miR-483-5p promotes invasion and metastasis of lung adenocarcinoma by targeting RhoGDI1 and ALCAM.

abstract：:Metastasis requires cytoskeletal remodeling for migration, adhesion, and extravasation of metastatic cells. Although protein kinase C (PKC) is involved in tumor promotion/progression and cytoskeletal remodeling, its role in metastasis has not been defined. PKCdelta levels are increased in highly metastatic 13762NF mam...

journal_title：Cancer research

authors： Kiley SC,Clark KJ,Goodnough M,Welch DR,Jaken S

更新日期：1999-07-01 00:00:00

abstract：:Thymus, spleen, and bone marrow of 1-month-old neonatally Moloney murine leukemia virus-inoculated mice have been transferred to 400-R-irradiated syngeneic recipients of the opposite sex. The donor or recipient origin of T-cell lymphomas arising in the host animal was identified by the sex chromosome marker. Spleen an...

journal_title：Cancer research

authors： Asjö B,Skoog L,Palminger I,Wiener F,Isaak D,Cerny J,Fenyö EM

更新日期：1985-03-01 00:00:00

abstract：:Sixteen clones (RASK-1 to -16) of murine monoclonal antibodies were raised against ras Mr 21,000 protein (p21). The p21 produced by Escherichia coli with inserted v-Ki-ras genes was used as immunogen. RASK-1 was found to be specific for Ki-ras p21, whereas RASK-2 to -16 reacted with the p21s of Ki-, N-, and Ha-ras gen...

journal_title：Cancer research

authors： Yoshida K,Hamatani K,Koide H,Ikeda H,Nakamura N,Akiyama M,Tsuchiyama H,Nakayama E,Shiku H

更新日期：1988-10-01 00:00:00

abstract：:We have studied the lipid composition and the acyl group composition, transport, and metabolism of doxorubicin-sensitive and -resistant rat glioblastoma cells in monolayer cultures (C6 clone). No difference in lipid composition was evidenced; the acyl group composition was, in contrast, highly modified in resistant ce...

journal_title：Cancer research

authors： Vrignaud P,Montaudon D,Londos-Gagliardi D,Robert J

更新日期：1986-07-01 00:00:00

abstract：:The ability of osteosarcoma cells to form lung metastases has been inversely correlated to cell surface Fas expression. Downregulation of Fas allows osteosarcoma cells to circumvent FasL-mediated apoptosis upon entrance into the FasL(+) lung microenvironment. However, the mechanism of Fas regulation remains unclear. H...

journal_title：Cancer research

authors： Huang G,Nishimoto K,Zhou Z,Hughes D,Kleinerman ES

更新日期：2012-02-15 00:00:00

abstract：:Human enhancer of filamentation 1 (HEF1; also known as NEDD9 or Cas-L) is a scaffolding protein that is implicated in regulating diverse cellular processes, such as cellular attachment, motility, cell cycle progression, apoptosis, and inflammation. Here, we identify HEF1 as a novel hypoxia-inducible factor-1alpha (HIF...

journal_title：Cancer research

authors： Kim SH,Xia D,Kim SW,Holla V,Menter DG,Dubois RN

更新日期：2010-05-15 00:00:00

abstract：:: Cancer cells in quiescence (G0 phase) are resistant to death, and re-entry of quiescent cancer cells into the cell-cycle plays an important role in cancer recurrence. Here we show that two p53-responsive miRNAs utilize distinct but complementary mechanisms to promote cancer cell quiescence by facilitating stabilizat...

journal_title：Cancer research

authors： La T,Liu GZ,Farrelly M,Cole N,Feng YC,Zhang YY,Sherwin SK,Yari H,Tabatabaee H,Yan XG,Guo ST,Liu T,Thorne RF,Jin L,Zhang XD

更新日期：2018-12-01 00:00:00

abstract：:Hypoxia occurs in two forms in tumors. Chronic or diffusion-limited hypoxia is relatively well characterized. In contrast, intermittent or perfusion-limited hypoxia is not well characterized, and it is not known how common it is in tumors. The purpose of this study was to determine whether spontaneous fluctuations in ...

journal_title：Cancer research

authors： Kimura H,Braun RD,Ong ET,Hsu R,Secomb TW,Papahadjopoulos D,Hong K,Dewhirst MW

更新日期：1996-12-01 00:00:00

abstract：:A synthetic peptide from the inner globule of the B1 chain of laminin, termed peptide F-9 (RYVVLPRPVCFEKGMNYTVR; residues 641-660), has been shown to have heparin-binding and cell adhesion-promoting activities for diverse cell types (Charonis et al., J. Cell. Biol., 107: 1253-1260, 1988). In this study, the metastatic...

journal_title：Cancer research

authors： Skubitz AP,McCarthy JB,Zhao Q,Yi XY,Furcht LT

更新日期：1990-12-01 00:00:00

abstract：:Wnt ligand-driven tumor growth is inhibited by the soluble Wnt inhibitor Fzd8CRD, but the mechanism through which this effect is mediated is unknown. In the MMTV-Wnt1 mouse model, regression of mammary tumors by Fzd8CRD treatment coincides with an acute and strong induction of insulin-like growth factor (IGF)-binding ...

