Lack of correlation of N-myc gene amplification with prognosis in localized neuroblastoma: a Pediatric Oncology Group study.

abstract：:The increased proteolytic activity of membrane-bound and secreted proteases on the surface of cancer cells and in the transformed stroma is a common characteristic of aggressive metastatic prostate cancer. We describe here the development of an active site-specific probe for detecting a secreted peritumoral protease e...

journal_title：Cancer research

authors： LeBeau AM,Sevillano N,Markham K,Winter MB,Murphy ST,Hostetter DR,West J,Lowman H,Craik CS,VanBrocklin HF

更新日期：2015-04-01 00:00:00

abstract：:Tumor relapses remain a serious problem after allogeneic stem cell transplantation (alloSCT), despite the long-term persistence of minor histocompatibility antigen (MiHA)-specific memory CD8(+) T cells specific for the tumor. We hypothesized that these memory T cells may lose their function over time in transplanted p...

journal_title：Cancer research

authors： Norde WJ,Maas F,Hobo W,Korman A,Quigley M,Kester MG,Hebeda K,Falkenburg JH,Schaap N,de Witte TM,van der Voort R,Dolstra H

更新日期：2011-08-01 00:00:00

abstract：:Loss of chromosome 10q is a frequently observed genetic defect in prostate cancer. Recently, the PTEN/MMAC1 tumor suppressor gene was identified and mapped to chromosome 10q23.3. We studied PTEN structure and expression in 4 in vitro cell lines and 11 in vivo xenografts derived from six primary and nine metastatic hum...

journal_title：Cancer research

authors： Vlietstra RJ,van Alewijk DC,Hermans KG,van Steenbrugge GJ,Trapman J

更新日期：1998-07-01 00:00:00

abstract：:Cytogenetic analysis of tumor cells from a human malignant melanoma was performed on both the primary tumor colony-forming cells and a cell line (HA-A) established subsequently from the clonogenic population. Chromosome-banding analysis demonstrated identical karyotypic alterations in both the tumor colony-forming cel...

journal_title：Cancer research

authors： Trent JM,Thompson FH,Ludwig C

更新日期：1984-01-01 00:00:00

abstract：:Head and neck squamous cell carcinomas (HNSCC) often metastasize to locoregional lymph nodes, and lymph node involvement represents one of the most important prognostic factors of poor clinical outcome. HNSCCs are remarkably lymphangiogenic and represent a clear example of a cancer that utilizes the lymphatic vasculat...

journal_title：Cancer research

authors： Doçi CL,Mikelis CM,Lionakis MS,Molinolo AA,Gutkind JS

更新日期：2015-07-15 00:00:00

abstract：:T-cell receptor (TCR) gene transfer for cancer immunotherapy is limited by the availability of large numbers of tumor-specific T cells. TCR alpha and beta chains were isolated from a highly lytic HLA-A2-restricted cytotoxic T lymphocyte (CTL) clone recognizing the melanoma-associated Melan-A/MART-1 antigen and inserte...

journal_title：Cancer research

authors： Bobisse S,Rondina M,Merlo A,Tisato V,Mandruzzato S,Amendola M,Naldini L,Willemsen RA,Debets R,Zanovello P,Rosato A

更新日期：2009-12-15 00:00:00

abstract：:Four of seven human melanoma cell lines were sensitive to killing by L-dopa (D37 1.0-4.7 microM) compared with fibroblasts, Hela, and three ovarian tumor cell lines (D37 12-59 microM). All seven melanoma lines, however, were sensitive to DL-buthionine(S,R)sulfoximine (BSO) (D37 0.73-8.5 microM) compared with the nonme...

journal_title：Cancer research

authors： Kable EP,Favier D,Parsons PG

更新日期：1989-05-01 00:00:00

abstract：:Hematogenous carcinoma metastasis is supported by aggregated platelets and leukocytes, forming tumor cell emboli. Early tumor cell-platelet interactions can be mediated by P-selectin binding to tumor cell surface ligands and this process is blocked by heparin. We previously showed that L-selectin deficiency also atten...

