Bone sialoprotein mediates the tumor cell-targeted prometastatic activity of transforming growth factor beta in a mouse model of breast cancer.

abstract：:Ultrastructural studies of the effects of adriamycin on liver and cardiac cell nucleoli of the rat showed that nucleolar segregation occurred within 1 hr after an i.v. injection of a 40-mg/kg dose. Between 3 and 27 hr after this single dose, liver cell nucleoli progressively reverted to a normal ultrastructure. Nucleo...

journal_title：Cancer research

authors： Merski JA,Daskal I,Busch H

更新日期：1976-05-01 00:00:00

abstract：:NGR-TNF is a derivative of TNF-α that targets tumor blood vessels and enhances penetration of chemotherapeutic drugs. Because of this property, NGR-TNF is being tested in combination with chemotherapy in various phase II and III clinical trials. Here we report that chromogranin A (CgA), a protein present in variable a...

journal_title：Cancer research

authors： Dondossola E,Gasparri AM,Colombo B,Sacchi A,Curnis F,Corti A

更新日期：2011-09-01 00:00:00

abstract：:Myc transcriptional activity is frequently deregulated in human cancers, but a Myc-driven gene signature with prognostic ability across multiple tumor types remains lacking. Here, we selected 18 Myc-regulated genes from published studies of Myc family targets in epithelial ovarian cancer (EOC) and neuroblastoma. A Myc...

journal_title：Cancer research

authors： Jung M,Russell AJ,Liu B,George J,Liu PY,Liu T,DeFazio A,Bowtell DD,Oberthuer A,London WB,Fletcher JI,Haber M,Norris MD,Henderson MJ

更新日期：2017-02-15 00:00:00

abstract：:It is estimated that familial aggregation and genetic susceptibility play a role in as many as 10% of pancreatic ductal adenocarcinomas. To investigate the role of germ-line mutations in the etiology of pancreatic cancer, we have analyzed samples from patients with pancreatic cancer enrolled in the NFPTR for mutations...

journal_title：Cancer research

authors： Murphy KM,Brune KA,Griffin C,Sollenberger JE,Petersen GM,Bansal R,Hruban RH,Kern SE

更新日期：2002-07-01 00:00:00

abstract：:The relation of in vitro properties to tumorigenicity was studied using eight sublines of the human breast cancer cell line MCF-7. Four of the eight were tumorigenic in estrogen-treated nude mice. The sublines differed for each of the in vitro properties measured, and no property correlated perfectly with tumorigenici...

journal_title：Cancer research

authors： Butler WB,Berlinski PJ,Hillman RM,Kelsey WH,Toenniges MM

更新日期：1986-12-01 00:00:00

abstract：:Noscapine, a benzylisoquinoline alkaloid derived from opium, was recently reported to exhibit activity against a variety of cancers through a poorly understood mechanism. Because the transcription factor NF-kappaB has been linked with inflammation, survival, proliferation, invasion, and angiogenesis in tumors, we hypo...

journal_title：Cancer research

authors： Sung B,Ahn KS,Aggarwal BB

更新日期：2010-04-15 00:00:00

abstract：:In the course of development of a "library" of monoclonal antibodies to nucleolar proteins, a monoclonal antibody to a nuclear antigen with a molecular weight of 150,000 was obtained. Using this monoclonal antibody as an immunocytochemical probe, low immunofluorescence was demonstrated in human peripheral blood lympho...

journal_title：Cancer research

authors： Chatterjee A,Durban E,Busch H

更新日期：1988-12-15 00:00:00

abstract：:Genome-wide association studies (GWAS) of bladder cancer have identified a number of susceptibility loci in European populations but have yet to uncover the genetic determinants underlying bladder cancer incidence among other ethnicities. Therefore, we performed the first GWAS in a Chinese cohort comprising 3,406 case...

