Kinetics of induction and growth of enzyme-deficient islands involved in hepatocarcinogenesis.

abstract：:We are developing a noninvasive approach for targeting imaging and therapeutic radionuclides to prostate cancer. Our method, Enzyme-Mediated Cancer Imaging and Therapy (EMCIT), aims to use enzyme-dependent, site-specific, in vivo precipitation of a radioactive molecule within the extracellular space of solid tumors. A...

journal_title：Cancer research

authors： Pospisil P,Wang K,Al Aowad AF,Iyer LK,Adelstein SJ,Kassis AI

更新日期：2007-03-01 00:00:00

abstract：:Studies of V79-171 cells were undertaken to determine what extracellular or intracellular derivative of the drug WR-2721 is associated with radioprotection. The effect of preincubation at 23 +/- 1 degree C with WR-2721, and with derivatives of WR-2721 produced in medium containing alkaline phosphatase, upon survival o...

journal_title：Cancer research

authors： Smoluk GD,Fahey RC,Calabro-Jones PM,Aguilera JA,Ward JF

更新日期：1988-07-01 00:00:00

abstract：:In the vascular system, circulating tumor cells interact with endothelial cells. Tumor-endothelial cross-talk transforms the intravascular milieu to a prothrombotic, proinflammatory, and cell-adhesive state called endothelial cell activation (ECA). In the present study, we analyze the potential of metastatic tumor-der...

journal_title：Cancer research

authors： Goerge T,Barg A,Schnaeker EM,Poppelmann B,Shpacovitch V,Rattenholl A,Maaser C,Luger TA,Steinhoff M,Schneider SW

更新日期：2006-08-01 00:00:00

abstract：:The human papillomavirus (HPV) 16 E7 oncoprotein has been reported previously to stimulate DNA damage and to activate host cell DNA damage checkpoints. How HPV-16 E7 maintains proliferation despite activated DNA damage checkpoints is incompletely understood. Here, we provide evidence that cells expressing the HPV-16 E...

journal_title：Cancer research

authors： Spardy N,Covella K,Cha E,Hoskins EE,Wells SI,Duensing A,Duensing S

更新日期：2009-09-01 00:00:00

abstract：:The Nijmegen Breakage Syndrome (NBS) is a rare autosomal recessive disorder associated with immune deficiency, chromosome fragility, and increased susceptibility to lymphoid malignancies. The aim of the present study was to elucidate the potential role of the gene mutated in NBS (NBS1) in the pathogenesis and disease ...

journal_title：Cancer research

authors： Varon R,Reis A,Henze G,von Einsiedel HG,Sperling K,Seeger K

更新日期：2001-05-01 00:00:00

abstract：:The single-dose toxicokinetics of N-nitrosomethyl(2-hydroxyethyl)amine (NMHA) has been characterized in 8-week-old Fischer 344 rats by analysis using high-performance liquid chromatography of serial blood samples. An i.v. bolus dose of 0.6 mumol/kg to male rats revealed biphasic first-order elimination with a terminal...

journal_title：Cancer research

authors： Streeter AJ,Nims RW,Hrabie JA,Heur YH,Keefer LK

更新日期：1989-04-01 00:00:00

abstract：:Epithelial ovarian cancer comprises three major histological subtypes (serous, mucinous, and endometrioid), and it is becoming clear that the developmental pathways for these subtypes are fundamentally different. In particular, endometrioid ovarian cancers probably arise by the malignant transformation of ectopic endo...

journal_title：Cancer research

authors： Obata K,Morland SJ,Watson RH,Hitchcock A,Chenevix-Trench G,Thomas EJ,Campbell IG

更新日期：1998-05-15 00:00:00

abstract：:The phospholipids of both mitochondrial and microsomal membranes from normal liver, host liver, and Morris hepatoma 7777 were isolated, separated, and quantitated. The total as well as the individual fatty acid concentrations and compositions were determined. The total phosphlipids isolated from tumor mitochondria wer...

journal_title：Cancer research

authors： Reitz RC,Thompson JA,Morris HP

更新日期：1977-02-01 00:00:00

abstract：:This paper describes the use of the bromodeoxyuridine/propidium iodide method to assess the effects of bioactive and cytotoxic agents on the kinetic characteristics of acute myelogenous leukemia cells. By careful selection of gates, the following parameters can be measured simultaneously using only 50,000 cells: the p...

journal_title：Cancer research

authors： Preisler HD,Gopal V,Banavali SD,Finke D,Bokari SA

更新日期：1992-08-01 00:00:00

abstract：:Our recent studies have shown that the FoxM1B transcription factor is overexpressed in human glioma tissues and that the level of its expression correlates directly with glioma grade. However, whether FoxM1B plays a role in the early development of glioma (i.e., in transformation) is unknown. In this study, we found t...

journal_title：Cancer research

authors： Dai B,Pieper RO,Li D,Wei P,Liu M,Woo SY,Aldape KD,Sawaya R,Xie K,Huang S

