Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion.

abstract：:Claudin proteins form a large family of integral membrane proteins crucial for tight junction formation and function. Our previous studies have revealed that claudin-3 and claudin-4 proteins are highly overexpressed in ovarian cancer. To clarify the roles of claudins in ovarian tumorigenesis, we have generated human o...

journal_title：Cancer research

authors： Agarwal R,D'Souza T,Morin PJ

更新日期：2005-08-15 00:00:00

abstract：:All mammalian cells express 3 closely related Ras proteins, termed H-Ras, K-Ras, and N-Ras, that promote oncogenesis when they are mutationally activated at codon 12, 13, or 61. Although there is a high degree of similarity among the isoforms, K-Ras mutations are far more frequently observed in cancer, and each isofor...

journal_title：Cancer research

authors： Prior IA,Lewis PD,Mattos C

更新日期：2012-05-15 00:00:00

abstract：:Orthotopic transplantation of human tumors in nude mice reproduces the pattern of local growth and distal dissemination. The aim of our study was to determine the pattern of genetic alterations in human carcinomas of the exocrine pancreas orthotopically implanted and perpetuated in nude mice. Eight of the sixteen orth...

journal_title：Cancer research

authors： Reyes G,Villanueva A,García C,Sancho FJ,Piulats J,Lluís F,Capellá G

更新日期：1996-12-15 00:00:00

abstract：:Thymidine phosphorylase (TP) is an enzyme involved in the reversible conversion of thymidine to thymine and is identical to an angiogenic factor, platelet-derived endothelial cell growth factor. TP is expressed at higher levels in a wide variety of solid tumors than in the adjacent nonneoplastic tissues. Patients with...

journal_title：Cancer research

authors： Matsushita S,Nitanda T,Furukawa T,Sumizawa T,Tani A,Nishimoto K,Akiba S,Miyadera K,Fukushima M,Yamada Y,Yoshida H,Kanzaki T,Akiyama S

更新日期：1999-04-15 00:00:00

abstract：:The biosynthesis of distinct prostatic and lysosomal acid phosphatases is demonstrated using a human prostatic carcinoma cell line, PC-3SF12. The biosynthesis and maturation of the acid phosphatases was studied by metabolic labeling with radioactive leucine, specific immunoprecipitation, sodium dodecyl sulfate-polyacr...

journal_title：Cancer research

authors： Waheed A,Van Etten RL

更新日期：1986-09-01 00:00:00

abstract：:The glutathione transferase P (GST-P) gene is known for its specific expression during chemical hepatocarcinogenesis of the rat and is used as a tumor marker for hepatocellular carcinoma. We have shown recently that the upstream 2.9-kb region of the GST-P gene is sufficient for conferring tumor-specific expression of ...

journal_title：Cancer research

authors： Suzuki T,Imagawa M,Hirabayashi M,Yuki A,Hisatake K,Nomura K,Kitagawa T,Muramatsu M

更新日期：1995-06-15 00:00:00

abstract：:Metastatic cases of breast cancer pose the primary challenge in clinical management of this disease, demanding the identification of effective therapeutic strategies that remain wanting. In this study, we report that elevated levels of α-tubulin acetylation are a sufficient cause of metastatic potential in breast canc...

journal_title：Cancer research

authors： Boggs AE,Vitolo MI,Whipple RA,Charpentier MS,Goloubeva OG,Ioffe OB,Tuttle KC,Slovic J,Lu Y,Mills GB,Martin SS

更新日期：2015-01-01 00:00:00

abstract：:The migration of three human prostate tumor epithelial cell lines (TSU-pr1, PC-3, DU-145) in response to secreted protein from a human prostate stromal cell line was investigated by using the modified blind-well Boyden chamber assay. Migrated cells were quantified by spectrophotometrically measuring the concentration ...