journal_title：Cancer research

authors： Wang M,Li Z,Chu H,Lv Q,Ye D,Ding Q,Xu C,Guo J,Du M,Chen J,Song Z,Yin C,Qin C,Gu C,Zhu Y,Xia G,Liu F,Zhang Z,Yuan L,Fu G,Hu Z,Tong N,Shen J,Liu K,Sun J,Sun Y,Li J,Li X,Shen H,Xu J,Shi Y,Zhang

更新日期：2016-06-01 00:00:00

abstract：:We reported recently that medium conditioned with mouse lung microvessel endothelial cells possessed chemotactic activity for a highly lung-metastatic variant (L17) of the RAW117 murine large-cell lymphoma cell line but not for the poorly metastatic parental cells (P) or a liver-metastasizing variant (H10). The chemot...

journal_title：Cancer research

authors： Wakabayashi H,Cavanaugh PG,Nicolson GL

更新日期：1995-10-01 00:00:00

abstract：:When compared to normal esophageal epithelium, marked alterations in keratin protein and cross-linked envelope expression were found in human esophageal carcinomas. Examination of the pattern of keratin proteins extracted from either several primary esophageal tumors or carcinomas xenotransplanted in nude mice reveale...

journal_title：Cancer research

authors： Banks-Schlegel SP,Harris CC

更新日期：1984-03-01 00:00:00

abstract：:Age-adjusted mortality rates for non-Hodgkin's lymphoma in counties of the contiguous United States were examined by sex and race during 1950 to 1975 and were correlated through 1969 with demographic and industrial data. Mortality was consistently elevated in counties with large populations, especially in those with h...

journal_title：Cancer research

authors： Cantor KP,Fraumeni JF Jr

更新日期：1980-08-01 00:00:00

abstract：:N-Nitrosodibutylamine and its omega-hydroxylated metabolite N-nitrosobutyl(4-hydroxybutyl)amine (NB4HBA) induce tumors in the urine bladder of different animal species through their common urinary metabolite N-nitrosobutyl(3-carboxypropyl)amine (NB3CPA), resulting from the oxidation of the alcoholic group of NB4HBA to...

journal_title：Cancer research

authors： Bonfanti M,Magagnotti C,Bonati M,Fanelli R,Airoldi L

更新日期：1988-07-01 00:00:00

abstract：:Sulindac is the most extensively investigated clinically relevant chemopreventive nonsteroidal anti-inflammatory drug. Sulindac sulfide is one of the major metabolites of sulindac that is believed to mediate its antitumorigenic effects by inducing apoptosis. Recent evidence suggests that sulindac sulfide engages the m...

journal_title：Cancer research

authors： Huang Y,He Q,Hillman MJ,Rong R,Sheikh MS

更新日期：2001-09-15 00:00:00

abstract：:Rational therapeutic approaches based on synthetic lethality may improve cancer management. On the basis of a high-throughput drug screen, we provide preclinical proof of concept that targeting the mitochondrial Hsp90 chaperone network (mtHsp90) and inhibition of Bcl-2, Bcl-xL, and Mcl-1 is sufficient to elicit synthe...

journal_title：Cancer research

authors： Karpel-Massler G,Ishida CT,Bianchetti E,Shu C,Perez-Lorenzo R,Horst B,Banu M,Roth KA,Bruce JN,Canoll P,Altieri DC,Siegelin MD

更新日期：2017-07-01 00:00:00

abstract：:Thirteen patients with metastatic breast carcinoma were given injections of 50-1593 micrograms of 131I-monoclonal antibody (MAb) B6.2 immunoglobulin G and F(ab')2 for pharmacokinetic evaluation and radioimmunoimaging. Blood clearance of the 131I-MAb-B6.2 was biphasic. The mean half-times (t 1/2 alpha, t 1/2 beta) for ...