journal_title：Cancer research

authors： Läubli H,Stevenson JL,Varki A,Varki NM,Borsig L

更新日期：2006-02-01 00:00:00

abstract：:Multiple myeloma cells secrete more disulfide bond-rich proteins than any other mammalian cell. Thus, inhibition of protein disulfide isomerases (PDI) required for protein folding in the endoplasmic reticulum (ER) should increase ER stress beyond repair in this incurable cancer. Here, we report the mechanistically unb...

journal_title：Cancer research

authors： Vatolin S,Phillips JG,Jha BK,Govindgari S,Hu J,Grabowski D,Parker Y,Lindner DJ,Zhong F,Distelhorst CW,Smith MR,Cotta C,Xu Y,Chilakala S,Kuang RR,Tall S,Reu FJ

更新日期：2016-06-01 00:00:00

abstract：:Suppression of gluconeogenesis elevates glycolysis and is commonly observed in tumors derived from gluconeogenic tissues including liver and kidney, yet the definitive regulatory mechanism remains elusive. Here, we screened an array of transcription regulators and identified the enhancer of zeste homolog 2 (EZH2) as a...

journal_title：Cancer research

authors： Liao K,Deng S,Xu L,Pan W,Yang S,Zheng F,Wu X,Hu H,Liu Z,Luo J,Zhang R,Kuang DM,Dong J,Wu Y,Zhang H,Zhou P,Bei JX,Xu Y,Ji Y,Wang P,Ju HQ,Xu RH,Li B

更新日期：2020-02-15 00:00:00

abstract：:Cell signaling plays a central role in the etiology of cancer. Numerous therapeutics in use or under development target signaling proteins; however, off-target effects often limit assignment of positive clinical response to the intended target. As direct measurements of signaling protein activity are not generally fea...

journal_title：Cancer research

authors： Ochs MF,Rink L,Tarn C,Mburu S,Taguchi T,Eisenberg B,Godwin AK

更新日期：2009-12-01 00:00:00

abstract：:Nineteen transplantable tumor lines were established from individual spontaneous mammary tumors of the DBA/2 Ha-DD mouse. Of these lines, 5 were classified as fast growing, 8 as medium growing, and 6 as slow growing, based on the time required for the tumors to reach a size of 10 mm in average diameter and on the aver...

journal_title：Cancer research

authors： Hosokawa M,Orsini F,Mihich E

更新日期：1975-10-01 00:00:00

abstract：:Recent data have demonstrated that cancer drug resistance reflects complex biologic factors, including tumor heterogeneity, varying growth, differentiation, apoptosis pathways, and cell density. As a result, there is a need to find new ways to incorporate these complexities in the mathematical modeling of multidrug re...

journal_title：Cancer research

authors： Lavi O,Greene JM,Levy D,Gottesman MM

更新日期：2013-12-15 00:00:00

abstract：:Previous studies from our laboratory have shown that the activation of G(2)-M checkpoint after exposure of MCF-7 breast cancer cells to gamma-irradiation (IR) is dependent on the activation of extracellular signal-regulated kinase 1/2 (ERK1/2) signaling. Studies presented in this report indicate that IR exposure of MC...

journal_title：Cancer research

authors： Yan Y,Black CP,Cao PT,Haferbier JL,Kolb RH,Spieker RS,Ristow AM,Cowan KH

更新日期：2008-07-01 00:00:00

abstract：:We examined the genetic requirements for the Myc family of oncogenes in normal Sonic hedgehog (Shh)-mediated cerebellar granule neuronal precursor (GNP) expansion and in Shh pathway-induced medulloblastoma formation. In GNP-enriched cultures derived from N-myc(Fl/Fl) and c-myc(Fl/Fl) mice, disruption of N-myc, but not...

