Distinct roles for mammalian target of rapamycin complexes in the fibroblast response to transforming growth factor-beta.

abstract：:Macrophages play important roles in both physiologic and pathologic processes and arise from successive waves of embryonic and adult hematopoiesis. Monocyte-derived macrophages (MOMF) exert distinct functions under pathologic conditions, and leukemia-associated macrophages (LAM) show considerable diversities in activa...

journal_title：Cancer research

authors： Yang F,Feng W,Wang H,Wang L,Liu X,Wang R,Chen C,Yang X,Zhang D,Ren Q,Zheng G

更新日期：2020-09-01 00:00:00

abstract：:Toll-like receptors (TLR) expressed on inflammatory cells play a key role in host defense against pathogens, benefiting the host. TLR are also expressed on tumor cells. To evaluate the role of TLR in tumor cells, we investigated TLR4 signaling effects on human head and neck squamous cell carcinoma (HNSCC). Tumor tissu...

journal_title：Cancer research

authors： Szczepanski MJ,Czystowska M,Szajnik M,Harasymczuk M,Boyiadzis M,Kruk-Zagajewska A,Szyfter W,Zeromski J,Whiteside TL

更新日期：2009-04-01 00:00:00

abstract：:The reason for estrogen independence of C3H mouse mammary tumors has been sought in the initial steps of estradiol action. The characteristics of the estrogen receptors were similar to those observed in estrogen-responsive tissues: high affinity and binding specificity, DNA binding and 8S sedimentation constant as sho...

journal_title：Cancer research

authors： Vignon F,Rochefort H

更新日期：1978-06-01 00:00:00

abstract：:Ataxia-telangiectasia (A-T) is a human disease characterized by high cancer risk, immune defects, radiation sensitivity, and genetic instability. Although A-T homozygotes are rare, the A-T gene may play a role in sporadic breast cancer and other common cancers. Abnormalities of DNA repair, genetic recombination, chrom...

journal_title：Cancer research

authors： Meyn MS

更新日期：1995-12-15 00:00:00

abstract：:We used comparative genomic hybridization to study malignant fibrous histiocytomas (MFHs) from 19 patients to detect changes in the copy number of DNA sequences, along entire chromosomes. Together with losses and gains in various chromosomal regions, distinct high-level amplifications were found at six loci (4q12-21, ...

journal_title：Cancer research

authors： Sakabe T,Shinomiya T,Mori T,Ariyama Y,Fukuda Y,Fujiwara T,Nakamura Y,Inazawa J

更新日期：1999-02-01 00:00:00

abstract：:Advocates bring unique and important viewpoints to the cancer research process, ensuring that scientific and medical advances are patient-centered and relevant. In this article, we discuss the benefits of engaging advocates in cancer research and underscore ways in which both the scientific and patient communities can...

journal_title：Cancer research

authors： Salamone JM,Lucas W,Brundage SB,Holloway JN,Stahl SM,Carbine NE,London M,Greenwood N,Goyes R,Chisholm DC,Price E,Carlin R,Winarsky S,Baker KB,Maues J,Shajahan-Haq AN

更新日期：2018-10-15 00:00:00

abstract：:As a specific competitive inhibitor of 5alpha-reductase, an intracellular enzyme that converts testosterone to dihydrotestosterone, finasteride is being extensively used for the treatment of benign prostatic hyperplasia and in experimental settings for prostate cancer. In this study, we showed that finasteride markedl...

journal_title：Cancer research

authors： Wang LG,Liu XM,Kreis W,Budman DR

更新日期：1997-02-15 00:00:00

abstract：:beta 1-4 N-acetylglucosaminyltransferase (GnT-III) catalyzes the formation of bisecting N-acetylglucosamine (GlcNAc) in the biosynthesis of N-linked oligosaccharides. To examine the effect of bisecting GlcNAc on the natural killer (NK) cytotoxicity, the GnT-111 gene was introduced into NK-sensitive K562 cells that hav...

journal_title：Cancer research

authors： Yoshimura M,Ihara Y,Ohnishi A,Ijuhin N,Nishiura T,Kanakura Y,Matsuzawa Y,Taniguchi N

更新日期：1996-01-15 00:00:00

abstract：:Structural and functional abnormalities in tumor blood vessels impact the delivery of oxygen and nutrients to solid tumors, resulting in chronic and cycling hypoxia. Although chronically hypoxic regions exhibit treatment resistance, more recently it has been shown that cycling hypoxic regions acquire prosurvival pathw...

journal_title：Cancer research

authors： Matsumoto S,Batra S,Saito K,Yasui H,Choudhuri R,Gadisetti C,Subramanian S,Devasahayam N,Munasinghe JP,Mitchell JB,Krishna MC

更新日期：2011-10-15 00:00:00

abstract：:Mammalian DNA polymerase beta is a DNA repair enzyme expressed constitutively at a low level. In vitro, purified DNA polymerase (Pol) beta incorporates the nucleotide analogues 2'-3' deoxycytidine (ddC)-triphosphate and 3'-azido-3'-deoxythymidine (AZT)-triphosphate into DNA, causing chain termination. We have tested t...

