MAPK kinase 3 is a tumor suppressor with reduced copy number in breast cancer.

abstract：:The phosphatidylinositol 3' kinase/Akt pathway is frequently dysregulated in cancer, which can have unfavorable consequences in terms of cell proliferation, survival, metabolism, and migration. Increasing evidence suggests that Akt1, Akt2, and Akt3 play unique roles in breast cancer initiation and progression. We have...

journal_title：Cancer research

authors： Dillon RL,Muller WJ

更新日期：2010-06-01 00:00:00

abstract：:Recently the putative tumor suppressor gene p16INK4 was mapped to human chromosome 9p21, which is homologous to rat chromosome 5. Monosomy of rat chromosome 5 occurs with high frequency in rat kidney tumor-derived cell lines (ERC lines). Thus, we studied these lines in order to investigate the involvement of p15INK4B ...

journal_title：Cancer research

authors： Knapek DF,Serrano M,Beach D,Trono D,Walker CL

更新日期：1995-04-15 00:00:00

abstract：:Cardiotoxicity limits the use of anthracyclines which are potent anticancer agents. In the isolated rat heart, we investigated the mechanism of acute anthracycline cardiotoxicity and compared a new anthracycline, carminomycin, with daunomycin which is in established use. Daunomycin 1.75 X 10(-5) M produced a fall in c...

journal_title：Cancer research

authors： Saman S,Jacobs P,Opie LH

更新日期：1984-04-01 00:00:00

abstract：:IgG polyclonal antiserum was generated in New Zealand White rabbits immunized with a 16-mer peptide consisting of a specific amino acid sequence at residues corresponding to the sixth to seventh predicted transmembrane domain of the human reduced folate carrier (RFC). Using Western immunoblotting to examine the cytoso...

journal_title：Cancer research

authors： Trippett TM,Garcia S,Manova K,Mody R,Cohen-Gould L,Flintoff W,Bertino JR

更新日期：2001-03-01 00:00:00

abstract：:Alkaline phosphatase activity in human endometrial cancer cells of the estrogen-responsive Ishikawa line was markedly stimulated (3-20-fold in 4 days) by estrogens, 5 alpha-dihydrotestosterone, and dehydroepiandrosterone but not by testosterone, medroxyprogesterone acetate, glucocorticoids, several peptide hormones, p...

journal_title：Cancer research

authors： Holinka CF,Hata H,Kuramoto H,Gurpide E

更新日期：1986-06-01 00:00:00

abstract：:It has been proposed that occult, disseminated metastatic cells are refractory to chemotherapy due to lack of proliferation. We have shown that p38 activation induces dormancy of squamous carcinoma cells. We now show that p38 signaling in these cells activates a prosurvival mechanism via the up-regulation of the endop...

journal_title：Cancer research

authors： Ranganathan AC,Zhang L,Adam AP,Aguirre-Ghiso JA

更新日期：2006-02-01 00:00:00

abstract：:WWOX is a tumor suppressor that functions as a modular protein partner of transcription factors. WWOX contains two WW domains that mediate protein-protein interactions. In this report, we show that WWOX, via its first WW domain, specifically associates with the proline-rich motif of c-Jun proto-oncogene. Our data show...

journal_title：Cancer research

authors： Gaudio E,Palamarchuk A,Palumbo T,Trapasso F,Pekarsky Y,Croce CM,Aqeilan RI

更新日期：2006-12-15 00:00:00

abstract：:The peroxiredoxins (Prx) are conserved antioxidant proteins that use cysteine as the primary site of oxidation during the reduction of peroxides. Many organisms have more than one isoform of Prx. Deletion of TSA1, one of five Prxs in yeast Saccharomyces cerevisiae, results in accumulation of a broad spectrum of mutati...

journal_title：Cancer research

authors： Iraqui I,Faye G,Ragu S,Masurel-Heneman A,Kolodner RD,Huang ME

更新日期：2008-02-15 00:00:00

abstract：:hsa-mir-483 is located within intron 2 of the IGF2 locus. We found that the mature microRNA (miRNA) miR-483-3p is overexpressed in 100% of Wilms' tumors. In addition, colon, breast, and liver cancers exhibit high or even extremely high levels of miR-483-3p in approximately 30% of the cases. A coregulation with IGF2 mR...

journal_title：Cancer research

authors： Veronese A,Lupini L,Consiglio J,Visone R,Ferracin M,Fornari F,Zanesi N,Alder H,D'Elia G,Gramantieri L,Bolondi L,Lanza G,Querzoli P,Angioni A,Croce CM,Negrini M

更新日期：2010-04-15 00:00:00

abstract：:The RNA-binding protein PNO1 is critical for ribosome biogenesis, but its potential role in cancer remains unknown. In this study, online data mining, cDNA, and tissue microarrays indicated that PNO1 expression was higher in colorectal cancer tissue than in noncancerous tissue, and its overexpression was associated wi...

