Pheophorbide a is a specific probe for ABCG2 function and inhibition.

abstract：:(-)-Epigallocatechin-3-gallate (EGCG), the principal polyphenol in green tea, has been shown to inhibit the growth of many cancer cell lines and to suppress the phosphorylation of epidermal growth factor receptor (EGFR). We observed similar effects of EGCG in esophageal squamous cell carcinoma KYSE 150 cells and epide...

journal_title：Cancer research

authors： Hou Z,Sang S,You H,Lee MJ,Hong J,Chin KV,Yang CS

更新日期：2005-09-01 00:00:00

abstract：:Human papillomaviruses (HPV), especially genotypes 16 and 18, are probable effectors of human urogenital malignancies. Although the male urethra is a proposed reservoir of HPV transmission, the association between HPV and squamous cell carcinoma (SCC) of the male urethra has not been studied. The highly sensitive tech...

journal_title：Cancer research

authors： Wiener JS,Liu ET,Walther PJ

更新日期：1992-09-15 00:00:00

abstract：:Antibody titer to Bacillus Calmette-Guérin (BCG) was determined by complement fixation in 111 normal volunteers and 83 melanoma patients. In 43 of these melanoma patients, sequential determination of antibody titer was made and correlated with clinical course. Low titers of antibody to BCG were found frequently in nor...

journal_title：Cancer research

authors： Wile AG,Sparks FC,Morton DL

更新日期：1977-07-01 00:00:00

abstract：:The tumor suppressor gene p53 regulates G1 checkpoint prior to the initiation of DNA synthesis, which can either induce G1 arrest or signal apoptosis. The involvement of p53 in apoptosis may also be related to its ability to down-regulate transcription of the bcl-2 gene. The bcl-2 gene product prevents most types of a...

journal_title：Cancer research

authors： Upadhyay S,Li G,Liu H,Chen YQ,Sarkar FH,Kim HR

更新日期：1995-10-15 00:00:00

abstract：:The transcription factor NRF2 (NFE2L2) is a pivotal activator of genes encoding cytoprotective and detoxifying enzymes that limit the action of cytotoxic therapies in cancer. NRF2 acts by binding antioxidant response elements (ARE) in its target genes, but there is relatively limited knowledge about how it is negative...

journal_title：Cancer research

authors： Wang H,Liu K,Geng M,Gao P,Wu X,Hai Y,Li Y,Li Y,Luo L,Hayes JD,Wang XJ,Tang X

更新日期：2013-05-15 00:00:00

abstract：:The role of glutathione (GSH) as a determinant of cellular sensitivity to the cytotoxic and DNA-damaging effects of cyclophosphamide (CP) was studied in a dual culture system of rat hepatocytes and K562 human chronic myeloid leukemia cells, which have elevated aldehyde dehydrogenase activity with a corresponding insen...

journal_title：Cancer research

authors： Crook TR,Souhami RL,Whyman GD,McLean AE

更新日期：1986-10-01 00:00:00

abstract：:Promoter hypermethylation and histone deacetylation are common epigenetic mechanisms implicated in the transcriptional silencing of tumor suppressor genes in human cancer. We treated two immortalized glioma cell lines, T98 and U87, and 10 patient-derived primary glioma cell lines with trichostatin A (TSA), a histone d...

journal_title：Cancer research

authors： Foltz G,Ryu GY,Yoon JG,Nelson T,Fahey J,Frakes A,Lee H,Field L,Zander K,Sibenaller Z,Ryken TC,Vibhakar R,Hood L,Madan A

更新日期：2006-07-01 00:00:00

abstract：:Variant cell lines that are sensitive to density-dependent inhibition of growth have been isolated from three of four SV40-transformed human fibroblast cell lines. Variants were isolated by plating the transformed cells at low density, by treating them with 5-fluorodeoxyuridine, or by growing them on glutaraldehyde-fi...

journal_title：Cancer research

authors： Rosenberg N,Schaeffer WI,Diamond L

更新日期：1975-08-01 00:00:00

abstract：:4-Hydroxyandrostenedione (CGP32349; 4-OHA) is a clinically effective treatment for advanced postmenopausal breast cancer by both the parenteral and p.o. routes, as a result of its inhibition of aromatase and consequent suppression of plasma estrogen levels. Thirty patients were randomized to treatment with 250 mg 4-OH...

journal_title：Cancer research

authors： Dowsett M,Cunningham DC,Stein RC,Evans S,Dehennin L,Hedley A,Coombes RC

更新日期：1989-03-01 00:00:00

abstract：:Expression of HEPSIN, a type II transmembrane serine protease in prostate cancer (CaP), has been highlighted by several studies analyzing CaP-specific gene expression alterations by cDNA microarray. Evaluations of the biological functions of HEPSIN in CaP cells are warranted for better assessment of its utility as a b...

