A noninvasive procedure for early-stage discrimination of malignant and precancerous vocal fold lesions based on laryngeal dynamics analysis.

abstract：:A single application of various hepatocarcinogens to rats results in the formation of islands of enzyme-deficient liver cells, which are mainly irreversible and very probably represent the first cellular stage involved in the process of liver cancer formation. Comparison of the island-size distributions obtained for d...

journal_title：Cancer research

authors： Scherer E,Emmelot P

更新日期：1976-07-01 00:00:00

abstract：:Continuous cell lines are widely used, but can result in invalid, irreproducible research data. Cell line misidentification is a common problem that can be detected by authentication testing; however, misidentified cell lines continue to be used in publications. Here we explore the impact of one misidentified cell lin...

journal_title：Cancer research

authors： Vaughan L,Glänzel W,Korch C,Capes-Davis A

更新日期：2017-06-01 00:00:00

abstract：:Between 5% and 10% of women who survive a first primary breast cancer will subsequently develop a second primary cancer in the contralateral breast. The Women's Environment, Cancer, and Radiation Epidemiology Study was designed to identify genetic and environmental determinants of contralateral breast cancer (CBC). In...

journal_title：Cancer research

authors： Concannon P,Haile RW,Børresen-Dale AL,Rosenstein BS,Gatti RA,Teraoka SN,Diep TA,Jansen L,Atencio DP,Langholz B,Capanu M,Liang X,Begg CB,Thomas DC,Bernstein L,Olsen JH,Malone KE,Lynch CF,Anton-Culver H,Bernstein JL,

更新日期：2008-08-15 00:00:00

abstract：:Glioblastoma multiforme (GBM) is characterized by a pathogenic vasculature that drives aggressive local invasion. Recent work suggests that GBM cells recruit bone marrow-derived progenitor cells (BMDC) to facilitate recurrence after radiotherapy, but how this may be achieved is unclear. In this study, we established t...

journal_title：Cancer research

authors： Burrell K,Singh S,Jalali S,Hill RP,Zadeh G

更新日期：2014-07-15 00:00:00

abstract：:Dicer1 functions as a tumor suppressor in mouse models. In humans, somatic mutations are associated with many cancers in adults, and patients with DICER1 syndrome with DICER1 germline mutations are susceptible to childhood cancers. Dicer is phosphorylated by the ERK-MAP kinase pathway and because this pathway is activ...

journal_title：Cancer research

authors： Aryal NK,Pant V,Wasylishen AR,Rimel BJ,Baseler L,El-Naggar AK,Mutch DG,Goodfellow PJ,Arur S,Lozano G

更新日期：2019-05-15 00:00:00

abstract：:Three Burkitt's lymphoma cell lines were studied for their response to cis-diamminedichloroplatinum(II) (cis-DDP) and L-phenylalanine mustard (L-PAM) with the objective of relating cytotoxicity to DNA cross-linking in human cells. Cytotoxicity was measured by cell proliferation and colony formation assays. DNA interst...

journal_title：Cancer research

authors： Ducore JM,Erickson LC,Zwelling LA,Laurent G,Kohn KW

更新日期：1982-03-01 00:00:00

abstract：:The cyclin-dependent kinase (Cdk)-associated protein phosphatase (KAP) is a human dual specificity protein phosphatase that dephosphorylates Cdk2 on threonine 160 in a cyclin-dependent manner. To investigate whether mutations of this enzyme occur in hepatocellular carcinoma (HCC), KAP mRNA was analyzed by reverse tran...

journal_title：Cancer research

authors： Yeh CT,Lu SC,Chen TC,Peng CY,Liaw YF

更新日期：2000-09-01 00:00:00

abstract：:TP53 gene mutation is associated with poor prognosis in breast cancer, but additional biomarkers that can further refine the impact of the p53 pathway are needed to achieve clinical utility. In this study, we evaluated a role for the HDMX-S/FL ratio as one such biomarker, based on its association with other suppressor...

journal_title：Cancer research

authors： Grawenda AM,Møller EK,Lam S,Repapi E,Teunisse AF,Alnæs GI,Børresen-Dale AL,Kristensen VN,Goding CR,Jochemsen AG,Edvardsen H,Bond GL

更新日期：2015-02-15 00:00:00

abstract：:Antisense DNA has shown an ability to target specific oncogene transcripts and inhibit their expression in cells, but the degree to which sustained treatment can suppress total levels of an oncogenic product and alter tumorigenesis in vivo remains to be determined. In this study, NIH-3T3 cells transformed by the activ...

journal_title：Cancer research

authors： Gray GD,Hernandez OM,Hebel D,Root M,Pow-Sang JM,Wickstrom E

更新日期：1993-02-01 00:00:00

abstract：:Cancer immunotherapy may become a major treatment backbone in many cancers over the next decade. There are numerous immune cell types found in cancers and many components of an immune reaction to cancer. Thus, the tumor has many strategies to evade an immune response. It has been proposed that four different types of ...