journal_title：Cancer research

authors： Bouayadi K,Hoffmann JS,Fons P,Tiraby M,Reynes JP,Cazaux C

更新日期：1997-01-01 00:00:00

abstract：:Identification of the molecular mechanism of action (MoA) of bioactive compounds is a crucial step for drug development but remains a challenging task despite recent advances in technology. In this study, we applied multidimensional proteomics, sensitivity correlation analysis, and transcriptomics to identify a common...

journal_title：Cancer research

authors： Peuget S,Zhu J,Sanz G,Singh M,Gaetani M,Chen X,Shi Y,Saei AA,Visnes T,Lindström MS,Rihani A,Moyano-Galceran L,Carlson JW,Hjerpe E,Joneborg U,Lehti K,Hartman J,Helleday T,Zubarev R,Selivanova G

更新日期：2020-04-01 00:00:00

abstract：:The human small cell lung cancer NCI-H69 cell line selected for resistance to etoposide (H69/VP) has been reported previously to sequentially overexpress both the MRP and MDR1 multidrug resistance-conferring genes. In addition, immunocytochemistry of H69/VP cells demonstrated a distinct extranuclear localization of th...

journal_title：Cancer research

authors： Wessel I,Jensen PB,Falck J,Mirski SE,Cole SP,Sehested M

更新日期：1997-10-15 00:00:00

abstract：:The binding of tritium-labeled 5-methylchrysene to DNA of CD-1 mouse skin 24 hr after treatment has been studied. DNA was isolated from the treated skin areas of mice and hydrolyzed enzymatically to deoxyribonucleosides, and the hydrolysate was chromatographed on a Sephadex LH-20 column using a methanol:water gradient...

journal_title：Cancer research

authors： Melikian AA,LaVoie EJ,Hecht SS,Hoffmann D

更新日期：1982-04-01 00:00:00

abstract：:The Ku70/80 autoantigens (Ku) are the DNA-binding components of a DNA-dependent protein kinase (PK) involved in DNA double strand breaks repairing a V(D)J recombination. Because apoptosis is associated with DNA fragmentation and, consequently, creation of double strand breaks, and a variety of DNA-damaging drugs kill ...

journal_title：Cancer research

authors： Kim SH,Kim D,Han JS,Jeong CS,Chung BS,Kang CD,Li GC

更新日期：1999-08-15 00:00:00

abstract：:Because of their short range and high linear energy transfer, alpha-particles may be particularly effective in the treatment of neoplastic meningitis. Monoclonal antibody 81C6 was labeled with alpha-particle-emitting 211At using N-succinimidyl3-[211At]astatobenzoate, and the efficacy and toxicity of this immunoconjuga...

journal_title：Cancer research

authors： Zalutsky MR,McLendon RE,Garg PK,Archer GE,Schuster JM,Bigner DD

更新日期：1994-09-01 00:00:00

abstract：:In this issue of Cancer Research, Xia and colleagues show that MYC-induced metabolic reprograming results in dependency on the serine-glycine-one-carbon (SGOC) metabolic pathway in neuroblastoma. This occurs through MYCN and ATF4 activation of the SGOC biosynthetic pathway in MYCN-amplified cells. Furthermore, inhibit...

journal_title：Cancer research

authors： Garcia AR,Arsenian-Henriksson M

更新日期：2019-08-01 00:00:00

abstract：:Focal adhesion kinase (FAK) functions downstream of integrins and growth factor receptors to promote tumor cell motility and invasion. In colorectal cancer, FAK is activated by amidated gastrin, a protumorigenic hormone. However, it is unclear how FAK receives signals from the gastrin receptor or other G-protein-coupl...

journal_title：Cancer research

authors： Yu HG,Nam JO,Miller NL,Tanjoni I,Walsh C,Shi L,Kim L,Chen XL,Tomar A,Lim ST,Schlaepfer DD

更新日期：2011-01-15 00:00:00

abstract：:We compared the effect of nine N-nitroso compounds, given by gavage to adult rats, on specific radioactivity of the trichloroacetic acid-precipitable liver proteins, 1 hr after the injection of [14C]leucine. The specific radioactivity was decreased by dimethylnitrosamine, diethylnitrosamine, methyl-n-butylnitrosamine,...

journal_title：Cancer research

authors： Chu C,Mirvish SS

更新日期：1977-05-01 00:00:00

abstract：:An assay has been developed and measurements of aryl hydrocarbon [benzo(a)pyrene] hydroxylase have been made in peripheral blood monocytes from a human population. Treatment with benz(a)anthracene in cell culture increased aryl hydrocarbon hydroxylase activity from 6.5 to 37-fold in monocytes from each of 25 apparentl...

journal_title：Cancer research

authors： Bast RC Jr,Okuda T,Plotkin E,Tarone R,Rapp HJ,Gelboin HV

更新日期：1976-06-01 00:00:00

abstract：:2-Methoxyestradiol (2ME(2)), a physiologic metabolite of 17beta-estradiol (estrogen), has emerged as a promising cancer therapy because of its potent growth-inhibitory and proapoptotic effects on both endothelial and tumor cells. 2ME(2) also suppresses osteoclast differentiation and induces apoptosis of mature osteocl...