journal_title：Cancer research

authors： Shen A,Chen Y,Liu L,Huang Y,Chen H,Qi F,Lin J,Shen Z,Wu X,Wu M,Li Q,Qiu L,Yu N,Sferra TJ,Peng J

更新日期：2019-05-01 00:00:00

abstract：:Tumor antigen-induced inhibition of leukocyte adherence was adapted and modified for use in glass test tubes for the study of cell-mediated antitumor immunity to human adenocarcinoma of the breast. Peripheral blood leukocytes from 40 to 47 patients with proven breast cancer responded to an antigenic extract of breast ...

journal_title：Cancer research

authors： Grosser N,Thomson DM

更新日期：1975-09-01 00:00:00

abstract：:PTEN loss or PI3K/AKT signaling pathway activation correlates with human prostate cancer progression and metastasis. However, in preclinical murine models, deletion of Pten alone fails to mimic the significant metastatic burden that frequently accompanies the end stage of human disease. To identify additional pathway ...

journal_title：Cancer research

authors： Mulholland DJ,Kobayashi N,Ruscetti M,Zhi A,Tran LM,Huang J,Gleave M,Wu H

更新日期：2012-04-01 00:00:00

abstract：:Tumor infiltrating lymphocytes (TIL) were isolated from 22 tumors obtained from 15 patients with metastatic melanoma. In 18 of the 22 tumors, a substantial number of lymphocytes was isolated with an average lymphoid cell:tumor cell ratio of 1.26. The TIL were predominantly cytotoxic/suppressor T-lymphocytes with an av...

journal_title：Cancer research

authors： Itoh K,Tilden AB,Balch CM

更新日期：1986-06-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is characterized by therapeutic resistance for which the basis is poorly understood. Here, we report that the DNA and p53-binding protein ATDC/TRIM29, which is highly expressed in PDAC, plays a critical role in DNA damage signaling and radioresistance in pancreatic cancer cells....

journal_title：Cancer research

authors： Wang L,Yang H,Palmbos PL,Ney G,Detzler TA,Coleman D,Leflein J,Davis M,Zhang M,Tang W,Hicks JK,Helchowski CM,Prasad J,Lawrence TS,Xu L,Yu X,Canman CE,Ljungman M,Simeone DM

更新日期：2014-03-15 00:00:00

abstract：:Epidermal growth factor receptor vIII (EGFRvIII) is a tumor-specific, ligand-independent, constitutively active variant of the EGFR. Its expression has been detected in gliomas and various other human malignancies. To more fully characterize the function and potential biological role of EGFRvIII in regulating cell pro...

journal_title：Cancer research

authors： Tang CK,Gong XQ,Moscatello DK,Wong AJ,Lippman ME

更新日期：2000-06-01 00:00:00

abstract：:The antitumor effect of combined use of cis-diamminedichloroplatinum(II) (CDDP) and verapamil, a calcium influx blocker, was examined in neuroblastoma transplanted to BALB/c athymic mice. The response of the tumor to CDDP was related to the dose administered. Regression of the tumor was observed when CDDP was administ...

journal_title：Cancer research

authors： Ikeda H,Nakano G,Nagashima K,Sakamoto K,Harasawa N,Kitamura T,Nakamura T,Nagamachi Y

更新日期：1987-01-01 00:00:00

abstract：:Thirty patients with lung cancer were studied using the leukocyte migration-inhibition assay. Cryostat sections of autologous and homologous carcinoma tissues and normal lung were used as antigens. Although no inhibition of migration was seen using autologous cancer tissues, seven of 30 patients (23%) demonstrated inh...

journal_title：Cancer research

authors： Erickson AD

更新日期：1980-10-01 00:00:00

abstract：:The antitumor effects of methotrexate with 5-fluorouracil against the Sarcoma 180 mouse tumor model were found to be schedule dependent. Pretreatment of tumor-bearing animals with methotrexate significantly enhanced the antitumor activity of the combination relative to simultaneous treatment or to those with methotrex...

journal_title：Cancer research

authors： Bertino JR,Sawicki WL,Lindquist CA,Gupta VS

更新日期：1977-01-01 00:00:00

abstract：:We have recently found that human pancreatic adenocarcinomas exhibit strong immunostaining for the three mammalian transforming growth factor beta (TGF-beta) isoforms. These important growth-regulating polypeptides bind to a number of proteins, including the type I TGF-beta receptor (T beta R-I), type II TGF-beta rece...

journal_title：Cancer research

authors： Friess H,Yamanaka Y,Büchler M,Berger HG,Kobrin MS,Baldwin RL,Korc M

更新日期：1993-06-15 00:00:00

abstract：:Metastasis is the main reason for lung cancer-related mortality, but little is known about specific determinants of successful dissemination from primary tumors and metastasis initiation. Here, we show that CD133(+)/CXCR4(+) cancer-initiating cells (CIC) directly isolated from patient-derived xenografts (PDX) of non-s...