journal_title：Cancer research

authors： Teng MW,Ngiow SF,Ribas A,Smyth MJ

更新日期：2015-06-01 00:00:00

abstract：:Cells lacking the tumor suppressor gene LKB1/STK11 alter their metabolism to match the demands of accelerated growth, leaving them highly vulnerable to stress. However, targeted therapy for LKB1-deficient cancers has yet to be reported. In both Kras/p53/Lkb1 cell lines and a genetically engineered mouse model of Kras/...

journal_title：Cancer research

authors： Liu Y,Li Y,Wang X,Liu F,Gao P,Quinn MM,Li F,Merlino AA,Benes C,Liu Q,Gray NS,Wong KK

更新日期：2017-09-15 00:00:00

abstract：:A novel metastasis-associated gene was identified with a differential display system in murine carcinoma cells showing a high rate of metastasis to the liver. A human homologue was also identified using a PCR-based strategy. The protein coded by this gene was named cystatin-like metastasis-associated protein (CMAP) an...

journal_title：Cancer research

authors： Morita M,Yoshiuchi N,Arakawa H,Nishimura S

更新日期：1999-01-01 00:00:00

abstract：:The development of myeloid and lymphoid neoplasms related to overexpression of FGFR1 kinases as a result of chromosome translocations depends on the promotion of a stem cell phenotype, suppression of terminal differentiation, and resistance to apoptosis. These phenotypes are related to the stem cell leukemia/lymphoma ...

journal_title：Cancer research

authors： Hu T,Chong Y,Lu S,Wang R,Qin H,Silva J,Kitamura E,Chang CS,Hawthorn L,Cowell JK

更新日期：2018-07-01 00:00:00

abstract：:Creation of a nuclear export signal (NES) motif and loss of tryptophans (W) 288 and 290 (or 290 only) at the COOH terminus of nucleophosmin (NPM) are both crucial for NPM aberrant cytoplasmic accumulation in acute myelogenous leukemia (AML) carrying NPM1 mutations. Hereby, we clarify how these COOH-terminal alteration...

journal_title：Cancer research

authors： Bolli N,Nicoletti I,De Marco MF,Bigerna B,Pucciarini A,Mannucci R,Martelli MP,Liso A,Mecucci C,Fabbiano F,Martelli MF,Henderson BR,Falini B

更新日期：2007-07-01 00:00:00

abstract：:A complex of polyinosinic-polycytidylic acid [poly(I) x poly(C)] and cationic liposome (LIC) inhibited the growth of many tumor cell lines at low concentration in vitro, but poly(I) x poly(C) alone had no such antiproliferative effect. The IC50 values of LIC against the tumor cells ranged from 0.1 to 1000 ng/ml. LIC h...

journal_title：Cancer research

authors： Hirabayashi K,Yano J,Inoue T,Yamaguchi T,Tanigawara K,Smyth GE,Ishiyama K,Ohgi T,Kimura K,Irimura T

更新日期：1999-09-01 00:00:00

abstract：:Although adoptive transfer of cytotoxic T lymphocytes (CTL) offer a promising cancer therapeutic direction, the generation of antigen-specific CTL from patients has faced difficulty in efficient expansion in ex vivo culture. To resolve this issue, several groups have proposed that induced pluripotent stem cell technol...

journal_title：Cancer research

authors： Maeda T,Nagano S,Ichise H,Kataoka K,Yamada D,Ogawa S,Koseki H,Kitawaki T,Kadowaki N,Takaori-Kondo A,Masuda K,Kawamoto H

更新日期：2016-12-01 00:00:00

abstract：:Phorbol diester (PDE) tumor promoters have differing effects on normal and neoplastic hematopoietic cells in vitro. The effects of PDEs on cells are apparently mediated by specific cellular receptors for these ligands. The purpose of this study was to determine if the different phenotypic responses of cells of differe...

journal_title：Cancer research

authors： Weinberg JB,Misukonis MA,Goodwin BJ

更新日期：1984-03-01 00:00:00

abstract：:The cyclin dependent kinase (CDK) inhibitors p15, p16, p21, and p27 are frequently deleted, silenced, or downregulated in many malignancies. Inactivation of CDK inhibitors predisposes mice to tumor development, showing that these genes function as tumor suppressors. Here, we describe high-throughput murine leukemia vi...

journal_title：Cancer research

authors： Kool J,Uren AG,Martins CP,Sie D,de Ridder J,Turner G,van Uitert M,Matentzoglu K,Lagcher W,Krimpenfort P,Gadiot J,Pritchard C,Lenz J,Lund AH,Jonkers J,Rogers J,Adams DJ,Wessels L,Berns A,van Lohuizen M

更新日期：2010-01-15 00:00:00

abstract：:Potent luteinizing hormone-releasing hormone analogues are known to cause regression of hormone-dependent mammary tumors. We have observed that high and long-lasting serum levels of a potent luteinizing hormone-releasing hormone analogue [desglycyl10-(D-leucyl6) luteinizing hormone-releasing hormone ethylamide, leupro...

