Interaction between p53 mutation and a somatic HDMX biomarker better defines metastatic potential in breast cancer.

abstract：:Inherent and acquired therapeutic resistance in breast cancer remains a major clinical challenge. In human breast cancer samples, overexpression of the oncogenic transcription factor FoxM1 has been suggested to be a marker of poor prognosis. In this study, we report that FoxM1 overexpression confers resistance to the ...

journal_title：Cancer research

authors： Carr JR,Park HJ,Wang Z,Kiefer MM,Raychaudhuri P

更新日期：2010-06-15 00:00:00

abstract：:We have searched for the presence of genetic alterations in serum DNA obtained from 44 colorectal cancer patients. Microsatellite analysis using highly polymorphic markers revealed loss of heterozygosity and/or microsatellite instability in 35 of 44 (80%) primary tumors. No alterations were detected in the paired seru...

journal_title：Cancer research

authors： Hibi K,Robinson CR,Booker S,Wu L,Hamilton SR,Sidransky D,Jen J

更新日期：1998-04-01 00:00:00

abstract：:Hemodynamic (blood flow rate, hematocrit, hemoglobin concentration, and blood viscosity) and pH responses to glucose (6 g/kg, i.p.) injections were studied in ten Walker 256 carcinoma tumors (0.5-1.8 g) grown in the "tissue-isolated" tumor preparation. A maximum blood flow reduction of 57 +/- 19% (SD) occurred concurr...

journal_title：Cancer research

authors： Sevick EM,Jain RK

更新日期：1988-03-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) plays critical roles in many biological processes and in tumorigenesis. Here, we show that two mutated EGFRs found in lung and other malignancies, EGFR-G719S and EGFR-L858R, could transform Ba/F3 cells to interleukin-3 (IL-3)-independent growth, in a ligand-independent manner, a...

journal_title：Cancer research

authors： Jiang J,Greulich H,Jänne PA,Sellers WR,Meyerson M,Griffin JD

更新日期：2005-10-01 00:00:00

abstract：:Standardized and reproducible preclinical models that recapitulate the dynamics of prostate cancer are urgently needed. We established a bank of transplantable patient-derived prostate cancer xenografts that capture the biologic and molecular heterogeneity currently confounding prognostication and therapy development....

journal_title：Cancer research

authors： Lin D,Wyatt AW,Xue H,Wang Y,Dong X,Haegert A,Wu R,Brahmbhatt S,Mo F,Jong L,Bell RH,Anderson S,Hurtado-Coll A,Fazli L,Sharma M,Beltran H,Rubin M,Cox M,Gout PW,Morris J,Goldenberg L,Volik SV,Gleave ME,Collins

更新日期：2014-02-15 00:00:00

abstract：:OX40 is a potent costimulatory receptor that can potentiate T-cell receptor signaling on the surface of T lymphocytes, leading to their activation by a specifically recognized antigen. In particular, OX40 engagement by ligands present on dendritic cells dramatically increases the proliferation, effector function, and ...

journal_title：Cancer research

authors： Curti BD,Kovacsovics-Bankowski M,Morris N,Walker E,Chisholm L,Floyd K,Walker J,Gonzalez I,Meeuwsen T,Fox BA,Moudgil T,Miller W,Haley D,Coffey T,Fisher B,Delanty-Miller L,Rymarchyk N,Kelly T,Crocenzi T,Bernstein E,

更新日期：2013-12-15 00:00:00

abstract：:The fate of circulating tumor cells is an important determinant of their ability to form distant metastasis. Here, we demonstrate the use of in vivo flow cytometry as a powerful new method for detecting quantitatively circulating cancer cells. We specifically examine the circulation kinetics of two prostate cancer cel...

journal_title：Cancer research

authors： Georgakoudi I,Solban N,Novak J,Rice WL,Wei X,Hasan T,Lin CP

更新日期：2004-08-01 00:00:00

abstract：:After 10 years of clinical trials in patients with advanced cancer, monoclonal antibodies (mAbs) against cell surface antigens have not lived up to their initial promise. One such cell surface antigen is the ganglioside GD2. GD2 is richly expressed at the cell surfaces of human neuroblastomas, sarcomas, and melanomas....

journal_title：Cancer research

authors： Zhang H,Zhang S,Cheung NK,Ragupathi G,Livingston PO

更新日期：1998-07-01 00:00:00

abstract：:Treatment of exponentially growing 9L monolayer cells with graded concentrations of methotrexate or 5-fluorouracil (5-FUra) resulted in approximately 95% cell kill, corresponding to the percentage of cells in this system labeled by autoradiography (98%). Additional cell kill could be obtained if 5-FUra was administere...

journal_title：Cancer research

authors： Weizsaecker M,Hoshino T,Deen DF,Kobayashi S

更新日期：1981-10-01 00:00:00

abstract：:A case-control study was undertaken to evaluate the roles of the hepatitis B virus (HBV), cigarette smoking, and alcohol use in the etiology of hepatocellular carcinoma (HCC). A major purpose of the study was to evaluate the effect of cigarette smoking on HCC among hepatitis B surface antigen (HBsAg)-negative persons,...