journal_title：Cancer research

authors： Bertolini G,D'Amico L,Moro M,Landoni E,Perego P,Miceli R,Gatti L,Andriani F,Wong D,Caserini R,Tortoreto M,Milione M,Ferracini R,Mariani L,Pastorino U,Roato I,Sozzi G,Roz L

更新日期：2015-09-01 00:00:00

abstract：:The expressions of albumin and alpha-fetoprotein (AFP) genes were studied in early preneoplastic liver lesions produced by the Solt-Farber protocol using "in situ" hybridization with single stranded RNA probes. In normal rat liver, albumin was expressed at a lower level in the centrilobular than in the periportal area...

journal_title：Cancer research

authors： Evarts RP,Nagy P,Marsden E,Thorgeirsson SS

更新日期：1987-10-15 00:00:00

abstract：:In a previous study, we found that the small-molecule epidermal growth factor receptor (EGFR) inhibitor gefitinib (ZD1839, Iressa) blocked cell proliferation at biologically relevant concentrations in approximately one third (6 of 17) of human bladder cancer cell lines examined. Here, we studied the effects of gefitin...

journal_title：Cancer research

authors： Shrader M,Pino MS,Lashinger L,Bar-Eli M,Adam L,Dinney CP,McConkey DJ

更新日期：2007-02-15 00:00:00

abstract：:Certain ductal carcinoma in situ (DCIS) lesions overexpress the HER-2/neu receptor at this early stage of breast cancer development. Recently, we showed that a HER-2-targeted dendritic cell vaccine could be used to eliminate HER-2-overexpressing cells in patients that harbor these high-risk DCIS lesions. Our findings ...

journal_title：Cancer research

authors： Czerniecki BJ,Roses RE,Koski GK

更新日期：2007-07-15 00:00:00

abstract：:Two principal virus-directed antigens have been identified on the surface of oncornavirus-infected chick embryo cells. One is identical with the major virus type-specific envelope antigen, which is a glycoprotein with a molecular weight of 85,000. The 2nd antigen (tumor-specific cell surface antigen) is specific for t...

journal_title：Cancer research

authors： Bauer H,Kurth R,Rohrschneider L,Gelderblom H

更新日期：1976-02-01 00:00:00

abstract：:A nationwide study of all 3183 female patients with breast cancer in Israel diagnosed over a 7-year period (1960 to 1966) was conducted. Monthly series analysis showed a clear seasonal pattern in the symptomatology of the disease most pronounced in patients younger than 55 years, in all ethnic groups, mainly confined ...

journal_title：Cancer research

authors： Cohen P,Wax Y,Modan B

更新日期：1983-02-01 00:00:00

abstract：:The identification of proteins that are preferentially expressed on the membrane of metastatic tumor cells is of fundamental importance in cancer research. Here, we report the systematic comparison of the membrane proteome of two closely related murine teratocarcinoma cell lines (F9B9 and F9DR), of which only one (F9D...

journal_title：Cancer research

authors： Roesli C,Borgia B,Schliemann C,Gunthert M,Wunderli-Allenspach H,Giavazzi R,Neri D

更新日期：2009-07-01 00:00:00

abstract：:A high-affinity localization of [2H]methylcholanthrene and/or its metabolites to a specific nuclear fraction (Fraction l) between 4 and 72 hr of exposure is described. Other carcinogenic hydrocarbons, such as benzo(a)pyrene and dibenz(a,h)anthracene, demonstrate a similar markded localization in Fraction l after 24 hr...

journal_title：Cancer research

authors： Spelsberg TC,Zytkovicz TH,Moses HL

更新日期：1977-05-01 00:00:00

abstract：:Carefully orchestrated interactions between mitochondrial proteins that facilitate cell death remain a topic of intense research, however, key steps remain to be elucidated, especially those that drive selective killing in cancer cells. How mitochondrial dysfunction and its regulation in cancer can be robustly leverag...

journal_title：Cancer research

authors： Rao VA

更新日期：2019-12-15 00:00:00

abstract：:Aberrant epidermal growth factor receptor (EGFR) signaling is a major cause of tumor progression and metastasis; the underlying mechanisms, however, are not well understood. In particular, it remains elusive whether deregulated EGFR pathway is involved in epithelial-mesenchymal transition (EMT), an early event that oc...

journal_title：Cancer research

authors： Lo HW,Hsu SC,Xia W,Cao X,Shih JY,Wei Y,Abbruzzese JL,Hortobagyi GN,Hung MC

更新日期：2007-10-01 00:00:00

abstract：:APCL, a central nervous system-specific sequence homologue of the adenomatous polyposis coli tumor suppressor, can regulate the cytoplasmic level of beta-catenin as the adenomatous polyposis coli tumor suppressor does, but its overall biological function remains unclear. Using a yeast two-hybrid system, we attempted t...

journal_title：Cancer research

authors： Nakagawa H,Koyama K,Murata Y,Morito M,Akiyama T,Nakamura Y

更新日期：2000-01-01 00:00:00