment is essential for understanding tumorigenesis and for the development of immunotherapeutic strategies. However, it remains unclear how β-catenin signaling regulates the tumor immune ...

journal_title：Cancer research

authors： Ji L,Qian W,Gui L,Ji Z,Yin P,Lin GN,Wang Y,Ma B,Gao WQ

更新日期：2020-05-15 00:00:00

abstract：:Epidemiological and animal studies (reviewed in Y. I. Kim, J. Nutr. Biochemistry, 10: 66-88, 1999; J. B. Mason and T. Levesque, Oncology, 10: 1727-1743, 1996) suggest that dietary folate intake is inversely related to the risk of colorectal cancer. However, the optimal timing of folate intervention and mechanisms by w...

journal_title：Cancer research

authors： Song J,Sohn KJ,Medline A,Ash C,Gallinger S,Kim YI

更新日期：2000-06-15 00:00:00

abstract：:Loss of susceptibility to apoptosis signals is a crucial step in carcinogenesis. Therefore, sensitization of tumor cells to apoptosis is a promising therapeutic strategy. c-Jun-N-terminal-kinases (JNK) have been implicated in stress-induced apoptosis, but may also contribute to survival signaling. Here we show that CD...

journal_title：Cancer research

authors： Kuntzen C,Sonuc N,De Toni EN,Opelz C,Mucha SR,Gerbes AL,Eichhorst ST

更新日期：2005-08-01 00:00:00

abstract：:Incubation of adherent human breast epithelial HBL100 cells with epidermal growth factor (EGF) decreased [3H]dexamethasone binding by 35% with no effect on affinity. Maximal inhibition was obtained at 3 nM EGF and the 50% effective dose was 0.2 nM EGF. Decreased dexamethasone binding induced by 3 nM EGF was maximal by...

journal_title：Cancer research

authors： Rao KV,Williams RE,Fox CF

更新日期：1987-11-15 00:00:00

abstract：:Clinical and pathological studies of cutaneous T-cell lymphomas (CTCL) reveal variations in tumor cell morphology and surface membrane phenotype that are of diagnostic and prognostic importance. Our study investigates blastic transformation and surface antigen change on CTCL cells in vitro under the influence of tumor...

journal_title：Cancer research

authors： Kadin ME,Nasu K,Sako D,Su IJ

更新日期：1984-08-01 00:00:00

abstract：:This paper describes the reactions of purine nucleosides and nucleic acids with 2,3-epoxy-4-hydroxynonanal. 2,3-Epoxy-4-hydroxynonanal was produced with tert-butyl hydroperoxide by epoxidation of trans-4-hydroxy-2-nonenal, a lipid peroxidation product. The epoxy aldehyde exists as a pair of diastereomers, I and II. Be...

journal_title：Cancer research

authors： Sodum RS,Chung FL

更新日期：1991-01-01 00:00:00