journal_title：Cancer research

authors： Hatton BA,Knoepfler PS,Kenney AM,Rowitch DH,de Alborán IM,Olson JM,Eisenman RN

更新日期：2006-09-01 00:00:00

abstract：:We observed stronger cytotoxic effect of CHS 828 on poly(ADP-ribose) polymerase-1(PARP-1) knock-out cells as compared with the normal counterpart. The proliferation of PARP-1 -/- cells was inhibited by a drug concentration approximately 3-fold lower than that in the normal cells. The monitoring of p53 levels revealed ...

journal_title：Cancer research

authors： Lövborg H,Wojciechowski J,Larsson R,Wesierska-Gadek J

更新日期：2002-08-01 00:00:00

abstract：:The uptake of m-[125I]iodobenzylguanidine (mIBG), a compound structurally analogous to the antihypertensive drug guanethidine, was examined in various human cell lines. Of three neuroblastoma lines, SK-N-LO, IMR-32, and SK-N-SH, only the last showed specific uptake of the compound. In contrast, only a nonspecific upta...

journal_title：Cancer research

authors： Buck J,Bruchelt G,Girgert R,Treuner J,Niethammer D

更新日期：1985-12-01 00:00:00

abstract：:Similar histologic subtypes of cancers often exhibit different spectrum of genetic and epigenetic alterations. The heterogeneity observed due to lack of consistent and defined alterations affecting a unique set of gene(s) or gene products in cancers derived from a specific tissue, or an organ, pose a challenge in unra...

journal_title：Cancer research

authors： Thiagalingam S

更新日期：2006-08-01 00:00:00

abstract：:Medulloblastoma and central nervous system primitive neuroectodermal tumors (CNS-PNET) are aggressive, poorly differentiated brain tumors with limited effective therapies. Using Sleeping Beauty (SB) transposon mutagenesis, we identified novel genetic drivers of medulloblastoma and CNS-PNET. Cross-species gene expressi...

journal_title：Cancer research

authors： Beckmann PJ,Larson JD,Larsson AT,Ostergaard JP,Wagner S,Rahrmann EP,Shamsan GA,Otto GM,Williams RL,Wang J,Lee C,Tschida BR,Das P,Dubuc AM,Moriarity BS,Picard D,Wu X,Rodriguez FJ,Rosemarie Q,Krebs RD,Molan AM,Dem

更新日期：2019-03-01 00:00:00

abstract：:Various chemical compounds have been described to induce photosensitization of tumor cells resulting in cell death. We studied the effect of merocyanine-540 (MC-540) on both leukemic and normal bone marrow (BM) cells. Acute promyelocytic leukemia (HL-60) and common acute lymphoblastic leukemia antigen-positive non-T, ...

journal_title：Cancer research

authors： Atzpodien J,Gulati SC,Clarkson BD

更新日期：1986-10-01 00:00:00

abstract：:A monoclonal antibody prepared against the Rauscher virus envelope glycoprotein with a molecular weight of 70,000 targeted to neoplastic cells and cured the Rauscher leukemia virus-induced erythroleukemia in BALB/c mice. This antibody, 103A, specifically reacted with the Rauscher and Friend erythroleukemia viruses and...

journal_title：Cancer research

authors： Scheinberg DA,Strand M

更新日期：1982-01-01 00:00:00

abstract：:Inhibition of the survival kinase Akt can trigger apoptosis, and also has been found to activate autophagy, which may confound tumor attack. In this study, we investigated regulatory mechanisms through which apoptosis and autophagy were modulated in tumor cells subjected to Akt inhibition by MK-2206, the first alloste...

journal_title：Cancer research

authors： Cheng Y,Ren X,Zhang Y,Patel R,Sharma A,Wu H,Robertson GP,Yan L,Rubin E,Yang JM