journal_title：Cancer research

authors： Djakiew D,Pflug BR,Delsite R,Onoda M,Lynch JH,Arand G,Thompson EW

更新日期：1993-03-15 00:00:00

abstract：:The majority of advanced prostate cancer therapies aim to inhibit androgen receptor (AR) signaling. However, AR reactivation inevitably drives disease progression to castration-resistant prostate cancer (CRPC). Here we demonstrate that protein arginine methyltransferase 5 (PRMT5) functions as an epigenetic activator o...

journal_title：Cancer research

authors： Beketova E,Fang S,Owens JL,Liu S,Chen X,Zhang Q,Asberry AM,Deng X,Malola J,Huang J,Li C,Pili R,Elzey BD,Ratliff TL,Wan J,Hu CD

更新日期：2020-11-15 00:00:00

abstract：:A monoclonal antibody, 44-3A6, was raised against the human pulmonary adenocarcinoma cell line A549. This antibody recognizes a protein antigen at the cell surface, which is preserved after formalin fixation and paraffin embedding. Immunohistochemical staining of lung tissue with this antibody revealed diffuse immunor...

journal_title：Cancer research

authors： Lee I,Radosevich JA,Ma YX,Combs SG,Rosen ST,Gould VE

更新日期：1985-11-01 00:00:00

abstract：:Immunologic targeting of the oncoprotein HER2/neu with monoclonal antibodies is an important component of current therapeutic strategies for patients with locally and systemically advanced breast cancer. Engineered antibodies targeting HER2 may have agonist or antagonist effects on HER2, but little is known about whet...

journal_title：Cancer research

authors： Montgomery RB,Makary E,Schiffman K,Goodell V,Disis ML

更新日期：2005-01-15 00:00:00

abstract：:Aggressive cancer cells typically show a high rate of energy-consuming anabolic processes driving the synthesis of lipids, proteins, and DNA. Here, we took advantage of the ability of the cell-permeable nucleoside 5-aminoimidazole-4-carboxamide (AICA) riboside to increase the intracellular levels of AICA ribotide, an ...

journal_title：Cancer research

authors： Swinnen JV,Beckers A,Brusselmans K,Organe S,Segers J,Timmermans L,Vanderhoydonc F,Deboel L,Derua R,Waelkens E,De Schrijver E,Van de Sande T,Noël A,Foufelle F,Verhoeven G

更新日期：2005-03-15 00:00:00

abstract：:The regulation of cyclic adenosine 3:5-monophosphate (cyclic AMP) phosphodiesterase activity in homogenates of malignant and cyclic AMP-induced "differentiated" neuroblastoma cells was studied. Neuroblastoma cells of at least three mouse and one human clone had both the low (2 to 4 muM) and the high (66 to 106 muM) Km...

journal_title：Cancer research

authors： Kumar S,Becker G,Prasad KN

更新日期：1975-01-01 00:00:00

abstract：:beta 1-4 N-acetylglucosaminyltransferase (GnT-III) catalyzes the formation of bisecting N-acetylglucosamine (GlcNAc) in the biosynthesis of N-linked oligosaccharides. To examine the effect of bisecting GlcNAc on the natural killer (NK) cytotoxicity, the GnT-111 gene was introduced into NK-sensitive K562 cells that hav...

journal_title：Cancer research

authors： Yoshimura M,Ihara Y,Ohnishi A,Ijuhin N,Nishiura T,Kanakura Y,Matsuzawa Y,Taniguchi N

更新日期：1996-01-15 00:00:00

abstract：:In the last decade, large-scale genomic studies in patients with hematologic malignancies identified recurrent somatic alterations in epigenetic modifier genes. Among these, the de novo DNA methyltransferase DNMT3A has emerged as one of the most frequently mutated genes in adult myeloid as well as lymphoid malignancie...

journal_title：Cancer research

authors： Venugopal K,Feng Y,Shabashvili D,Guryanova OA

更新日期：2021-01-15 00:00:00

abstract：:Administration of alpha/beta-interferon (IFN) exerts a marked antitumor effect in DBA/2 mice given injections i.v. of large numbers of IFN-alpha/beta-resistant erythroleukemia cells (FLC). To investigate the possible mechanisms of FLC tumor inhibition in the liver of interferon-treated mice, we developed an in vitro m...