journal_title：Cancer research

authors： Liu BY,Soloviev I,Huang X,Chang P,Ernst JA,Polakis P,Sakanaka C

更新日期：2012-03-15 00:00:00

abstract：:Serological identification of tumor antigens by cDNA expression cloning is a technique used to isolate cDNAs encoding tumor antigens that are recognized by IgG antibodies in sera from cancer patients. It is also useful for the isolation of tumor antigens recognized by T cells. We applied this method to identify melano...

journal_title：Cancer research

authors： Kiniwa Y,Fujita T,Akada M,Ito K,Shofuda T,Suzuki Y,Yamamoto A,Saida T,Kawakami Y

更新日期：2001-11-01 00:00:00

abstract：:Enhanced glucose and lipid metabolism is one of the most common properties of malignant cells. ATP citrate lyase (ACLY) is a key enzyme of de novo fatty acid synthesis responsible for generating cytosolic acetyl-CoA and oxaloacetate. To evaluate its role in lung cancer progression, we here analyzed ACLY expression in ...

journal_title：Cancer research

authors： Migita T,Narita T,Nomura K,Miyagi E,Inazuka F,Matsuura M,Ushijima M,Mashima T,Seimiya H,Satoh Y,Okumura S,Nakagawa K,Ishikawa Y

更新日期：2008-10-15 00:00:00

abstract：:Although a majority of malignant testicular Leydig cell tumors induced in the mouse by chronic estrogenization remain dependent upon estrogen stimulation for growth during early transplant generations, we have observed tumors of two lines, no longer growth dependent upon estrogen, that regressed when hosts bearing pal...

journal_title：Cancer research

authors： Huseby RA

更新日期：1983-11-01 00:00:00

abstract：:Pheophorbide a (PhA), a chlorophyll catabolite, was shown to be an ABCG2 substrate based on Abcg2(-/-) knockout mouse studies (J. W. Jonker et al., Proc. Natl. Acad. Sci. USA, 99: 15649-15654, 2002). We developed a functional assay for ABCG2 using PhA and the ABCG2 inhibitor fumitremorgin C. In selected cell lines exp...

journal_title：Cancer research

authors： Robey RW,Steadman K,Polgar O,Morisaki K,Blayney M,Mistry P,Bates SE

更新日期：2004-02-15 00:00:00

abstract：:Thirteen variables were evaluated for their significance in predicting the survival of 148 patients in a retrospective study with clinical Stage I cutaneous malignant melanoma. The variables studied were histological type, tumor thickness, level of invasion, mitotic activity, pigmentation type, existence of ulceration...

journal_title：Cancer research

authors： Hacene K,Le Doussal V,Brunet M,Lemoine F,Guerin P,Hebert H

更新日期：1983-06-01 00:00:00

abstract：:Alkaline hydrolysate of dialyzed formaldehyde-treated RNA, in which 39% of purine nucleotides are modified to methylene bis derivatives (R-CH2-R'), displays cytotoxic activity toward cultured human tumor cells. The alkaline hydrolysate of dialyzed formaldehyde-treated RNA is substantially less toxic to normal human em...

journal_title：Cancer research

authors： Feldman MY,Balabanova H,Bachrach U,Pyshnov M

更新日期：1977-02-01 00:00:00

abstract：:In the epidermis, p53 plays an important role in UV-B protection that led us to examine the role, if any, that p63, a p53 homologue highly expressed in the basal layer of the epidermis, might play in the epidermal UV-B response. One p63 isoform, deltaNp63alpha, decreased dramatically in normal keratinocytes or newborn...

journal_title：Cancer research

authors： Liefer KM,Koster MI,Wang XJ,Yang A,McKeon F,Roop DR

更新日期：2000-08-01 00:00:00

abstract：:The effects of streptozotocin (SZ) and N-nitrosobis(2-oxopropyl)amine (BOP), separately or in combination, on the pancreas, common duct, and gallbladder, all target tissues of BOP, were studied in Syrian golden hamsters. Groups of hamsters were treated with either a single dose (20 mg/kg body weight) of BOP (BOP group...

journal_title：Cancer research

authors： Pour PM,Kazakoff K,Carlson K

更新日期：1990-03-01 00:00:00

abstract：:MicroRNAs (miRNA) are a recently discovered class of noncoding RNAs that negatively regulate gene expression. Recent evidence indicates that miRNAs may play an important role in cancer. However, the mechanism of their deregulation in neoplastic transformation has only begun to be understood. To elucidate the role of t...

journal_title：Cancer research

authors： Corney DC,Flesken-Nikitin A,Godwin AK,Wang W,Nikitin AY

更新日期：2007-09-15 00:00:00

abstract：:Metastatic nonseminomatous testicular germ cell tumors are curable using combination chemotherapy in approximately 80% of patients. In contrast, most other patients with other types of cancer either present with or acquire drug-resistant disease following chemotherapy. Cell lines derived from testis tumors retain hype...