journal_title：Cancer research

authors： Austin H,Delzell E,Grufferman S,Levine R,Morrison AS,Stolley PD,Cole P

更新日期：1986-02-01 00:00:00

abstract：:Our previous study showed that spleen cells from BALB/c mice bearing RL male 1 lymphoma inhibited the growth of RL male 1 lymphoma by the Winn-type adoptive transfer assay. Although this antitumor activity was mediated by the T-cell subset manifesting the surface phenotype of cytotoxic T-lymphocytes (CTLs), this antit...

journal_title：Cancer research

authors： Fuyama S,Yamamoto H,Fujii Y,Arai S

更新日期：1986-11-01 00:00:00

abstract：:Increased sialyltransferase (ST) activity promotes cancer cell metastasis, and overexpression of cell surface sialic acid correlates with poor prognosis in cancer patients. To seek therapies targeting metastasis for cancer treatment, we developed a novel ST inhibitor, Lith-O-Asp, and investigated its antimetastatic an...

journal_title：Cancer research

authors： Chen JY,Tang YA,Huang SM,Juan HF,Wu LW,Sun YC,Wang SC,Wu KW,Balraj G,Chang TT,Li WS,Cheng HC,Wang YC

更新日期：2011-01-15 00:00:00

abstract：:The human checkpoint kinase 2 (Chk2) plays a central role in regulation of the cellular response to DNA damage, resulting in cell cycle arrest, DNA repair, or apoptosis depending on severity of DNA damage and the cellular context. Chk2 inhibitors are being developed as sensitizers for chemotherapeutic agents. In contr...

journal_title：Cancer research

authors： Chen CR,Wang W,Rogoff HA,Li X,Mang W,Li CJ

更新日期：2005-07-15 00:00:00

abstract：:Two human breast carcinoma cell lines, EP and MW, were established in culture from malignant pleural effusions. In addition to producing tumors in antithymocyte serum-immunosuppressed mice, both cell lines showed epithelial characteristics and anchorage-independent growth in soft agar. EP and MW differed in morphology...

journal_title：Cancer research

authors： Chu MY,Hagerty MG,Wiemann MC,Tibbetts LM,Sato S,Cummings FJ,Bogaars HA,Leduc EH,Calabresi P

更新日期：1985-03-01 00:00:00

abstract：:Chromosomal passenger complex (CPC) has been demonstrated to be a potential target of cancer therapy by inhibiting Aurora B or survivin in different types of cancer including neuroblastoma. However, chemical inhibition of either Aurora B or survivin does not target CPC specifically due to off-target effects or CPC-ind...

journal_title：Cancer research

authors： Sun M,Veschi V,Bagchi S,Xu M,Mendoza A,Liu Z,Thiele CJ

更新日期：2019-10-01 00:00:00

abstract：:Rapid or accelerated tumor cell repopulation after significant tumor cell killing induced by various cytotoxic agents often compromises the expected therapeutic benefit of such tumor responses. Here, we discuss the concept that tumor cell repopulation after certain cytotoxic therapies, using vascular disrupting agents...

journal_title：Cancer research

authors： Shaked Y,Kerbel RS

更新日期：2007-08-01 00:00:00

abstract：:The high uptake and prolonged renal retention of monoclonal antibody fragments that are conjugated with radiometal chelates precludes their routine clinical use due to high background counts, which may hinder detection of nearby lesions and/or cause renal radiotoxicity. We report on the potential use of Lys as a pharm...

journal_title：Cancer research

authors： DePalatis LR,Frazier KA,Cheng RC,Kotite NJ

更新日期：1995-11-15 00:00:00

abstract：:Previously, we had reported that a single i.p. injection of 15 mg cyclophosphamide (CY) per kg cured most mice bearing large MOPC-315 tumors (20 to 25 mm; Day 12 to Day 16 tumors) but rarely cured mice bearing nonpalpable tumors (Day 4 tumors). Also, mice that were not cured if treated with CY, 15 mg/kg, when they had...

journal_title：Cancer research

authors： Mokyr MB,Hengst JC,Dray S

更新日期：1982-03-01 00:00:00

abstract：:The discovery of oncogenic driver mutations and the subsequent developments in targeted therapies have led to improved outcomes for subsets of lung cancer patients. The identification of additional oncogenic and drug-sensitive alterations may similarly lead to new therapeutic approaches for lung cancer. We identify an...

journal_title：Cancer research

authors： Tanizaki J,Ercan D,Capelletti M,Dodge M,Xu C,Bahcall M,Tricker EM,Butaney M,Calles A,Sholl LM,Hammerman PS,Oxnard GR,Wong KK,Jänne PA

更新日期：2015-08-01 00:00:00

abstract：:Studies in animals and humans show that blockade of nerve growth factor (NGF) attenuates both malignant and nonmalignant skeletal pain. While reduction of pain is important, a largely unanswered question is what other benefits NGF blockade might confer in patients with bone cancer. Using a mouse graft model of bone sa...

