Revelation of a cryptic major histocompatibility complex class II-restricted tumor epitope in a novel RNA-processing enzyme.

abstract：:A naturally occurring human antibody potentiates dendritic cell function on cross-linking B7-DC (PD-L2), supporting robust T-cell responses in vitro. Moreover, treatment of dendritic cells with B7-DC cross-linking antibody resulted in secretion of interleukin-12, suggesting a TH1 polarization of this response. Here we...

journal_title：Cancer research

authors： Radhakrishnan S,Nguyen LT,Ciric B,Flies D,Van Keulen VP,Tamada K,Chen L,Rodriguez M,Pease LR

更新日期：2004-07-15 00:00:00

abstract：:A synthetic DNA template has been constructed that is suitable for the quantitation of mRNAs encoding gastrin, transforming growth factor alpha (TGF alpha), cholecystokinin, and the 78-kDa gastrin-binding protein. The template was used to measure levels of gastrin and TGF alpha mRNA in 7 colonic and 2 gastric carcinom...

journal_title：Cancer research

authors： Baldwin GS,Zhang QX

更新日期：1992-04-15 00:00:00

abstract：:Despite our improved understanding of cancer, the 5-year survival rate for head and neck squamous cell carcinomas (HNSCC) patients remains relatively unchanged at 50% for the past three decades. HNSCCs often metastasize to locoregional lymph nodes, and lymph node involvement represents one of the most important progno...

journal_title：Cancer research

authors： Patel V,Marsh CA,Dorsam RT,Mikelis CM,Masedunskas A,Amornphimoltham P,Nathan CA,Singh B,Weigert R,Molinolo AA,Gutkind JS

更新日期：2011-11-15 00:00:00

abstract：:MicroRNAs (miRNAs) are small noncoding RNAs, thought to be involved in physiologic and developmental processes by negatively regulating expression of target genes. We have previously reported frequent down-regulation of the let-7 miRNA family in lung cancers and, in the present study, assessed alteration in a panel of...

journal_title：Cancer research

authors： Hayashita Y,Osada H,Tatematsu Y,Yamada H,Yanagisawa K,Tomida S,Yatabe Y,Kawahara K,Sekido Y,Takahashi T

更新日期：2005-11-01 00:00:00

abstract：:The mechanism of the previously reported cytotoxicity of liposomes containing plant phosphatidylinositol (PI) against numerous tumor cell lines was examined in detail by using liposomes containing synthetic PI specifically labeled either with radioactive myo-inositol, or in the sn-2 position with radioactive linoleic ...

journal_title：Cancer research

authors： Jett M,Chudzik J,Alving CR,Stanacev NZ

更新日期：1985-10-01 00:00:00

abstract：:Exposure of HeLa cells to 0.2 mM O6-methylguanine for 4 h or longer led to a 70-80% loss in the activity of the DNA-repair protein, O6-alkylguanine-DNA alkyltransferase. The decline in alkyltransferase activity brought about by O6-methylguanine was reversible on removing the base but at least 48 h were required for co...

journal_title：Cancer research

authors： Dolan ME,Morimoto K,Pegg AE

更新日期：1985-12-01 00:00:00

abstract：:Loss of hSNF5 function is usually observed in malignant rhabdoid tumor (MRT), a highly aggressive pediatric neoplasm. Previous studies have shown that reexpression of hSNF5 in MRT cell lines causes G1 cell cycle arrest with p16(INK4A), p21(CIP1/WAF1), and cyclin D1 playing key roles in MRT cell growth control. However...

journal_title：Cancer research

authors： Kuwahara Y,Charboneau A,Knudsen ES,Weissman BE

更新日期：2010-03-01 00:00:00

abstract：:The kinetics of a model reaction between the antitumor drug cis-diamminedichloroplatinum(II)(cis-DDP) and the signal nucleotide diadenosine 5',5"'-P1,P4-tetraphosphate (Ap4A) has been investigated by spectrophotometry. The formation of the reactive platinum aquated species was first analyzed by potentiometry using a c...

journal_title：Cancer research

authors： Segal E,Le Pecq JB

更新日期：1985-02-01 00:00:00

abstract：:Macrophage migration inhibition responses of mice immunized with mutant polyoma viruses or with cells transformed and/or infected by them have been studied. The macrophage migration inhibition reaction revealed individual differences. In several cases, mice immunized with a mutant virus responded preferentially or exc...

journal_title：Cancer research

authors： Szigeti R,Dalianis T,Ramqvist T,Ito Y,Klein G

更新日期：1984-03-01 00:00:00

abstract：:Although regulatory T cells (Tregs) have been detected in clinically apparent and experimentally induced tumors, the significance of their presence is obscured because past studies examined late-stage tumors that had formed in immunocompetent hosts and thus had evolved mechanisms to escape immunologic recognition and/...

journal_title：Cancer research

authors： Bui JD,Uppaluri R,Hsieh CS,Schreiber RD

更新日期：2006-07-15 00:00:00

abstract：:Overexpression of PRL-3, an oncogenic phosphatase, was identified as a novel cluster in patients with newly diagnosed multiple myeloma. However, the regulation and oncogenic activities of PRL-3 in multiple myeloma warrant further investigation. Here, we report that IL6 activates STAT3, which acts as a direct transcrip...

