Abstract：
:Carefully orchestrated interactions between mitochondrial proteins that facilitate cell death remain a topic of intense research, however, key steps remain to be elucidated, especially those that drive selective killing in cancer cells. How mitochondrial dysfunction and its regulation in cancer can be robustly leveraged for anticancer cell killing in a heterogeneous population of cells within a tumor also remains a promising but unfulfilled premise. Toward this goal, in this issue of Cancer Research, Seo and colleagues have identified the protein complex between mitochondrial fission factor (MFF1 and MFF2) and voltage-dependent anion channel (VDAC1) as a novel regulator of mitochondrial cell death and a potential target for selective cancer cell killing.See related article by Seo et al., p. 6215.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Rao VAdoi
10.1158/0008-5472.CAN-19-3276subject
Has Abstractpub_date
2019-12-15 00:00:00pages
6074-6075issue
24eissn
0008-5472issn
1538-7445pii
79/24/6074journal_volume
79pub_type
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