journal_title：Cancer research

authors： Cicek M,Iwaniec UT,Goblirsch MJ,Vrabel A,Ruan M,Clohisy DR,Turner RR,Oursler MJ

更新日期：2007-11-01 00:00:00

abstract：:Although phosphoramide mustard (PM) is generally recognized as being the most genotoxic metabolite of cyclophosphamide (CP), the contribution of acrolein to the cytogenetic toxicity of CP is unclear. Besides covalently binding to DNA, acrolein can inactivate critical proteins necessary for replicative DNA synthesis, R...

journal_title：Cancer research

authors： Wilmer JL,Erexson GL,Kligerman AD

更新日期：1990-08-01 00:00:00

abstract：:This study shows that it is not possible to cause regression of the immunogenic SA-1 sarcoma by adoptive immunotherapy with tumor-sensitized T-cells, unless the tumor-bearing recipient is exposed to a sublethal dose of gamma-irradiation to remove a barrier that prevents adoptive immunity from being expressed. This bar...

journal_title：Cancer research

authors： Awwad M,North RJ

更新日期：1990-04-15 00:00:00

abstract：:Culture of human peripheral blood leukocytes with interleukin 2 (IL-2) stimulates their differentiation into lymphokine-activated killer (LAK) cells, with a broad range of cytotoxicity against fresh tumor cells and tumor cell lines (Grimm et al., J. Exp. Med., 155: 1823-1841, 1982). We chose to utilize a molecular app...

journal_title：Cancer research

authors： Kovacs EJ,Beckner SK,Longo DL,Varesio L,Young HA

更新日期：1989-02-15 00:00:00

abstract：:The cell surface molecules controlling apoptosis in cortical neurons are largely unknown. A monoclonal antibody was derived that induces cultured neocortical neurons to undergo apoptosis. A Fab fragment of the antibody, however, lacked the ability to induce cell death. The antigen was purified, and characterized by co...

journal_title：Cancer research

authors： Zhong LT,Manzi A,Skowronski E,Notterpek L,Fluharty AL,Faull KF,Masada I,Rabizadeh S,Varsanyi-Nagy M,Ruan Y,Oh JD,Butcher LL,Bredesen DE

更新日期：2001-08-01 00:00:00

abstract：:The expression of genes which may be involved in the regulation of human mammary epithelial cell growth [transforming growth factors alpha and beta] and tumorigenesis [c-myc, erbB2, epidermal growth factor receptor (EGFR), Ha-ras, pS2] has been compared in similarly cultured normal cell strains and tumor cell lines. W...

journal_title：Cancer research

authors： Zajchowski D,Band V,Pauzie N,Tager A,Stampfer M,Sager R

更新日期：1988-12-15 00:00:00

abstract：:Despite esophageal adenocarcinoma (EAC) being the most widespread among gastrointestinal cancers, with an 11-fold increase in the risk of cancer for patients with Barrett esophagus (BE), its prognosis is still poor. There is a critical need to better perceive the biology of cancer progression and identification of spe...

journal_title：Cancer research

authors： Urbanska AM,Ponnazhagan S,Mozafari M

更新日期：2018-07-15 00:00:00

abstract：:Poly(ADP-ribose) polymerase (PARP) inhibitors are approved for treatment of cancers with BRCA1 or BRCA2 defects. In this study, we prepared and characterized a very long-acting PARP inhibitor. Synthesis of a macromolecular prodrug of talazoparib (TLZ) was achieved by covalent conjugation to a PEG40kDa carrier via a β-...

journal_title：Cancer research

authors： Fontaine SD,Ashley GW,Houghton PJ,Kurmasheva RT,Diolaiti M,Ashworth A,Peer CJ,Nguyen R,Figg WD,Beckford-Vera DR,Santi DV

更新日期：2020-12-15 00:00:00

abstract：:Multicellular spheroids composed of transformed cells are known to mimic the growth characteristics of tumors and to develop gradients in proliferation with increasing size. This progressive accumulation of quiescent cells is presumably an active process that occurs in response to the microenvironmental stresses that ...

journal_title：Cancer research

authors： LaRue KE,Khalil M,Freyer JP

更新日期：2004-03-01 00:00:00

abstract：:After many years of productive study on the signaling networks, posttranslational regulatory control of effector molecules remains an intensely investigated and continuously evolving field of research to connect signaling with phenotypic changes. In recent years, there have been intriguing results on the interaction o...

journal_title：Cancer research

authors： Kumar R,Hung MC

更新日期：2005-04-01 00:00:00

abstract：:In this study, we examine the potential role of receptor-associated protein 80 (RAP80), a nuclear protein containing two ubiquitin-interacting motifs (UIM), in DNA damage response and double-strand break (DSB) repair. We show that following ionizing radiation and treatment with DNA-damaging agents, RAP80 translocates ...

journal_title：Cancer research

authors： Yan J,Kim YS,Yang XP,Li LP,Liao G,Xia F,Jetten AM

更新日期：2007-07-15 00:00:00