journal_title：Cancer research

authors： Srikantan V,Valladares M,Rhim JS,Moul JW,Srivastava S

更新日期：2002-12-01 00:00:00

abstract：:Continued monitoring of a family for new malignant tumors has revealed diverse immunological and neoplastic disorders during a 15-year period. In 1966, the proband developed lymphoma. In 1975, his antibody titers to Epstein-Barr virus (EBV) became elevated, and again, he developed a malignant lymphoma. He also had bor...

journal_title：Cancer research

authors： Purtilo DT,Liao SA,Sakamoto K,Snyder LM,DeFlorio D Jr,Bhawan J,Paquin L,Yang JP,Hutt-Fletcher LM,Muralidharan K,Raffa P,Saemundsen AK,Klein G

更新日期：1981-11-01 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in combination with chemotherapeutic drugs induces a synergistic apoptotic response in cancer cells. TRAIL death receptors have also been implicated in chemotherapeutic drug-induced apoptosis. This has lead to TRAIL being proposed as a potential cancer tr...

journal_title：Cancer research

authors： Gibson EM,Henson ES,Haney N,Villanueva J,Gibson SB

更新日期：2002-01-15 00:00:00

abstract：:Glioblastoma is an aggressive brain tumor characterized by an abnormal blood vasculature that is hyperpermeable. Here, we report a novel role for CD93 in regulating angiogenesis in this setting by modulating cell-cell and cell-matrix adhesion of endothelial cells. Tissue microarray analysis demonstrated that vascular ...

journal_title：Cancer research

authors： Langenkamp E,Zhang L,Lugano R,Huang H,Elhassan TE,Georganaki M,Bazzar W,Lööf J,Trendelenburg G,Essand M,Pontén F,Smits A,Dimberg A

更新日期：2015-11-01 00:00:00

abstract：:Pemetrexed is a novel antifolate effective in the treatment of mesothelioma. Studies were undertaken to characterize the transport of this antifolate in this tumor. We report the presence of a novel, concentrative high-affinity transport activity in three human mesothelioma cell lines, characterized in detail in the N...

journal_title：Cancer research

authors： Wang Y,Zhao R,Chattopadhyay S,Goldman ID

更新日期：2002-11-15 00:00:00

abstract：:Patients with human papillomavirus (HPV+)-associated head and neck cancer (HNC) show significantly improved survival outcome compared with those with HPV-negative (HPV-) tumors. Published data examining this difference offers conflicting results to date. We systematically investigated the radiation sensitivity of all ...

journal_title：Cancer research

authors： Kimple RJ,Smith MA,Blitzer GC,Torres AD,Martin JA,Yang RZ,Peet CR,Lorenz LD,Nickel KP,Klingelhutz AJ,Lambert PF,Harari PM

更新日期：2013-08-01 00:00:00

abstract：:Glucocorticoid receptor (GR) has been shown to suppress activator protein 1 (AP-1)-mediated transcription by several molecular mechanisms. We previously showed that activation of endogenous AP-1 is essential for cellular transformation induced by oncogenes, such as v-src and c-Ha-ras. In the present study, we have ana...

journal_title：Cancer research

authors： Kameda T,Iba H

更新日期：1998-03-01 00:00:00

abstract：:Resistance to chemotherapy predicts an unfavorable outcome for patients with radioiodine-insensitive thyroid cancer. To investigate the mechanisms underlying this resistance, we evaluated the expression of four different inhibitor of apoptosis proteins, and their antagonist, Smac, in thyroid cancer cells that survived...

journal_title：Cancer research

authors： Tirrò E,Consoli ML,Massimino M,Manzella L,Frasca F,Sciacca L,Vicari L,Stassi G,Messina L,Messina A,Vigneri P

更新日期：2006-04-15 00:00:00

abstract：:Rabbit skin was infected with Shope papilloma virus and grafted orthotopically to nude mice. Typical Shope rabbit papillomas developed in most of the grafts, but similarly treated nude mouse skin grafts were not altered. These results demonstrated that xenogeneic tissues retained susceptibility to oncogenic agents aft...

journal_title：Cancer research

authors： Kreider JW,Bartlett GL,Sharkey FE

更新日期：1979-01-01 00:00:00

abstract：:The levels of serum thymic factor(s) (STF), of Thy-1.2 positivity of splenocytes [as measured by their azathioprine (AZ) sensitivity], and of Thy-1.2-positive "spontaneous" spleen rosette-forming cells (SSRFCs), as well as the presence of infectious virus in the thymus, were assessed as a function of time after virus ...

journal_title：Cancer research

authors： Tonietti G,Rossi GB,Del Gobbo V,Accinni L,Ranucci A,Titti F,Premrov MG,Garaci E

更新日期：1983-09-01 00:00:00

abstract：:Recent evidence from our laboratory and from others suggested that pretreatment with alpha-difluoromethylornithine (DFMO) sensitizes some human and rodent tumor cell lines to 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). Many human tumor cells are resistant to chloroethylnitrosourea-induced DNA interstrand cross-linkin...