journal_title：Cancer research

authors： Hayes DF,Zalutsky MR,Kaplan W,Noska M,Thor A,Colcher D,Kufe DW

更新日期：1986-06-01 00:00:00

abstract：:Fibroblast growth factor receptor 3 (FGFR3) plays important roles in cell proliferation, differentiation, and angiogenesis. FGFR3 is abnormally upregulated in hepatocellular carcinoma (HCC), where it correlates positively with clinicopathologic index, HCC differentiation, and advanced nuclear grade. In this study, we ...

journal_title：Cancer research

authors： Li K,Shen B,Cheng X,Ma D,Jing X,Liu X,Yang W,Peng C,Qiu W

更新日期：2016-07-15 00:00:00

abstract：:Quantitative micromethods have been used for measuring reactive protein thiols (PSHr), total reactive protein sulfur (TRPS), total protein thiols (PSHt), and protein disulfides (PDS) in fixed frozen sections of human uterine cervix. PSHr and TRPS were stained using 2,2'-dihydroxy-6,6'-dinaphthyl disulfide; PSHt and PD...

journal_title：Cancer research

authors： Benedetto C,Bajardi F,Ghiringhello B,Marozio L,Nöhammer G,Phitakpraiwan P,Rojanapo W,Schauenstein E,Slater TF

更新日期：1990-10-15 00:00:00

abstract：:During 2007, approximately 200,000 people in the United States will be diagnosed with brain tumors. Gliomas account for 77% of primary malignant brain tumors, and the prognosis has hardly changed in the past 20 years, with only 30% of patients with malignant glioma surviving 5 years after diagnosis. Oncolytic adenovir...

journal_title：Cancer research

authors： Alonso MM,Cascallo M,Gomez-Manzano C,Jiang H,Bekele BN,Perez-Gimenez A,Lang FF,Piao Y,Alemany R,Fueyo J

更新日期：2007-09-01 00:00:00

abstract：:The incidence, distribution, size, and histopathology of grossly visible colonic tumors induced by parenteral administration of 1,2-dimethylhydrazine were examined in rats fed either a chemically defined fiber-free diet or a nutritionally and calorically equivalent diet containing a purified fiber component, microcrys...

journal_title：Cancer research

authors： Freeman HJ,Spiller GA,Kim YS

更新日期：1978-09-01 00:00:00

abstract：:The mechanism of in vitro cytotoxicity by tumor necrosis serum (TNS) and a purified fraction was examined using sensitive L-M cells. Cell death was assessed by uptake of the dye trypan blue and/or by release of radiolabeled chromium. Cell killing was time and dose dependent. Cell survival was assessed by counting the ...

journal_title：Cancer research

authors： Kull FC Jr,Cuatrecasas P

更新日期：1981-12-01 00:00:00

abstract：:Anti-idiotype monoclonal antibodies (Mabs) to mLL2, an anti-B-cell lymphoma and CD22-specific murine IgG2a-kappa Mab, were generated by hybridoma technology from splenocytes of Copenhagen rats immunized with mLL2 F(ab')2. Mab WN, an IgG2a-kappa, was selected based on its specific binding to mLL2 and not other IgG isot...

journal_title：Cancer research

authors： Losman MJ,Leung SO,Shih LB,Shevitz J,Shukla R,Haraga L,Goldenberg DM,Hansen HJ

更新日期：1995-12-01 00:00:00

abstract：:Ovarian cancer is mainly confined in peritoneal cavity and its metastasis is often associated with the formation of malignant ascites. As lysophosphatidic acid (LPA) is present at high levels in ascites of ovarian cancer patients and potently stimulates cell migration, we reason that LPA-stimulated cell migration may ...

journal_title：Cancer research

authors： Chen H,Wu X,Pan ZK,Huang S

更新日期：2010-12-01 00:00:00

abstract：:The neu oncogene has been demonstrated to be a potent transforming gene in rodent fibroblasts. The overexpression of the human erbB-2/neu oncogene has been implicated in the development and/or prognosis of several human carcinomas including that of the prostate. To assess the transforming potential of the activated ra...