journal_title：Cancer research

authors： Yasui H,Proietti E,Vignaux F,Eid P,Gresser I

更新日期：1990-06-15 00:00:00

abstract：:Emerging studies indicate that DNA damage in cancer cells triggers antitumor immunity, but its intrinsic regulatory mechanism in breast cancer cells remains poorly understood. Here, we show that ZMYND8 is upregulated and inhibits micronucleus formation and DNA damage in breast cancer cells. Loss of ZMYND8 triggered ac...

journal_title：Cancer research

authors： Wang Y,Luo M,Chen Y,Wang Y,Zhang B,Ren Z,Bao L,Wang Y,Wang JE,Fu YX,Luo W,Wang Y

更新日期：2020-11-04 00:00:00

abstract：:TNF-α, produced by most malignant cells, orchestrates the interplay between malignant cells and myeloid cells, which have been linked to tumor growth and metastasis. Although TNF-α can exist as one of two isoforms, a 26-kDa membrane tethered form (mTNF-α) or a soluble 17-kDa cytokine (sTNF-α), the vast majority of pub...

journal_title：Cancer research

authors： Ardestani S,Li B,Deskins DL,Wu H,Massion PP,Young PP

更新日期：2013-07-01 00:00:00

abstract：:The N-myc gene is transiently expressed during normal embryonic development and abnormally expressed in several tumors of neuroendocrine origin. Little is known of the function of the N-myc gene product in either normal or neoplastic tissue. We utilized synthetic antisense oligodeoxynucleotides to specifically inhibit...

journal_title：Cancer research

authors： Rosolen A,Whitesell L,Ikegaki N,Kennett RH,Neckers LM

更新日期：1990-10-01 00:00:00

abstract：:miRNAs that translocate from the nucleus to mitochondria are referred to as mitochondrial microRNAs (mitomiR). mitomiRs have been shown to modulate the translational activity of the mitochondrial genome, yet their role in mitochondrial DNA (mtDNA) transcription remains to be determined. Here we report that the mitomiR...

journal_title：Cancer research

authors： Fan S,Tian T,Chen W,Lv X,Lei X,Zhang H,Sun S,Cai L,Pan G,He L,Ou Z,Lin X,Wang X,Perez MF,Tu Z,Ferrone S,Tannous BA,Li J

更新日期：2019-03-15 00:00:00

abstract：:The objective of this study was to investigate the induction of liver tumors by arylhydroxamic acids. The potential involvement of sulfate conjugation was minimized by the administration of a N-hydroxy-4-acylaminobiphenyl to female CD rats. This experimental design provided for the exposure of a target organ that has ...

journal_title：Cancer research

authors： Shirai T,Lee MS,Wang CY,King CM

更新日期：1981-06-01 00:00:00

abstract：:HER2/Neu/ERBB2 is a receptor tyrosine kinase overexpressed in approximately 20% of human breast tumors. Truncated or mutant isoforms that show increased oncogenicity compared with the wild-type receptor are found in many breast tumors. Here, we report that constitutively active ERBB2 sensitizes human breast epithelial...

journal_title：Cancer research

authors： Martín-Pérez R,Palacios C,Yerbes R,Cano-González A,Iglesias-Serret D,Gil J,Reginato MJ,López-Rivas A

更新日期：2014-03-15 00:00:00

abstract：:To investigate the influence of interleukin 6 (IL-6) production on malignancy of tumor cells we transfected cells of the high-metastatic, low-immunogenic D122 clone of the Lewis lung carcinoma with a mammalian expression vector containing the human IL-6 complementary DNA. In vitro, IL-6 positive transfectants showed g...

journal_title：Cancer research

authors： Porgador A,Tzehoval E,Katz A,Vadai E,Revel M,Feldman M,Eisenbach L

更新日期：1992-07-01 00:00:00

abstract：:The ability of cancer cells to evade apoptosis is dictated by a shift in the balance between proapoptotic and antiapoptotic gene expression programs. Monocyte chemotactic protein-induced protein 1 (MCPIP1) is a zinc-finger RNA binding protein with important roles in mediating inflammatory responses. Overexpression of ...