journal_title：Cancer research

authors： Seidenfeld J,Barnes D,Block AL,Erickson LC

更新日期：1987-09-01 00:00:00

abstract：:In this report, we describe methods used to analyze the protein composition of sectioned frozen prostatic tissues by two-dimensional gel electrophoresis. Our results show a high degree of homology in two-dimensional electrophoretograms of proteins extracted from frozen sections of malignant prostate glands. Such homol...

journal_title：Cancer research

authors： Guevara J Jr,Herbert BH,Raymond AK,Batsakis JG

更新日期：1986-07-01 00:00:00

abstract：:Our laboratory has found genomic imprinting of a large genomic domain of human 11p15.5, identifying six imprinted genes within this domain: (a) insulin-like growth factor II (IGF-II), an important autocrine growth factor in a wide variety of malignancies; (b) H19, an untranslated RNA that is a putative growth suppress...

journal_title：Cancer research

authors： Feinberg AP

更新日期：1999-04-01 00:00:00

abstract：:The effect of basic fibroblast growth factor (b-FGF), one of the commonest angiogenic factors in various cancer types, on lymphocyte adhesion and transmigration across the endothelial cell monolayer was investigated using human umbilical vein-derived endothelial cells (HUVEC) and type I collagen gel. Forty-eight h exp...

journal_title：Cancer research

authors： Kitayama J,Nagawa H,Yasuhara H,Tsuno N,Kimura W,Shibata Y,Muto T

更新日期：1994-09-01 00:00:00

abstract：:Increased activity of the proto-oncogene c-Src and elevated levels of integrin alpha(v)beta(3) are found in melanomas and multiple carcinomas. Regulation of c-Src involves "priming" through disruption of intramolecular interactions followed by "activation" through phosphorylation in the kinase domain. Interactions wit...

journal_title：Cancer research

authors： Huveneers S,van den Bout I,Sonneveld P,Sancho A,Sonnenberg A,Danen EH

更新日期：2007-03-15 00:00:00

abstract：:A slight induction of granulocytic differentiation of HL-60 cells occurred after treatment with antileukemia chemotherapeutic agents Adriamycin (ADM) and daunomycin (DM). Addition of an inhibitor (sphinganine, SP) of protein kinase C (PKC) enhanced 2-4-fold the ADM or DM-induced differentiation. This phenomenon was ac...

journal_title：Cancer research

authors： Yung BY,Luo KJ,Hui EK

更新日期：1992-07-01 00:00:00

abstract：:ErbB-2 (HER-2/neu) is a transforming oncogene expressed by a substantial fraction of breast cancers, and monoclonal antibody therapy directed toward this antigen is an established treatment modality. However, not all tumors respond, and with a monoclonal antibody directed to a single epitope, there is always the risk ...

journal_title：Cancer research

authors： Park JM,Terabe M,Steel JC,Forni G,Sakai Y,Morris JC,Berzofsky JA

更新日期：2008-03-15 00:00:00

abstract：:The toxicity and pharmacokinetics of cis-diamminedichloroplatinum (cisplatin) (90 mg/sq m) administered as a single 4-hr peritoneal dialysis, with or without concurrent i.v. infusion of sodium thiosulfate, 0.43 or 2.13 g/sq m/hr for 12 hr, were studied on 20 courses of treatment. When given without thiosulfate, the to...

journal_title：Cancer research

authors： Howell SB,Pfeifle CE,Wung WE,Olshen RA

更新日期：1983-03-01 00:00:00

abstract：:A two site enzyme immunoassay which quantitatively identifies types I, II, and III of protein kinase C isozymes has been designed. The soluble protein kinase C isozymes were selectively immobilized by type-specific monoclonal antibodies, MC-1a, -2a, and -3a (H. Hidaka et al., J Biol. Chem., 263: 4523-4526, 1988) which...

journal_title：Cancer research

authors： Hagiwara M,Hachiya T,Watanabe M,Usuda N,Iida F,Tamai K,Hidaka H

更新日期：1990-09-01 00:00:00

abstract：:The thiopurines 6-thioguanine (6TG) and 6-mercaptopurine (6MP) are cytotoxic to proliferating cells by a mechanism involving incorporation into DNA via the purine salvage pathway, and resistance to these agents can be conferred by lack of the salvage pathway enzyme hypoxanthine-guanine phosphoribosyltransferase. Howev...

journal_title：Cancer research

authors： Morgan CJ,Chawdry RN,Smith AR,Siravo-Sagraves G,Trewyn RW

更新日期：1994-10-15 00:00:00

abstract：:Anaplastic large cell lymphomas (ALCL) are mainly characterized by the reciprocal translocation t(2;5)(p23;q35) that involves the anaplastic lymphoma kinase (ALK) gene and generates the fusion protein NPM-ALK with intrinsic tyrosine kinase activity. NPM-ALK triggers several signaling cascades, leading to increased cel...

journal_title：Cancer research

authors： Voena C,Conte C,Ambrogio C,Boeri Erba E,Boccalatte F,Mohammed S,Jensen ON,Palestro G,Inghirami G,Chiarle R

更新日期：2007-05-01 00:00:00