更新日期：2011-04-01 00:00:00

abstract：:beta 1-4 N-acetylglucosaminyltransferase (GnT-III) catalyzes the formation of bisecting N-acetylglucosamine (GlcNAc) in the biosynthesis of N-linked oligosaccharides. To examine the effect of bisecting GlcNAc on the natural killer (NK) cytotoxicity, the GnT-111 gene was introduced into NK-sensitive K562 cells that hav...

journal_title：Cancer research

authors： Yoshimura M,Ihara Y,Ohnishi A,Ijuhin N,Nishiura T,Kanakura Y,Matsuzawa Y,Taniguchi N

更新日期：1996-01-15 00:00:00

abstract：:To better understand immune responses to brain tumors and to develop possible approaches for immunotherapy, we have investigated the leukocyte populations infiltrating the rat 9L gliosarcoma. By immunocytochem-ical analyses of the cells infiltrating the tumor, we observed a substantial number of cells expressing natur...

journal_title：Cancer research

authors： Chambers WH,Bozik ME,Brissette-Storkus SC,Basse P,Redgate E,Watkins S,Boggs SS

更新日期：1996-08-01 00:00:00

abstract：:Multiple tobacco smoke-related premalignant and malignant lesions develop synchronously or metachronously in various organ sites, including the oral cavity. Both field cancerization and clonal migration seem to contribute to the occurrence of multiple tumors. Although the importance of endogenous factors (e.g., oncoge...

journal_title：Cancer research

authors： Du B,Leung H,Khan KM,Miller CG,Subbaramaiah K,Falcone DJ,Dannenberg AJ

更新日期：2007-09-15 00:00:00

abstract：:During 2007, approximately 200,000 people in the United States will be diagnosed with brain tumors. Gliomas account for 77% of primary malignant brain tumors, and the prognosis has hardly changed in the past 20 years, with only 30% of patients with malignant glioma surviving 5 years after diagnosis. Oncolytic adenovir...

journal_title：Cancer research

authors： Alonso MM,Cascallo M,Gomez-Manzano C,Jiang H,Bekele BN,Perez-Gimenez A,Lang FF,Piao Y,Alemany R,Fueyo J

更新日期：2007-09-01 00:00:00

abstract：:Cyclooxygenase (COX)-2 and vascular endothelial growth factor (VEGF) are significantly associated with tumor growth and metastasis. Here we show that phorbol ester-mediated induction of VEGF and COX-2 expression in colon carcinoma cells is inhibited by 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)). This cyclop...

journal_title：Cancer research

authors： Grau R,Iñiguez MA,Fresno M

更新日期：2004-08-01 00:00:00

abstract：:Previous studies have shown that the invasion of V2 carcinoma cells in the rabbit mesentery is associated with marked extracellular matrix synthesis leading eventually to an overall increase in mesenteric mass. The purpose of the present study was to investigate the structural and biochemical composition of the extrac...

journal_title：Cancer research

authors： Iozzo RV,Müller-Glauser W

更新日期：1985-11-01 00:00:00

abstract：:As with many types of cancer, cell motility is an important factor in the progression and metastasis of hepatocellular carcinomas (HCC). HCC is associated with significant fibrosis in the liver. The fibrotic microenvironment in the liver is characterized by an altered composition of the extracellular matrix (ECM) and ...

journal_title：Cancer research

authors： Yang C,Zeisberg M,Lively JC,Nyberg P,Afdhal N,Kalluri R

更新日期：2003-12-01 00:00:00

abstract：:Molecular insights into how chronic stress affects lung tumorigenesis may offer new routes to chemoprevention. In this study, we show that chronic stress in mice chemically or genetically initiated for lung cancer leads to the release of norepinephrine and other catecholamines, thereby promoting lung tumorigenesis. Me...

journal_title：Cancer research

authors： Jang HJ,Boo HJ,Lee HJ,Min HY,Lee HY

更新日期：2016-11-15 00:00:00