journal_title：Cancer research

authors： Okada H,Sakura Y,Kawaji H,Yashiki T,Mima H

更新日期：1983-04-01 00:00:00

abstract：:Serially cultivated keratinocytes of human and rat epidermis and esophagus were compared with respect to their sensitivity to toxic effects of 3-methylcholanthrene and ability to metabolize benzo(a)pyrene. 3-Methylcholanthrene was highly toxic to the human keratinocytes and to early-passage rat epidermal keratinocytes...

journal_title：Cancer research

authors： Heimann R,Rice RH

更新日期：1983-10-01 00:00:00

abstract：:In this paper, we describe the production of a panel of monoclonal antibodies which define antigens which distinguish between hepatocytes and oval cells. These antibodies were obtained from hybridomas constructed from the spleens of mice immunized by a novel protocol designed to suppress response to unwanted or immuno...

journal_title：Cancer research

authors： Hixson DC,Allison JP

更新日期：1985-08-01 00:00:00

abstract：:Transforming growth factor betas (TGF-beta) play a dual role in carcinogenesis, functioning as tumor suppressors early in the process, and then switching to act as prometastatic factors in late-stage disease. We have previously shown that high molecular weight TGF-beta antagonists can suppress metastasis without the p...

journal_title：Cancer research

authors： Nam JS,Suchar AM,Kang MJ,Stuelten CH,Tang B,Michalowska AM,Fisher LW,Fedarko NS,Jain A,Pinkas J,Lonning S,Wakefield LM

更新日期：2006-06-15 00:00:00

abstract：:In the epidermis, p53 plays an important role in UV-B protection that led us to examine the role, if any, that p63, a p53 homologue highly expressed in the basal layer of the epidermis, might play in the epidermal UV-B response. One p63 isoform, deltaNp63alpha, decreased dramatically in normal keratinocytes or newborn...

journal_title：Cancer research

authors： Liefer KM,Koster MI,Wang XJ,Yang A,McKeon F,Roop DR

更新日期：2000-08-01 00:00:00

abstract：:The SMAD4 (DPC4) gene was initially isolated as a candidate tumor suppressor from the convergent site of homozygous deletions on 18q in a panel of pancreatic carcinoma cell lines. It encodes a common cytoplasmic signaling molecule shared by the transforming growth factor-beta, activin, and bone morphogenic pathways. W...

journal_title：Cancer research

authors： Takaku K,Miyoshi H,Matsunaga A,Oshima M,Sasaki N,Taketo MM

更新日期：1999-12-15 00:00:00

abstract：:Cancer cells contain multiple genetic and epigenetic abnormalities. Despite this complexity, their growth and survival can often be impaired by the inactivation of a single oncogene. This phenomenon, called "oncogene addiction," provides a rationale for molecular targeted therapy. The efficacy of this strategy require...

journal_title：Cancer research

authors： Weinstein IB,Joe A

更新日期：2008-05-01 00:00:00

abstract：:In the present study, we examined the role of prolactin and glucocorticoids in regulating bcl-x transcription in mammary epithelial cells. We report that dexamethasone, but not prolactin, induced native bcl-x gene expression in a dose-dependent manner in HC11 cells and enhanced serum-starved HC11 cell survival. This e...

journal_title：Cancer research

authors： Schorr K,Furth PA

更新日期：2000-11-01 00:00:00

abstract：:Bik was initially identified as a BH3-domain-only protein that interacts with E1B 19K. Although systemically administered wild-type Bik significantly inhibited tumor growth and metastasis in an orthotopic nude mouse model, the proapoptotic potency of Bik can be modulated by posttranslational phosphorylation. Here, we ...

journal_title：Cancer research

authors： Li YM,Wen Y,Zhou BP,Kuo HP,Ding Q,Hung MC

更新日期：2003-11-15 00:00:00

abstract：:CD4+ T-cell responses against human tumor antigens are a potentially critical component of the antitumor immune response. Molecular methods have been devised for rapidly identifying MHC class II-restricted tumor antigens and elucidating the recognized epitopes. We describe here the identification of neo-poly(A) polyme...

journal_title：Cancer research

authors： Topalian SL,Gonzales MI,Ward Y,Wang X,Wang RF

更新日期：2002-10-01 00:00:00

abstract：:Tumor relapses remain a serious problem after allogeneic stem cell transplantation (alloSCT), despite the long-term persistence of minor histocompatibility antigen (MiHA)-specific memory CD8(+) T cells specific for the tumor. We hypothesized that these memory T cells may lose their function over time in transplanted p...

journal_title：Cancer research

authors： Norde WJ,Maas F,Hobo W,Korman A,Quigley M,Kester MG,Hebeda K,Falkenburg JH,Schaap N,de Witte TM,van der Voort R,Dolstra H

更新日期：2011-08-01 00:00:00

abstract：:TuAg.1 is a tumor-associated membrane glycoprotein first identified in rat hepatocellular carcinoma by monoclonal antibodies (mAbs) 324.5 and 324.9. This oncofetal antigen is also expressed by hepatocytes in cell culture but not normal adult hepatocytes in vivo. Affinity chromatography and preparative continuous eluti...

journal_title：Cancer research

authors： Lim YP,Fowler LC,Hixson DC,Wehbe T,Thompson NL

更新日期：1996-09-01 00:00:00