journal_title：Cancer research

authors： Lu W,Ning H,Gu L,Peng H,Wang Q,Hou R,Fu M,Hoft DF,Liu J

更新日期：2016-03-15 00:00:00

abstract：:Integrin β3 is critical for tumor invasion, neoangiogenesis, and inflammation, making it a promising cancer target. However, preclinical and clinical data of integrin β3 antagonists have demonstrated no benefit or worse outcomes. We hypothesized that integrin β3 could affect tumor immunity and evaluated tumors in mice...

journal_title：Cancer research

authors： Su X,Esser AK,Amend SR,Xiang J,Xu Y,Ross MH,Fox GC,Kobayashi T,Steri V,Roomp K,Fontana F,Hurchla MA,Knolhoff BL,Meyer MA,Morgan EA,Tomasson JC,Novack JS,Zou W,Faccio R,Novack DV,Robinson SD,Teitelbaum SL,DeNar

更新日期：2016-06-15 00:00:00

abstract：:Mutated ras genes are powerful transforming agents in vitro and are found in a wide variety of human tumors in vivo. We characterized the histopathology and p21 protein expression associated with tumorigenesis in line 69 transgenic mice carrying an activated, human c-Ha-ras gene on the Y-chromosome (A. C. Andres, C. A...

journal_title：Cancer research

authors： Nielsen LL,Discafani CM,Gurnani M,Tyler RD

更新日期：1991-07-15 00:00:00

abstract：:Lipid peroxidation is considered a unifying mechanistic pathway through which known risk factors induce renal cell carcinoma (RCC). We hypothesized that genes selected a priori for their role in lipid peroxidation would modify cancer risk. We genotyped 635 single nucleotide polymorphisms (SNP) in 38candidate genes in ...

journal_title：Cancer research

authors： Moore LE,Brennan P,Karami S,Menashe I,Berndt SI,Dong LM,Meisner A,Yeager M,Chanock S,Colt J,Schwartz K,Davis F,Zaridze D,Mattveev V,Janout V,Kollarova H,Bencko V,Navratilova M,Szeszenia-Dabrowska N,Mates D,Holcato

更新日期：2009-10-15 00:00:00

abstract：:Acute endothelial cell apoptosis and microvascular compromise couple gastrointestinal tract irradiation to reproductive death of intestinal crypt stem cell clonogens (SCCs) following high-dose radiation. Genetic or pharmacologic inhibition of endothelial apoptosis prevents intestinal damage, but as the radiation dose ...

journal_title：Cancer research

authors： Rotolo JA,Mesicek J,Maj J,Truman JP,Haimovitz-Friedman A,Kolesnick R,Fuks Z

更新日期：2010-02-01 00:00:00

abstract：:Gene targeting studies in mice have shown that the transcription factor Ikaros plays an essential role in lymphoid development and as a tumor suppressor in T cells, whereas the related gene Aiolos functions as a tumor suppressor in B cells. We analyzed the expression levels of the Ikaros gene family, Ikaros and Aiolos...

journal_title：Cancer research

authors： Nakase K,Ishimaru F,Avitahl N,Dansako H,Matsuo K,Fujii K,Sezaki N,Nakayama H,Yano T,Fukuda S,Imajoh K,Takeuchi M,Miyata A,Hara M,Yasukawa M,Takahashi I,Taguchi H,Matsue K,Nakao S,Niho Y,Takenaka K,Shinagawa K,

更新日期：2000-08-01 00:00:00

abstract：:Down-regulation of gelsolin, an actin-binding protein, is frequently found in several types of transformed cells and tumors. The present study demonstrates that gelsolin protein and RNA were absent or markedly reduced in human breast cancer cell lines relative to "normal" mortal human mammary epithelial cells and beni...

journal_title：Cancer research

authors： Asch HL,Head K,Dong Y,Natoli F,Winston JS,Connolly JL,Asch BB

更新日期：1996-11-01 00:00:00