journal_title：Cancer research

authors： McCaffrey G,Thompson ML,Majuta L,Fealk MN,Chartier S,Longo G,Mantyh PW

更新日期：2014-12-01 00:00:00

abstract：:In 10 separate experiments, mice with established chemically induced or UV light-induced skin papillomas were treated continuously with green tea in the drinking water or with i.p. injections of a green tea polyphenol fraction or (-)-epigallocatechin gallate three times a week for 4-10 weeks. Partial tumor regression ...

journal_title：Cancer research

authors： Wang ZY,Huang MT,Ho CT,Chang R,Ma W,Ferraro T,Reuhl KR,Yang CS,Conney AH

更新日期：1992-12-01 00:00:00

abstract：:Estradiol and progesterone receptors were assayed in tumors from 79 patients with primary colorectal and 56 patients with stomach adenocarcinomas. Eighteen of 79 colorectal cancers contained estradiol receptor, while 34 specimens were positive for progesterone receptor. In stomach cancer, the positive samples were 8 f...

journal_title：Cancer research

authors： Sica V,Nola E,Contieri E,Bova R,Masucci MT,Medici N,Petrillo A,Weisz A,Molinari AM,Puca GA

更新日期：1984-10-01 00:00:00

abstract：:N-4-Hydroxyphenylretinamide (fenretinide or 4HPR), a derivative of retinoic acid, has been demonstrated to decrease the development of prostate cancer in a rat carcinogenesis model. This study was undertaken to determine if 4HPR is an effective agent for the treatment of established prostate cancer. In vitro, 4HPR was...

journal_title：Cancer research

authors： Pienta KJ,Nguyen NM,Lehr JE

更新日期：1993-01-15 00:00:00

abstract：:Kinase inhibitors are used widely to treat various cancers, but adaptive reprogramming of kinase cascades and activation of feedback loop mechanisms often contribute to therapeutic resistance. Determining comprehensive, accurate maps of kinase circuits may therefore help elucidate mechanisms of response and resistance...

journal_title：Cancer research

authors： Olow A,Chen Z,Niedner RH,Wolf DM,Yau C,Pankov A,Lee EP,Brown-Swigart L,van 't Veer LJ,Coppé JP

更新日期：2016-04-01 00:00:00

abstract：:We have constructed a DNA plasmid encoding the full length complementary DNA for human carcinoembryonic antigen (CEA) driven by the cytomegalovirus early promoter/enhancer (plasmid DNA encoding human CEA) and demonstrated that this plasmid can function as a polynucleotide vaccine. This polynucleotide vaccine induced h...

journal_title：Cancer research

authors： Conry RM,LoBuglio AF,Kantor J,Schlom J,Loechel F,Moore SE,Sumerel LA,Barlow DL,Abrams S,Curiel DT

更新日期：1994-03-01 00:00:00

abstract：:Development of novel approaches for quantitative analysis of gene expression in intact tumor cells should provide new means for cancer detection and for studying the response of cancer cells to biological and therapeutic reagents. We developed procedures for detecting the levels of expression of multiple genes in fixe...

journal_title：Cancer research

authors： Peng XH,Cao ZH,Xia JT,Carlson GW,Lewis MM,Wood WC,Yang L

更新日期：2005-03-01 00:00:00

abstract：:Nucleoside kinases from several species are investigated as suicide genes for treatment of malignant tumors by combined gene/chemotherapy. In the present study, we have investigated a novel strategy where nucleoside kinase proteins are directly delivered to cells without delivery of genetic material. We used a mix of ...

journal_title：Cancer research

authors： Zheng X,Lundberg M,Karlsson A,Johansson M

更新日期：2003-10-15 00:00:00

abstract：:Twenty-four patients suspected of having ovarian carcinoma received i.v. injection with a combination of radiolabeled intact IgG (1 mg) and F(ab')2 fragments (1 mg) of the chimeric monoclonal antibody MOv18, each form labeled with 1.85 MBq 131I or 125I. Laparotomy was performed either 2 or 6 days after injection, and ...

journal_title：Cancer research

authors： Buist MR,Kenemans P,den Hollander W,Vermorken JB,Molthoff CJ,Burger CW,Helmerhorst TJ,Baak JP,Roos JC

更新日期：1993-11-15 00:00:00

abstract：:5,6-Dimethylxanthenone-4-acetic acid (DMXAA) and combretastatin A4 phosphate (CA-4-P) markedly inhibit tumor blood flow in mice and are both currently in clinical trial. One of the challenges in clinical evaluation of antivascular agents is the monitoring of tumor blood flow inhibition in individual patients. This stu...

journal_title：Cancer research

authors： Siim BG,Laux WT,Rutland MD,Palmer BN,Wilson WR

更新日期：2000-08-15 00:00:00

abstract：:Mice fed a diet containing 0.3 or 0.03% triethanolamine developed malignant tumors. Females showed a high incidence of tumors in lymphoid tissues, while this type was absent in males. Tumors in other tissues were produced at a considerable rate in both sexes, but no hepatoma was found. Triethanolamine was not mutageni...

journal_title：Cancer research

authors： Hoshino H,Tanooka H

更新日期：1978-11-01 00:00:00