Abstract：
:Estradiol and progesterone receptors were assayed in tumors from 79 patients with primary colorectal and 56 patients with stomach adenocarcinomas. Eighteen of 79 colorectal cancers contained estradiol receptor, while 34 specimens were positive for progesterone receptor. In stomach cancer, the positive samples were 8 for estradiol and 14 for progesterone receptors. In both types of tumors, the Kd was in the range of 10(-10) M for estradiol and 10(-9) M for progesterone receptor, respectively. In colorectal adenocarcinomas, the presence of progesterone receptor seems to be partially correlated to the presence of estradiol receptor while, in stomach tumors, this correlation is lost. The positivity of at least one receptor in colorectal cancers is higher in the female sex. The contrary occurs for stomach cancer. Sucrose gradient centrifugation showed that cytoplasmic estradiol receptor of stomach cancer sedimented at 8S or 4 to 5S at low ionic strength. The isoelectric point of stomach cancer estradiol receptor is 6.5.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Sica V,Nola E,Contieri E,Bova R,Masucci MT,Medici N,Petrillo A,Weisz A,Molinari AM,Puca GAsubject
Has Abstractpub_date
1984-10-01 00:00:00pages
4670-4issue
10eissn
0008-5472issn
1538-7445journal_volume
44pub_type
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