journal_title：Cancer research

authors： Chong PSY,Zhou J,Lim JSL,Hee YT,Chooi JY,Chung TH,Tan ZT,Zeng Q,Waller DD,Sebag M,Chng WJ

更新日期：2019-09-15 00:00:00

abstract：:The therapeutic potential of cisplatin, one of the most active and widely used anticancer drugs, is severely limited by the occurrence of cellular resistance. In this study, using budding yeast Saccharomyces cerevisiae as a model organism to identify novel drug resistance genes, we found that disruption of the yeast g...

journal_title：Cancer research

authors： Schenk PW,Boersma AW,Brandsma JA,den Dulk H,Burger H,Stoter G,Brouwer J,Nooter K

更新日期：2001-10-01 00:00:00

abstract：:The deregulation of several cell cycle-related genes participates in neoplastic transformation. Cell cycle progression is driven by cyclin-dependent kinases, which are positively regulated by association with cyclins and negatively regulated by binding to inhibitory subunits. The activity of cyclin-dependent kinases i...

journal_title：Cancer research

authors： Gasparotto D,Maestro R,Piccinin S,Vukosavljevic T,Barzan L,Sulfaro S,Boiocchi M

更新日期：1997-06-15 00:00:00

abstract：:The cytoskeleton, the shape, and the adhesion complexes of MCF-7 breast carcinoma cells have been studied by fluorescence, phase contrast, and interference reflection microscopy. Cells have been grown in media containing different concentrations of estrogen and with or without the addition of the antiestrogen tamoxife...

journal_title：Cancer research

authors： Sapino A,Pietribiasi F,Bussolati G,Marchisio PC

更新日期：1986-05-01 00:00:00

abstract：:Elucidation of the underlying molecular mechanisms of immune evasion in cancer is critical for the development of immunotherapies aimed to restore and stimulate effective antitumor immunity. Here, we evaluate the role of the actin cytoskeleton in breast cancer cell resistance to cytotoxic natural killer (NK) cells. A ...

journal_title：Cancer research

authors： Al Absi A,Wurzer H,Guerin C,Hoffmann C,Moreau F,Mao X,Brown-Clay J,Petrolli R,Casellas CP,Dieterle M,Thiery JP,Chouaib S,Berchem G,Janji B,Thomas C

更新日期：2018-10-01 00:00:00

abstract：:Patients suffering from bone metastases of follicular thyroid carcinoma (FTC) have a poor prognosis because of the lack of effective treatment strategies. The overexpression of epidermal growth factor receptor (EGFR) associated with increased vascularity has been implicated in the pathogenesis of FTC and subsequent bo...

journal_title：Cancer research

authors： Younes MN,Yigitbasi OG,Park YW,Kim SJ,Jasser SA,Hawthorne VS,Yazici YD,Mandal M,Bekele BN,Bucana CD,Fidler IJ,Myers JN

更新日期：2005-06-01 00:00:00

abstract：:In an attempt to develop better combination therapies for use with local radiation, the interaction between bleomycin and hyperthermia +/- radiation was studied in the FSaIIC tumor system. In cells exposed in vitro to bleomycin at 37 degrees C and at pH 7.40, the drug was substantially more toxic toward normally oxyge...

journal_title：Cancer research

authors： Teicher BA,Herman TS,Holden SA

更新日期：1988-11-15 00:00:00

abstract：:The histone demethylase KDM4B is frequently overexpressed in various cancer types, and previous studies have indicated that the primary oncogenic function of KDM4B is its ability to demethylate H3K9me3 in different tumors, resulting in altered gene expression and genome instability. A genome-wide analysis to evaluate ...

journal_title：Cancer research

authors： Xiang Y,Yan K,Zheng Q,Ke H,Cheng J,Xiong W,Shi X,Wei L,Zhao M,Yang F,Wang P,Lu X,Fu L,Lu X,Li F

更新日期：2019-01-01 00:00:00

abstract：:The insulin-like growth factor receptor (IGF-IR) and insulin receptor are either overactivated and/or overexpressed in a wide range of tumor types and contribute to tumorigenicity, proliferation, metastasis, and drug resistance. Here, we show that BMS-554417, a novel small molecule developed as an inhibitor of IGF-IR,...

journal_title：Cancer research

authors： Haluska P,Carboni JM,Loegering DA,Lee FY,Wittman M,Saulnier MG,Frennesson DB,Kalli KR,Conover CA,Attar RM,Kaufmann SH,Gottardis M,Erlichman C

更新日期：2006-01-01 00:00:00

abstract：:Failure of cytokinesis results in tetraploidy and can increase the genomic instability frequently observed in cancer. The peptidyl-prolyl isomerase Pin1, which is deregulated in many tumors, regulates several processes, including cell cycle progression. Here, we show a novel role for Pin1 in cytokinesis. Pin1 knockout...