journal_title：Cancer research

authors： Parris CN,Walker MC,Masters JR,Arlett CF

更新日期：1990-12-01 00:00:00

abstract：:We tried to purify carcinoembryonic antigen (CEA)-related antigens in normal human feces and found that, besides nonspecific cross-reacting antigen (fecal NCA), there are three other molecular species of CEA-related antigens which have been inclusively called normal fecal antigen (NFA). These were designated normal fe...

journal_title：Cancer research

authors： Kuroki M,Koga Y,Matsuoka Y

更新日期：1981-02-01 00:00:00

abstract：:Natural killer (NK) immune cells mediate antibody-dependent cellular cytotoxicity (ADCC) by aggregating FcγRIIIA/CD16, contributing significantly to the therapeutic effect of CD20 monoclonal antibodies (mAb). In this study, we show that CD16 ligation on primary human NK cells by the anti-CD20 mAb rituximab or ofatumum...

journal_title：Cancer research

authors： Capuano C,Romanelli M,Pighi C,Cimino G,Rago A,Molfetta R,Paolini R,Santoni A,Galandrini R

更新日期：2015-10-01 00:00:00

abstract：:Anchorage-independent growth is a hallmark of tumor cells. We compared gene expression profiles of anchored and nonanchored human mammary carcinoma cells to study this phenomenon. In this study, we show that anchorage had striking effects on cell growth and morphology but altered transcript levels from a limited numbe...

journal_title：Cancer research

authors： Goldberg GS,Jin Z,Ichikawa H,Naito A,Ohki M,El-Deiry WS,Tsuda H

更新日期：2001-02-15 00:00:00

abstract：:There are conflicting data in the literature as to whether cytotoxicity of the cytidine antimetabolite 5'-azacytidine (AZC) is a consequence of its incorporation into RNA, DNA, or both. Because apoptosis appears to be the predominant mode of tumor cell death after treatment with most antitumor drugs, and in the case o...

journal_title：Cancer research

authors： Murakami T,Li X,Gong J,Bhatia U,Traganos F,Darzynkiewicz Z

更新日期：1995-07-15 00:00:00

abstract：:The nucleus has been shown to be a site for the inositol lipid cycle that can be affected by treatment of quiescent cells with growth factors such as insulin-like growth factor I (IGF-I). Indeed, the exposure of Swiss 3T3 cells to IGF-I results in a rapid and transient increase in nuclear phospholipase C (PLC) beta1 a...

journal_title：Cancer research

authors： Manzoli L,Billi AM,Rubbini S,Bavelloni A,Faenza I,Gilmour RS,Rhee SG,Cocco L

更新日期：1997-06-01 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) promotes a multitude of diverse biological processes, including growth arrest of epithelial cells and proliferation of fibroblasts. Although the TGF-beta signaling pathways that promote inhibition of epithelial cell growth are well characterized, less is known about the mecha...

journal_title：Cancer research

authors： Rahimi RA,Andrianifahanana M,Wilkes MC,Edens M,Kottom TJ,Blenis J,Leof EB

更新日期：2009-01-01 00:00:00

abstract：:Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy and constitutes 15% of adult leukemias. Although overall prognosis for pediatric ALL is favorable, high-risk pediatric patients and most adult patients have significantly worse outcomes. Multiagent chemotherapy is standard of care for both pedi...

journal_title：Cancer research

authors： Chao MP,Alizadeh AA,Tang C,Jan M,Weissman-Tsukamoto R,Zhao F,Park CY,Weissman IL,Majeti R

更新日期：2011-02-15 00:00:00

abstract：:Glucuronidation is an important pathway in the metabolism of nicotine, with previous studies suggesting that ∼22% of urinary nicotine metabolites are in the form of glucuronidated compounds. Recent in vitro studies have suggested that the UDP-glucuronosyltransferases (UGT) 2B10 and 2B17 play major roles in nicotine gl...

journal_title：Cancer research

authors： Chen G,Giambrone NE Jr,Dluzen DF,Muscat JE,Berg A,Gallagher CJ,Lazarus P

更新日期：2010-10-01 00:00:00

abstract：:The human cytomegalovirus (HCMV), potentially associated with the development of malignancies, encodes the constitutively active chemokine receptor US28. Previously, we have shown that US28 expression induces an oncogenic phenotype both in vitro and in vivo. Microarray analysis revealed differential expression of gene...

journal_title：Cancer research

authors： Maussang D,Langemeijer E,Fitzsimons CP,Stigter-van Walsum M,Dijkman R,Borg MK,Slinger E,Schreiber A,Michel D,Tensen CP,van Dongen GA,Leurs R,Smit MJ

更新日期：2009-04-01 00:00:00

abstract：:Alkaline phosphatase activity in human endometrial cancer cells of the estrogen-responsive Ishikawa line was markedly stimulated (3-20-fold in 4 days) by estrogens, 5 alpha-dihydrotestosterone, and dehydroepiandrosterone but not by testosterone, medroxyprogesterone acetate, glucocorticoids, several peptide hormones, p...

journal_title：Cancer research

authors： Holinka CF,Hata H,Kuramoto H,Gurpide E

更新日期：1986-06-01 00:00:00