更新日期：2010-04-01 00:00:00

abstract：:The p53 tumor suppressor gene product is known to be active in mediating radiation-induced G1-S cell cycle arrest and apoptosis in a number of normal cell lines. These functions are compromised by inactivation of p53, which promotes tumor progression. Because the p53 gene appears to play an important role in the cellu...

journal_title：Cancer research

authors： Gallardo D,Drazan KE,McBride WH

更新日期：1996-11-01 00:00:00

abstract：:Overexpression of colony-stimulating factor-1 (CSF-1) and its receptor in breast cancer is correlated with poor prognosis. Based on the hypothesis that blockade of CSF-1 would be beneficial in breast cancer treatment, we developed a murinized, polyethylene glycol-linked antigen-binding fragment (Fab) against mouse (ho...

journal_title：Cancer research

authors： Paulus P,Stanley ER,Schäfer R,Abraham D,Aharinejad S

更新日期：2006-04-15 00:00:00

abstract：:A glutathione S-transferase (GST) P1 polymorphism results in an amino acid substitution, Ile105Val; the Val-containing enzyme has reduced activity toward alkylating agents. Cancer patients with the variant enzyme may differ in removal of treatment agents and in outcomes of therapy. We evaluated survival according to G...

journal_title：Cancer research

authors： Sweeney C,McClure GY,Fares MY,Stone A,Coles BF,Thompson PA,Korourian S,Hutchins LF,Kadlubar FF,Ambrosone CB

更新日期：2000-10-15 00:00:00

abstract：:Soluble membrane fractions derived from polyoma tumor cells trigger lymphocytes, derived from polyoma-immunized animals, but not from nonimmunized controls, to release the lymphokine, macrophage migration-inhibitory factor. The reaction can be blocked by sera from polyoma-bearing animals. Absorption of these sera with...

journal_title：Cancer research

authors： Ramqvist T,Dalianis T,Reinholdsson G,Klein G,Szigeti R

更新日期：1986-10-01 00:00:00

abstract：:Angiogenesis is essential for tumor growth and metastasis. It is regulated by numerous angiogenic factors, one of the most important being vascular endothelial growth factor (VEGF). Recently VEGF-B and VEGF-C, two new VEGF family members, have been identified that bind to the tyrosine kinase receptors flt-1 (VEGFR1), ...

journal_title：Cancer research

authors： Gunningham SP,Currie MJ,Han C,Turner K,Scott PA,Robinson BA,Harris AL,Fox SB

更新日期：2001-04-01 00:00:00

abstract：:Overexpression of ABCB1 (MDR1) P-glycoprotein, a multidrug efflux pump, is one mechanism by which tumor cells may develop multidrug resistance (MDR), preventing the successful chemotherapeutic treatment of cancer. Sesquiterpenes from Celastraceae family are natural compounds shown previously to reverse MDR in several ...

journal_title：Cancer research

authors： Muñoz-Martínez F,Lu P,Cortés-Selva F,Pérez-Victoria JM,Jiménez IA,Ravelo AG,Sharom FJ,Gamarro F,Castanys S

更新日期：2004-10-01 00:00:00

abstract：:Oncomir-1 is an oncogenic cluster of microRNAs (miRNA) located on chromosome 13. Previous in vitro studies showed that it is transcriptionally regulated by the transcription factor E2F3. In this report, we combine expression profiling of both mRNA and miRNAs in Wilms' tumor (WT) samples to provide the first evidence t...

journal_title：Cancer research

authors： Kort EJ,Farber L,Tretiakova M,Petillo D,Furge KA,Yang XJ,Cornelius A,Teh BT

更新日期：2008-06-01 00:00:00

abstract：:Testicular germ cell cancer is one of the very few cancers that are highly sensitive to and curable by cisplatin-based chemotherapy even in an advanced stage. However, in a few cases resistance to cisplatin occurs and patients subsequently die from progressive disease. The molecular basis for this resistance remains t...

journal_title：Cancer research

authors： Mueller T,Voigt W,Simon H,Fruehauf A,Bulankin A,Grothey A,Schmoll HJ

更新日期：2003-01-15 00:00:00

abstract：:3-phosphoinositide-dependent protein kinase-1 (PDK1) plays a pivotal role in coupling growth factor receptor signaling to tumor cell proliferation, survival, and invasion. Protein kinase C (PKC) alpha, but not Akt1, was found previously to be downstream of PDK1-mediated transformation of mammary epithelial cells. To d...

journal_title：Cancer research

authors： Xie Z,Zeng X,Waldman T,Glazer RI

更新日期：2003-09-01 00:00:00

abstract：:To improve tumor:tissue ratios in immunoscintigraphy, a three-step targeting method has been developed. The reagents used were (a) a radioactive, low molecular weight chelate prepared from ionic gallium and a phenolic polyaminocarboxylic acid, which can be labeled either with the single-photon emitter 67Ga or with the...