journal_title：Cancer research

authors： van der Horst A,Khanna KK

更新日期：2009-08-15 00:00:00

abstract：:N-Demethylated metabolites of the antineoplastic agent hexamethylmelamine were synthesized, and their toxicities and antitumor activities were determined in vivo. Determinations of the lethal dose for 10% of the male C57BL X DBA/2 F1 (hereafter called BD2F1) mice showed hexamethylmelamine toxicity to be decreased by N...

journal_title：Cancer research

authors： Lake LM,Grunden EE,Johnson BM

更新日期：1975-10-01 00:00:00

abstract：:Putative preneoplastic hepatocytes were isolated from male Fischer 344 rats treated with a single dose of diethylnitrosamine, 2-acetylaminofluorene feeding, and partial hepatectomy (Solt-Farber model). The isolation procedure involved, after collagenase dispersion of the liver, separation of the hepatocytes into small...

journal_title：Cancer research

authors： Evarts RP,Marsden E,Hanna P,Wirth PJ,Thorgeirsson SS

更新日期：1984-12-01 00:00:00

abstract：:Vascular permeability factor (VPF)/vascular endothelial growth factor (VEGF) is an angiogenic cytokine expressed by many human and animal tumors. Hypoxia often up-regulates VPF/VEGF expression further. To better define the role of VPF/VEGF in tumor biology, we screened tumorigenic lines for those expressing minimal co...

journal_title：Cancer research

authors： Claffey KP,Brown LF,del Aguila LF,Tognazzi K,Yeo KT,Manseau EJ,Dvorak HF

更新日期：1996-01-01 00:00:00

abstract：:Adaptive therapy seeks to exploit intra-tumoral competition to avoid, or at least delay, the emergence of therapy resistance in cancer. Motivated by promising results in prostate cancer, there is growing interest in extending this approach to other neoplasms. As such, it is urgent to understand the characteristics of ...

journal_title：Cancer research

authors： Strobl MAR,West J,Viossat Y,Damaghi M,Robertson-Tessi M,Brown JS,Gatenby RA,Maini PK,Anderson ARA

更新日期：2020-11-10 00:00:00

abstract：:The lipid hydrolase enzyme acid sphingomyelinase (ASM) is required for the conversion of the lipid cell membrane component sphingomyelin into ceramide. In cancer cells, ASM-mediated ceramide production is important for apoptosis, cell proliferation, and immune modulation, highlighting ASM as a potential multimodal the...

journal_title：Cancer research

authors： Kachler K,Bailer M,Heim L,Schumacher F,Reichel M,Holzinger CD,Trump S,Mittler S,Monti J,Trufa DI,Rieker RJ,Hartmann A,Sirbu H,Kleuser B,Kornhuber J,Finotto S

更新日期：2017-11-01 00:00:00

abstract：:Three human colon cancer lines (SW 480, SW 620, WIDR) were characterized as to their production of molecules with transforming growth factor (TGF)-like activity. Production of both TGF alpha-like and TGF beta-like activity was quantitated, as were cellular receptors for these molecules, and growth response in soft aga...

journal_title：Cancer research

authors： Coffey RJ Jr,Shipley GD,Moses HL

更新日期：1986-03-01 00:00:00

abstract：:Mutations in the adenomatous polyposis coli (APC) gene and K-ras occur in the majority of human colorectal cancers. Loss of functional APC protein activates the Wnt signal transduction pathway, allowing the nuclear accumulation of beta-catenin, which then binds to T-cell factor-4 (Tcf-4), causing increased transcripti...

journal_title：Cancer research

authors： Araki Y,Okamura S,Hussain SP,Nagashima M,He P,Shiseki M,Miura K,Harris CC

更新日期：2003-02-01 00:00:00

abstract：:1-Nitropyrene, a direct-acting mutagenic component of extracts of diesel exhaust and ambient air particulates, is one of the major nitroarenes found in products of incomplete combustion. Injection of this compound into newborn Sprague-Dawley-derived CD rats at 100 mumol/kg body weight s.c. once a week for 8 weeks indu...

journal_title：Cancer research

authors： Hirose M,Lee MS,Wang CY,King CM

更新日期：1984-03-01 00:00:00

abstract：:In 1984, we reported that while immunoreactive levels of serum alpha-1 proteinase inhibitor (API) increased significantly in nine patients with advanced solid tumors, the functional activity of the inhibitor, as measured by the serum trypsin inhibitory capacity, did not increase proportionately. This suggested that a ...

journal_title：Cancer research

authors： Chawla RK,Lawson DH,Sarma PR,Nixon DW,Travis J

更新日期：1987-02-15 00:00:00

abstract：:To examine genetic instability during carcinogenesis, we screened 171 carcinomas of the breast, liver, proximal colon, stomach, pancreas, uterine cervix, and ovary for replication error at four microsatellite marker loci on chromosome 2, 3, and 17. A significantly high incidence of genetic instability was observed in ...

journal_title：Cancer research

authors： Han HJ,Yanagisawa A,Kato Y,Park JG,Nakamura Y

更新日期：1993-11-01 00:00:00