journal_title：Cancer research

authors： Sikes RA,Chung LW

更新日期：1992-06-01 00:00:00

abstract：:Cellular retinoic acid-binding protein (cRABP) was detected in the cytosol of virus-induced papilloma (Shope) of rabbit skin. The Shope papilloma cRABP showed the same ligand specificity and sedimentation value (2S) as was found in other animal species. The level of cRABP in the papillomatous tissue was significantly ...

journal_title：Cancer research

authors： Rattanapanone V,Tashiro S,Tokuda H,Rattanapanone N,Ito Y

更新日期：1981-04-01 00:00:00

abstract：:The potentiation of monoclonal antibody/ligand toxin (immunotoxin) cytotoxicity by the ionophore monensin (Mo) or by human serum albumin-monensin (HSA-Mo) conjugates was investigated. Since disulfide cross-linked HSA-Mo (HSA-SPDP-Mo) is rapidly inactivated by human serum (M. Colombatti et al., Cancer Res., 50: 1385-13...

journal_title：Cancer research

authors： Candiani C,Franceschi A,Chignola R,Pasti M,Anselmi C,Benoni G,Tridente G,Colombatti M

更新日期：1992-02-01 00:00:00

abstract：:SR31747A is a sigma ligand with potent antiproliferative activity against tumor cells and for which three binding proteins have been identified to date: (a) SRBP-1 (also called sigma 1); (b) HIS; and (c) sigma 2. In this study, we characterized an additional SR31747A binding site, i.e., SRBP-2 (SR31747A-binding protei...

journal_title：Cancer research

authors： Vidal H,Mondesert G,Galiègue S,Carrière D,Dupuy PH,Carayon P,Combes T,Bribes E,Simony-Lafontaine J,Kramar A,Loison G,Casellas P

更新日期：2003-08-15 00:00:00

abstract：:The biological activity of two novel 14-epi-analogues of 1,25(OH)2D3, 19-nor-14-epi-23-yne-1,25(OH)2D3 (TX 522) and 19-nor-14,20-bisepi-23-yne-1,25(OH)2D3 (TX 527), is described. Both analogues were at least 10 times more potent than 1,25(OH)2D3 in inhibiting in vitro cell proliferation and had much lower in vivo calc...

journal_title：Cancer research

authors： Verlinden L,Verstuyf A,Van Camp M,Marcelis S,Sabbe K,Zhao XY,De Clercq P,Vandewalle M,Bouillon R

更新日期：2000-05-15 00:00:00

abstract：:Recent studies demonstrated that the resistance of cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) could be reversed by various chemotherapeutic agents. In the present study, we investigated the role of Akt in the apoptosis resistance to TRAIL and chemotherapeutic agents-induced TRAIL s...

journal_title：Cancer research

authors： Asakuma J,Sumitomo M,Asano T,Asano T,Hayakawa M

更新日期：2003-03-15 00:00:00

abstract：:The growth and survival of many types of cancer cells are known to be supported by specific growth factor/cytokine systems. Among these, the activation of c-kit receptor and its ligand steel factor participates in several types of human carcinogenesis. W mutations of laboratory mouse strains are loss of functional mut...

journal_title：Cancer research

authors： Li Q,Kondoh G,Inafuku S,Nishimune Y,Hakura A

更新日期：1996-10-01 00:00:00

abstract：:Hypoxia is a common feature of solid tumors. Prolyl hydroxylase enzymes (PHD1-3) are molecular oxygen sensors that regulate hypoxia-inducible factor activity, but their functions in metastatic disease remain unclear. Here, we assessed the significance of PHD enzymes during the metastatic spread of colorectal cancer. P...

journal_title：Cancer research

authors： Radhakrishnan P,Ruh N,Harnoss JM,Kiss J,Mollenhauer M,Scherr AL,Platzer LK,Schmidt T,Podar K,Opferman JT,Weitz J,Schulze-Bergkamen H,Koehler BC,Ulrich A,Schneider M

更新日期：2016-04-15 00:00:00