journal_title：Cancer research

authors： Schuhmacher J,Klivényi G,Matys R,Stadler M,Regiert T,Hauser H,Doll J,Maier-Borst W,Zöller M

更新日期：1995-01-01 00:00:00

abstract：:The spontaneous development of juvenile-onset ovarian granulosa cell tumors in mice of the SWXJ-9 recombinant inbred strain is a model for juvenile-type granulosa cell tumors that appear in very young girls. To expedite gene discovery in this mouse model of childhood cancer, we did a gene mapping study with the SWXJ-9...

journal_title：Cancer research

authors： Dorward AM,Shultz KL,Horton LG,Li R,Churchill GA,Beamer WG

更新日期：2005-02-15 00:00:00

abstract：:The influence of microtubule-associated proteins on the interaction of vincristine with microtubules and tubulin was examined. Microtubules containing associated proteins were prepared in vitro from tubulin preparations which contained the proteins or from pure 6S tubulin and isolated microtubule-associated proteins. ...

journal_title：Cancer research

authors： Donoso JA,Haskins KM,Himes RH

更新日期：1979-05-01 00:00:00

abstract：:We have compared the rate and extent of adhesion of various types of mouse tumor cells to endothelial cells derived from different organ sources. Our panel of tumors has included sarcoma, bladder carcinoma, glioma, teratoma, hepatoma, endothelioma, mammary adenocarcinoma, and lymphoma cells. Endothelial cell monolayer...

journal_title：Cancer research

authors： Auerbach R,Lu WC,Pardon E,Gumkowski F,Kaminska G,Kaminski M

更新日期：1987-03-15 00:00:00

abstract：:We demonstrated previously elevated caveolin-1 expression in metastatic mouse and human prostate cancer cells both in vitro and in vivo. In this study, we analyzed its prognostic value for progression of clinically confined human prostate cancer. Immunohistochemical staining with a caveolin-1-specific antibody was per...

journal_title：Cancer research

authors： Yang G,Truong LD,Wheeler TM,Thompson TC

更新日期：1999-11-15 00:00:00

abstract：:The increased proteolytic activity of membrane-bound and secreted proteases on the surface of cancer cells and in the transformed stroma is a common characteristic of aggressive metastatic prostate cancer. We describe here the development of an active site-specific probe for detecting a secreted peritumoral protease e...

journal_title：Cancer research

authors： LeBeau AM,Sevillano N,Markham K,Winter MB,Murphy ST,Hostetter DR,West J,Lowman H,Craik CS,VanBrocklin HF

更新日期：2015-04-01 00:00:00

abstract：:Thirteen variables were evaluated for their significance in predicting the survival of 148 patients in a retrospective study with clinical Stage I cutaneous malignant melanoma. The variables studied were histological type, tumor thickness, level of invasion, mitotic activity, pigmentation type, existence of ulceration...

journal_title：Cancer research

authors： Hacene K,Le Doussal V,Brunet M,Lemoine F,Guerin P,Hebert H

更新日期：1983-06-01 00:00:00

abstract：:Murine melanoma B16-F1 cells of low metastatic potential were transfected with the human gene for the prepro form of urokinase in an SV40 expression vector (plasmid pSV2-uPA), and cells expressing high amounts of the human urokinase gene product were selected for by an enzyme-linked immunosorbent assay specific for hu...

journal_title：Cancer research

authors： Yu HR,Schultz RM

更新日期：1990-12-01 00:00:00

abstract：:Macrophages play important roles in both physiologic and pathologic processes and arise from successive waves of embryonic and adult hematopoiesis. Monocyte-derived macrophages (MOMF) exert distinct functions under pathologic conditions, and leukemia-associated macrophages (LAM) show considerable diversities in activa...

journal_title：Cancer research

authors： Yang F,Feng W,Wang H,Wang L,Liu X,Wang R,Chen C,Yang X,Zhang D,Ren Q,Zheng G

更新日期：2020-09-01 00:00:00

abstract：:The stress harbored by the solid phase of tumors is known as solid stress. Solid stress can be either applied externally by the surrounding normal tissue or induced by the tumor itself due to its growth. Fluid pressure is the isotropic stress exerted by the fluid phase. We recently showed that growth-induced solid str...

journal_title：Cancer research

authors： Stylianopoulos T,Martin JD,Snuderl M,Mpekris F,Jain SR,Jain RK

更新日期：2013-07-01 00:00:00

abstract：:To identify genetic alterations underlying rectal carcinogenesis, we used global gene expression profiling of a series of 17 locally advanced rectal adenocarcinomas and 20 normal rectal mucosa biopsies on oligonucleotide arrays. A total of 351 genes were differentially expressed (P < 1.0e-7) between normal rectal muco...

journal_title：Cancer research

authors： Grade M,Ghadimi BM,Varma S,Simon R,Wangsa D,Barenboim-Stapleton L,Liersch T,Becker H,Ried T,Difilippantonio MJ

更新日期：2006-01-01 00:00:00